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| 1 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 2 | Thermohydraulics of Turbulent Flow Through Heat Exchanger Tubes Fitted with Circular-rings and Twisted Tapes显示文摘circular-ring turbulators (CRT ) 和扭曲的磁带(TT ) 的影响打漩在一个圆试管的热转移改进,压力落下和热表演因素特征上的发电机被报导。circular-ring turbulators 个别地被采用并且和扭曲的磁带打漩在试管的激烈的节的发电机。三不同沥青比率(l/D = 1.0, 1.5,和 2.0 ) CRT 和三不同扭曲比率(y/W = 3, 4,和 5 ) TT 被介绍。实验在一个一致的墙热流动条件下面作为工作液体用空气被进行,为在 6000 和 20000 之间的雷纳兹数字。试验性的结果表明热转移率,磨擦因素和联合 CRT 和 TT 的热表演因素独自比 CRT 的那些更加高。为检验的范围,在与联合设备装备的试管,分别地,吝啬的 Nusselt 数字,磨擦因素和热性能的增加在在试管的那些上是 25.8% , 82.8% 和 6.3% 与 CRT 独自一个。1.42 的最高热的表演因素被作出对有利的裁决与 l/D = 由 CRT 组成的联合设备 1.0 并且有 y/W = 的 TT 3。Nusselt 数字,磨擦因素和有联合设备的试管的热表演因素的关联也以雷纳兹数字, Prandtl 数字,扭曲比率和沥青比率被开发。 | Smith Eiamsa-ard Vichan Kongkaitpaiboon Kwanchai Nanan | 2013 | Chinese Journal of Chemical Engineering2013，21，6： | 6 |
| 3 | A brief review of equatorial ionization anomaly and ionospheric irregularities显示文摘Following a brief history and progress of ionospheric research, this paper presents a brief review of the recent developments in the understanding of two major phenomena in low and mid latitude ionosphere—the equatorial ionization anomaly(EIA) and involved equatorial plasma fountain(EPF) and ionospheric irregularities. Unlike the easy-to-understand misinterpretations, the EPF involves field perpendicular E×B plasma drift and field-aligned plasma diffusion acting together and plasma flowing in the direction of the resultant at all points along the field lines at all altitudes. The EIA is formed mainly from the removal of plasma from around the equator by the upward E×B drift creating the trough and consequently the crests with small accumulation of plasma at the crests when the crests are within ~±20° magnetic latitudes and no accumulation when they are beyond ~±25° magnetic latitudes. The strong EIA under magnetically active conditions arises from the simultaneous impulsive action of eastward prompt penetration electric field and equatorward neutral wind. Intense ionospheric irregularities develop in the post-sunset bottom-side equatorial ionosphere when it rises to high altitudes, and evolve nonlinearly into the topside. Pre-reversal enhancement(PRE) of the vertical upward E×B drift and its fluctuations amplified during PRE provide the driving force and seed, with neutral wind and gravity waves being the primary sources. At low solar activity especially in summer when fast varying PRE is absent, the slow varying gravity waves including large scale waves(LSW)seem to act as both driver and seed for weak irregularities. At mid latitudes, the irregularities are weak and associated with medium scale traveling ionospheric disturbances(MSTIDs). A low latitude minimum in the occurrence of the irregularities at March equinox predicted by theoretical models is identified. The minimum occurs on the poleward side of the EIA crest and shifts equatorward from ~25° magnetic latitudes at high solar activity to below 17° at low solar activity. | Nanan Balan LiBo Liu HuiJun Le | 2018 | Earth and Planetary Physics2018，2，4： | 3 |
| 4 | Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease显示文摘 | Cheng Hiang Lee Peter Hsu Brigitte Nanan Ralph Nanan Melanie Wong Kevin J. Gaskin Rupert W. Leong Ryan Murchie Aleixo M. Muise Michael O. Stormon | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 5 | Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor:2 -methyl -6 -(phenylethynyl) -pyridine (MPEP),and (E)-6-methyl-2-styryl-pyridine (SIB 1893)显示文摘 | Chapman AG Nanan K Williams M | 2000 | Neuropharmacology2000，39，9： | 1 |
