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| 1 | Head mass in chronic pancreatitis: Inflammatory or malignant显示文摘Chronic pancreatitis increases the risk of developing pancreatic cancer. This often presents as a mass lesion in the head of pancreas. Mass lesion in the head of pancreas can also occur secondary to an inflammatory lesion. Recognising this is crucial to avoid unnecessary surgery. This is sometimes difficult as there is an overlap in clinical presentation and conventional computed tomography(CT) abdomen findings in inflammatory andmalignant mass. Advances in imaging technologies like endoscopic ultrasound in conjunction with techniques like fine needle aspiration, contrast enhancement and elastography as well as multidetector row CT, magnetic resonance imaging and positron emission tomography scanning have been shown to help in distinguishing inflammatory and malignant mass. Research is ongoing to develop molecular techniques to help characterise focal pancreatic mass lesions. This paper reviews the current status of imaging and molecular techniques in differentiating a benign mass lesion in chronic pancreatitis and from malignancy. | Amit K Dutta Ashok Chacko | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 16 |
| 2 | Attributable cost of a nosocomial infection in the intensive care unit: A prospective cohort study显示文摘AIM To study the impact of hospital-acquired infections(HAIs) on cost and outcome from intensive care units(ICU) in India. METHODS Adult patients(> 18 years) admitted over 1-year, to a 24-bed medical critical care unit in India, were enrolled prospectively. Treatment cost and outcome data were collected. This cost data was merged with HAI data collected prospectively by the Hospital Infection Control Committee. Only infections occurring during ICU stay were included. The impact of HAI on treatment cost and mortality was assessed. RESULTS The mean(± SD) age of the cohort(n = 499) was42.3 ± 16.5 years. Acute physiology and chronic health evaluation-Ⅱ score was 13.9(95%CI: 13.3-14.5); 86% were ventilated. ICU and hospital length of stay were 7.8 ± 5.5 and 13.9 ± 10 d respectively. Hospital mortality was 27.9%. During ICU stay, 76(15.3%) patients developed an infection(ventilator-associated pneumonia 50; bloodstream infection 35; urinary tract infections 3), translating to 19.7 infections/1000 ICU days. When compared with those who did not develop an infection, an infection occurring during ICU stay was associated with significantly higher treatment cost [median(inter-quartile range, IQR) INR 92893(USD 1523)(IQR 57168-140286) vs INR 180469(USD 2958)(IQR 140030-237525); P < 0.001 and longer duration of ICU(6.7 ± 4.5 d vs 13.4 ± 7.0 d; P < 0.01) and hospital stay(12.4 ± 8.2 d vs 21.8 ± 13.9 d; P < 0.001)]. However ICU acquired infections did not impact hospital mortality(31.6% vs 27.2%; P = 0.49).CONCLUSION An infection acquired during ICU stay was associated with doubling of treatment cost and prolonged hospitalization but did not significantly increase mortality. | Binila Chacko Kurien Thomas Thambu David Hema Paul Lakshmanan Jeyaseelan John Victor Peter | 2017 | World Journal of Critical Care Medicine2017，6，1： | 11 |
| 3 | Influence of environmental factors on the onset and courseof inflammatory bowel disease显示文摘Numerous environmental factors have been linked with inflammatory bowel disease. These include smoking, diet, hygiene, drugs, geographical and psychosocial factors. These factors may either increase the risk of or protect against developing this condition and can also affect the course of illness in a positive or negative manner. A number of studies have examined the influence of environmental factors on inflammatory bowel diseases as a whole as well as on ulcerative colitis and Crohn's disease separately. As there are differences in the pathogenesis of ulcerative colitis and Crohn's disease, the effect of environmental factors on their onset and course is not always similar. Some factors have shown a consistent association, while reports on others have been conflicting. In this article we discuss the current evidence on the roles of these factors on inflammatory bowel disease, both as causative/protective agents and as modifiers of disease course. | Amit Kumar Dutta Ashok Chacko | 2016 | World Journal of Gastroenterology2016，22，3： | 5 |
| 4 | A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT OF MEN WITH SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC ENLARGEMENT: THE CLasP STUDY显示文摘 | JENNY L. DONOVAN TIM J. PETERS DAVID E. NEAL SARA T. BROOKES SANDEEP GUJRAL K. NINAN CHACKO MARK WRIGHT L. GAIL KENNEDY PAUL ABRAMS | 2000 | The Journal of Urology2000，，1： | 3 |
