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| 1 | Optimized design and test for a pendulum suspension of the crop spray boom in dynamic conditions based on a six DOF motion simulator显示文摘Spray deposit distribution from a field sprayer is mainly affected by the boom movements when the tractor is driven over a rough soil surface,the pendulum suspension that used to reduce and control the movement of spray boom by isolating the boom from vibrations of the tractor will directly enhance uniform deposition of chemicals.However,how to match the parameters of the suspension with the properties of the boom is the key problem.The dynamic rigid-flexible coupling model of the virtual prototype of the spray boom suspension system was established by using ADAMS and ABAQUS software.An optimization of the suspension parameters for a large spay boom was carried out based on the optimal Latin hypercube design,radial basis function neural network,and multi-objective genetic algorithm NSGA-II.After modified parameters of the suspension,the travel of the sprayer on a typical field motion track was simulated based on a six DOF motion simulator,and the dynamic behavior of the boom suspension was measured.The results show that RMS of the measured boom roll angle and the boom center displacement for optimized solution were reduced by 14.76%and 12.43%compared with the original suspension.Finally,the inertial measurement unit(IMU)was used to measure the movements of the sprayer vehicle during the pesticide application on the Hongze Lake Farm,the experiment of field condition reproduced by using the six DOF motion simulator,the standard deviation of the roll angle and vibration displacement for the optimized sprayer boom are only 0.6382°and 62.279 mm respectively.The research provides theoretical basis and experimental method for parameter optimization of large scale boom suspension. | Longfei Cui Hanping Mao Xinyu Xue Suming Ding Baiyu Qiao | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 9 |
| 2 | Inhibition of KIT RNAi mediated with adenovirus in gastrointestinal stromal tumor xenograft显示文摘AIM: To investigate a therapeutic method for gastrointestinal stromal tumor (GIST) based on KIT RNA interference (RNAi) with AdMax adenovirus. METHODS: KIT short hairpin RNA (shRNA), whose lateral sides were decorated with restriction endonuclease sequences, was designed. T 4 DNA ligase catalyzed the joint of the KIT shRNA and the green fluorescent protein-containing PDC316-EGFP-U6 to form PDC316EGFP-U6-KIT. Homologous recombination of AdEGFPU6-KIT was performed with the AdMax system. Heterotopically transplanted GISTs were established in nude mice. AdEGFP-U6-KIT was intratumorally injected. The volume, inhibition ratio of tumor and CD117 expression of GIST graft tumor in nude mice were compared between test and control groups. RESULTS: The length of KIT shRNA was determined to be about 50bp by agarose electrophoresis. Gene se-quencing detected the designed KIT RNAi sequence in PDC316-EGFP-U6-KIT. After transfection with AdEGFPU6-KIT, 293 cells displayed green fluorescence. The physical and infective titers of AdEGFP-U6-KIT were 5 × 10 11 viral particles/mL and 5.67 × 10 7 plaque forming units/mL, respectively. The mean volume of the grafted tumor was significantly smaller in test mice than in control mice (75.3 ± 22.9 mm 3 vs 988.6 ± 30.5 mm 3 , t = -18.132, P < 0.05). The inhibition ratio of the tumors was 59.6% in the test group. CD117 positive expression was evident in two cases (20%) in the test group and 10 cases (100%) in the control group (χ 2 = 10.2083, P < 0.005). CONCLUSION: AdEGFP-U6-KIT is successfully constructed, and KIT RNAi mediated with Admax vector system can effectively inhibit the expression of the KIT gene and the growth of GIST in nude mice. | Tian-Bao Wang Wen-Sheng Huang Wei-Hao Lin HanPing Shi Wen-Guang Dong | 2010 | World Journal of Gastroenterology2010，16，40： | 6 |
