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| 1 | Detection of dietary plant-based small RNAs in animals显示文摘 | Jian Yang Lisa M Farmer Abia AA Agyekum Kendal D Hirschi | 2015 | Cell Research2015，25，4： | 9 |
| 2 | Semistructured interviewing in primary care research:a balance of relationship and rigour显示文摘Semistructured in-depth interviews are commonly used in qualitative research and are the most frequent qualitative data source in health services research.This method typically consists of a dialogue between researcher and participant,guided by a flexible interview protocol and supplemented by follow-up questions,probes and comments.The method allows the researcher to collect open-ended data,to explore participant thoughts,feelings and beliefs about a particular topic and to delve deeply into personal and sometimes sensitive issues.The purpose of this article was to identify and describe the essential skills to designing and conducting semistructured interviews in family medicine and primary care research settings.We reviewed the literature on semistructured interviewing to identify key skills and components for using this method in family medicine and primary care research settings.Overall,semistructured interviewing requires both a relational focus and practice in the skills of facilitation.Skills include:(1)determining the purpose and scope of the study;(2)identifying participants;(3)considering ethical issues;(4)planning logistical aspects;(5)developing the interview guide;(6)establishing trust and rapport;(7)conducting the interview;(8)memoing and reflection;(9)analysing the data;(10)demonstrating the trustworthiness of the research;and(11)presenting findings in a paper or report.Semistructured interviews provide an effective and feasible research method for family physicians to conduct in primary care research settings.Researchers using semistructured interviews for data collection should take on a relational focus and consider the skills of interviewing to ensure quality.Semistructured interviewing can be a powerful tool for family physicians,primary care providers and other health services researchers to use to understand the thoughts,beliefs and experiences of individuals.Despite the utility,semistructured interviews can be intimidating and challenging for researchers not familiar with qualitative approaches.In order to elucidate this method,we provide practical guidance for researchers,including novice researchers and those with few resources,to use semistructured interviewing as a data collection strategy.We provide recommendations for the essential steps to follow in order to best implement semistructured interviews in family medicine and primary care research settings. | Melissa DeJonckheere Lisa M Vaughn | 2019 | Family Medicine and Community Health2019，7，2： | 8 |
| 3 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 4 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 5 | Limb symmetry index in competitive alpine ski racers:Reference values and injury risk identification according to age-related performance levels显示文摘Purpose: The aims of this study were to assess differences of limb symmetry index(LSI) in strength-and coordination-related tasks between high-level, competitive, noninjured ski racers of different age-related performance levels and to prospectively assess limb differences as a possible risk factor for traumatic and overuse injury in youth ski racers.Methods: The study(Study 1) included 285 high-level competitive ski racers(125 females, 160 males) of 3 age-related performance levels and based on the school system: 95 youth(10à14 years, secondary modern school), 107 adolescent(15à19 years, grammar school), and 83 elite athletes(20à34 years). To investigate the second aim(Study 2), 67 of the 95 youth athletes were included and any traumatic or overuse injuries were prospectively recorded over 2 seasons. All athletes performed 4 unilateral tests(strength related: one-leg counter movement jump(OL-CMJ) and one-leg isometric/isokinetic press strength test(OL-ILS); coordination related: one-leg stability test(OL-ST) and one-leg speedy jump test(OL-SJ)). The LSI was calculated by dividing the dominant leg by the nondominant leg and multiplying by 100. Kruskal-Wallis H tests and binary logistic regression analyses were conducted.Results: There were significant differences between the LSI of the 3 age-related performance-level groups only in the strength-related tests: the OL-CMJ(x2(2, 285) = 9.09; p = 0.01) and the OL-ILS(x2(2, 285) = 14.79; p < 0.01). The LSI for OL-ILS was found to be a significant risk factor for traumatic injury in youth ski racers(Wald = 7.08; p < 0.01). No significant risk factors were found for overuse injuries.Conclusion: Younger athletes display slightly greater LSI values only in the strength-related tests. The cut-off value of limb differences of <10%for return to sport decisions seems to be appropriate for elite athletes, but for youth and adolescent athletes it has to be critically discussed. It seems to be necessary to define thresholds based on specific performance tasks(strength vs. coordination related) rather than on generalizations,and age-related performance levels must be considered. Limb differences in unilateral leg extension strength represent a significant injury risk factor in youth ski racers. | Lisa Steidl-Müller Carolin Hildebrandt Erich Müiller Christian Fink Christian Raschner | 2018 | Journal of Sport and Health Science2018，7，4： | 6 |
