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| 1 | 黄芪甲苷Ⅳ对非酒精性脂肪肝小鼠肝脏脂质代谢的作用显示文摘目的探讨黄芪甲苷Ⅳ(AS-Ⅳ)对非酒精性脂肪肝(NAFLD)小鼠肝脏脂质代谢的影响。方法 5周龄雄性C57BL/6小鼠随机分为正常饮食组、高脂高糖组、高脂高糖+AS-Ⅳ[30 mg/(kg·d)]组、高脂高糖+AS-Ⅳ[60 mg/(kg·d)]组、高脂高糖+AS-Ⅳ[120 mg/(kg·d)]组。高脂高糖饮食构建NAFLD小鼠动物模型,同时用不同浓度的AS-Ⅳ[30、60、120 mg/(kg·d)]进行灌胃。正常饮食组给予等体积1%羧甲基纤维素(1%CMC)灌胃,每周测体质量、随机血糖,干预13周后,处死小鼠,留取并称量肝脏,采用H&E染色以及油红O染色检测小鼠肝脏脂质沉积情况。结果高脂高糖诱导的NAFLD小鼠较正常饮食组小鼠的体质量、肝脏湿重及随机血糖增加(P <0.05);AS-Ⅳ未显著减轻NAFLD小鼠的体质量、肝脏湿重及随机血糖(P> 0.05)。与正常饮食组相比,高脂高糖诱导的NAFLD小鼠肝脏脂滴形成增加(P <0.05);而与高脂高糖组相比,不同浓度的AS-Ⅳ干预后,小鼠肝脏脂滴形成减少,以浓度为60 mg/(kg·d)的AS-Ⅳ组最明显(P <0.01)。结论黄芪甲苷Ⅳ能改善非酒精性脂肪肝小鼠的肝脏脂质沉积。 | 杨小颖 胡芳 韦晓虹 HEAN Povkanha 孙辽 | 2018 | 实用医学杂志2018，34，24： | 10 |
| 2 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 3 | Modelling hybrid distribution channels: a game-theoretic analysis显示文摘 | Seong Y Park Hean Tat Keh | 2003 | Journal of Retailing and Consumer Services2003，，3： | 3 |
| 4 | Functional MRI of cerebral activation during encoding and retrieval of words显示文摘 | Hean R Klose U Jesson F | 1999 | Human Brain Mapp1999，8，4： | 2 |
| 5 | Evolution of the book publishing industry Structural changes and strategic implications显示文摘 | Hean Tat Keh | 1998 | Journal of Management History1998，，2： | 1 |
| 6 | The effects of entrepreneurial orientation and marketing informa- tion on the performance of SMEs 显示文摘 | HEAN TATKEH THI TUYET MAI NGUYEN HWEI PING NG | 2007 | Journal of Business Venturing2007，22，： | 1 |
| 7 | Corporate Reputation and Customer Behavior Intentions:The Roles of Trust, Identification and Commitment 显示文摘 | Hean Tat Keh Yi Xie | 2009 | Industrial Marketing Management2009，，38： | 1 |
| 8 | Solubility of red palm oil in supercritical carbon dioxide: Measurement and modelling显示文摘The solubility of red palm oil(RPO) in supercritical carbon dioxide(scCO_2) was determined using a dynamic method at 8.5–25 MPa and, 313.15–333.15 K and at a fixed scCO_2 flow rate of 2.9 g·min^(-1) using a full factorial design. The solubility was determined under low pressures and temperatures as a preliminary study for RPO particle formation using scCO_2. The solubility of RPO was 0.5–11.3 mg·(g CO_2)^(-1) and was significantly affected by the pressure and temperature. RPO solubility increased with pressure and decreased with temperature. The Adachi–Lu model showed the best-fit for RPO solubility data with an average relative deviation of 14% with a high coefficient of determination, R^2 of 0.9667, whereas the Peng–Robinson equation of state thermodynamic model recorded deviations of 17%–30%. | Wan Jun Lee Chin Ping Tan Rabiha Sulaiman Gun Hean Chong | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 1 |
| 9 | Impacting the positioning of teaching as life-long carcer显示文摘 | Lim Lee Hean | 2003 | Educational research for policy and practice2003，，7： | 1 |
| 10 | RARE imaging: a fast imaging method for cilinical MR显示文摘 | Heanning J Nauerth A Friendbxury H | 1986 | Magn Reson Med1986，3，： | 1 |
| 11 | High strength elec trospun polymer nanofihers made from BPDA PDA polyimide 显示文摘 | H uang Chaobo Wang Suqing Zhang Hean | 2006 | European Polymer Journal2006，42，： | 1 |
| 12 | Investigating the factors influencing professional identity of first-year health and social care students显示文摘 | Adams Kim Hean | 2006 | Learning in Health and Social Care2006，5，2： | 1 |
| 13 | Risk factors forintrahepatic recurrence after hepatectomy for hepatocellularcarcinoma显示文摘 | Ibrahim S Roychowdhury A Hean TK | 2007 | Am J Surg2007，194，： | 1 |
| 14 | Modelling hybrid distribution channels: a game-theoretic analysis显示文摘 | SEONG Y P HEAN T K | 2003 | Journal of Retailing and Consumer Service2003，10，3： | 1 |
| 15 | The Complexities of Perceived Risk in Cross-Cultural Services Marketing显示文摘 | Keh Hean Tat Jin Sun | 2008 | Journal of International Marketing2008，16，1： | 1 |
| 16 | Review: Treatment of Gastroesophageal Reflux Disease in the Elderly显示文摘 | Choo Hean Poh Tomás Navarro-Rodriguez Ronnie Fass | 2010 | The American Journal of Medicine2010，，6： | 1 |
| 17 | Electrode fabrication for proton exchange membrane fuel cells by pulse electrodeposition显示文摘 | Hean K Sung K H Hee L T | 1998 | J Power Sources1998，75，： | 1 |
| 18 | Risk factors for intrahepatic recurrence after hepatectomy for hepatocellular carcinoma 显示文摘 | Ibrahim S Roychowdhury A Hean T K | 2007 | Am J Surg2007，194，1： | 1 |
| 19 | Modelling hybrid distribution channels:Agame-theoretic analysis显示文摘 | Seong Y P Hean T K | 2003 | Journal of Retailing and ConsumerServices2003，10，3： | 1 |
| 20 | Phylogeography and genetic ancestry of tigers(Panthera tigris)显示文摘 | Luo S J Kim JH Johnson WE van der Walt J Martenson J Yuhki N Miquelle DG Uphyrkina O Goodrich JM Quigley HB Tilson R Brady G Martelli P Subramaniam V McDougal C Hean S Huang SQ Pan W Karanth UK Sunquist M Smith JLD O'Brien SJ | | 0，，： | 1 |
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