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| 1 | Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome/maturity onset diabetes of the young type 5显示文摘在那里的目的是出版工作的少量系统地与肾的包囊和年轻类型的糖尿病症候群(RCAD )/maturity 发作糖尿病评估基因异例或病人的临床的特征 5 (MODY5 ) 。这评论的目的是系统地估计察觉率,基因并且异质接合的正染色体的主导的 TCF2 anomalies.Data 来源 MEDLINE 数据库的 phenotypic 含意被寻找选择从 1997 ~ 2008 用英语记录的文章。焦点是 monoallelic germline TCF2 基因变化 / 删除。 Biallelic inactivation ,多型性, DNA 修正( hypomethylation 和 hypermethylation ),与癌症风险联系的 loci ,和体的 TCF2 异例都是在寻找文学以后的 excluded.Study 选择, 50 篇文章是 TCF2 异例的察觉率是的 selected.Results 9.7%并且在 MODY (1.4%)之中更加变化了,肾的结构异例( RSA )(21.4%)和有 MODY (41.2%)亚群的 RSA 。变化惊人地位于 DNA 有约束力的域以内并且在 DNA 有约束力的域的 exons 之中变化了:exons 2 和 4 是最热的点,当变化在 exon 是偶发地分布式的时 3。一致显型是 RSA (89.6%) 和糖尿病 mellitus (DM )(45.0%) 。然而, RSA 和 DM 的同时发生是相对低的(27.5%) ,它妨碍基因测试和及时诊断的获得的最佳的表演。另外的机关参与为有 TCF2 异例的病人的早鉴定补足、必要。TCF2 点变化的显型的分析根据变化类型然而并非 utation location.Conclusion 处于 RSA,损害肾的功能(IRF ) 和 DM 的察觉率显示出重要差别以前没收到足够的注意的 TCF2 异例的这些珍贵特征不应该被忽视。 | CHEN Yi-zhi GAO Qing ZHAO Xue-zhi CHEN Ying-zhang Craig L Bennett XIONG Xi-shan MEI Chang-lin SHI Yong-quan CHEN Xiang-mei | 2010 | Chinese Medical Journal2010，，22： | 21 |
| 2 | Management of distal humeral coronal shear fractures显示文摘Coronal shear fractures of the distal humerus are rare,complex fractures that can be technically challenging to manage. They usually result from a low-energy fall and direct compression of the distal humerus by the radial head in a hyper-extended or semi-flexed elbow or from spontaneous reduction of a posterolateral subluxation or dislocation. Due to the small number of soft tissue attachments at this site, almost all of these fractures are displaced. The incidence of distal humeral coronal shear fractures is higher among women because of the higher rate of osteoporosis in women and the difference in carrying angle between men and women. Distal humeral coronal shear fractures may occur in isolation, may be part of a complex elbow injury, or may be associated with injuries proximal or distal to the elbow. An associated lateral collateral ligament injury is seen in up to 40% and an associated radial head fracture is seen in up to 30% of these fractures. Given the complex nature of distal humeral coronal shear fractures, there is preference for operative management. Operative fixation leads to stable anatomic reduction, restores articular congruity, and allows initiation of early range-of-motion movements in the majority of cases. Several surgical exposure and fixation techniques are available to reconstruct the articular surface fol owing distal humeral coronal shear fractures. The lateral extensile approach and fixation with countersunk headless compression screws placed in an anterior-to-posterior fashion are commonly used. We have found a two-incision approach(direct anterior and lateral) that results in less soft tissue dissection and better outcomes than the lateral extensile approach in our experience. Stiffness, pain, articular incongruity, arthritis, and ulnohumeral instability may result if reduction is non-anatomic or if fixation fails. | Shahram S Yari Nathan L Bowers Miguel A Craig Lee M Reichel | 2015 | World Journal of Clinical Cases2015，3，5： | 15 |
| 3 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 4 | Epidemiological investigation of infectious hematopoietic necrosis virus in salt water net-pen reared Atlantic salmon in British Columbia, Canada显示文摘 | Sophie St-Hilaire Carl S Ribble Craig Stephen Eric Anderson Gael Kurath Michael L Kent | 2002 | Aquaculture2002，，1： | 2 |
