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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | High thermal conductivity of suspended few-layer hexagonal boron nitride sheets显示文摘推迟的很少层的热传导六角形的硼氮化物(h-BN ) 表试验性地用一个 noncontact micro-Raman 光谱学方法被调查。为单层(1L ) 的一阶的温度系数, bilayer (2L ) 并且九层(9L ) h-BN 表被测量是(当时, electrospinning 准备的 3.41 xide nanofibers 被期望减少了热电导率与体积样品相比。自从它包含复杂样品准备方法,热电导率正在质问的 nanofibers 的大小。在这个工作,我们在场对单个 nanofiber 的热电导率的大小合适的一个新奇方法。一 microelectro 机械(MEMS ) 设备被设计了并且制作了在单个 nanofiber 上执行热传导性大小。一个特殊 Si 模板被设计收集并且转单个 nanofibers 到 MEMS 设备名上吗? | Haiqing Zhou Jixin Zhu Zheng Liu Zheng Yan Xiujun Fan Jian Lin Gunuk Wang Qingyu Yan Ting Yu Pulickel M. Ajayan James M. Tour | 2014 | Nano Research2014，7，8： | 9 |
| 4 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 5 | Low-temperature Sintering of FeCuCo based Pre-alloyed Powder for Diamond Bits显示文摘We studied the effects of sintering temperature on FeCuCo based pre-alloyed powder for diamond bits.The FeCuCo composite was fabricated by co-precipitation method.With the addition of tungsten carbide(WC),sintering under different temperatures was investigated.Mechanical properties of the FeCuCo based matrix were systematically studied.The structure of the composite was evaluated by X-ray diffraction(XRD) and scanning electron microscope(SEM) was used to analyze the surface of the powder and matrix.The suitable sintering temperature was determined through differential scanning calorimeter(DSC).Micro drilling experiments were performed,and 820 ℃ was identified to be the ideal sintering temperature,at which the matrix shows the best mechanical properties and drilling performance. | 谢德龙 万隆 SONG Dongdong QIN Haiqing PAN Xiaoyi LIN Feng FANG Xiaohu | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 4 |
| 6 | Satellite-based RAR performance simulation for measuring directional ocean wave spectrum based on SAR inversion spectrum显示文摘Some missions have been carried out to measure wave directional spectrum by synthetic aperture radar (SAR) and airborne real aperture radar (RAR) at a low incidence.Both them have their own advantages and limitations.Scientists hope that SAR and satellite-based RAR can complement each other for the research on wave properties in the future.For this study,the authors aim to simulate the satellite-based RAR system to validate performance for measuring the directional wave spectrum.The principal measurements are introduced and the simulation methods based on the one developed by Hauser are adopted and slightly modified.To enhance the authenticity of input spectrum and the wave spectrum measuring consistency for SAR and satellite-based RAR,the wave height spectrum inversed from Envisat ASAR data by cross spectrum technology is used as the input spectrum of the simulation system.In the process of simulation,the sea surface,backscattering signal,modulation spectrum and the estimated wave height spectrum are simulated in each look direction.Directional wave spectrum are measured based on the simulated observations from 0 ? to 360 ? .From the estimated wave spectrum,it has an 180 ? ambiguity like SAR,but it has no special high wave number cut off in all the direction.Finally,the estimated spectrum is compared with the input one in terms of the dominant wave wavelength,direction and SWH and the results are promising.The simulation shows that satellite-based RAR should be capable of measuring the directional wave properties.Moreover,it indicates satellite-based RAR basically can measure waves that SAR can measure. | REN Lin MAO Zhihua HUANG Haiqing GONG Fang | 2010 | Acta Oceanologica Sinica2010，29，4： | 2 |
| 7 | Thermal quantum and classical correlations and entanglement in the XY spin model with three-spin interaction显示文摘 | Li Yanchao Lin Haiqing | 2011 | Phys Rev A2011，83，05： | 1 |
| 8 | Microstructures and rheological dynamics of viscoelastic solutions in a catanionic surfactant system显示文摘 | Yin Haiqing Lin Yiyang Huang Jianbing | 2009 | Journal of Colloid and Interface Science2009，338，： | 1 |
