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| 1 | 保护性耕作对旱地麦-豆双序列轮作农田土壤水分及利用效率的影响显示文摘选择黄土高原陇中丘陵半干旱典型区———定西地区,在前期试验研究的基础上,2002~2004年通过对保护性耕作条件下旱地春小麦—豌豆双序列轮作农田土壤水分及利用效率的试验研究,结果表明:保护性耕作能够显著提高0~200cm土层土壤贮水量及含水量,这种作用在降水较少年份表现更为突出。免耕及免耕覆草较常规耕作土壤贮水量分别提高1 93%~7 25%和0 06%~3 58%。休闲轮作有利于提高土壤对降水的保蓄,具有良好的蓄水保墒作用,但不同的轮作序列表现不同。P/W各处理小麦收获期土壤0~50cm含水量均比W/P各处理小麦收获期土壤0~50cm含水量有所增加,增幅为0 33%~0 62%。0~200cm土壤含水量呈反S型变化,播种期、五叶期及收获期土壤具有较高含水量,而开花期土壤含水量则较低。免耕覆草处理的产量及水分利用效率分别为3709 69kg/hm2和10 45kg/hm2·mm,分别较常规耕作提高30 28%和40 08%。 | 郭清毅 黄高宝 Guangdi Li YIN Chan | 2005 | 水土保持学报2005，19，3： | 105 |
| 2 | 不同保护性耕作措施对旱作农田土壤水分的影响显示文摘研究了黄土高原西部旱农区传统耕作措施和五种保护性耕作措施对土壤水分垂直分布、动态变化、作物耗水量、水分利用效率及作物产量的影响.结果表明,不同保护性耕作措施对表层0~10cm土壤水分含量影响较大,免耕秸秆覆盖(NTS)在作物播种期可以显著增加播种期表层土壤含水量.0~200cm土壤剖面贮水量年变化分春夏作物旺盛生长失墒期(5月中旬~7月中旬)、夏秋雨季增墒期(7月中旬~10月下旬)和冬春稳墒期(11月~翌年5月上旬)3个阶段.尽管不同保护性耕作措施对0~200cm剖面贮水量影响不大,但作物耗水量却存在显著差异.免耕秸秆覆盖在增加作物耗水量的同时也提高了作物产量以及水分利用效率.地膜覆盖在有些年份也有利于降水的高效利用和作物产量的提高,但与秸秆覆盖相比不利于土壤肥力的持续提高.而且,如果种植小麦,出苗前若一次性降水较多时地膜覆盖将造成严重板结,影响出苗,进而降低产量和水分利用效率.因此,在黄土高原西部旱农区实施免耕+秸秆覆盖的保护性耕作措施,既有利于作物对有限降水的高效利用,提高作物产量,也可以促进农业可持续发展. | 李玲玲 黄高宝 张仁陟 晋小军 Guangdi LI Kwong Yin CHAN | 2005 | 生态学报2005，25，9： | 160 |
| 3 | 免耕秸秆覆盖对旱作农田土壤水分的影响显示文摘通过20012004年的田间试验研究了免耕秸秆覆盖旱作农田的土壤水分效应。结果表明,免耕秸秆覆盖对表层土壤水分含量影响较大,在作物播种期可以减少表层水分蒸发,显著增加表层土壤含水量,但随着生育进程的推进,秸秆覆盖的抑蒸效果逐渐减弱。免耕秸秆覆盖对各个时期0200 cm土壤剖面上水分总量的影响不大,但年际间变化较大。采用免耕秸秆覆盖可以提高小麦-豌豆轮作系统作物产量以及水分利用效率、促进农田生态系统的良性循环,持续提高土壤肥力。 | 李玲玲 黄高宝 张仁陟 晋小军 Guangdi LI Kwong Yin CHAN | 2005 | 水土保持学报2005，19，5： | 103 |
| 4 | 免耕秸秆覆盖对旱作麦田土壤温度的影响显示文摘通过2001~2004年的大田试验研究了免耕秸秆覆盖对黄土高原西部旱地麦田土壤温度的影响。结果表明,土壤温度与气温关系密切;雨季土壤贮水多会导致土壤比热增大而来年早春地温回升慢;免耕秸秆覆盖与传统耕作的地温差不受天气状况的影响。与传统耕作相比,免耕秸秆覆盖可以稳定土壤温度,白天升温较慢,下午至夜间降温更慢。免耕秸秆覆盖降低春小麦全生育期的平均温度0.5℃~1.6℃,拔节至成熟期降低得更多,但对休闲期土壤温度影响不大。免耕秸秆覆盖春小麦经济产量可提高8.8%~28.8%,但产量与耕层平均地温无明显相关性。 | 黄高宝 李玲玲 张仁陟 蔡立群 Guangdi Li Kwong Yin CHAN | 2006 | 干旱地区农业研究2006，24，5： | 65 |
| 5 | 长期保护性耕种方式对农田表层土壤性质的影响显示文摘研究了不同耕种方式对澳大利亚同一地区3种土壤表层(0-5cm)理化性质的作用,以揭示保护性耕作对土壤质量恢复的影响。结果表明:免耕穴播/保留残茬(DD/SR)、多年生人工草地(PP)和自然草地(NP)表层土壤的〉2mm水稳性团聚体含量、全氮、有机碳含量、田间持水量均显著高于其相应对照传统耕作/秸秆焚烧(CC/SB)、人工草地/作物轮作(PPC)和耕作(CT)的;土壤全氮含量、田间持水量分别与有机碳含量之间有极显著的正相关关系(r=0.994**,r=0.996**,n=6),而受土壤质地等因素的影响较小;在同一类型的土壤上,土壤有机碳含量与水稳定性团聚体含量之间存在显著的相关性;在不同试验区,耕作措施对表层土壤容重和孑L隙分布的影响存在较大差异;秸秆焚烧和施用石膏对表层土壤的pH及交换性阳离子含量有较大的影响。研究表明长期保护性耕作、草田轮作或多年生草地有利于提高表层土壤有机碳含量和结构稳定性,从而改善土壤的供肥供水能力。 | 张国盛 K Y Chan G D Li D P Heenan | 2008 | 生态学报2008，28，6： | 45 |
| 6 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 7 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 8 | Does erroneous differentiation of tendon-derived stem cells contribute to the pathogenesis of calcifying tendinopathy?显示文摘钙化的 tendinopathy 是有钙存款在的腱混乱中间物质长期的活动相关的疼痛,温柔,本地浮肿和使无能力的各种各样的度地介绍了。因为它的内在的致病糟糕被理解,处理通常是征兆的,大多数当前的处理既不有效也不基于证据。理解钙化的 tendlinopathy 的致病为它的有效基于证据的管理是必要的。钙化的 tendinopathy 的关键组织病理学说的特征之一是包围石灰质的存款的 chondrocyte 显型的存在,建议石灰质的存款的形成是参予 chondrocyte 显型和骨化的形成的房间的起源仍然是的 cellmediated.Although 未知,许多证据建议了错误的腱房间区别涉及这个过程。最近的研究在人,马,老鼠和老鼠腱纸巾与自强和多区别潜力显示出干细胞的存在。我们假设了到 chondrocytes 或造骨细胞的导出腱的干细胞(TDSC ) 的错误的区别导致 chondrometaplasia 和骨化和因此更弱的腱,愈合没有通过并且疼痛,在钙化的 tendinopathy。我们在场到支持的致病和证据上的一个假想模型这个假设。在贡献他们的错误的区别的钙化的 tendinopathy 和机制的致病理解 TDSC 的关键角色将为钙化的 tendinopathy 的管理提供新机会。到为 tenogenic 区别的 MSCsprogrammed 的 tenogenic 或补充的居民 TDSC 的区别的重定向可能在 e 未来为钙化的 tendinopathy 的管理正在诱惑目标。 | RUI Yun-feng LUI Pauline Po-yee CHAN Lai-shan CHAN Kai-ming FU Sai-chuen LI Gang | 2011 | Chinese Medical Journal2011，，4： | 28 |