| 6 | Cabozantinib in Progressive Medullary Thyroid Cancer显示文摘 | Rossella Elisei Martin J. Schlumberger Stefan P. Müller Patrick Sch?ffski Marcia S. Brose Manisha H. Shah Lisa Licitra Barbara Jarzab Viktor Medvedev Michael C. Kreissl Bruno Niederle Ezra E.W. Cohen Lori J. Wirth Haythem Ali Colin Hessel Yifah Yaron Doug | 2013 | Journal of Clinical Oncology2013，，29： | 3 |
| 7 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 8 | 基层保健研究中的半结构化访谈:关系与严谨的平衡显示文摘半结构化深度访谈常用于定性研究,是健康服务研究中最常见的定性数据来源。这种方法通常包括研究者和参与者之间的对话,在可灵活调整的访谈协议框架下,辅以后续问题、调查和评价。该方法允许研究者收集开放式数据,探索参与者对某一特定主题的想法、感受和信念,深入研究个人问题,有时是敏感问题。本文旨在确定和描述在家庭医学和基层保健研究环境中设计和进行半结构化访谈的基本技能。本文回顾了有关半结构化访谈的文献,以确定在家庭医学和基层保健研究环境中使用这种方法的关键技能和内容。总的来说,半结构化访谈既需要关注关系,也需要促进技能的实践。技能包括:(1)确定研究的目的和范围;(2)确定参与者;(3)考虑道德伦理问题;(4)规划后勤方面;(5)制定访谈指南;(6)建立信任和融洽关系;(7)进行访谈;(8)记录和反思;(9)分析数据;(10)证明研究的可信程度;(11)在论文或者报告中展示研究结果。半结构化访谈为家庭医生在基层保健研究环境中进行研究提供了一种有效、可行的研究方法。采用半结构化访谈进行数据收集的研究者应关注关系,并注意访谈技能,以确保质量。半结构化访谈可以成为家庭医生、基层保健从业人员和其他卫生服务研究者用来了解个人想法、信念和经验的一个强有力工具。尽管如此,对于不熟悉定性方法的研究者来说,半结构化访谈可能让人感到害怕,颇具挑战。为了阐明这一方法,本文为研究者(包括新手和资源较少的研究者)提供了实践指导,使其能够运用半结构化访谈来进行数据收集。为了在家庭医学和基层保健研究环境中更好地实施半结构化访谈,本文给出了必要步骤的建议。 | Melissa DeJonckheere Lisa M Vaughn 赵新月(译) 韩建军 许岩丽 杨辉(审校) | 2019 | 中国全科医学2019，22，23： | 3 |
| 9 | Multiband emission from single β-NaYF_(4)(Yb,Er) nanoparticles at high excitation power densities and comparison to ensemble studies显示文摘Ensemble and single particle studies of the excitation power density (P)-dependent upconversion luminescence (UCL) of core and core-shell β-NaYF_(4):Yb,Er upconversion nanoparticles (UCNPs) doped with 20% Yb^(3+) and 1% or 3% Er^(^(3+)) performed over a P regime of 6 orders of magnitude reveal an increasing contribution of the emission from high energy Er^(3+) levels at P > 1 kW/cm^(2). This changes the overall emission color from initially green over yellow to white. While initially the green and with increasing P the red emission dominate in ensemble measurements at P < 1 kW/cm^(2), the increasing population of higher Er^(^(3+)) energy levels by multiphotonic processes at higher P in single particle studies results in a multitude of emission bands in the ultraviolet/visible/near infrared (UV/vis/NIR) accompanied by a decreased contribution of the red luminescence. Based upon a thorough analysis of the P-dependence of UCL, the emission bands activated at high P were grouped and assigned to 2–3, 3–4, and 4 photonic processes involving energy transfer (ET), excited-state absorption (ESA), cross-relaxation (CR), back energy transfer (BET), and non-radiative relaxation processes (nRP). This underlines the P-tunability of UCNP brightness and color and highlights the potential of P-dependent measurements for mechanistic studies required to manifest the population pathways of the different Er^(3+) levels. | Florian Frenzel Christian Würth Oleksii Dukhno Frédéric Przybilla Lisa MWiesholler Verena Muhr Thomas Hirsch Yves Mély Ute Resch-Genger | 2021 | Nano Research2021，14，11： | 3 |
| 10 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 11 | Perspectives on the clinical development of mmunotherapy in prostate cancer显示文摘 | Lisa M Cordes James L Gulley Ravi A Madan | 2018 | Asian Journal of Andrology2018，20，3： | 2 |
| 12 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 13 | Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia显示文摘ObjectiveTo 在在检验生活和资源使用的质量的 17 所澳大利亚的疗养院的代表性的研究的 Australia.MethodsAs 部分住在疗养院的更老的成年人与认知功能和痴呆的诊断检验在心血管的系统药使用之间的协会,我们检验了在认知缺陷和心血管的药使用之间的协会(使用解剖治疗学的分类系统识别)用一般线性回归和逻辑 regressio 正在收到生活照顾的结束的人是包括的 excluded.ResultsParticipants 有一个平均数的 541 个居民 85.5 | Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty | 2017 | Journal of Geriatric Cardiology2017，14，6： | 2 |
| 14 | Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study显示文摘 | Daniel J Drucker John B Buse Kristin Taylor David M Kendall Michael Trautmann Dongliang Zhuang Lisa Porter | 2008 | The Lancet2008，，9645： | 2 |
| 15 | Overexpression,senomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugese in human carcinomas of diverse anatomic origin显示文摘 | Klaus W Wagner Lisa M Sapinoso Wa'el El-Rifai | 2004 | Oncogene2004，23，39： | 1 |
| 16 | Ecotourism in Rural Developing Gommunities 显示文摘 | | 1999 | Annals of Tourism Research1999，26，3： | 1 |
| 17 | Using computational auditory models to predict simultaneous masking data: model comparison显示文摘 | LISA G H LESLIE M C | 1999 | IEEETransactions on Biomedical Engineering1999，46，12： | 1 |
| 18 | Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure red-uction in Nodeificient hypertension显示文摘 | Abdelrahman A M David B Lisa R S | 2005 | JPET Fast Forward2005，12，3： | 1 |
| 19 | Revisiting the role of retinoid signaling in skeletal development显示文摘 | Andrea D Weston Lisa M | 2003 | Birth Defects Research C Embryo Today2003，69，2： | 1 |
| 20 | Leptin is a four - helix bundle:secondary structure by NMR显示文摘 | Allen D K Gerald W B Lisa M C | 1997 | FEBS Letters1997，407，2： | 1 |
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