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| 1 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 2 | Sequence and analysis of rice chromosome 4显示文摘 | Feng Q Zhang Y Hao P | 2002 | Nature2002，420，： | 2 |
| 3 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 4 | In situ fixation of metals in soils using bauxite residue: chemical assessment显示文摘 | Enzo Lombi Fang-Jie Zhao Gangya Zhang Bo Sun Walter Fitz Hao Zhang Steve P McGrath | 2002 | Environmental Pollution2002，，3： | 2 |
| 5 | Mercury emission and speciation of coal-fired power plants in China显示文摘 | Wang S. X. Zhang L. Li G. H. Wu Y. Hao J. M. Pirrone N. Sprovieri F. Ancora M. P | 2010 | Atmospheric Chemistry and Physics2010，，188： | 2 |
| 6 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 7 | Allelopathic potential of watermelon tissues and root exudates显示文摘 | HAO ZP WANG Q CHRISTIE P | 2007 | Scientia Horticulturae2007，112，3： | 1 |
| 8 | Single amino acid alteration between Valine and Isoleucine determines the distinct pyrabactin selectivity by PYLI and PYL2 显示文摘 | Yuan X Yin P Hao Q | 2010 | J Biol Chem2010，285，28： | 1 |
| 9 | Color image segmentation using fuzzy C-mean and eigenspace projections显示文摘 | YANG J F HAO S S CHUNG P C | 2002 | Signal Prooeming2002，82，3： | 1 |
| 10 | 显示文摘 | Hao Y M Gao Y Qu J P | 2002 | J Appl Phys2002，91，： | 1 |
| 11 | Hybrid evolutionary algorithms for graph eoloring显示文摘 | Gatinier P Hao J K | 1999 | Journal of Combinatorial Optimization1999，3，4： | 1 |
| 12 | Determination of tertiary butylhydroquinone in edible vegetable oils by liquid chromatography/ion trap mass spectrometry显示文摘 | Hao P P Ni J R Sun W L | 2007 | Food Chemistry2007，105，4： | 1 |
| 13 | Novel porous solids for carbon dioxide capture显示文摘 | Hao G P Li WC Lu A H | 2011 | Journal of Materials Chemistry2011，21，18： | 1 |
| 14 | Shift of path- ways during initiation of thermophilie methanogenesis at different initial pH显示文摘 | Hao L P LII F Li L Shao L M He P J | 2012 | Bioresour Technd2012，126，： | 1 |
| 15 | Heterotrophic nitrifica- tion and aerobic devitrification by the bacterium Pseud- omonas stutzeri YZN-O01 显示文摘 | Zhang J Wu P Hao B | 2011 | Bioresour Technol2011，102，21： | 1 |
| 16 | A Polyblend Electrolyte ( PVP/PEG + KI + I2 ) for Dye-Sensitized Nanocrystalline TiO2 Solar Cells显示文摘 | Wu J H Li P J Hao S C | 2007 | Electrochimica Acta2007，52，17： | 1 |
| 17 | Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions显示文摘 | Hao X P Willis J E Pretlow T G | 2000 | Cancer Res2000，60，1： | 1 |
| 18 | Matrix factorizations for reversible integer mapping显示文摘 | Hao P and Shi Q | 2001 | IEEE Transactions on Signal Processing2001，49，10： | 1 |
| 19 | The second total synthesis of diazonamide A显示文摘 | Nicolaou K C Rao P B Hao J | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 20 | Dielectric properties of dehydrated apples as affected by moisture and temperature显示文摘 | FENG Hao TANG Juming CAVALIERI R P | 2002 | Transactions of the ASAE2002，45，1： | 1 |
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