| 9 | Adsorption of basic dyes by dried waste sludge: kinetic,equilibrium and desorption studies显示文摘 | WANG Xuesong LIN Haiqing | 2011 | Desalination and Water Treatment2011，29，123： | 1 |
| 10 | Effect of traditional Chinese medicine shu-mai-tang on angiogenesis,arteriogenesis and cardiac function in rats with myocardial ischemia 显示文摘 | Huiqiu Yin Jidong Zhang Haiqing Lin | 2009 | Phytother Res2009，23，： | 1 |
| 11 | From information commons to knowledge commons: building a collaborative knowledge sharing environment for innovative communities 显示文摘 | REN Shuhuai SHENG Xingjun LIN Haiqing | 2009 | Electronic Library2009，27，2： | 1 |
| 12 | Improvement of antioxidant activity of peptides with molecular weights ranging from 1 to 10<ce:hsp sp='0.25'/>kDa by PEF technology显示文摘 | Jia Wang Ke Wang Songyi Lin Ping Zhao Gregory Jones Hung Trang Jingbo Liu Haiqing Ye | 2012 | International Journal of Biological Macromolecules2012，，3： | 1 |
| 13 | Effect of pulsed electric fields on the activity of neutral trehalase from beer yeast and RSM analysis显示文摘 | Haiqing Ye Yan Jin Songyi Lin Mingyuan Liu Yi Yang Meishuo Zhang Ping Zhao Gregory Jones | 2012 | International Journal of Biological Macromolecules2012，，5： | 1 |
| 14 | Block-block entanglement and quantum phase transitions in the one- dimensional extended Hubbard model 显示文摘 | DENG Shusa GU Shijian LIN Haiqing | 2006 | Phys Rev B2006，74，4： | 1 |
| 15 | Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma显示文摘 | Haiqing Cai Lijun Lin Haikang Cai Mingjie Tang Zhigang Wang | 2013 | Medical Oncology2013，，2： | 1 |
| 16 | Superconductivity in One-atomic-layer Metal Films显示文摘Superconductivity is a peculiar quantum phenomenon which originates from the pairing of conduction electrons, followed by phase coherent condensation. Since the discovery by K. Onnes in 1911, superconductivity has been one of the hottest topics in physics for an entire century, and still attracts people's great interest. One of the intriguing issues is | ZHANG Tong CHENG Peng LI Wenjuan SUN Yujie WANG Guang ZHU Xiegang HE Ke WANG Lili MA Xucun CHEN Xi WANG Yayu LIU Ying LIN Haiqing JIA Jinfeng XUE Qikun | 2011 | Bulletin of the Chinese Academy of Sciences2011，25，4： | 1 |
| 17 | Ultralow specific ON-resistance high-k LDMOS with vertical field plate显示文摘An ultralow specific on-resistance high-k LDMOS with vertical field plate(VFP HK LDMOS) is proposed. The high-k dielectric trench and highly doped interface N+ layer are made in bulk silicon to reduce the surface field of the drift region in the VFP HK LDMOS. The gate vertical field plate(VFP) pinning in the high-k dielectric trench can modulate the bulk electric field. The high-k dielectric not only provides polarized charges to assist depletion of the drift region, so that the drift region and high-k trench maintain charge balance adaptively,but also can fully assist in depleting the drift region to increase the drift doping concentration and reshape the electric field to avoid premature breakdown. Compared with the conventional structure, the VFP HK LDMOS has the breakdown voltage of 629.1 V at the drift length of 40 μm and the specific on-resistance of 38.4 mΩ·cm^2 at the gate potential of 15 V. Then the power figure of merit is 10.31 MW/cm^2. | Lijuan Wu Limin Hu Lin Zhu Hang Yang Bing Lei Haiqing Xie | 2018 | Journal of Semiconductors2018，39，10： | 1 |
| 18 | Microstructures and theological dynamics of viscoelastic solutions in catanionic surfactant system 显示文摘 | Yin Haiqing Lin Yinyang Huang Jianbin | 2009 | J Colloid Interface Sci2009，338，1： | 1 |
| 19 | Power plant post-combustion carbon dioxide capture: An opportunity for membranes显示文摘 | Merkel Tim C Haiqing Lin Xiaotong Wei | 2010 | Journal of Membrane Science2010，359，1： | 1 |
| 20 | From information commons to knowledge commons: Building a collaborative knowledge sharing environment for innovative communities显示文摘 | Ren Shuhuai Sheng Xingjun Lin Haiqing | 2008 | rhe Electronic Library2008，27，2： | 1 |
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