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| 1 | A photothermal reservoir for highly efficient solar steam generation without bulk water显示文摘A solid photothermal reservoir is designed to implement solar-steam generation in the absence of bulk water.The photothermal reservoir is composed of a water absorbing core encapsulated by a photothermal reduced graphene oxide based aerogel sheet which absorbs light and converts it into heat thus evaporating the stored water.The photothermal reservoir is able to store 6.5 times its own weight in water,which is sufficient for one day solar evaporation,thus no external water supplement is required.During solar-steam generation,since no bulk water is involved,the photothermal reservoir minimizes heat conduction loss,and maximizes both of the exposed evaporation surface area and net energy gain from the environment,leading to an energy efficiency beyond the theoretical limit.An extremely high water evaporation rate of 4.0 kg m-2 h-1(normalized to projection area)is achieved in laboratory studies over a cylinder photothermal reservoir with a diameter of 5.2 cm and a height of 15 cm under 1.0 sun irradiation.Practical evaluation of the photothermal reservoir outdoors as part of a desalination device demonstrates a similar evaporation rate where the salinity of the clean water produced is lower than 24 ppb.Thus the photothermal reservoir shows great potential for real world applications in portable solarthermal desalination. | Xuan Wu Ting Gao Chenhui Han Jingsan Xu Gary Owens Haolan Xu | 2019 | Science Bulletin2019，64，21： | 9 |
| 2 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 3 | Design and simulation of a compact ultra-wideband bandpass filter with a notched band using multiple-mode resonator technique显示文摘A novel, compact, and highly selective ultra-wideband(UWB) bandpass filter with a narrow notched band is presented. Apart from having a basic structure of a slotline multiple-mode resonator(MMR) and microstrip feed lines, this novel design introduces a cross-coupling between the input and output feed lines to enhance the filter selectivity. The design strictly follows the theory and verified by electromagnetic(EM) simulation and experiments. In addition, the narrow notched band is introduced by embedding a pair of split ring resonators(SRR) in order to reject any undesired existing radio signals that may interfere with the Federal Communications Commission(FCC)-defined UWB band. By changing the structural parameters of SRR, it can be easily tuned to any desired frequency. This filter can be integrated in UWB communication systems and efficiently improve the interference immunity from undesired signals such as wireless local area network(WLAN). | Yang Hong Chen Jing Yang Haolan Liu Yunlong Yang Yuchuan | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，1： | 6 |
| 4 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 5 | Multiscale modeling of electrolytes in porous electrode:From equilibrium structure to non-equilibrium transport显示文摘Understanding the mechanisms and properties of various transport processes in the electrolyte,porous electrode,and at the interface between electrode and electrolyte plays a crucial role in guiding the improvement of electrolytes,materials and microstructures of electrode.Nanoscale equilibrium properties and nonequilibrium ion transport are substantially different to that in the bulk,which are difficult to observe from experiments directly.In this paper,we introduce equilibrium and no-equilibrium thermodynamics for electrolyte in porous electrodes or electrolyte-electrode interface.The equilibrium properties of electrical double layer(EDL)including the EDL structure and capacitance are discussed.In addition,classical non-equilibrium thermodynamic theory is introduced to help us understand the coupling effect of different transport processes.We also review the recent studies of nonequilibrium ion transport in porous electrode by molecular and continuum methods,among these methods,dynamic density functional theory(DDFT)shows tremendous potential as its high efficiency and high accuracy.Moreover,some opportunities for future development and application of the non-equilibrium thermodynamics in electrochemical system are prospected. | Haolan Tao Cheng Lian Honglai Liu | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 6 | Brain neural effects of the ’tonifying kidney and benefiting marrow’ method in the treatment of osteoporosis显示文摘In Traditional Chinese Medicine(TCM),the'tonifying kidney and benefiting marrow'(TKBM)method is based on the theory that kidney controls bones,while marrow moistens bones.There have been aboundant theoretical studies on kidney controlling bones since Huangdi's Internal Classics.Howev-er,there are too few ones about the marrow moistening the bones.Researchers generally use the tonifying kidney method instead of the TKBM method,which causes lack of a unified standard and theoretical basis