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| 1 | Scalable synthesis of nanoporous silicon microparticles for highly cyclable lithium-ion batteries显示文摘Nanoporous silicon is a promising anode material for high energy density batteries due to its high cycling stability and high tap density compared to other nanostructured anode materials.However,the high cost of synthesis and low yield of nanoporous silicon limit its practical application.Here,we develop a scalable,low-cost top-down process of controlled oxidation of Mg2Si in the air,followed by HCl removal of MgO to generate nanoporous silicon without the use of HF.By controlling the synthesis conditions,the oxygen content,grain size and yield of the porous silicon are simultaneously optimized from commercial standpoints.In situ environmental transmission electron microscopy reveals the reaction mechanism;the Mg2Si microparticle reacts with O2 to form MgO and Si,while preventing SiO2 formation.Owing to the low oxygen content and microscale secondary structure,the nanoporous silicon delivers a higher initial reversible capacity and initial Coulombic efficiency compared to commercial Si nanoparticles(3,033 mAh/g vs.2,418 mAh/g,84.3%vs.73.1%).Synthesis is highly scalable,and a yield of 90.4%is achieved for the porous Si nanostructure with the capability to make an excess of 10 g per batch.Our synthetic nanoporous silicon is promising for practical applications in next generation lithium-ion batteries. | Jiangyan Wang William Huang Yong Seok Kim You Kyeong Jeong Sang Cheol Kim Jeffrey Heo Hiang Kwee Lee Bofei Liu Jaehou Nah Yi Cui | 2020 | Nano Research2020,13,6: | 9 |
| 2 | Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification显示文摘Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement. | Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam Puay Hoon Tan Min-Han Tan | 2011 | Chinese Journal of Cancer2011,30,2: | 6 |
| 3 | Clinical applications, limitations and future role of transient elastography in the management of liver disease显示文摘Transient elastography(TE) is a reliable tool for the non-invasive assessment of liver fibrosis in routine clinical practice. TE is currently approved for use in Europe, Asia and the United States. The widespread adoption of this technology is certain to increase the use of TE worldwide. Although TE has been well validated in chronic viral hepatitis, its clinical role in other liver diseases remains less clear. The advent of new treatment for chronic hepatitis C and emerging prevalence of non-alcoholic steatohepatitis raises new questions on the role of TE in current clinical practice. This review aims to examine the clinical applications, limitations and future role of TE in current clinical practice in light of the changing epidemiology of liver diseases and new clinical management paradigms. In current clinical practice, TE is the most accurate noninvasive method for diagnosis of liver cirrhosis. TE is useful to rule out fibrosis and cirrhosis but does not have sufficient accuracy to discern between various stages of fibrosis. The clinical role of TE has evolved from cross-sectional point-in-time assessment of fibrosis and cirrhosis to the more relevant role of prediction of vital clinical end-points. This provides clinicians with the ability to modify treatment strategies based on the information provided by TE. TE has evolved over the past decade to become an essential tool to assist the clinician in the management of chronic liver disease. | Pik Eu Chang George Boon-Bee Goh Jing Hieng Ngu Hiang Keat Tan Chee Kiat Tan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016,7,1: | 5 |
| 4 | Change in model for end-stage liver disease score at two weeks,as an indicator of mortality or liver transplantation at 60 days in acute-on-chronic liver failure显示文摘Background:Acute-on-chronic liver failure(ACLF)is characterised by a sudden deterioration of underlying chronic liver disease,resulting in increased rates of mortality and liver transplantation.Early prognostication can benefit optimal allocation of resources.Methods:ACLF was defined as per the disease criteria of the Asian Pacific Association for the Study of the Liver.Inpatient discharge summaries from between January 2001 and April 2013 were reviewed.The primary outcome was mortality or liver transplantation within 60 days from onset of ACLF.Absolute‘model for end-stage liver disease’(MELD)score and change in MELD at Weeks 