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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | 印度尼西亚竹子栽培与利用(英文)显示文摘竹子在印度尼西亚广为使用,尤其是在乡村,因为它生长快,易采伐,使用方便,性能好。本文“印度尼西亚竹子栽培与利用”报道了目前印尼竹子的栽培、加工及研究、开发方面的进展。在印尼,许多竹种的栽植历史已有好几百年。传统的繁殖方法是用秆及鞭,而其它栽培繁殖方法尚处于试验阶段。可以这样说,印尼的竹子栽培研究尚处于早期的开拓时期。竹子在印尼有许多用途,如建筑材料,家具,墙,篮子,家庭器具,造纸,篱笆,手工艺品,农具,乐器及食品。目前,印尼竹子加工利用技术研究正处于全面的开发阶段。今后竹子作为工业用材的前景非常广阔,然而也存在一些问题。为提高竹子对乡村社会的贡献,促进竹子工业利用的发展,我们应该对竹子的生物学特性,营林,社会经济,新产品设计、开发,防蛀防霉,精加工等等进行更深入的研究。 | Subyakto and Bambang Subiyanto(R&D Centre for Applied Physics—Indonesia Institute of Sciences Puspiptek Serpong 15310,Indonesia)Sandra A.Azis(Department of Agronomy,Bogor Agricultural University, Bogor,Indonesia) | 1997 | 竹子研究汇刊1997，16，2： | 8 |
| 3 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 4 | Systematic review of cystic duct closure techniques in relation to prevention of bile duct leakage after laparoscopic cholecystectomy显示文摘AIM To study the effect of different techniques of cystic duct closure on bile leakage after laparoscopic cholecystectomy(LC) for biliary disease.METHODS A systematic search of MEDLINE, Cochrane and EMBASE was performed. Rate of cystic duct leakage(CDL) was the primary outcome. Risk of bias was evaluated. Odds ratios were analyzed for comparison of techniques and pooled event rates for non-comparative analyses. Pooled event rates were compared for each of included techniques.RESULTS Out of 1491 articles, 38 studies were included. A total of 47491 patients were included, of which 38683(81.5%)underwent cystic duct closure with non-locking(metal)clips. All studies were of low-moderate methodological quality. Only two studies reported separate data on uncomplicated and complicated gallbladder disease. For overall CDL, an odds ratio of 0.4(95%CI: 0.06-2.48)was found for harmonic energy vs clip closure and an odds ratio of 0.17(95%CI: 0.03-0.93) for locking vs non-locking clips. Pooled CDL rate was around 1% for harmonic energy and metal clips, and 0% for locking clips and ligatures. CONCLUSION Based on available evidence it is not possible to either recommend or discourage any of the techniques for cystic duct closure during LC with respects to CDL,although data point out a slight preference for locking clips and ligatures vs other techniques. No separate recommendation can be made for complicated gallbladder disease. | Aafke H van Dijk Stijn van Roessel Philip R de Reuver Djamila Boerma Marja A Boermeester Sandra C Donkervoort | 2018 | World Journal of Gastrointestinal Surgery2018，10，6： | 3 |
| 5 | Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia显示文摘 | Nancy Freitag Irene Tirado-González Gabriela Barrientos Florian Herse Victor L. J. L. Thijssen Susanne M. Weedon-Fekj?r Herbert Schulz Gerd Wallukat Burghard F. Klapp Tania Nevers Surendra Sharma Anne Cathrine Staff Ralf Dechend Sandra M. Blois | 2013 | Proceedings of the National Academy of Sciences2013，，28： | 2 |
| 6 | Selective ligninolysis of wheat straw and wood chips by the white-rot fungus Lentinula edodes and its influence on in vitro rumen degradability显示文摘Background: The present work investigated the influence of lignin content and composition in the fungal treatment of lignocellulosic biomass in order to improve rumen degradability. Wheat straw and wood chips,differing in lignin composition, were treated with Lentinula edodes for 0, 2, 4, 8 and 12 wk and the changes occurring during fungal degradation were analyzed using pyrolysis-gas chromatography-mass spectrometry and detergent fiber analysis.Results: L. edodes preferentially degraded lignin, with only limited cellulose degradation, in wheat straw and wood chips, leaving a substrate enriched in cellulose. Syringyl(S)-lignin units were preferentially degraded than guaiacyl(G)-lignin units, resulting in a decreased S/G ratio. A decreasing S/G ratio(wheat straw: r =-0.72, wood chips: r =-0.75) and selective lignin degradation(wheat straw: r =-0.69, wood chips: r =-0.88) were correlated with in vitro gas production(IVGP), a good indicator for rumen degradability.Conclusions: L. edodes treatment increased the IVGP of wheat straw and wood chips. Effects on IVGP were similar for wheat straw and wood chips indicating that lignin content and 3D-structure of cell walls influence in vitro rumen degradability more than lignin composition. | Sandra J.A.van Kuijk José C.del Río Jorge Rencoret Ana Gutiérrez Anton S.M.Sonnenberg Johan J.P.Baars Wouter H.Hendriks John W.Cone | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 2 |
| 7 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 8 | Toll-like receptor expression and signaling in human diabetic wounds显示文摘AIM: To examine the contribution of toll-like receptors(TLRs) expression and activation to the prolonged inflammation often seen in human diabetic wounds.METHODS: Debridement wound tissue was collected from diabetic patients with informed consent. Total RNA and protein were isolated and subjected to real-time polymerase chain reaction and Western blot analyses. RESULTS: TLR1, 2, 4, and 6 mRNA expressions were increased significantly in wounds of diabetic patients compared with non-diabetic wounds(P < 0.05). MyD88 protein expression was significantly increased in diabetic wounds compared to non-diabetic wounds. Interleukin-1beta, tumor necrosis factor-alpha concentration nuclear factor-kappa B activation, and thiobarbituric acid reactive substances were increased in diabetic wounds compared to non-diabetic wounds(P < 0.01). CONCLUSION: Collectively, our novel findings show that increased TLR expression, signaling, and activation may contribute to the hyper inflammation in the human diabetic wounds. | Mohan R Dasu Sandra J Martin | 2014 | World Journal of Diabetes2014，5，2： | 2 |
| 9 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 10 | Bivalacqua, adrian barbul arginase inhibition promotes wound healing in mice显示文摘 | Sandra L Kavalukas Aarti R | 2011 | Surgery2011，151，2： | 1 |
| 11 | Flavour analysis of Greek white wine by solid-phase microextraction-capillary gas chromatography-mass spectrometry显示文摘 | DEMYTTENAERE J C R DAGHER C SANDRA P | 2003 | J Chromatogr A2003，985，12： | 1 |
| 12 | Influence of H2O2 and Fe(Ⅲ) in the photodegradation显示文摘 | MIGUEL R ANDREAS K SANDRA C | 2000 | Photochem & Photobiol A:Chem2000，133，： | 1 |
| 13 | Water absorption, dimensional change and radial pressure in resin matrix dental restorative materials 显示文摘 | John F M Sandra R | 2004 | Biomaterials2004，25，： | 1 |
| 14 | Rate equation for the degradation of nitrobenzene by 'Fenton-like' reagent显示文摘 | Miguel R Andreas K Sandra C et ol | 2003 | Advances in EnvironmentalResearch2003，7，2： | 1 |
| 15 | Sulphite and oxida- tive-reductive depolymerization reactions 显示文摘 | Loma A Paterson Sandra E Hill John R | 1997 | Food Chemistry1997，60，2： | 1 |
| 16 | Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia 显示文摘 | Axel MH Sandra H Sibylle R | 2005 | Am J Hum Genet2005，77，1： | 1 |
| 17 | A review of cost-accounting methods for nursing services显示文摘 | Edwardson S R Sandra R Phyllis B G | 1987 | Nurs Econ1987，5，3： | 1 |
| 18 | Clinical outcome 2 years after in- traeoronary administration of bone marrow-derived progenitor cells in acyte myocardial infarction显示文摘 | B irgit A Andreas R Sandra E | 2010 | Circ Heart Fail2010，3，： | 1 |
| 19 | Identification of a novel,multifunctional β-defensin (humanβ-defensin-3) with specific antimicrobial activity显示文摘 | Jose R Sandra S Javier R | 2003 | Cell Tissue Res2003，306，： | 1 |
| 20 | Alteration of nipple and areola sensitivity by reduction mammaplasty: a prospective comparison of five techniques 显示文摘 | Ingrid S Sandra R Michael S | 2005 | Plast Reconstr Surg2005，115，： | 1 |
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