in evaluating the TKBM method.Herein,we first proposed the hypothesis that deficiency of marrow sea causes osteoporosis.Next,we prove the scientific validity of this hypothesis from the side of the TCM theory on the relationship among kidney,bone and marrow sea physiologically and pathologically.Based on this,we find that the TCM theory provides theoretical basis for deficiency of marrow sea causing osteoporosis.On the other side,Western Medicine theory holds that(a)physiologically,the brain regulates the bone mass via three pathways:the neuro-osteogenic network,neuro-endocrine-bone network,and neuropeptide-bone network;(b)pathologically,brain impacts bone mass via three major passways including the regulation of the sympathetic nervous system,secreting hormones that directly act on bone cells and regulating the synthesis and secretion of hormones in the intermediary organs,and neuropeptides such as neuropeptide Y(NPY),substance P(SP),and calcitonin gene-related peptide(CGRP).Evidences involving estrogen deficiency,sympatheticotonia,or neuropeptides imbalance prove that brain-bone mass regulation plays an important role in the pathogenesis of osteoporosis.Finally,we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network,and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis,which thus influences bone metabolism without clinically significant estro-gen-like side effects,and regulate NPY,CGRP and SP involved in the bone metabolism.These further support our hypothesis by revealing the brain neural mechanism of the TCM kidney invigoration method for preventing and treating osteoporosis.In the future,neuroimaging techniques may be useful in exploring its neural effects and also aid in developing new strategies for treating osteoporosis. | Xu Yunxiang Liu Xueqin Li Haolan Liu Hongyuan Pan Zhanxia Chen Guizhen | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 5 |
| 7 | Targeting p53 pathways:mechanisms,structures,and advances in therapy显示文摘The TP53 tumor suppressor is the most frequently altered gene in human cancers,and has been a major focus of oncology research.The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle,apoptosis,and genomic stability,and is widely regarded as the“guardian of the genome”.Accumulating evidence has shown that p53 also regulates cell metabolism,ferroptosis,tumor microenvironment,autophagy and so on,all of which contribute to tumor suppression.Mutations in TP53 not only impair its tumor suppressor function,but also confer oncogenic properties to p53 mutants.Since p53 is mutated and inactivated in most malignant tumors,it has been a very attractive target for developing new anti-cancer drugs.However,until recently,p53 was considered an“undruggable”target and little progress has been made with p53-targeted therapies.Here,we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression.We also discuss key structural features of the p53 protein and its inactivation by oncogenic mutations.In addition,we review the efforts that have been made in p53-targeted therapies,and discuss the challenges that have been encountered in clinical development. | Haolan Wang Ming Guo Hudie Wei Yongheng Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 4 |
| 8 | Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non–Small-Cell Lung Cancer: Results From a Randomized, Double-Blind, Multicenter Phase II Study显示文摘 | Thomas J. Lynch Igor Bondarenko Alexander Luft Piotr Serwatowski Fabrice Barlesi Raju Chacko Martin Sebastian Joel Neal Haolan Lu Jean-Marie Cuillerot Martin Reck | 2012 | Journal of Clinical Oncology2012，，17： | 2 |
| 9 | Template synthesis of multi- shelled CuzO hollow spheres with a single-crystalline shell wall显示文摘 | Xu Haolan Wang Wenzhong | 2007 | Angew Chem Int Ed2007，46，9： | 1 |
| 10 | Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non–Small-Cell Lung Cancer: Results From a Randomized, Double-Blind, Multicenter Phase II Study显示文摘 | Thomas J. Lynch Igor Bondarenko Alexander Luft Piotr Serwatowski Fabrice Barlesi Raju Chacko Martin Sebastian Joel Neal Haolan Lu Jean-Marie Cuillerot Martin Reck | 2012 | Journal of Clinical Oncology2012，，17： | 1 |
| 11 | Rapid seeded growth of monodisperse, quasi-spherical, citrate-stabilized gold nanoparticles via H202 reduction 显示文摘 | Liu Xiaokong Xu Haolan Wang Dayang | 2012 | Langmuir2012，28，13： | 1 |
| 12 | Partial pressure of NH3 in cirrhotic patients with and without hepatic encephyalopathy 显示文摘 | He Yong Li Guixing Song Haolan etal | 2011 | J gastrointestin Liver Dis2011，20，2： | 1 |
| 13 | Bi2O3hierarchical nanostructures:controllable synthesis,growth mechanism,and their application in photocatalysis显示文摘 | ZHOU Lin WANG Wenzhong XU Haolan | 2009 | Chemistry-A European Journal2009，15，7： | 1 |
| 14 | A facile strat- egy to porous materials: Coordination-assisted heteroge neous dissolution route to the spherical Cu2O single crystallites with hierarchical pores 显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | Micropor Meso- por Mater2006，95，： | 1 |