| 9 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 10 | Vertical structures of PM_(10) and PM_(2.5) and their dynamical character in low atmosphere in Beijing urban areas显示文摘The vertical structures and their dynamical character of PM2.5 and PM10 over Beijing urban areas are revealed using the 1 min mean continuous mass concentration data of PM2.5 and PM10 at 8, 100, and 320 m heights of the meteorological observation tower of 325 m at Institute of Atmospheric Physics, Chinese Academy of Sciences (IAP CAS tower hereafter) on 10―26 August, 2003, as well as the daily mean mass concentration data of PM2.5 and PM10 and the continuous data of CO and NO2 at 8, 100 (low layer), 200 (middle layer), and 320 m (high layer) heights, in combination with the same period meteorological field observation data of the meteorological tower. The vertical distributions of aerosols observed on IAP CAS tower in Beijing can be roughly divided into two patterns: gradually and rapidly decreasing patterns, I.e. The vertical distribution of aerosols in calm weather or on pollution day belongs to the gradually decreasing pattern, while one on clean day or weak cold air day belongs to the rapidly decreasing pattern. The vertical distributive characters of aerosols were closely related with the dynamical/thermal structure and turbulence character of the atmosphere boundary layer. On the clean day, the low layer PM2.5 and PM10 concentrations were close to those at 8 m height, while the concentrations rapidly decreased at the high layer, and their values were only one half of those at 8 m, especially, the concentration of PM2.5 dropped even more. On the clean day, there existed stronger turbulence below 150 m, aerosols were well mixed, but blocked by the more stronger inversion layer aloft, and meanwhile, at various heights, especially in the high layer, the horizontal wind speed was larger, resulting in the rapid decrease of aerosol concentration, I.e. Resulting in the obvious vertical difference of aerosol concentrations between the low and high layers. On the pollution day, the concentrations of PM2.5 and PM10 at the low, middle, and high layers dropped successively by, on average, about 10% for each layer in comparison with those at 8 m height. On pollution days, in company with the low wind speed, there existed two shallow inversion layers in the boundary layer, but aerosols might be, to some extent, mixed below the inversion layer, therefore, on the pollution day the concentrations of PM2.5 and PM10 dropped with height slowly; and the observational results also show that the concentrations at 320 m height were obviously high under SW and SE winds, but at other heights, the concentrations were not correlated with wind directions. The computational results of footprint analysis suggest that this was due to the fact that the 320 m height was impacted by the pollutants transfer of southerly flow from the southern peripheral heavier polluted areas, such as Baoding, and Shijiazhuang of Hebei Province, Tianjin, and Shandong Province, etc., while the low layer was only affected by Beijing's local pollution source. The computational results of power spectra and periods preliminarily reveal that under the condition of calm weather, the periods of PM10 concentration at various heights of the tower were on the order of minutes, while in cases of larger wind speed, the concentrations of PM2.5 and PM10 at 320 m height not only had the short periods of minute-order, but also the longer periods of hour order. Consistent with the conclusion previously drawn by Ding et al., that air pollutants at different heights and at different sites in Beijing had the character of 'in-phase' variation, was also observed for the diurnal variation and mean diurnal variation of PM2.5 and PM10 at various heights of the tower in this experiment, again confirming the 'in-phase' temporal/spatial distributive character of air pollutants in the urban canopy of Beijing. The gentle double-peak character of the mean diurnal variation of PM2.5 and PM10 was closely related with the evident/similar diurnal variation of turbulent momentum fluxes, sensible heat fluxes, and turbulent kinetic energy at various heights in the urban canopy. Besides, under the condition of calm weather, the concentration of PM2.5 and PM10 declined with height slowly, it was 90% of 8 m concentration at the low layer, a little lesser than 90% at the middle layer, and 80% at the high layer, respectively. Under the condition of weak cold air weather, the concentration remarkably dropped with height, it was 70% of 8 m concentration at the low layer, and 20%―30% at the middle and high layers, especially the concentration of PM2.5 was even lower. | CHAN Chuenyu LI Yoksheung WONG Kamhang | 2005 | Science China Earth Sciences2005，48，z2： | 18 |
