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| 1 | Fura-2/AM法测定突触体内游离Ca^(2+)浓度的方法显示文摘采用新型Ca2+荧光指示剂Fura-2,测定冷冻伤性脑水肿时突触体内游离钙的离子浓度。 | Chen Liuhua Yan Yujia He Zhengwen, et al(Neurological and Neurosurgical Institute of Ncurosurgery, Xiangya Hospital, Hunan Medical University, Changsha 410008) | 1998 | 湖南医科大学学报1998，23，4： | 9 |
| 2 | Efficacy of Yangyin Yiqi Huoxue Granule (养阴益气活血颗粒) in Treatment of Ischemic Stroke Patients with Qi-Yin Deficiency and Blood Stasis Syndrome: A Randomized, Double-Blind, Multicenter, Phase-2 Clinical Trial显示文摘Objective To evaluate the efficacy and safety of Yangyin Yiqi Huoxue Granule(养阴益气活血颗粒,YYHG)in the treatment of ischemic stroke(IS)patients with qi-yin deficiency and blood stasis syndrome(QYDBSS),and to explore its effective dosage.Methods The total of 288 patients were randomly assigned to the YYHG high-dose,YYHG low-dose,positive control(administered Xiaoshuantong Granule,XSTG,消栓通颗粒),or placebo control(administered inert granule)groups(72 cases per group)by software-drived competitive block randomization.The trial was conducted for a 28-day period,with a 180-day follow-up period.The primary outcome was the comprehensive curative evaluation,and secondary outcomes were the National Institute of Health Stroke Scale(NIHSS)score,Barthel activities of daily living(ADL)index score,the quality of life index(QLI)score,and the Chinese medicine syndrome(CMS)score.All analyses were done on an intention-to-treat basis.The clinical safety was also assessed.Results The total of 288 participants were recruited between June 1,2008 and September 30,2009,and 287 patients received intervention;the treatment groups were well balanced at baseline.The comprehensive cure rates of YYHG high-dose,low-dose,positive and placebo control groups were 63.38%,31.94%,36.11%and 6.14%,respectively;there was a statistical difference between the two groups(P<0.01),while the high-dose YYHG treatment group was significantly higher than the other 3 groups(P<0.01).The improvement of NIHSS,ADL,QLI and CMS scores of the YYHG high-dose and low-dose groups was significantly better than that of the positive control group and the placebo control group(P<0.05).In terms of improving the classification of the NIHSS scale and the assessment of the ADL scale,the YYHG high-dose group was significantly better than the other three groups(P<0.05),and the YYHG low-dose group was better than the placebo control group(P<0.01).At the same time,except for the QLI score,the high-dose group was better than the low-dose group(P<0.05).In terms of safety,adverse reactions after YYHG treatment were generally mild(3.78%),and no serious adverse reactions have been reported.Conclusion YYHG is safe and effective in the treatment of IS patients with QYDBSS. | WANG Yu YANG Jie-hong WAN Hai-tong HE Yu XU Bin Al Chang-shan ZHOU Hui-fen YU Li WAN Hao-fang BIE Xiao-dong | 2021 | Chinese Journal of Integrative Medicine2021，27，11： | 4 |
| 3 | Theory of optimal blocking for fractional factorial split-plot designs显示文摘The issue of optimal blocking for fractional factorial split-plot (FFSP) designs is considered under the two criteria of minimum aberration and maximum estimation capacity. The criteria of minimum secondary aberration (MSA) and maximum secondary estimation capacity (MSEC) are developed for discriminating among rival nonisomorphic blcoked FFSP designs. A general rule for identifying MSA or MSEC blocked FFSP designs through their blocked consulting designs is established. | Al Mingyao & HE Shuyuan Key Laborartory of Pure and Applied Mathematics, School of Mathematical Sciences, Peking University, Beijing 100871, China | 2005 | Science China Mathematics2005，48，5： | 2 |
| 4 | A new mixed micellar electrokinetic chromatography method for analysis of natural and synthetic anabolic steroids 显示文摘 | Zhang L Chen J He Y eZ al | 2009 | Talanta2009，77，3： | 1 |
| 5 | The MYB transcription factor super-family of Arabidopsis:expression analysis and phylogenetic comparisonwith the rice MYB family显示文摘 | CHEN Y H YANG X Y HE Ke t al | 2006 | Plant Molecular Biology2006，60，： | 1 |
| 6 | Functional and structural con- neelivity between the perigenual anterior cingulate and amygda- la in bipolar disorder显示文摘 | Wang F Kalmar JH He Y el al | 2009 | Biol Psychiatry2009，66，5： | 1 |
| 7 | Quantum-dot-conjugated graphene as a probe for simultaneous cancer-targeted fluores- cent imaging,tracking,and monitoring drug delivery显示文摘 | Chen M L He Y J Chen X W et al | 2013 | Biocon- jugate Chemistry2013，24，3： | 1 |
| 8 | Selenium:biochemical role as a component of glutathione peroxidase 显示文摘 | Pope Al Ganther HE | 1973 | Science1973，179，： | 1 |
| 9 | Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs显示文摘 | Broome HE Yu AL Diccianni M | 2002 | Leuk Res2002，26，3： | 1 |
| 10 | Face Recognition Using Laplacianfaces显示文摘 | HE X F YAN S C HU Y X Et Al | 2005 | IEEE Transactions On Pattern Analysis And Machine Intelligence2005，27，3： | 1 |
| 11 | Characteristics of aerobic granules 显示文摘 | Tay J H Pan S He Y X et aL Effect of organic loading rate on aerobic granulation: Part II | 2004 | J Environ Eng2004，130，： | 1 |
| 12 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 13 | Image reconstraction for echo planner imaging with non-equidistance κ-space sampling显示文摘 | Bruder H Fischer H Reinfelder HE et al | 1992 | Magnetic Resonance in Medicine1992，23，： | 1 |
| 14 | 230 cases of videoassisted thoracoscopic surgery 显示文摘 | HE J X YANG Y Y WEI B ef al | 1996 | Chin J Surg1996，34，2： | 1 |
| 15 | Themml characterization of an epoxy- I)ast underfill material for flip chip packaging 显示文摘 | He Y Moreira B E Overson A el al | 2000 | llmnnochinfiea Aeta2000，3573，14： | 1 |
| 16 | The choice of anestheticmaintenance technique influences the antiinflammatory cytokine re-sponse to abdominal surgery显示文摘 | Gilliland HE Armstrong MA Carabine U ef al | 1997 | Anesth Analg1997，85，6： | 1 |
| 17 | Estimating land use im- pacts on regional scale urban water balance and groundwa- ter recharge显示文摘 | He B Wang Y Takase K el al | 2009 | Water Resources Manage2009，，23： | 1 |
| 18 | Concentration of thymidine kinasc 1 in serum(S-TK1) is a more sensitive proliferation marker in hu mare solid tumors than its activity显示文摘 | He Q Zhang P Zou L ct al | 2005 | Oncol Rep2005，14，4： | 1 |
| 19 | Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein显示文摘 | Park JS Svetkauskaite D He Q et 'al | 2004 | J Biol Chem2004，279，9： | 1 |
| 20 | Chronic-intermittent hypoxia:a model of sympathetic activation in the rat显示文摘 | Sica AL Greenberg HE Ruggiero DA | 2000 | Respir Physiol2000，121，： | 1 |
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