|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | 选择性环氧化酶2抑制剂和传统非甾体抗炎药增加粥样血栓形成的风险吗?随机试验的荟萃分析显示文摘目的:评价选择性环氧化酶2(COX-2)抑制剂和传统的非甾体类抗炎药(NSMDs)在发生血管事件上的风险性。设计:对已发表和未发表随机试验的表格式资料进行荟萃分析,对传统 NSAIDs 的作用进行间接评估。资料来源:资料分别来源于 Medline 和 Embase(1966年1月至2005年4月);食品与药品管理局记录;以及诺华、辉瑞、默克公司的资料。回顾方法:符合以下条件的随机试验入组本研究:一种选择性 COX-2抑制剂与安慰剂比较或一种选择性 COX-2抑制剂与一种传统的 NSAID之间对比;用药持续时间至少4周;包含严重血管事件方面的信息,如心肌梗死、卒中或由于血管事件死亡。各个独立研究者和药厂为本研究提供了有关随机化的病人数目、血管事件的数目以及每个随机化小组中随访的人时(Person time)等信息。结果:在与安慰剂对比的试验中,选择性COX-2抑制剂使严重血管事件发生率增加42%(1.2%/年比0.9%/年;率比1.42,95%可信区间1.13~1.78;P=0.005);不同的选择性 COX-2抑制剂之间没有显著性差异。这主要归因于心肌梗死的风险增加(0.6%/年比0.3%/年;1.86,1.33~2.59;P=0.0003),在其他血管性事件上没有明显的区别。在为时至少1年的试验中(平均2.7年),血管事件的率比是1.45(1.12~1.89;P=0.005)。总的来说,严重血管事件的发生率在选择性 COX-2抑制剂和任何传统 NSAID 之间没有差异(1.0%/年比0.9%/年;1.16,0.97~1.38;P=0.1)。然而,在选择性 COX-2抑制剂与萘普生对比的试验(1.57,1.21~2.03)和选择性COX-2抑制剂与非萘普生类 NSAIDs 相比较的试验之间(0.88,O.69~1.12),我们发现了统计学差异。与安慰剂比较血管事件的总体比率如下:萘普生0.92(0.67~1.26),布洛芬1.51(0.96~2.37),双氯芬酸1.63(1.12~2.37)。结论:选择性 COX-2抑制剂可以中等度增加血管事件的风险性,大剂量布洛芬和双氯芬酸同样具有此作用,但大剂量萘普生不明显增加血管事件的风险性。 | Patricia M Kearney Colin Baigent Jon Godwin Heather Halls Jonathan R Emberson Carlo Patrono 徐东(译) 张卓莉(校) | 2006 | 英国医学杂志中文版2006，9，5： | 4 |
| 3 | Randomised trial of flush saphenofemoral ligation for primary great saphenous varicose veins 显示文摘 | WINTERBORN R J FOY C HEATHER B P | 2008 | Eur J Vasc Endovasc Surg2008，36，4： | 1 |
| 4 | The mini clinicalevaluation exercise (mini-CEX) for assessing clinicalperformance of international medical graduates显示文摘 | Balakrishnan R Nair Heather G Alexander | 2008 | Med JAust2008，189，3： | 1 |
| 5 | The effect of operational parameters on the photocatalytic degradation of humic acid显示文摘 | Fiona L Palmer Brian R Eggins Heather M Coleman | 2002 | Journal of Photochemistry & Photobiology, A: Chemistry2002，，1： | 1 |
| 6 | Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy显示文摘 | Eric R Lutz Heather Kinkead Elizabeth M Jaffee Lei Zheng | 2014 | OncoImmunology2014，，： | 1 |
| 7 | The influence of personal and workplace resources on new graduate nurses' job satisfaction显示文摘 | Lisa M Heather K Sandra R | 2013 | J Nurs Manag2013，7，12： | 1 |
| 8 | Calcium signaling in Arabidopsis thaliana responding to drought and salinity 显示文摘 | HEATHER K ANTHONY J MARC R K | 1997 | The Plant Journal1997，12，： | 1 |
| 9 | Biosensor system for continuous monitoring of organophosphate aerosols 显示文摘 | Heather R L Roby G Mike H B | 2007 | Biosensors and Bioelectronics2007，23，： | 1 |
| 10 | One year an atomic and quality of life outcomes after the prolife procedure for treatment of pushy directory prolapsed显示文摘 | Heather M Vincent R Stephanie M | 2008 | Am J Obstetric Gynecol2008，199，： | 1 |
| 11 | DC-SIGN Is a receptor for human herpes virus 8 on dendritic cells and macrophages显示文摘 | Giovanna R Frank J J Heather R H | 2006 | J Immunol2006，176，3： | 1 |
| 12 | Administration of Wine and Grape Juice Inhibits In Vivo Platelet Activity and Thrombosis in Stenosed Canine Coronary Arteries 显示文摘 | HEATHER S DEMROW B S PETER R | 1995 | Circulation1995，91，： | 1 |
| 13 | TheM2 splice isoform ofpyruvate kinase is important for cancer metabolism and tumour growth显示文摘 | Heather R Matthew G MarianH | 2008 | Nature2008，45，2： | 1 |
| 14 | Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer显示文摘 | RICKY A S HEATHER R M KIRSTI A H | 2001 | Clin Cancer Res2001，7，7： | 1 |
| 15 | A new silver sulfadiazine water soluble gel 显示文摘 | Andrew JL Gear Timothy B Hellewell Heather R Wright | 1997 | Bums1997，23，5： | 1 |
| 16 | An analysis of multinational “audit failures”显示文摘 | Heather M Hermanson Dana R Hermanson Joseph V Carcello | 1996 | International Journal of Accounting1996，，3： | 1 |
| 17 | Room temperature ionic liquids as novel media for 'clean' liq uid-liquid extraction 显示文摘 | Huddleston Jonathan G Willauer Heather D Swatloski R P | 1998 | Chemical Communications1998，16，1： | 1 |
| 18 | The management of short saphenous varicose veins: a survey of the members of the vascular surgical society of Great Britain and Ireland显示文摘 | Winterbom R J Campbell WB Heather BP | 2004 | Eur J Vasc Endovasc Surg2004，28，4： | 1 |
| 19 | Application of GIS processing techniques for producing mineral prospectivity mapsa case study: Mesothermal Au in the Swayze Greenstone Belt,Ontario, Canada 显示文摘 | HARRIS J R WILKINSON L HEATHER K | 2001 | Natural Resources Research2001，10，2： | 1 |
| 20 | Application of GIS processing techniques for producing mineral prospectivity maps: A case study: mesothermal Au in the Swayze greenstone belt, Ontario, Canada显示文摘 | Harris J R Wilkinson L Heather K | 2001 | Natural Resources Research2001，10，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员