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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase,carboxyterminal propeptide of typeⅠprocollagen,and carboxyterminal cross-linked telepeptide of typeⅠcollagen in malignant tumor patients with bone metastasis显示文摘OBJECTIVE: To investigate the effect of Yishengukang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase(BAP), carboxyterminal propeptide of type Ⅰ procollagen(PICP), and carboxyterminal cross-linked telepeptide of type Ⅰ collagen(ICTP), in cancer patients with bone metastasis.METHODS: Patients(n = 180) were divided into three groups:(a) bone metastasis patients treated with Yishengukang and pamidronate disodium injection(treatment group, n = 60);(b) bone metastasis patients treated with pamidronate disodium injection alone(control group, n = 60);(c) cancer patients without metastatic bone lesion(non-bone metastasis group, n = 60). Serum levels of the metabolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and post-therapy.RESULTS: A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control group.CONCLUSION: Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis,and may represent the molecular mechanism underpinning the effects of Yishengukang decoction. | Yin Yukun Feng Li Zhou Lei Li Jie Gao Yin Wang Ningjun Yu Jianhua Jiang Zhenglong He Shengqi Lu Dianrong Wang Fang Du Yanlin | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 6 |
| 3 | Technology for high performance TRIP steel显示文摘Thermodynamics of martensite transformation in low alloy TRIP steel was evaluated.It follows from the calculation that ε phase might be formed at above room temperature in the low Mn steel.Tested steel was therefore prepared according to the estimation result.High volume fraction of retained austenite(above 20%) containing 1.37%C was obtained in the steel after continuous annealing treatment.Tensile test showed that the ultimate strength of the steel was 1248 MPa,elongation rate 25%,the product of strength and elongation rate 31200 MPa%,reaching the grade of the third generation automobile steel.XRD detection indicated that after tensile test there existed ' martensite while TEM revealed that ε martensite also existed in the steel.Strengthening-toughening of the steel was thus raised due to the effect of transformation induced plasticity of two kinds of martensite.In addition,the phase stability of carbonitrates containing V was estimated and the complex micro-alloying effect was applied to the steel to control the size of austenite(about 1 μm) and enhance the stability of austenite. | LI Lin GAO Yi ZHU NaQiong HE YanLin LIU RenDong HE ZhongPing SHI Wen ZHANG Mei | 2012 | Science China(Technological Sciences)2012，55，7： | 5 |
| 4 | Abscisic acid receptors maintain abscisic acid homeostasis by modulating UGT71C5 glycosylation activity显示文摘Uridine diphosphate-glucosyltransferases(UGTs)maintain abscisic acid(ABA)homeostasis in Arabidopsis thaliana by converting ABA to abscisic acid-glucose ester(ABA-GE).UGT71C5 plays an important role in the generation of ABA-GE.Abscisic acid receptors are crucial upstream components of the ABA signaling pathway,but how UGTs and ABA receptors function together to modulate ABA levels is unknown.Here,we demonstrated that the ABA receptors RCAR12/13 and UGT71 C5 maintain ABA homeostasis in Arabidopsis following rehydration under drought stress.Biochemical analyses show that UGT71C5 directly interacted with RCAR8/12/13 in yeast cells,and the interactions between UGT-71C5 and RCAR12/13 were enhanced by ABA treatment.Enzyme activity analysis showed that ABA-GE contents were significantly elevated in the presence of RCAR12 or RCAR13,suggesting that these ABA receptors enhance the activity of UGT71C5.Determination of the content of ABA and ABA-GE in Arabidopsis following rehydration under drought stress revealed that ABA-GE contents were significantly higher in Arabidopsis plants overexpressing RCAR12 and RCAR13 than in nontransformed plants and plants overexpressing RCAR11 following rehydration under drought stress.These observations suggest that RCAR12 and RCAR13 enhance the activity of UGT71C5 to glycosylate excess ABA into ABA-GE following rehydration under drought stress,representing a rapid mechanism for regulating plant growth and development. | Yanlin Ma Jing Cao Qiaoqiao Chen Jiahan He Zhibin Liu Jianmei Wang Xufeng Li Yi Yang | 2021 | Journal of Integrative Plant Biology2021，63，3： | 3 |