| 11 | Benefits of Conservation Agriculture on Soil and Water Conservation and Its Progress in China显示文摘Conservation agriculture has been practised for three decades and has been spread widely. There are many nomenclatures surrounding conservation agriculture and differ to each other lightly. Conservation agriculture (CA) is a system approach to soil and water conservation, high crop productivity and profitability, in one word, it is a system approach to sustainable agriculture. Yet, because conservation agriculture is a knowledge-intensive and a complex system to learn and implement, and also because of traditions of intensive cultivation, adoption rates have been low, since to date, only about seven percent of the world's arable and permanent cropland area is farmed under conservation agriculture. The practice and wider extention of conservation agriculture thus requires a deeper understanding of its ecological underpinnings in order to manage its various elements for sustainable intensification, where the aim is to conserve soil and water and improve sustainability over the long term. This paper described terms related to conservation agriculture, presented the effects of conservation agriculture on soil and water conservation, crop productivity, progress and adoption of CA worldwide, emphasized obstacles and possible ways to increase CA adoption to accelerate sustainable development of China agriculture. | LI Ling-ling HUANG Gao-bao ZHANG Ren-zhi Bill Bellotti Guangdi Li Kwong Yin Chan | 2011 | Agricultural Sciences in China2011，10，6： | 15 |
| 12 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 13 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 14 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 15 | Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells显示文摘AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) cells.METHODS:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) assay.The expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were examined.SiRNA targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was examined.Overexpression of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,respectively.The expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene system.RESULTS:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell lines.The suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β1.Our data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent manner.CONCLUSION:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells. | Lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung | 2012 | World Journal of Gastroenterology2012，18，17： | 13 |
| 16 | Chemical screen identifies a geroprotective role of quercetin in premature aging显示文摘Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. | Lingling Geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu | 2019 | Protein & Cell2019，10，6： | 13 |
