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| 1 | 陆地棉种子发育过程中microRNA的挖掘与功能研究显示文摘microRNAs(miRNAs)广泛参与调控植物的生长和发育,但这类分子是否对棉花胚珠和纤维的生长发育起到重要的作用,还有待验证。对这些小分子的认识,一般先要从序列信息的获得上开始。应用基因芯片对TM-1+5 DPA(开花后5 d)胚珠总RNA进行了miRNA的筛选研究。结果显示,含有352个探针的芯片成功钓取到199个陆地棉miRNA,其中绝大多数为首次报道。此外,对miR399研究发现,它与纤维中磷的含量变化相关;miR169可能与干旱应激反应有关。 | Wang Gaskin 余道乾 杜雄明 | 2014 | 棉花学报2014，26，1： | 6 |
| 2 | Circadian clock gene expression regulates cancer cell growth through glutaminase显示文摘夫酸安是为恶意的肿瘤房间的必要氨基酸。使夫酸安产生代射变化的 Glutaminase 到达肿瘤立即在最大的增长前评估的最大的 expressionin。肿瘤房间在日子期间以不同的率成长。我们 postulatedthat 在肿瘤房间的 glutaminase 的活动服从于生理节奏的钟基因的规定。我们测量了由在在六 equispaced 时间的肝和 tumorcells 的即时聚合酶链反应的西方的污点分析和生理节奏的钟基因表示削尖的 glutaminaseby 在一张 12/12 h 光 / 黑暗时间表的单个鼠标今日。结果显示出 thatthe 忍受肿瘤的鼠标,在正常下面日报条件,生理节奏地被乘火车,由正常主机 locomotoractivity 节奏和有韵律的肝钟基因表示思考了。在这些老鼠以内的肿瘤生理节奏地也被组织,由生理节奏的钟基因(Bmal1 ) 的 asreflected 表示。是很显著的的,是肾类型 glutaminase 也在一样的模式 withtumor 显示出生理节奏的节奏在肝癌症异种皮移植模型的生理节奏的钟基因表示,有条件地显示那禁止 glutaminaseactivity 可以为癌症提供一个新目标治疗。 | Aixia Huang Bingbo Bao H Rex Gaskins Haijun Liu Xueli Zhang Liwen Lu Shan Gao Yihai Shi Ming Zhang Yuanzhou Shan Jing Feng Guoxiang Yao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 3 |
| 3 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 4 | Identification and Characterization of Cotton Genes Involved in Fuzz-Fiber Development显示文摘棉花微毛纤维象 Arabidopsis 毛状体一样,是伸长的 unicells。GLABRA1 (GL1 ) 的 transcriptional 建筑群, GLABRA3 (GL3 ) ,和透明 TESTAGLABRA1 (TTG1 ) 可能在在在酵母由他们的物理相互作用证实了的 Arabidopsis 的存在,这被要求,并且建筑群调整控制毛状体房间区别的 GLABRA2 (GL2 ) 的表示;TRIPTYCHON (尝试) 和突变(CPC ) 在附近的房间抵抗复杂形成,这也被假定。这里,相当或相同的事物 GaMYB23 (GL1 的一个相当或相同的事物) , GaDEL65 (GL3 的一个相当或相同的事物) , GaTTG1, GaCPC 和 GaTRY 在 Gossypium arboreum 被识别。我们证明那 GaMYB23 能绑在并且激活 GaCPC, GaGL2 和 GaTRY 的倡导者,并且那 GaMYB23, GaTRY 和 GaTTG1 能在酵母并且在 planta 与 GaDEL65 交往。在分析显示出的 situ,那 GaMYB23, GaGL2, GaDEL65,和 GaTRY 主要在蛋白质首先在不发达的表皮的房间被发现的微毛纤维,而是 GaTRY 被表示。G。有一致地高级的 GaMYB23 抄本的无微毛的异种失去了的 arboreum GaGL2 建筑群的可检测的 GaMYB23 倡导者,相应于 GaGL2 的严厉地减少的抄写。我们到调整 Arabidopsis 毛状体区别的基因分子的棉花相当或相同的事物在小卵和冗余的 GaMYB23 的外皮交往了的结果支持在微毛纤维 patterning 用作一个否定管理者。 | Gaskin Wang Guo-Hong Zhao Yin-Hua Jia Xiong-Ming Du | 2013 | Journal of Integrative Plant Biology2013，55，7： | 3 |
| 5 | Measurement of Soil Water Content Using a Simplified Impedance Measuring Technique显示文摘 | G.J. Gaskin J.D. Miller | 1996 | Journal of Agricultural Engineering Research1996，，2： | 2 |