| 5 | Risk factors of thrombosis in abdominal veins显示文摘AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups. | Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair Vikram Mathews | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 6 | Significance of serum carcinoembryonic antigen in metastatic breast cancer patients:A prospective study显示文摘BACKGROUND Carcinoembryonic antigen(CEA)is an important serum tumour marker with a substantial role in diagnosis and monitoring of various solid tumours.About 36%-70%of breast cancers have elevated serum CEA.And the available studies show discrepancy in addressing the prognostic significance of CEA in advanced breast cancer.AIM To estimate the serum CEA level in our metastatic breast cancer patients and correlate it with response to treatment and clinical outcome.METHODS This was a prospective clinical study conducted on 50 metastatic breast cancer patients treated at breast clinic,with newly diagnosed metastatic breast cancer planned for palliative chemotherapy,targeted therapy,and hormonal treatment.We estimated the proportion of patients with elevated serum CEA level at baseline and after palliative treatment and also studied the association of serum CEA levels with known prognostic factors.The response to treatment was correlated with the serum CEA levels in the context of responders and nonresponders.RESULTS The median pre-treatment and post-treatment CEA levels were 7.9(1.8-40.7)ng/mL and 4.39(1.4-12.15)ng/mL,respectively,in the whole study population(P=0.032).No statistically significant difference was seen in baseline serum CEA between responders and non-responders.Even in the luminal group,pretreatment serum CEA was not a predictor of response,but post-treatment CEA was a significant predictor of tumour progression.In patients with liver and lung metastases,post-treatment CEA level difference was not statistically significant in both responders and non-responders though the values were higher in nonresponders.Among those with bone metastases,69.5%had elevated post-treatment serum CEA,and only 37.5%had elevated serum CEA in those with no bone metastases.CONCLUSION Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy.Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases.Elevated serum CEA and hormonal status are significant predictors of treatment response. | Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 7 | Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non–Small-Cell Lung Cancer: Results From a Randomized, Double-Blind, Multicenter Phase II Study显示文摘 | Thomas J. Lynch Igor Bondarenko Alexander Luft Piotr Serwatowski Fabrice Barlesi Raju Chacko Martin Sebastian Joel Neal Haolan Lu Jean-Marie Cuillerot Martin Reck | 2012 | Journal of Clinical Oncology2012，，17： | 2 |
| 8 | Heart rate recovery predicts mortality and cardiovascular events in patients with type 2 diabetes显示文摘 | Chacko KM Bauer TA Dale RA | 2008 | Med Sci Sports Exerc2008，40，2： | 1 |
| 9 | From brain drain to brain gain: reverse mi- gration to Bangalore and Hyderabad, India's globalizing high tech cities 显示文摘 | Chacko E | 2007 | GeoJournal2007，68，2： | 1 |
| 10 | Histological correlation of diffusion tensor imaging metrics in experimental spinal cord injury显示文摘 | Herrera JJ Chacko T Narayana PA | 2008 | J Neurosci Res2008，86，2： | 1 |
| 11 | Improving medication adherence in chronic pediatric health conditions a focus on ADHD in youth 显示文摘 | Chacko A Newcom JH Feirsen N | 2010 | Curr Pharm Des2010，16，22： | 1 |
| 12 | Immediate oral amiodarone re-challenge following the development of parenteral-induced acute liver toxicity显示文摘Dear editor,Amiodarone is a class Ⅲ antiarrhythmic medication commonly used in the emergency department (ED) and other critical care settings to treat several types of arrhythmias while also serving as a fixture of the Advanced Cardiac Life Support algorithm.[1] Its mechanism of action primarily involves blocking potassium channel currents during myocyte repolarization with additional effects on betaadrenergic receptors and both sodium and calcium channel blockade.[2] One of amiodarone’s less known complications is the development of acute hepatotoxicity with intravenous(IV) administration.[3] While discontinuation has been recommended, there is limited literature to help guide management when clinical factors warrant its continuation. | Joseph Off enbacher Farnam Kazi Niel Chen Mohamed Mohamed Jasmine Chacko Nils Guttenplan Vincent Nguyen | 2021 | World Journal of Emergency Medicine2021，12，4： | 1 |
| 13 | Alterations inliver ATP homemostasis in human nonalcoholicsteatohepatitis : a pilot study 显示文摘 | Cortez -Pinto H Chatham J Chacko CP | 1999 | JAMA1999，282，17： | 1 |
| 14 | Beneficial effects of green tea: a literature review显示文摘 | M Chacko S Thambi PT Kuttan R | 2010 | Chin Med2010，5，1： | 1 |
| 15 | Differential control of eosinophil survival by glucocorticoids显示文摘 | Bloom JW Chacko J Lohman IC | 2004 | Apoptosis2004，9，1： | 1 |
| 16 | Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging 显示文摘 | Mori S Crain BJ Chacko VP | 1999 | Ann Neurol1999，45，2： | 1 |
| 17 | Persistent non- specific FDG uptake on PET imaging following hip arthroplast显示文摘 | Zhuang H Chacko TK Hickeson M | 2002 | Eur J Nucl Med Mol Imaging2002，29，10： | 1 |
| 18 | ECT and tardive dyskinesia:two cases and a review显示文摘 | Chacko RC Root L | 1983 | J Clin Psychiatry1983，44，7： | 1 |
| 19 | Histological correlation of diffusion tensor imaging metrics in experimental spinal cord injury显示文摘 | Herrera J J Chacko T Narayana PA | 2008 | J Neurosci Res2008，86，： | 1 |
| 20 | Methionine transmethylation and transsulfuration in the piglet gastrointestinal traet 显示文摘 | Riedijk M A Stoll B Chacko S | 2007 | Proc Nat Acad Sci USA2007，104，： | 1 |
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