| 3 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 4 | Nondestructive diagnostics of soluble sugar,total nitrogen and their ratio of tomato leaves in greenhouse by polarized spectra-hyperspectral data fusion显示文摘Polarized spectra-hyperspectral data fusion technique was used to estimate the soluble sugar(SS),total nitrogen(N),and their ratio(SS/N),of greenhouse tomato leaves.Fresh tomato leaves of five different growth stages(seedling,flowering,initial fruiting,mid-fruiting and picking stage)and five different nitrogen treatments(severe stress 25%,moderate stress 50%,mild stress 75%,normal 100%,and excess 150%)at every stage were collected for spectra acquisition and SS and N determination.Polarized reflectance spectra were acquired with a polarization reflectance spectrum spectro-goniophotometer system and four polarization degree features were extracted.Hyperspectral data were collected with a hyperspectral imaging system and four reflectance spectrum features and eight image features were extracted.Initially,models were built with polarization degree features,image features,and spectral features respectively.Linear and nonlinear fusion methods were comparatively used for modeling based on normalized data of the three sources.The results suggest that the performances of SS/N models are better than those of N and SS models,and the prediction capability of the Support Vector Machine(SVM)models of N and SS/N are superior to those obtained with single kind feature.This work indicates that the polarized spectrum-hyperspectral multidimensional information detecting method can feasibly judge the tomato nutrient stress conditions.Multi-features data fusion analysis technique can enhance the prediction accuracy of spectral diagnostics technology in precision agriculture. | Wenjing Zhu Jinyang Li Lin Li Aichen Wang Xinhua Wei Hanping Mao | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 5 |
| 5 | Interactions of Copper, Evaporite, and Organic Matter and Genesis of Sandstone-Hosted Copper Deposits in the Chuxiong Basin, Yunnan Province显示文摘Studies on organic geochemistry indicate that the origin, type and maturity of organic matter are different among coal-bearing, copper-bearing and evaporite formations in the Mesozoic continental Chuxiong Basin, Yunnan, China. A mechanism has been proposed that (1) during the diagenetic mineralization stage the short-chain organic acids dervied from kerogen played an important role in remobilizing copper from source beds, while oils acted as important carrier of copper, and that (2) during the transformation or remolding mineralization stage, meteoric water leached the evaporite layers and formed downward-percolating oxidizing SO42-rich fluids; meanwhile, the copper-bearing fluids migrating upwards along growth faults from the basement was contaminated by the coal-bearing series on the way and formed reducing organic-rich fluids; oxidation-reduction occurred and sulfides formed when the two kinds of fluids met within sandstones. | Zhuang Hanping, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, GuizhouRan Chongying, He Mingqin, Geology Department, Kunming Institute of Technology, Kunming, Yunnanand Lu Jialan Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangdong | 1996 | Acta Geologica Sinica(English Edition)1996，70，4： | 5 |
| 6 | Organic/ Inorganic Occurrence of Metallic Elements of the Black Shale-Hosted Baiguoyuan Silver-Vanadium Deposit in Xingshan, Hubei显示文摘By means of kerogen purification, the proton induced X-ray emission (PIXE) and instrumental neutron activation analysis (INAA), the authors have studied the organic/inorganic occurrence modes of the metallic elements of the Baiguoyuan silver-vanadium deposit hosted in black shale in Hubei Province, China. The result shows that Au, Hg and Ta have a strong tendency to occur organically, with more than 70% of these elements being associated organically. Se, Ga, Ag and Hf are partly associated with organic matter, with more than 20% of them occurring organically. Compared with the above elements, Zn, Cu, As and Sb are weakly associated organically, and tend to be enriched in kerogen. However, Mn, Th, U, V, Co, Cr, Al, Fe and Sc usually occur inorganically. Of the rare earth elements (REE), La, Ce, Tb, Dy, Yb and Lu have stronger ability to be associated with organic matter than Sm and Eu. | ZHUANG Hanping LU Jialan FU Jiamo LIU Jinzhong REN Chigang ZOU Degang TIAN Weizhi | 1998 | Acta Geologica Sinica(English Edition)1998，72，3： | 4 |
| 7 | Health risk from heavy metals via consumption of food crops in the vicinity of Dabaoshan mine, South China显示文摘 | Ping Zhuang Murray B. McBride Hanping Xia Ningyu Li Zhian Li | 2008 | Science of the Total Environment2008，，5： | 3 |
| 8 | Lincang Superlarge Germanium Deposit in Yunnan Province,China: Sedimentation,Diagenesis,Hydrothermal Process and Mineralization显示文摘Gemineralizationincoalsassociatescloselywithcoalifi-cation.Manykindsofmineralizinginformationcanberecord-edbythestructure,tex... | Zhuang Hanping Lu Jialan Fu Jiamo Liu Jinzhong Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 | 1998 | Journal of Earth Science1998，17，2： | 3 |
