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| 1 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 2 | A barrier composed of chemically cross-linked hyaluronic Acid (incert)reduces postoperative adhesion formation formation显示文摘 | Haney M D Elissa Doty B S | 1997 | Fertility and Sterility1997，70，： | 1 |
| 3 | KRAS mutation: comparison of testing methods and tissue sampling techniques in colon cancer显示文摘 | Franklin WA Haney J Sugita M | 2010 | J Mol Diagn2010，12，1： | 1 |
| 4 | Mood and performance changes in women with premenstrual dysphoric disorder acute effects of alprazolam显示文摘 | Evans SM Haney M Levin FR | 1998 | Neuropsychopharmocology1998，19，： | 1 |
| 5 | Analysis of thermal stabilizing interactions in mesophilic and thermophilic adenylate kinases from the genus Methanococcus显示文摘 | Haney P J Stees M Konisky J | 1999 | J Biol Chem1999，274，28： | 1 |
| 6 | Skeletal effects of serotonin(5hydroxytryptamine)transporter inhibition:evidence from in vitro and animal-based studies显示文摘 | Warden S J Haney E M | 2008 | J Musculoskelet Neuronal Interact2008，8，2： | 1 |
| 7 | Inhibition of Chlorella growth by degradation and related products of linoleic and linolenic acids and the possible significance of polyunsaturated fatty acids in phytoplankton ecology显示文摘 | Ikawa M Sasner J J Haney J F | 1997 | Hydrobiologia1997，356，13： | 1 |
| 8 | Soil C extracted with water or K2 SO4 : pH effect on determination of microbial biomass 显示文摘 | HANEY R L FRANZLUEBBERS A J HONS F M | 1999 | Canadian Journal of Soil Science1999，79，4： | 1 |
| 9 | Cancellation of spurious arrivals in Green's function extraction and the generalized optical theorem显示文摘 | Snieder R van Wijk K Haney M | 2008 | Physical Review E2008，78，03： | 1 |
| 10 | Inhibition of Chlorellagrowth by the lipids of cyanobacterium Microcystis aeru-ginosa 显示文摘 | Ikawa M Haney JF Sasner JJ | 1996 | Hydrobiologia1996，331，： | 1 |
| 11 | Inhibition of Chlorellagrowth by degradation and related products of linoleicand linolenic acids and the possible significance of poly-unsaturated fatty acids in phytoplankton ecology 显示文摘 | Ikawa M Sasner JJ Haney JF | 1997 | Hy-drobiologia1997，356，： | 1 |
| 12 | Timing of Labor Induction after Premature Rupture of Membranes between 32 and 36 Week's Gestation显示文摘 | Cravcllo C Haney EI | 1999 | Am J Obstet Gynecol1999，180，2： | 1 |
| 13 | Activity of cyanobacterialand algal odor compounds found in lake waters on greenalga Chlorella pyrenoidosa growth 显示文摘 | Ikawa M Sasner JJ Haney JF | 2001 | Hydrobiologia2001，443，： | 1 |
| 14 | Scandinavian clinical practice guideline on choice of fluid in resuscitation of critically ill patients with acute circulatory failure 显示文摘 | PERNER A JUNTTILA E HANEY M | 2015 | Acta Anaesthesiol Scand2015，59，3： | 1 |
| 15 | Rural Hospital Nurse's Stressors and Coping Strategies:A Survey显示文摘 | LeSergent C M Haney C J | 2005 | Int J Nurs Stud2005，42，3： | 1 |
| 16 | Developing a program to promote stress resilience and self-care in first-year medical students显示文摘 | Thomas S E Haney M K Pelic C M | | 0，，01： | 1 |
| 17 | Rural hospital nurses's stressors and coping strategies: a survey显示文摘 | LESERGENT C M HANEY C J | 2005 | Int J Nurs Stud2005，42，3： | 1 |
| 18 | Bovine and human lactoferricin peptides: chimeras and new cyclic analogs 显示文摘 | Arias M McDonald LJ Haney EF | 2014 | Biometals2014，27，： | 1 |
| 19 | Interference by plastics additives in the HPLC determination of microcystin LR and YR显示文摘 | IKAWA M PHILLIPS N HANEY J F | 1999 | Toxicon1999，37，6： | 1 |
| 20 | Kras mutation: Comparison of testing methods and tissue sampling techniques in colon canner显示文摘 | FRANKLIN W A HANEY J SUGITA M | 2010 | Mol Diagn2010，12，1： | 1 |
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