| 5 | Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies显示文摘Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing more and more attentions.Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage.The influence of the linkages on the self-assembly,in vivo fate and antitumor activity of homodimeric prodrugs is the focus of research.Herein,three docetaxel(DTX)homodimeric prodrugs are developed using different lengths of diselenide bond-containing linkages.Interestingly,compared with the other two linkages,the longest diselenide bond-containing linkage could facilitate the self-delivery of DTX prodrugs,thus improving the stability,circulation time and tumor targeting of prodrug nanoassemblies.Besides,the extension of linkages reduces the redox-triggered drug release and cytotoxicity of prodrug nanoassemblies in tumor cells.Although the longest diselenide bond-containing prodrug nanoassemblies possessed the lowest cytotoxicity to 4T1 cells,their stable nanostructure maintained intact during circulation and achieve the maximum accumulation of DTX in tumor cells,which finally“turned the table”.Our study illustrates the crucial role of linkages in homodimeric prodrugs,and gives valuable proposal for the development of advanced nano-DDS for cancer treatment. | Lingxiao Li Shiyi Zuo Fudan Dong Tian Liu Yanlin Gao Yinxian Yang Xin Wang Jin Sun Bingjun Sun Zhonggui He | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 3 |
| 6 | Thermodynamic Assessment and Experimental Investigation of Fe-Al-C System显示文摘Phase diagram information of the Fe-C,Fe-Al and Al-C systems are reviewed and the Fe-Al-C system is assessed.A FeAlC database is created by combining a set of thermodynamic parameters established by Kumar and SSOL database in Thermo-Calc software package.Ternary phase diagrams are calculated with FeAlC and the newly developed Thermo-Calc databases SSOL2 and SSOL4.The FeAIC database is the best one to describe the Fe-Al-C system.A1 and A3 values on the vertical section containing 1.5 wt pct Al are calculated with the FeAlC database in this work.To validate the thermodynamic calculation,critical temperatures A_(C_1) and A_(C_3) are determined by using dilatometer analysis.There exist some errors between the calculated values and the experimental results.So further optimization of the Fe-Al-C system regarding bcc and fcc phases is necessary.The experimental data in this work could be of some value in further optimization. | Weiyan LU Lin LI Li WANG Yanlin HE Shuigen HUANG | 2008 | Journal of Materials Science & Technology2008，24，5： | 3 |
| 7 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 8 | Zhuifeng tougu capsules (追风透骨胶囊) improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway显示文摘OBJECTIVE: To investigate the efficacy of Zhuifeng tougu capsules(追风透骨胶囊, ZFTG) in the treatment of rheumatoid arthritis(RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B(TLR2/4-NF-κB) signaling pathway.METHODS: TypeⅡ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-,and low-dose ZFTG groups. The methotrexate(MTX) control group was treated with the corresponding drug intervention for 28 d. The joint temperature, pain threshold, joint swelling degree, and arthritis index(AI) score were measured. The production of C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), and rheumatoid factors(RFs) in the blood was detected by enzyme-linked immunosorbent assay. The protein expression of TLR2, TLR4, and NF-κB in synovial tissues was detected by Western blotting, and the m RNA expression of TLR2, TLR4, and NF-κB was detected by real-time polymerase chain reaction.RESULTS: Compared with the model group, the joint temperature in each treatment group, the MTX control group, and MTX group recovered, the degree of foot swelling, pain threshold, AI score decreased, serum CRP, ESR, RF level and the levels of TLR2, TLR4, and NF-κB in synovial tissue were decreased(P < 0.05). Among them, the curative effect in the medium-dose and MTX groups was more evident(P < 0.01).CONCLUSION: ZFTG has a significant effect on RA in rats, and its mechanism may involve regulating CRP levels, the ESR, and RFs via the TLR2/4-NF-κB signaling pathway. | GONG Hui KUANG Gaoyan WU Yongrong LU Fangguo DENG Yihui HE Yanlin WANG Hengxin | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 2 |