| 9 | Studies on the Effects of the Immunosuppressant FK-506 on the High-risk Corneal Graft Rejection显示文摘Purpose: To evaluate the clinical efficacy of FK-506 on suppressing high-risk cornea transplantation rejection.Methods: In a randomized controlled clinical trial, 56 eyes of 56 patients with high-risk keratoplasty (including total corneal transplantation TCT, total corneal transplantation with circular lamellar sclera CST, vascularization corneal transplantation and corneal retransplantation) were divided into the experimental group and the control group(each with 28 eyes).The experimental group was treated by FK-506 eyedrops (0.5 mg/ml) and TobraDex eyedrops, compared with the control group that was treated by 1% CsA eyedrops and TobraDex eyedrops. In the average 8.1-month follow-up period, the visual acuity, graft transparent duration and Rejection Index (RI) of grafts were observed. Results: In the follow-up period, the graft rejection rate of the experimental and the control group was 63.6% and 95.2% respectively (χ2=4. 72, P < 0. 05) with significant difference.Conclusions: The local application of FK-506 suppressed effectively the graft rejection of corneal transplantation of the patients at high risk. | Minhua Wang, Yuesheng Lin, Jiaqi Chen, Yongming Liu, Hanping Xie, Chengtian YeZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 3 |
| 10 | Design and experiment of electro hydraulic active suspension for controlling the rolling motion of spray boom显示文摘Boom sprayer is one of the most commonly used plant protection machinery for spraying pesticide.Studies have shown that the efficiency of chemicals is highly correlated with the uniformity of spray distribution patterns.As the boom is a large and flexible structure,boom rolling leads to overlapping and leakage of the pesticides.In order to improve spray uniformity,the boom attitude should be kept parallel to the ground slope or to the crop canopy beneath the boom.Passive suspension can attenuate frequencies above its resonance frequency,but nothing can be done to align the boom to the sloping ground.Therefore,an active suspension system is designed,which includes DSP-based controller,a servo valve,a hydraulic cylinder,two ultrasonic sensors,one inertial attitude sensor,and the developed control procedures.In order to prevent the wrong response of the control system caused by the high frequency component due to uneven crop canopy or rough ground.A special signal processing algorithm was proposed,including the limiting filter,smoothing algorithm and data fusion algorithm based on optimal weight.The transient and steady-state performances of the boom control system using velocity feedforward PID algorithm were tested on a six DOF motion simulator.It can be seen that the low-frequency tracking performance of the boom was greatly improved after the electro-hydraulic active suspension was added.At the resonance frequency,the peak angle of active suspension and passive suspensions are 0.72°and 1.29°respectively,and the resonance peak is greatly reduced.The controller was implemented on a self-propelled boom sprayer and validated under field conditions,the standard deviation of the roll angle of the boom with active suspension is 0.40°,compared with 1.04°of the sprayer chassis.Experimental results show that the active suspension control system can effectively reduce the effect of ground excitation disturbance on the application process,and has good tracking performance for low frequency terrain change. | Longfei Cui Xinyu Xue Feixiang Le Hanping Mao Suming Ding | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 3 |
| 11 | Characteristics of hemicellulose, cellulose and lignin pyrolysis显示文摘 | Haiping Yang Rong Yan Hanping Chen Dong Ho Lee Chuguang Zheng | 2006 | Fuel2006，，12： | 3 |
| 12 | Forest soil CO_2 fluxes as a function of understory removal and N-fixing species addition显示文摘We report on the effects of forest management practices of understory removal and N-fixing species(Cassia alata) addition on soil CO2 fluxes in an Eucalyptus urophylla plantation(EUp),Acacia crassicarpa plantation(ACp),10-species-mixed plantation(Tp),and 30-species-mixed plantation(THp) using the static chamber method in southern China.Four forest management treatments,including(1) understory removal(UR);(2) C.alata addition(CA);(3) understory removal and replacement with C.alata(UR+CA);and(4) control without any disturbances(CK),were applied in the above four forest plantations with three replications for each treatment.The results showed that soil CO2 fluxes rates remained at a high level during the rainy season(from April to September),followed by a rapid decrease after October reaching a minimum in February.Soil CO2 fluxes were significantly higher(P < 0.01) in EUp(132.6 mg/(m2.hr)) and ACp(139.8 mg/(m2.hr)) than in Tp(94.0 mg/(m2.hr)) and THp(102.9 mg/(m2.hr)).Soil CO2 fluxes in UR and CA were significantly higher(P < 0.01) among the four treatments,with values of 105.7,120.4,133.6 and 112.2 mg/(m2.hr) for UR+CA,UR,CA and CK,respectively.Soil CO2 fluxes were positively correlated with soil temperature(P < 0.01),soil moisture(P < 0.01),NO3?