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| 1 | Management of postoperative spinal infections显示文摘Postoperative surgical site infection(SSI) is a common complication after posterior lumbar spine surgery. This review details an approach to the prevention,diagnosis and treatment of SSIs. Factors contributing to the development of a SSI can be split into three categories:(1) microbiological factors;(2) factors related to the patient and their spinal pathology; and(3) factors relating to the surgical procedure. SSI is most commonly caused by Staphylococcus aureus. The virulence of the organism causing the SSI can affect its presentation. SSI can be prevented by careful adherence to aseptic technique,prophylactic antibiotics,avoiding myonecrosis by frequently releasing retractors and preoperatively optimizing modifiable patient factors. Increasing pain is commonly the only symptom of a SSI and can lead to a delay in diagnosis. C-reactive protein and magnetic resonance imaging can help establish the diagnosis. Treatment requires acquiring intra-operative cultures to guide future antibiotic therapy and surgical debridement of all necrotic tissue. A SSI can usually be adequately treated without removing spinalinstrumentation. A multidisciplinary approach to SSIs is important. It is useful to involve an infectious disease specialist and use minimum serial bactericidal titers to enhance the effectiveness of antibiotic therapy. A plastic surgeon should also be involved in those cases of severe infection that require repeat debridement and delayed closure. | Vishal Hegde Dennis S Meredith Christopher K Kepler Russel C Huang | 2012 | World Journal of Orthopedics2012，3，11： | 17 |
| 2 | Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells显示文摘基础切除修理(BER ) 是为由消除损坏的几打维持 genomic 完整的 evolutionarily 保存的进程(氧化或烷基 ated ) 或内长地被产生或由 genotoxicants 导致了的不恰当的库,主要反应的氧种类(ROS ) 。BER 包含由脱氧核糖核酸 glycosylase 以基础切除开始的 4-5 步骤,由通常包含 AP-endonuclease (无尾猿) 产生 3' 的一条普通小径列在后面哦在损坏地点的终点,与由脱氧核糖核酸连接酶封上的 DNA 和刻痕由修复合成列在后面。这条小径也负责修理脱氧核糖核酸单个海滨与 ROS 直接产生的堵住的终点决裂。将近所有 glycosylases,比他们特别地为氧化的底的底层损害少得多,宽广、重叠的底层变化,并且能用作备份酶体内。相反,哺乳动物的房间编码仅仅一无尾猿, APE1,不同于在更低的有机体的二无尾猿。尽管有全面类似,有在哺乳动物的不同潜水艇小径的 BER 比在 E 更复杂。关口 i。glycosylases 与下游的蛋白质形成建筑群经由不同潜水艇小径执行有效修理哪个之一,负责因为海滨的修理与 NEIL 家庭 glycosylases 或由 ROS 产生的 3' 磷酸盐终点决裂,要求多核苷酸 kinase 的磷酸酶活动而不是 APE1。不同建筑群可以利用不同 DNA 和 ligases。哺乳动物的 glycosylases 非在终点之一保存了延期、为酶的活动非必需却为和另外的 BER 并且非的相互作用需要 -- 为指向的复杂形成和细胞器的 BER 蛋白质。哺乳动物的酶 covalently 有时被修改它可以影响活动和复杂形成。这评论的焦点在在为氧化损坏的哺乳动物的 BER 的早步上。 | Muralidhar L Hegde Tapas K Hazra Sankar Mitra | 2008 | Cell Research2008，18，1： | 15 |
| 3 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 4 | 盐酸二甲双胍缓释片的溶胀机制与释放规律相关性研究显示文摘以羟丙甲纤维素(HPMC)为骨架材料,采用正交设计优化盐酸二甲双胍缓释片的处方。所得优化处方为:HPMCK100M-药物重量比为0.25∶1,聚乙烯吡咯烷酮(PVP)K90为黏合剂。测定了优化制品在不同pH介质(pH 1.0盐酸、pH 4.5乙酸盐缓冲液和pH 7.4磷酸盐缓冲液)中的溶胀因子和体外释放行为,并用不同模型拟合,继而考察药物释放与缓释片溶胀因子间的相关性。研究表明,所得制品的溶胀与体外释药况均符合Korsmeyer-Peppas模型;药物释放机制为Fick扩散。释药行为不依赖于介质pH的改变,且骨架片的溶胀对药物的释放起主导作用。本品中药物释放与骨架溶胀间具有良好的线性关系。 | 朱芳芳 高慧升 KULKARNI Anand HEGDE Deepak 涂家生 | 2013 | 中国医药工业杂志2013，44，4： | 6 |
| 5 | 山嵛酸甘油酯在药剂学中的应用显示文摘山嵛酸甘油酯是一类多用途的长链脂肪酸甘油酯,具有优良的生物相容性,广泛应用于食品、药品和化妆品领域。本文以Gattefosse的产品Compritol 888 ATO为例,从口服给药、注射给药和局部给药三个方面综述山嵛酸甘油酯在药剂学中的应用和研究进展。 | 张伟 贺小玲 杨怡静 Anand Kulkarni Deepak Anant Hegde 涂家生 | 2012 | 药学与临床研究2012，20，6： | 5 |
| 6 | Successful endoscopic treatment of an intraductal papillary neoplasm of the bile duct显示文摘We present a case of a 76-year-old man with right upper quadrant abdominal pain and weight loss,who was found to have an intraductal papillary neoplasm of the bile duct(IPNB)of the pancreaticobiliary subtype,deemed curatively resectable.The patient declined surgery and opted for endoscopic therapy.He underwent two sessions of endoscopic retrograde cholangiopancreatography(ERCP)-guided radiofrequency ablation(RFA).Ten months later,no evidence of recurrence was identified on repeat ERCP.To our knowledge,this is the first reported case of successful use of RFA as a primary treatment modality for resectable IPNB. | Nikola S Natov Laura C Horton Sanjay R Hegde | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，5： | 5 |
