|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 2 | The Role of Inflammation and Autoimmunity in the Pathophysiology of Pulmonary Arterial Hypertension显示文摘 | Nada Kherbeck Mathieu C. Tamby Guillaume Bussone Hanadi Dib Frederic Perros Marc Humbert Luc Mouthon | 2013 | Clinical Reviews in Allergy & Immunology2013，，1： | 1 |
| 3 | Serum interkeukin 6 is a major predictor of bone loss in women specific to the first decade astmenopause显示文摘 | Christa Scheist-Nave Hanadi Bismar Gudrun Leidig-Bruckner | | 0，，05： | 1 |
| 4 | Diagnosis and treatment of ectopic pregnancy显示文摘 | Heather M Hanadi B Trevor B | 2005 | CMAJ2005，173，8： | 1 |
| 5 | Chest swelling with adenopa thy:don' t forget tuberculosis显示文摘 | Hanadi A Sonia T Jamel A | 2011 | Respir Med CME2011，4，： | 1 |
| 6 | Microstructure and reten- tion of superplasticity of friction stir welded superplastic 2095 sheet显示文摘 | Hanadi G S Anthony P R Jed S L | 2002 | Seripta Materialia2002，46，： | 1 |
| 7 | Mierostructure and retention of superplasticity of friction stir welded superplastic 2095 sheet显示文摘 | HANADI G SALEM A ANTHONY P R | 2002 | Scripta Materialia2002，46，5： | 1 |
| 8 | Diagnosis and treatment of ectopic pregnancy显示文摘 | Heather Murray Hanadi Baakdah Trevor Bardell | | 0，，8： | 1 |
| 9 | Diagnosis and treatment of ectopic pregnancy 显示文摘 | Heather M Hanadi B Trevor B | 2005 | CMAJ2005，173，8： | 1 |
| 10 | Diagnosis and treat- ment of ectopic pregnancy 显示文摘 | Heather M Hanadi B Trevor B | 2005 | C MAJ2005，173，8： | 1 |
| 11 | Review of MTBE Biodegradation and Bioremediation显示文摘 | Stephnia Fiorenza Hanadi S Rifai | 2003 | Abstract Bioremediation Journal2003，7，1： | 1 |
| 12 | Friction stir weld evolution of dynamically recrystallized AA 2095 weldments 显示文摘 | Hanadi Salem G | 2003 | Scripta Materialia2003，，49： | 1 |
| 13 | Diagnosis and treatment of ectopic pregnancy显示文摘 | Herther M Hanadi B Trevor | 2005 | CMAJ2005，173，8： | 1 |
| 14 | Modeling point source plumes at high altitudes using a modified Gaussian model显示文摘 | Fariba Mehdizadeh Hanadi S. Rifai | 2003 | Atmospheric Environment2003，，6： | 1 |
| 15 | Potassium efficiency mechanisms of wheat,barley and sugar beet grown on a K fixing soil under controlled conditions显示文摘 | Hanadi E1Dessougi Norbert Clanssen Bemd Steingrobe | 2002 | Journal of Plant Nutrition and Soil Science2002，165，6： | 1 |
| 16 | Diagnosis and treatment of ectopic pregnancy显示文摘 | Heather M Hanadi B Trevor B | 2005 | CMAJ2005，173，8： | 1 |
| 17 | Diagnosis and treatment of ectopic pregnancy显示文摘 | Heather M Hanadi B Trevor B | 2005 | CMAJ2005，173，8： | 1 |
| 18 | Diagnosis and treatment of eetopic pregnancy显示文摘 | Heather M Hanadi B Trevor B | 2005 | CMAJ2005，173，8： | 1 |
| 19 | Identification of target antigens of anti-endothelial cell antibodies in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides: A proteomic approach显示文摘 | Alexis Régent Sébastien Lofek Hanadi Dib Guillaume Bussone Nicolas Tamas Christian Federici Cédric Broussard Lo?c Guillevin Luc Mouthon | 2014 | Clinical Immunology2014，，1： | 1 |
| 20 | Composition of in vitro denture plaque biofilms and susceptibility to antifungals显示文摘 | Hanadi L Al-Karaawi Z McCullough M | 2005 | FEMS Microbiology Letter2005，242，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员