| 17 | Fabrication of Microlens Array and Its Application:A Review显示文摘Microlens arrays are the key component in the next generation of 3D imaging system, for it exhibits some good optical properties such as extremely large field of view angles, low aberration and distortion, high temporal resolution and infinite depth of field. Although many fabrication methods or processes are proposed for manufacturing such precision component, however, those methods still need to be improved. In this review, those fabrication methods are categorized into direct and indirect method and compared in detail. Two main challenges in manufacturing microlens array are identified: how to obtain a microlens array with good uniformity in a large area and how to produce the microlens array on a curved surface? In order to effectively achieve control of the geometry of a microlens,indirect methods involving the use of 3D molds and replication technologies are suggested. Further development of ultraprecision machining technology is needed to reduce the surface fluctuation by considering the dynamics of machine tool in tool path planning. Finally, the challenges and opportunities of manufacturing microlens array in industry and academic research are discussed and several principle conclusions are drawn. | Wei Yuan Li-Hua Li Wing-Bun Lee Chang-Yuen Chan | 2018 | Chinese Journal of Mechanical Engineering2018，31，1： | 13 |
| 18 | Acupuncture treatment of lung-spleen Qi deficiency in stable chronic obstructive pulmonary disease: a randomized, open-label, controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,open-controlled trial in which the acupuncturist and the participants were not blinded,but the outcome evalu-ators and data analysts were blinded.One-hundred-and-two patients with stable COPD were randomly divided into two groups in a 1∶1 ratio.The acupuncture group received 30-minute sessions of acupuncture therapy at the same acupoints three times weekly for 6 weeks in addition to routine conventional Western Medicine treatment;the control group received routine conventional Western Medicine treatment alone.The primary outcome was the Borg scale score,which was assessed immediately after the 6-minute walk test.The secondary outcomes were the 6-minute walk distance,lung function,and oxygen saturation.Measurements were obtained at baseline and after 6 weeks of treatment.RESULTS:After 6 weeks of treatment,the Borg scale score in the acupuncture group was significantly better than that in the control group(2.02±0.71 versus 5.01±0.34,P<0.05).Furthermore,the post-treatment improvements in the 6-minute walk distance,lung function,and oxygen saturation were significantly greater in the acupuncture group than in the control group,showing that the acupuncture group had better exercise tolerance.CONCLUSION:The findings suggest that acupuncture that aims to reinforce the spleen to strengthen the lung is a safe and effective adjuvant therapy that effectively improves the exercise capacity of patients with stable COPD. | Li Yu Xiong Chan Zeng Yan Wei Hua Zhuang Guangtong Zhao Lihong Li Chenyi Li Lin Qin Erqi Chen Xiaoqin Fu Juanjuan | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 13 |
| 19 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 20 | ELASTICITY EFFECTS ON THE WATER IMPACT OF AN ELASTIC FLAT-BOTTOM BOX显示文摘To elucidate the effects of elasticity the hydrodynamic impact of a 2-D flat-bottom shell box onto a water surface was investigated in detail using the finite element code Dytran. An ALE coupling algorithm was employed to handle the interactions between the box and the fluids. In this study, both air and water were treated as compressible fluids and their properities were modeled through the equation of states. Calculated results show that the air cushion plays a very important role buffering the impinging. Under the deformed concave bottom an air cushion layer will be easier to form up. For high impact speed, the pressure for the elastic box is much lower than that for the rigid box. Excited by the impact, the impinging box oscillates with about its natural frequency. | Li, Wan-Ping Liu, Gui-Rong Chan, Eng-Song | 2002 | Journal of Hydrodynamics2002，14，2： | 12 |
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