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| 1 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 2 | Motilin and the interdigestive migrating motor complex in man显示文摘 | Dr. G. Vantrappen MD Agg HO J. Janssens MD Agg HO T. L. Peeters PhD S. R. Bloom MA MB MRCP N. D. Christofides BSc J. Hellemans MD Agg HO | 1979 | Digestive Diseases and Sciences1979，，7： | 2 |
| 3 | Microsatellites and their genomic distribution, evolution, function and applications: A review with special reference to fish genetics显示文摘 | Dimitry A. Chistiakov Bart Hellemans Filip A.M. Volckaert | 2005 | Aquaculture2005，，1： | 2 |
| 4 | How to do successful gene expression analysis using real-time PCR显示文摘 | Derveaux S Vandesompele J Hellemans J | 2010 | Methods2010，50，： | 1 |
| 5 | Accurate and objectivecopy number profiling using real - time quantitative PCR显示文摘 | D*Kaene B Vandesompele J Hellemans J | 2010 | Meth-ods2010，50，4： | 1 |
| 6 | MicroRNAs in ovarian cancer biology and therapy resistance显示文摘 | van Jaarsveld MT Helleman J Berns EM Wiemer EA | | 0，，： | 1 |
| 7 | Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells显示文摘 | Niki T Pekny M Hellemans K | 1999 | Hepatology1999，29，： | 1 |
| 8 | Osteopoikilosis, short stature and mental retardation as key features of a new microdeletion syndrome on 12q14 显示文摘 | Menten B Buysse K Zahir F Hellemans J Hamihon S J Costa T | 2007 | J Med Genet2007，44，7： | 1 |
| 9 | All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially显示文摘 | Hellemans K Grinko I Rombouts K | 1999 | Gut1999，45，1： | 1 |
| 10 | Microsatellites and their genomic distribution evolution,function and applications:A review with special reference to fish genetics显示文摘 | Chistiakov D A Hellemans B Volckaert F | 2006 | Aquaculture2006，255，14： | 1 |
| 11 | Micromechanical deformation and recovery qrocesses of nylon-6/rubber thermoplastic vulcanizates as studied by atomic force microscopy and transmission electron microscopy显示文摘 | Oderkerk J Schaetzen G D Goderis B Hellemans L Groeninckx G | 2002 | Macromolecules2002，35，17： | 1 |
| 12 | Impact of a standardizednurse observationprotocol including MEWS after Intensive CareUnit discharge显示文摘 | De Meester K Das T Hellemans K | 2013 | Resuscitation2013，84，2： | 1 |
| 13 | Adolescent enrichment partially reverses the social isolation syndrome显示文摘 | Hellemans KG Benge LC Olmstead MC | | 0，，02： | 1 |
| 14 | q Base relative quantification framework and software for management and automated analysis of real-time quantitative PCR data显示文摘 | HELLEMANS J MORTIER G De PAEPE A | 2007 | Genome Biol2007，8，2： | 1 |
| 15 | Adolescent enrich-ment partially reverses the social isolation syndrome 显示文摘 | Hellemans KG Benge LC Olmstead MC | 2004 | BrainRes Dev Brain Res2004，150，2： | 1 |
| 16 | Posttraumatic severe fat embolism syndrome, with uncommon CT findings显示文摘 | van den Brande FG Hellemans S De Schepper A | 2006 | Anaesth Intensive Care2006，34，1： | 1 |
| 17 | Loss-of-function mutations in LEMD 3 result in osteopoikilosis, Buschek-Ollendorff syndrome and mlorheostosis 显示文摘 | Hellemans J Preobrazhenska O Willaret A | 2004 | Nat Genet2004，36，11： | 1 |
| 18 | Post-traumatic severe fat embolism syndrome with uncommon CT findings显示文摘 | Vanden Brande FG Hellemans S De Schepper A | 2006 | Anaesth Intensive Care2006，34，1： | 1 |
| 19 | qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data显示文摘 | Hellemans J Mortier G De Paepe A | 2007 | Genome Biol2007，8，： | 1 |
| 20 | Integrated genomics of chemotherapy resistant ovarian cancer: A role for extracellular matrix, TGFbeta and regulating microRNAs显示文摘 | Helleman J Jansen MP Burger C | 2010 | Int J Biochem Cell Biol2010，42，1： | 1 |
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