|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 2 | Primary precursor B-cell lymphoblastic lymphoma of the Ovary: case report and review of the literature 显示文摘 | Sakurai N Tateokak K Taguchi J | 2008 | Gynecol Pathol2008，27，3： | 1 |
| 3 | Visualization of intracerebral arteries by synchrotron radiation microangiography显示文摘 | Myojin K Taguchi A Umetani K | 2007 | AJNR Am J Neuroradiol2007，28，： | 1 |
| 4 | Studies on the constituents of Gastrodia elata Blume显示文摘 | Taguchi H Yosioka I Yamasaki K | 1981 | Chem Pharm Bull1981，29，1： | 1 |
| 5 | Chromosomal localization of TIL,a gene encoding a protein related to the Drosophila transmembrane receptor Toll,to human chromosome 4 p14 显示文摘 | Taguchi T Mitcham J L Dower S K | 1996 | Genomics1996，32，3： | 1 |
| 6 | Dendritic cells in human squamous cell carcinoma of the oral cavity 显示文摘 | Kikuchi K Kusama K Taguchi K | 2002 | Anticancer Res2002，22，2： | 1 |
| 7 | Recombinant human interleukin-Ⅱ improved carboplatin-induce thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells显示文摘 | Saitoh M Taguchi k Momose K | 2002 | Cancer Chemother Pharmacol2002，49，2： | 1 |
| 8 | Neurophsiological and immunohistochemical studies on Guillain-Barre syndrome with IgG anti-GalNAc-GD1a antibodies-effects on neuromuscular transmission显示文摘 | Taguchi K Ren J Utsunomiya I | 2004 | Neurol Sci2004，225，12： | 1 |
| 9 | Diagnostic points and possible origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: A radiographic study of 77 mandibular osteomyelitis cases 显示文摘 | Suei Y Taguchi A Tanimoto K | 2003 | Rheumatology2003，42，11： | 1 |
| 10 | Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster显示文摘 | Taguchi A Yanagisawa K Tanaka M | 2008 | Cancer Res2008，68，14： | 1 |
| 11 | Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt/eNOS pathway显示文摘 | Taguchi K Hida M Hasegawa M | 2016 | Mol Nutr Food Res2016，60，3： | 1 |
| 12 | Image quality assessment of an iterative reconstruction algorithm applied to abdominal CT ima- ging显示文摘 | Funama Y Taguchi K Utsunomiya D | 2014 | Phys Med2014，30，： | 1 |
| 13 | Visual assessment of the mandibular cortex on panoramic radiographs to identify postmenopausal women with low bone mineral densities 显示文摘 | Lee K Taguchi A Ishii K | 2005 | Oral Surg Oral Medi Oral Path Oral Radiol Endod2005，100，2： | 1 |
| 14 | Optical trapping of dielectric particle and biological cell using optical fiber显示文摘 | TAGUCHI K UENO H HIRAMATSU T | 1997 | Electronics Letters1997，33，5： | 1 |
| 15 | Impairment of PI3K/AKT pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model显示文摘 | Kobayashi T Taguchi K Yasuhiro T | 2004 | Hypertension2004，44，6： | 1 |
| 16 | Auxiliary partial orthotopic living donor liver transplantation for a child with congenital absence of the portal vein显示文摘 | Soejima Y Taguchi T Ogita K | 2006 | Liver Transpl2006，12，5： | 1 |
| 17 | Use of soluble filters for preconcentration of trace elements in water显示文摘 | GOTO K TAGUCHI S | 1993 | Anal Sci1993，9，1： | 1 |
| 18 | Chromosomal localization of TIL,a gene encoding a protein related to the drosophila transmembrane receptor Toll,to human chromosome 4p14显示文摘 | Taguchi T Mitcham J L Dower S K | 1996 | Genomics1996，32，3： | 1 |
| 19 | Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats 显示文摘 | Tei K Kawakami - Kimura N Taguchi O | 2002 | Cancer research2002，62，21： | 1 |
| 20 | Enhanced expression of thrombospondin - 1 and hypovascularity in human cholangiocarcinoma显示文摘 | Kawahara N Ono M Taguchi K | 1998 | Hepatology1998，28，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员