-N(P < 0.05),and litterfall(P < 0.01),indicating that all these factors might be important controlling variables for soil CO2 fluxes.This study sheds some light on our understanding of soil CO2 flux dynamics in forest plantations under various management practices. | Haifang Li Shenglei Fu Hongting Zhao Hanping Xia | 2011 | Journal of Environmental Sciences2011，23，6： | 3 |
| 13 | Health risk from heavy metals via consumption of food crops in the vicinity of Dabaoshan mine, South China显示文摘 | Ping Zhuang Murray B. McBride Hanping Xia Ningyu Li Zhian Li | 2008 | Science of the Total Environment2008，，5： | 2 |
| 14 | Identification of a new potential Cd-hyperaccumulator Solanum photeinocarpum by soil seed bank-metal concentration gradient method显示文摘 | Xingfeng Zhang Hanping Xia Zhi’an Li Ping Zhuang Bo Gao | 2011 | Journal of Hazardous Materials2011，，1： | 2 |
| 15 | Identification of pesticide residue level in lettuce based on hyperspectra and chlorophyll fluorescence spectra显示文摘Fast identification of pesticide residue level in lettuce leaves plays a key role in the test of food safety.In order to identify the different concentrations pesticide residues of lettuce leaves in a fast and nondestructive way,the hyperspectra coupled with chlorophyll fluorescence spectra was used in this research.Transmission electron microscopy(TEM)was used to identify the microstructure changes of lettuce leaves under different concentrations of dimethoate residue.Besides,a method involving wavelet transform and MD-MCCV algorithm(WT-MD-MCCV)was developed for identifying the optimal wavelengths of the spectral data.The hyperspectra and chlorophyll fluorescence spectra data of 150 lettuce leaf samples at five different concentrations of pesticide residues were obtained using hyperspectral data acquisition device and Cary Eclipse Fluorescence Spectrophotometer.The combination of Savitzky-Golay(SG)algorithm and SNV algorithm(SG-SNV)preprocessing algorithms was used to preprocess the raw spectra.In addition,Principal Component Analysis(PCA),Successive Projections Algorithm(SPA)and wavelet transform coupled to MD-MCCV algorithm(WT-MD-MCCV)were applied to identify the optimal wavelengths of raw spectra including hyperspectra data,chlorophyll fluorescence spectra data and hyperspectra coupled with chlorophyll fluorescence spectra data.Support vector regression(SVR)was applied to build the prediction models based on preprocessed spectra feature in characteristic wavelengths coupled with different spectral data.The results showed that with the increase of the concentration of dimethoate pesticide spraying,lettuce chloroplast number of osmiophilic particles increased and the starch granules decreased.Besides,the intercellular space of lettuce leaves increased gradually,with the increase of dimethoate concentration.Different concentrations of pesticide residues of lettuce in the near infrared and fluorescence spectrum have a certain difference.In addition,the related parameters of the three preferably prediction models were Rp 2=0.956 and RMSEP=0.018,Rp 2=0.937 and RMSEP=0.161,Rp 2=0.987 and RMSEP=0.005,respectively,using WT-MD-MCCV algorithm combined with hyperspectra data,chlorophyll fluorescence spectra data and hyperspectra coupled to chlorophyll fluorescence spectra data.WT-MD-MCCV algorithm combined with hyperspectra and chlorophyll fluorescence spectra data performed best among the nine SVR models and the hyperspectra coupled with chlorophyll fluorescence spectra can be used to identify the pesticide residue level in lettuce leaves. | Sun Jun Zhou Xin Mao Hanping Wu Xiaohong Zhang Xiaodong Gao Hongyan | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 2 |