| 7 | Effect of TiO_2 nanoparticles on hydrogen evolution reaction activity of Ni coatings显示文摘The electrocatalytic activity of electrodeposited Ni and Ni–TiO_2 coatings with regard to the alkaline hydrogen evolution reaction(HER) was investigated. The Ni coatings were electrodeposited from an acid chloride bath at different current densities, and their HER activities were examined in a 1.0-mol·L^(-1) KOH medium. The variations in the HER activity of the Ni coatings with changes in surface morphology and composition were examined via the electrochemical dissolution and incorporation of nanoparticles. Electrochemical analysis methods were used to monitor the HER activity of the test electrodes; this activity was confirmed via the quantification of gases that evolved during the analysis. The obtained results demonstrated that the Ni–TiO_2 nanocomposite test electrode exhibited maximum activity toward the alkaline HER. The surface appearance, composition, and the phase structure of all developed coatings were analyzed using scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS), and X-ray diffraction(XRD), respectively. The improvement in the electrocatalytic activity of Ni–TiO_2 nanocomposite coating toward HER was attributed to the variation in surface morphology and increased number of active sites. | Revanna Kullaiah Liju Elias Ampar Chitharanjan Hegde | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，4： | 5 |
| 8 | Synthesis and photoswitching properties of azobenzene liquid crystals with a pentafluorobenzene terminal显示文摘The fluorine-substituted benzoate ester rod-shaped liquid crystals containing an azobenzene side chain linked with terminal double bonds were synthesized and characterized.The mesophase and photoswitching properties were determined by polarizing optical microscopy(POM),differential scanning calorimetry(DSC) and UV-visible spectrometry.The rod-shaped compound 4a having an odd number of carbon atoms in the alkyl chains exhibits nematic phase and SmA type phase whereas compound 4b having an even number of carbon atoms showed only nematic phase.Both fluorinecontaining compounds 4c and 4d showed only SmA type phases.The photoswitching properties of these compounds showed a rate of trans to cis isomerization ranging 19-20 s,whereas reverse process took around 230 min in solution.These materials may be ideal in the field of optically rewritable applications where both on and off rates should be crucial. | Md Lutfor Rahman Gurumuthy Hegde Shaheen M.Sarkar Mashitah Mohd Yusoff | 2014 | Chinese Chemical Letters2014，25，12： | 4 |
| 9 | Investigations on Heat Transfer Enhancement in Pool Boiling with Water-CuO Nano-Fluids显示文摘The main focus of the present work is to investigate Critical Heat Flux (CHF) enhancement using CuO nanofluid relative to CHF of pure water. To estimate the effect of nanoparticles on the CHF, pool boiling CHF values were measured for various volume concentrations of CuO nanofluid and compared with pure water. CHF enhancement of 130% was recorded at 0.2 % by volume of CuO nano-fluids. Surface roughness of the heater surface exposed to three measured heating cycles indicated surface modifications at different volume concentrations of nanofluid. SEM image of the heater surface revealed porous layer build up, which is thought to be the reason for CHF enhancement. | Ramakrishna N. Hegde Dr. Shrikantha S. Rao R. P. Reddy | 2012 | Journal of Thermal Science2012，21，2： | 4 |