1,2 and 4 were reviewed in order to identify the earliest point for prediction of mortality or liver transplantation.Results:Clinical data were collected on 53 subjects who fulfilled the inclusion and exclusion criteria.At 60 days from presentation,20 patients(37.7%)died and 4(7.5%)underwent liver transplantation.Increased MELD of-2 after 2 weeks was 75.0%sensitive and 75.9%specific for predicting mortality or liver transplantation.If the MELD score did not increase at 2 weeks,predictive chance of survival was 93.8%over the next 60 days.MELD change at 1 week showed poor sensitivity and specificity.Change at 4 weeks was too late for intervention.Conclusion:Change in MELD score at 2 weeks provides an early opportunity for prognostication in ACLF.A MELD score that does not deteriorate by Week 2 would predict 93.8%chance of survival for the next 60 days.This finding warrants further validation in larger cohort studies. | Rajneesh Kumar Thinesh Lee Krishnamoorthy Hiang Keat Tan Hock Foong Lui Wan Cheng Chow | 2015 | Gastroenterology Report2015,3,2: | 2 |
| 5 | Passive harmonic mode locking of gain-guided solitons in erbium-doped fiber lasers显示文摘We report the experimental observation of passive harmonic mode locking of gain-guided solitons in erbium-doped fiber lasers either made of purely normal dispersion fibers or operating in the net normal cavity dispersion regime. Harmonic-2 and harmonic-3 mode locking states of the gain-guided solitons with supermode suppression larger than 35 dB have been obtained. | ZHAO LuMing TANG DingYuan CHENG Tee Hiang TAM Hwa-Yaw LU Chao | 2008 | Chinese Science Bulletin2008,53,5: | 2 |
| 6 | Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease显示文摘 | Cheng Hiang Lee Peter Hsu Brigitte Nanan Ralph Nanan Melanie Wong Kevin J. Gaskin Rupert W. Leong Ryan Murchie Aleixo M. Muise Michael O. Stormon | 2014 | Journal of Crohn’s and Colitis2014,,: | 2 |
| 7 | : Matrix fracture strength in bonded brittle composites 显示文摘 | YIH-CHERNG C HIANG | 2006 | J MATER SCI2006,41,: | 1 |
| 8 | Inband crosstalk analysis of optical cross-connect architecture显示文摘 | Teck Yoong Chai Tee Hiang Cheng | 2005 | IEEE J Lightwave Technol2005,23,2: | 1 |
| 9 | Crosstalk analysis for limitedwavelength-interchanging cross connects显示文摘 | Teck Yoong Chai Tee Hiang Cheng | 2002 | IEEE Photon Technol Lett2002,14,5: | 1 |
| 10 | Micro powder injection moulding of alumina micro-channel part 显示文摘 | JUNHU MENG NGIAP HIANG LOHA GANG FU | 2011 | Journal of the European Ceramic Society2011,,31: | 1 |
| 11 | Long-Term Co-Memories and Short-Run Adjustment: Securitized Real Estate and Stock Markets显示文摘 | Kim Hiang Liow Haishan Yang | 2005 | The Journal of Real Estate Finance and Economics2005,,3: | 1 |
| 12 | A Power-Line Conditioner Based on Flying Capacitor Multilevel Voltage-Source Converter with Phase Shift SPWM显示文摘 | hiang Yiqiao Nwankpa C O | 2000 | IEEE Transactions on Industry Applications2000,36,96: | 1 |
| 13 | Replication and characterization of 316L stainless steel micro mixer by micro powder injection molding显示文摘 | JUNHU MENG NGIAP HIANG LOHA GANG FU | 2010 | Journal of Alloys and Compounds2010,,496: | 1 |
| 14 | A Study of the Impacts of Service Quality on Relationship Quality in Search-Experience- Credence Services 显示文摘 | Hsieh Y C Hiang S T | 2004 | Total Quality Management & Business Excellence2004,15,1: | 1 |
| 15 | Exhaled Breath Analysis: Novel Approach for Early Detection of Lung Cancer 显示文摘 | Hiang P C Craig L Paul S | 2009 | Lung Cancer2009,63,2: | 1 |
| 16 | Array interconnection for Rearrangeable 2-D MEMS optical switch显示文摘 | Teck Yoong Chai Tee Hiang Cheng Sanjay K Bose | 2003 | Journal of Lightwave Technology2003,21,5: | 1 |
| 17 | Operation of WDM Networks with Different Wavelength Conversion Capability显示文摘 | Shen Gangxiang Bose S K Cheng Tee Hiang | 2000 | Communications Letters IEEE2000,4,7: | 1 |
| 18 | Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth显示文摘 | RUAN Weimei HIANG A H L HUANG L G | 2014 | Natural Product Research:Formerly Natural Product Letters2014,28,24: | 1 |
| 19 | Dynamic Relationship between Stock and Property Markets 显示文摘 | Kim Hiang Liow | 2006 | Applied Financial Economics2006,16,5: | 1 |
| 20 | Changes in sea level, water salinity and wetland halitat linked to the late agricultural development in the Pearl River delta plain of China 显示文摘 | ZONG Y ZHENG Z HUANG K SUN Y WANG N TANG M HIANG G | 2013 | Quaternmy Science Reviews2013,70,: | 1 |