| 5 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 6 | Surgical management of osteonecrosis of the femoral head in patients with sickle cell disease显示文摘Sickle cell disease is a known risk factor for osteonecrosis of the hip.Necrosis within the femoral head may cause severe pain,functional limitations,and compromise quality of life in this patient population.Early stages of avascular necrosis of the hip may be managed surgically with core decompression with or without autologous bone grafting.Total hip arthroplasty is the mainstay of treatment of advanced stages of the disease in patients who have intractable pain and are medically fit to undergo the procedure.The management of hip pathology in sickle cell disease presents numerous medical and surgical challenges,and the careful perioperative management of patients is mandatory.Although there is an increased risk of medical and surgical complications in patients with sickle cell disease,total hip arthroplasty can provide substantial relief of pain and improvement of function in the appropriately selected patient. | Atul F Kamath Michael H McGraw Craig L Israelite | 2015 | World Journal of Orthopedics2015，6，10： | 2 |
| 7 | A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction显示文摘早熟的出生的率是惊人的并且威胁社会和世界范围的保健系统。早产在超过 50% 盒子导致早熟的出生。Preterm 出生说明婴儿病态和死亡的 three-quarters。在 34 星期怀孕期前熬过出生的孩子经常面对终生的残疾。为劳动正在想要的 preterm 的当前的处理。没有处理被发现了通常有效,任何一个都系统地没在 48 h 以外被评估。preterm 劳动的处理的新途径绝望地被需要。从我们的实验室的最近的研究建议子宫的肌肉是有不同于另外的光滑的肌肉的子宫的松驰的规定的唯一的分隔空间。这里,我们讨论最近的证据机械地激活的 2 毛孔钾隧道, TREK-1,可以贡献在子宫的光滑的肌肉和变体与人的劳动联系了的那 TREK-1 基因发信号的收缩松驰, preterm 劳动可以导致 preterm 劳动和它的可能的预防的更好的理解。 | Iain L O BUXTON Nathanael HEYMAN Yi-ying WU Scott BARNETT Craig ULRICH | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 8 | Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia显示文摘ObjectiveTo 在在检验生活和资源使用的质量的 17 所澳大利亚的疗养院的代表性的研究的 Australia.MethodsAs 部分住在疗养院的更老的成年人与认知功能和痴呆的诊断检验在心血管的系统药使用之间的协会,我们检验了在认知缺陷和心血管的药使用之间的协会(使用解剖治疗学的分类系统识别)用一般线性回归和逻辑 regressio 正在收到生活照顾的结束的人是包括的 excluded.ResultsParticipants 有一个平均数的 541 个居民 85.5 | Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty | 2017 | Journal of Geriatric Cardiology2017，14，6： | 2 |
| 9 | Reflective Tomography Images from Range-resolved Laser Radar Measurements 显示文摘 | PARKER J K CRAIG E B KLICK D L el al | 1988 | Applied Optics1988，27，13： | 1 |
| 10 | Vicilin with carbory-terminal KDEL is retained in the endoplasmic reticulum and accumulates to high levels in the leaves of transgenic plants显示文摘 | Wandelt C L Khan M R I Craig S | 1992 | Plant J1992，，2： | 1 |
| 11 | Lymphocyte Responses Following Open and Minimally Invasive Thoracic Surgery显示文摘 | Leaver H A Craig S R Yap P L | 2000 | Eur J Clin Investi2000，30，3： | 1 |
| 12 | Evaluation of the potential of FTIR and chemometrics for separation between defective and non-defective coffees 显示文摘 | Craig P A Franca S A Oliveira S L | 2012 | Food Chemistry2012，132，3： | 1 |
| 13 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 14 | 查看详情显示文摘 | Hof F Craig S L Nuckolls C Rebek J Jr | | 0，，： | 1 |
| 15 | Anti-Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis显示文摘 | Craig L Robert M Claus Z | 2012 | N Engl J Med2012，366，： | 1 |
| 16 | Three-tesla imaging of the knee:initial experience显示文摘 | Craig JG Go L Blechinger J | 2005 | Skeletal Radiol2005，34，8： | 1 |
| 17 | Acute phase responses following minimal access and conventional thoracic surgery显示文摘 | Craig S R Leaver H A Yap P L | 2001 | European Journal of Cardio-Thoracic Surgery2001，20，3： | 1 |
| 18 | Effects of short- term eelecoxib treatment in patients with invasive ransitional cell carcinoma of the urinary bladder 显示文摘 | DHAWA ND CRAIG BA CHENG L | 2010 | Mol Cancer Ther2010，9，： | 1 |
| 19 | Vasopressin: a new target for the treatment of heart failure显示文摘 | Craig R Lee Michael L Watkins J.Herbert Patterson Wendy Gattis Christopher M O'Connor Mihai Gheorghiade Kirkwood F Adams | 2003 | American Heart Journal2003，，1： | 1 |
| 20 | Selected themes in the literature on memory and their pertinence to archives显示文摘 | Craig B L | 2002 | American Archivist2002，，65： | 1 |
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