| 10 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 11 | Neural stem cell properties of Müller glia in the mammalian retina: Regulation by Notch and Wnt signaling显示文摘 | Ani V. Das Kavita B. Mallya Xing Zhao Faraz Ahmad Sumitra Bhattacharya Wallace B. Thoreson Ganapati V. Hegde Iqbal Ahmad | 2006 | Developmental Biology2006，，1： | 2 |
| 12 | Total Laparoscopic Hysterectomy with Earlier Uterine Artery Ligation显示文摘 | Rakesh Sinha Meenakshi Sundaram Yogesh A. Nikam Aparna Hegde Chaitali Mahajan | 2008 | The Journal of Minimally Invasive Gynecology2008，，： | 2 |
| 13 | Chemical composition of jackfruit ( Artocarpus heterophyllus Lam.) selections of Western Ghats of India显示文摘 | S.L. Jagadeesh B.S. Reddy G.S.K. Swamy Kirankumar Gorbal Laxminarayan Hegde G.S.V. Raghavan | 2006 | Food Chemistry2006，，1： | 2 |
| 14 | Modification of eutectic silicon in Al–Si alloys显示文摘 | Sathyapal Hegde K. Narayan Prabhu | 2008 | Journal of Materials Science2008，，9： | 2 |
| 15 | Development and characterization of a new tropical marine fish cell line from grouper, Epinephelus coioides susceptible to iridovirus and nodavirus显示文摘 | Q.W. Qin T.H. Wu T.L. Jia A. Hegde R.Q. Zhang | 2005 | Journal of Virological Methods2005，，1： | 2 |
| 16 | Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production显示文摘Sulfonic acid functionalized mesoporous silica based solid acid catalysts with different morphology were designed and fabricated.The synthesized materials were characterized by various physicochemical and spectroscopic techniques like scanning electron microscopeenergy dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,Brunauer–Emmett–Teller surface area,thermogravimetric analysis and n-butylamine acidity.The shape of catalysts particles plays an important role in its activity.The sulfonic acid functionalized mesoporous silica catalysts of spherical shape and the cube shape were assessed for catalytic activity in biodiesel production.The catalytic biodiesel production reaction over the catalysts were studied by esterification of free fatty acid,oleic acid with methanol.The effect of various reaction parameters such as catalyst concentration,acid/alcohol molar ratio,catalyst amount,reaction temperature and reaction time on catalytic activity were investigated to optimize the conditions for maximum conversion.It was sulfonated cubic shape mesoporous silica which exhibited better activity as compared to the spherical shape silica catalysts.Additionally,the catalyst was regenerated and reused up to three cycles without any significant loss in activity.The present catalysts exhibit superior performance in biodiesel production and it can be used for the several biodiesel feedstock’s that are rich in free fatty acids. | Vinayak Hegde Parimal Pandit Pranita Rananaware Varsha PBrahmkhatri | 2022 | Frontiers of Chemical Science and Engineering2022，16，8： | 2 |
| 17 | Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum 显示文摘 | Hegde RS Lingappa VR | 1997 | Cell1997，91，5： | 1 |
| 18 | Molecular basis of aggressive disease in chronic lymphocytic leukemia patients with 11q deletion and trisomy 12 chromosomal abnormalities显示文摘 | MITTAL A K HEGDE G V AOUN P | 2007 | Int J Mol Med2007，20，4： | 1 |
| 19 | Correlation of functional outcome and natural history with clinicoradiological factors in surgically managed pediatric Chiari I malformation 显示文摘 | Furtado S V Thakar S Hegde A S | 2011 | N eurosurgery2011，68，2： | 1 |
| 20 | Muscarinic receptor subtypes and smooth muscle function 显示文摘 | Eglen R M Hegde S S Watson N | 1996 | Pharmacol1996，48，4： | 1 |
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