| 9 | Computer simulation of W-C-Co-V system diffusion couples显示文摘Diffusion couples,WC/Co-1at.%C,V8C7/Co,and WC/Co-0.3wt.%V8C7 were constructed and annealed at tem-peratures ranging from 1100 to 1300°C. The concentration profile of V and W atoms in these couples were measured by EPMA. Aided by Thermo-calc & DICTRA software package,the concentration profiles of W and V in established diffu-sion couples were calculated by the moving boundary model according to revised dynamic parameters and MOB database,respectively. Then the concentration profile of W in Co binder during sintering WC-Co cemented carbide was simulated by the Cell model. It can provide reference for composition and sintering process design of cemented carbides with high per-formance. Meanwhile,the validity of revised dynamic parameters of the W-C-Co-V system is verified by the comparison of experimental and simulated results. | HE Yanlin LI Lin HUANG Shuigen Jef Vleugels Omer Van der Biest | 2007 | Rare Metals2007，26，5： | 2 |
| 10 | Modeling of Nucleation and Growth of M_(23)C_6 Carbide in Multi-component Fe-based Alloy显示文摘Three-dimensional atom probe (3DAP) technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800°C. 3D images indicate that the radius of M23C6 carbide after ageing for 10 min is about 9 nm. Concentration profiles of alloy elements in the carbide are also obtained. Combined with PANDAT and Thermo-Calc software, attempts to model the early stages of precipitation are present. The calculated particle size and composition of M23C6 carbide is in good agreement with 3DAP data. | Naqiong Zhu Yanlin He Wenqing Liu Lin Li Shuigen Huang Jef Vleugels Omer Van der Biest | 2011 | Journal of Materials Science & Technology2011，27，8： | 1 |
| 11 | Computer Simulation of Fe-Al-Si System Diffusion Couples显示文摘Diffusion couples, Fe-6.8 wt% Al-1.0 wt% Si/Fe and Fe-6.3 wt% Al-0.9 wt% Si/Fe were constructed and separately annealed at 1050°C for 3 h and at 1000°C for 64 h. The concentration profiles of Fe, Al and Si atoms in these couples were measured by electron probe micro-analysis (EPMA), while the diffusion behavior was also simulated by coupling thermodynamic and kinetic properties of Fe-Al-Si system. The simulation results were in good agreement with the measured concentration profiles showing the validity of dynamic parameters of Fe-Al-Si system. Calculation was made for Fe-7 wt% Al-1 wt% Si/Fe diffusion couples at 1000?C with different diffusion time. Silicon uphill was found under the influence of aluminum. | Zhongping He Yanlin He YiGao Lin Li Shuigen Huang Omer Van der Blest | 2011 | Journal of Materials Science & Technology2011，27，8： | 1 |
| 12 | Computer aided composition design of prehardened mould steel Plastics显示文摘 | He Yanlin Li Lin | | JMST0，，： | 1 |
| 13 | Challenges in hot-dip galvanizing of high strength dual phase steel: Surface selective oxidation and mechanical property degradation显示文摘 | Huachu Liu Fang Li Wen Shi Srinivasan Swaminathan Yanlin He Michael Rohwerder Lin Li | 2012 | Surface & Coatings Technology2012，，16： | 1 |
| 14 | Link between miR-19b and the mTOR signaling pathway in cancer prognosis显示文摘Objective Previous studies have reported differing conclusions regarding the prognostic value of miR-19b in cancers.Moreover,miR-19b may affect tumor growth by different pathways,mainly targeting PTENPI3K-AKT,which activates the downstream mTOR pathway.Therefore,we performed data mining to explore the possible correlation between miR-19b and mTOR in cancer prognosis.Methods We conducted online search and collected a total of 943 articles.According to different authors cross check and our study including/excluding criteria we at end retained 21 articles with 25 studies in this meta-analysis.Then TCGA data containing miR-19b level with cancer progression were obtained using OncomiR.Furthermore,Trial Sequential Analysis(TSA)was performed to determine whether the results of our meta-analysis could be used in clinical