| 15 | Recent strategies for constructing efficient interfacial solar evaporation systems显示文摘Interfacial solar evaporation(ISE)is a promising technology to relieve worldwide freshwater shortages owing to its high energy conversion efficiency and environmentally sustainable potential.So far,many innovative materials and evaporators have been proposed and applied in ISE to enable highly controllable and efficient solar-to-thermal energy conversion.With rational design,solar evaporators can achieve excellent energy management for lowering energy loss,harvesting extra energy,and efficiently utilizing energy in the system to improve freshwater production.Beyond that,a strategy of reducing water vaporization enthalpy by introducing molecular engineering for water-state regulation has also been demonstrated as an effective approach to boost ISE.Based on these,this article discusses the energy nexus in two-dimensional(2D)and three-dimensional(3D)evaporators separately and reviews the strategies for design and fabrication of highly efficient ISE systems.The summarized work offers significant perspectives for guiding the future design of ISE systems with efficient energy management,which pave pathways for practical applications. | Yida Wang Junqing Hu Li Yu Xuan Wu Yingying Zhang Haolan Xu | 2023 | Nano Research Energy2023，2，2： | 1 |
| 16 | Sonochemical synthesis of crystalline CuS nanoplates via an in situ template route显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | Materials Letters2006，60，1718： | 1 |
| 17 | Shape evolution and size-controllable synthesis of Cu2O octahedra and their morphology-dependent photocatalytic properties显示文摘 | Xu Haolan Wang Wenzhong Zhu Wei | 2006 | J Phys Chem B2006，110，13： | 1 |
| 18 | Harvesting,sensing and regulating light based on photo-thermal effect of Cu@CuO mesh显示文摘A system of light harvesting, sensing and regulating was designed based on the photo-thermal and Seebeck effect of flexible CuO nanostructures. Cu@CuO meshes were prepared via self-oxidation of Cu mesh and utilized as the photo-thermal material. Upon irradiation by visible light, the temperature of the Cu@CuO mesh dramatically increases. The temperature difference between the irradiated and non-irradiated parts of the Cu@CuO mesh produced a measurable voltage output due to the Seebeck effect. The generated voltage was then converted into a digital signal to control a rotary neutral-density disc to filter the received light. This enabled regulation of the intensity of the incident light at a selected region. This system is cost effective and has potential applications in greenhouses, factories and smart buildings to minimize energy consumption and improve wellbeing. | Xuan Wu Jie Xu George Y.Chen Rong Fan Xiaokong Liu Haolan Xu | 2017 | Green Energy & Environment2017，2，4： | 1 |
| 19 | Controllable syn- thesis of three-dimensional well-defined BiVQ mesoerys-tals via a facile additive-free aqueous strategy显示文摘 | Zhou Lin Wang Wenzhong Xu Haolan | 2008 | Crystal Growth & Design2008，8，2： | 1 |
| 20 | Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels显示文摘Cell migration plays a pivotal role in many pathological and physiological processes.So far,most of the studies have been focused on 2-dimensional cell adhesion and migration.Herein,the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization of methacrylated hyaluronic acid(HA-MA)and fibrinogen(Fg)with different ratios were studied.The Fg could be released to the medium gradually along with time prolongation,achieving the dynamic change of hydrogel structures and properties.Three types of cell spheroids,i.e.,endothelial cell(EC),smooth muscle cell(SMC),and EC-SMC spheroids,were prepared with 10,000 cells in each,whose diameters were about 343,108,and 224μm,respectively.The composite hydrogels with an intermediate ratio of Fg allowed the fastest 3D migration of cell spheroids.The ECs-SMCs migrated longest up to 3200μm at day 14,whereas the SMC spheroids migrated slowest with a distance of only~400μm at the same period of time.The addition of free RGD or anti-CD44 could significantly reduce the migration distance,revealing that the cell-substrate interactions take the major roles and the migration is mesenchymal dependent.Moreover,addition of anti-N-cadherin and MMP inhibitors also slowed down the migration rate,demonstrating that the degradation of hydrogels and cell-cell interactions are also largely involved in the cell migration.RT-PCR measurement showed that expression of genes related to cell adhesion and antiapoptosis,and angiogenesis was all upregulated in the EC-SMC spheroids than single EC or SMC spheroids,suggesting that the use of composite cell spheroids is more promising to promote cell-substrate interactions and maintenance of cell functions. | Xingang Zuo Haolan Zhang Tong Zhou Yiyuan Duan Hao Shou Shan Yu Changyou Gao | 2020 | Research2020，，1： | 1 |
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