| 16 | Assessing anxiety,depression,and stress among inpatients with cancer显示文摘Objective This study aimed to assess anxiety,depression,and stress among inpatients with cancer.Methods Two hundred thirty-five hospitalized patients with cancer were surveyed with the Depression Anxiety Stress Scales(simplified Chinese Version).The software program SPSS 25.0 was used for statistical analysis of the survey data.Results The average scores of depression,anxiety,and stress of inpatients with cancer were 12.17,11.84,and 13.98 respectively,which were higher than the normal range.The scores of anxiety and stress of inpatients with different caregivers were statistically different(P=0.024/0.036).The anxiety and stress scores of inpatients with spouses as caregivers were higher than those of inpatients with children as caregivers.There was a statistically significant difference in the incidence of stress between inpatients with cancer with religious beliefs and inpatients with cancer without religious beliefs(P=0.026),and those with religious beliefs had greater incidence of stress.The score of anxiety was significantly higher for inpatients with children than for inpatients without children(P=0.040).Conclusion The anxiety,depression,and stress levels of inpatients with cancer are relatively high.It is necessary to pay special attention to the psychological status of these patients during clinical diagnosis and treatment to improve their quality of life. | Honghong Xu Ruotong Xue Yi Cheng Yujie Zhang Jie Rao Mei Liu Shiying Yu Lingxiang Liu Yiqian Liu Yongqian Shu Liuqing Yang Hanping Shi | 2020 | Oncology and Translational Medicine2020，6，3： | 2 |
| 17 | THE INFLUENCE OF ELECTRO-ACUPUNCTURE AT NEIGUAN AND FIVE SHU POINTS OF TWELVE REGULAR MERIDIANS AT DIFFERENT TIME ON SYSTOLIC TIME INTERVAL OF NORMAL YOUNG ADULTS显示文摘The influence of electro-acupuncture at Neiguan (PC 6)and five shu points of twelve regular meridians at different time on systolic time interval (ST I) of normal young adultswere studied with 6×6 Latin square design in this work.In 12 groups according to 12 regular merldlans,the STIs were measured respectively just before and after electro-acupuncture on Neiguan andfive shu points at 00:00,04:00,08:00,12:00,16:00 and 20:00 of a day.It was found thatexcept the PEPI and PEPI/LVETI ratio among Shenmen(HT 7),Shaochong(HT 9)and Neiguan,Guanchong(TE)and Yemen(TE 2)points,the effects of electro-acupuncture at Neiguan pointand five shu points of twelve regular meridians on the indices of STI of normal young adults wereshowing no slgnificant differences.There also was no difference in different sex.But the indices ofSTI were changed when electroacupuncture on the different points of different meridians at differenttime. | Li Lei, Chen Hanping, Xi Yongjiang, Gu JieShanghai University of TCM, Shanghai 200032, China | 1994 | World Journal of Acupuncture-Moxibustion1994，4，1： | 2 |
| 18 | Ultra-high sensitivity of rhodamine B sensing based on NaGdF_4:Yb^(3+),Er^(3+)@NaGdF_4 core-shell upconversion nanoparticles显示文摘A series of mono-dispersed hexagon NaGdF_4:Yb^(3+),Er^(3+)@NaGdF_4 core-shell nanoparticles with different shell thickness were synthesized via a co-precipitation method. Nanoparticles with high upconversion fluorescent emissions result in large signal-to-noise ratio, which guarantees the accuracy of the sensitivity. Besides, the maximum sensitivity of these NPs as detection film increases first and then decreases with the shell thickness increasing. When the shell thickness is 2.3 nm(NaGdF_4-2), the maximum sensitivity(0.69959 ppm^(-1)) is reached. A large degree of overlap between the rhodamine B absorption band and the Er^(3+) green emission bands ensures that the NaGdF_4:Yb^(3+),Er^(3+)@NaGdF_4 nanoparticles can be used as fluorescent probe to detect the concentration of rhodamine B based on fluorescent intensity ratio technology. The linear relationship between the rhodamine B concentration and the intensity ratio(R) of green and red emission intensity(I_(S+H) and I_F) were studied systematically. The result shows that the maximum sensitivity can be obtained in low concentration rhodamine B(<4 ppm), which is lower than the reported minimum detection concentration. Thus, the ultra-high sensitivity detection by NaGdF_4:Yb^(3+),Er^(3+)@NaGdF_4 core-shell upconversion nanoparticles in low concentration can be realized,which provides promising applications in bio-detection filed. | Hanping Xiong Qiuhong Min Hongqing Ma Lei Zhao Wenbo Chen Jianbei Qiu Xue Yu Xuhui Xu | 2019 | Journal of Rare Earths2019，37，4： | 2 |
| 19 | Activation of retinal stem cells in the proliferating marginal region of RCS rats during development of retinitis pigmentosa显示文摘 | Qian Jian Haiwei Xu Hanping Xie Chunyu Tian Tongtao Zhao ZhengQin Yin | 2009 | Neuroscience Letters2009，，1： | 1 |
| 20 | Characteristics of hemicellulose, cellulose, and lignin pyrolysis显示文摘 | Haiping Yang Rong Yan Hanping Chen | 2007 | BB Fuel2007，86，1213： | 1 |
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