| 6 | Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease显示文摘 | Cheng Hiang Lee Peter Hsu Brigitte Nanan Ralph Nanan Melanie Wong Kevin J. Gaskin Rupert W. Leong Ryan Murchie Aleixo M. Muise Michael O. Stormon | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 7 | NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse显示文摘 | Hamaguchi K Gaskins HR Leiter EH | 2001 | Diabetes2001，40，7： | 1 |
| 8 | Fuzzy cost recovery in planning for sustainable water supply systems in developing countries显示文摘 | VIRJEE K GASKIN S | 2005 | Energy2005，30，8： | 1 |
| 9 | Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells显示文摘 | Deplancke B Gaskins HR | 2003 | FASEB J2003，17，： | 1 |
| 10 | Ef/ects of low-temperature pyrolysis conditions on biochar for agricultural use显示文摘 | Gaskin J W Steincr C Harris K | 2008 | Transactions of the ASABE2008，51，6： | 1 |
| 11 | Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis 显示文摘 | Jayne DR Gaskin G Rasmussen N | 2007 | J Am Soc Nephrol2007，18，7： | 1 |
| 12 | Dietary folate and re-productive success among women undergoing assisted reproduc- tion 显示文摘 | Gaskins AJ Afeiche MC Wright DL | 2014 | Obstet Gyneco12014，124，4： | 1 |
| 13 | Effect of low- temperature pyrolysis conditions in biochar agricultural use 显示文摘 | GASKIN J W STEINER C HARRIS K | 2008 | Fransaetions of the Asabe2008，51，6： | 1 |
| 14 | Enrollment of African Americans onto clinical treatment trials:study design barriers 显示文摘 | Adams-Campbell LL Ahaghotu C Gaskins M | 2004 | J Clin Oncol2004，22，4： | 1 |
| 15 | Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis显示文摘 | Jayne DR Gaskin G Rasmussen N | 2007 | J Am Soc Nephrol2007，18，7： | 1 |
| 16 | Chronic upper re spiratory tract disease of free-ranging desert tortoises(Xerobates agassizii)显示文摘 | Jacobson E R Gaskin J M Brown M B | 1990 | J Wildl Dis1990，27，： | 1 |
| 17 | The nonobese diabetic SCID mouse: model for spontaneous thymomagenesis associated with immunodeficiency显示文摘 | Prochazka M Gaskins H R Shultz L D | 1992 | Proc Natl Acad Sci U S A1992，89，8： | 1 |
| 18 | The intestinal immune system:Gut reac- tion and growth of the pig显示文摘 | Gaskins HR | 1996 | Journal of Animal Science1996，74，1： | 1 |
| 19 | Dietary fructooli-gosaccharide modulates large intestinalinflammatory responses to clostridium difficilein antibiotic-compromised mice 显示文摘 | Gaskins H R Mackie R I May T Garleb K A | 1996 | Microb Eeol Health Dis1996，9，： | 1 |
| 20 | From toxicological problem to therapeutic use: the discovery of the mode of actionof 2-( 2-nitro-4-trifluoromethylbenzoyl )-1, 3- cyclohexanedione (NTBC) , its toxicology and development as a drug显示文摘 | Lock EA Ellis MK Gaskin P | 1998 | J Inherit Metab Dis1998，21，5： | 1 |
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