applications.After that,articles regarding the mechanism of miR-19b in various cancers were analyzed and KEGG pathway database was used to find the main regulatory function of miR-19b in human cancers.Results Overall hazard ratio(HR)results showed that higher levels of miR-19b expression were correlated with shorter overall survival time[HR=1.54,95%confidence interval(CI)=1.20-1.98]by promoting distant metastasis,but had no correlation with disease-free survival(DFS)/progression-free survival(PFS;HR=0.61,95%CI=0.31–1.19).Data from The Cancer Genome Atlas also revealed the role of miR-19b in tumorigenesis.According to trial sequential analysis results,more evidence is required to confirm that miR-19b is not correlated with DFS/PFS.Exploration of the mechanism revealed a possible link between miR-19b and the mTOR pathway.Conclusion miR-19b may have a pro-carcinogenic role through the mTOR pathway and thus,it is likely to be a therapeutic target for cancers. | Yanlin Feng Souraka Tapara Dramani Maman Shuo Li Dingdong He Jiancheng Tu | 2020 | Oncology and Translational Medicine2020，6，4： | 1 |
| 15 | Prediction of carbide transormtion in mould steel for plastic by plastic by computer simulation显示文摘 | He Yanlin Li Lin Wollants Patrick | 2004 | Journal of Iron and Steel Research Inter- national2004，20，1： | 1 |
| 16 | Rapid and high-quality 3D fusion of heterogeneous CT and MRI data for the human brain显示文摘Data obtained from computed tomography(CT)and magnetic resonance imaging(MRI) that describe the human brain is commonly used in medical research and diagnosis (1)CT data are used to efficiently present high-density features, whereas MRI data are better suited for soft-tissue presentation (2)The complementary functions of CT and MRI may be used to further develop medicalcare procedures and brain exploration. CTand MRI were combined to realistically depict thediagnostic, anatomic, and pathological informationof the auditory and vestibular systems [3]. | Zexue HE Li ZHU Minjie LI Jinyao LI Yiran CHEN Yanlin LUO | 2019 | Science China(Information Sciences)2019，62，10： | 1 |
| 17 | Computer-aided designing and manufacturing of advanced steels显示文摘Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modern measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plas- ticity (TRIP) steel. The refining process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure. | LI Lin HE Yanlin B.C. De Cooman P. Wollants S. G. Huang J. Vleugels | 2006 | Rare Metals2006，25，5： | 1 |
| 18 | The efficacy of Kriging spatial interpolation for filling temporal gaps in daily air temperature data: A case study in northeast China显示文摘daily air temperature;;gap filling;;Kriging spatial interpolation;;northeast | YanLin Zhang XiaoLi Chang Ji Liang DongLiang Luo RuiXia He | 2016 | Research in Cold and Arid Regions2016，8，5： | 1 |
| 19 | Computer simulating the diffusion behavior of V and W in Co binder layer of WC-Co cemented carbide显示文摘 | He Yanlin | 2007 | Journal of Alloys and Compounds2007，436，： | 1 |
| 20 | Electrochemical performances of NiO/Ni2N nanocomposite thin film as anode material for lithium ion batteries显示文摘Despite the high specific capacities,the practical application of transition metal oxides as the lithium ion battery(LIB)anode is hindered by their low cycling stability,severe polarization,low initial coulombic efficiency,etc.Here,we report the synthesis of the NiO/Ni2N nanocomposite thin film by reactive magnetron sputtering with a Ni metal target in an atmosphere of 1 vol.% O2 and 99 vol.%N2.The existence of homogeneously dispersed nano Ni2N phase not only improves charge transfer kinetics,but also contributes to the one-off formation of a stable solid electrolyte interphase(SEI).In comparison with the NiO electrode,the NiO/Ni2N electrode exhibits significantly enhanced cycling stability with retention rate of 98.8%(85.6%for the NiO electrode)after 50 cycles,initial coulombic efficiency of 76.6%(65.0%for the NiO electrode)and rate capability with 515.3 mA·h·g^−1(340.1 mA·h·g^−1 for the NiO electrode)at 1.6 A·g^−1. | Yanlin JIA Zhiyuan MA Zhicheng LI Zhenli HE Junming SHAO Hong ZHANG | 2019 | Frontiers of Materials Science2019，13，4： | 1 |
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