| 6 | Forced convective heat transfer by swirling impinging jets issuing from nozzles equipped with twisted tapes显示文摘 | Nanan K Wongcharee K Nuntadusit C | 2012 | International Communications in Heat and Mass Transfer2012，39，6： | 1 |
| 7 | Expression of in- terleukin(IL) -2 and IL- 7 receptors discriminates between human regulatory and activated T cell 显示文摘 | Seddiki N Santner- Nanan B Martinson J | 2006 | J Exp Med2006，20，3： | 1 |
| 8 | Retrovirus - mediated expression of E2A - PBX1 blocks lymphoid fate but permits retention of myeloid potential in early hemato- poietic progenitors显示文摘 | Wooderoft MW Nanan K Thompson P | 2015 | PLoS One2015，10，13： | 1 |
| 9 | Forced convective heat transfer by swirling im- pinging jets issuing from nozzles equipped with twis- ted tapes显示文摘 | NANAN K WONGCHAREE K NUNTADUSIT C | 2012 | International Communications in Heat and Mass Transfer2012，39，： | 1 |
| 10 | Novel de novo mutations of the interleukin-10 receptor gene Lead to infantile onset inflammatory bowel disease显示文摘 | Lee CH Hsu P Nanan B | 2014 | J Crohns Colitis2014，8，11： | 1 |
| 11 | A Two-step Synthesis of Broadband Ridged Waveguide Bandpass Filters with Improved Performances显示文摘 | Nanan J C Tao J W Baudrand H | 1991 | IEEE Trans on Microwave Theory Tech1991，39，12： | 1 |
| 12 | Heat Transfer Augmentation by Helically Twisted Tapes as Swirl and Turbulence Promoters显示文摘 | Eiamsa-ard S Yongsiri K Nanan K | 2012 | Chem Eng Process2012，60，： | 1 |
| 13 | Yeast autolysate bait sprays for control of Queenland fruit fly on passionfruit in Queensland 显示文摘 | SMITH D NANAN L | 1988 | Queensland Journal of Agicultural and Animal Sciences1988，45，2： | 1 |
| 14 | Anticonvulsant activity of two metabotropic glutamate group Ⅰ antagonists selective for the mGlu5 receptor:2-methyl-6-(phenylethynyl)-pyridine (MPEP),and(E)-6-methyl-2-styryl-pyridine (SIB 1893)显示文摘 | Nanan K Williams M | 2000 | Neuropharmacology2000，39，9： | 1 |
| 15 | Heat transfer augmentation by helically twisted tapes as swirl and turbulence promoters显示文摘 | S. Eiamsa-ard K. Yongsiri K. Nanan C. Thianpong | 2012 | Chemical Engineering & Processing: Process Intensification2012，，： | 1 |
| 16 | 私营企业发展中存在的问题及对策──九部分私营企业的调查报告显示文摘通过对南岸区部分私营企业发展状况的调查,指出了制约私营企业发展的一些问题,并提出了解决问题的相应对策。 | Research Group (Nanan District Committee of Jiusan Academic Organization, Chongqing 400060, China) | 2000 | 重庆商学院学报2000，，6： | 1 |
| 17 | Expression of interleukin IL -2 and IL-7 receptors discriminates between human regulatory and activated T cells显示文摘 | Seddiki N Santner - Nanan B Martinson J | 2006 | J ExpMed2006，203，： | 1 |
| 18 | Therapeutic potential of stem cells in perinatal medicine 显示文摘 | Santner- Nanan B Peek M J McCullagh P | 2005 | Aust N Z J Obstet Gynaecol2005，45，2： | 1 |
| 19 | Arterial and ductus venosus Doppler in fetuses with absent or reverse end-diastolic flow in the umbilical artery:longitudinal analysis显示文摘 | Muller T Nanan R Rehn M | 2003 | Fetal Diagn Ther2003，18，3： | 1 |
| 20 | Anticonvulsant activity of two metabotropic glutamate group Ⅰ antagonists selective for the mGlu5 receptor: 2 -methyl -6 -(phenylethynyl) -pyridine(MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)显示文摘 | Chapman AG Nanan K Williams M | 2000 | Neuropharmacology2000，1039，9： | 1 |
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