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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 3 | Drought and biodiversity in grasslands显示文摘 | Tilman D El Haddi A | 1992 | Oecologia1992，89，： | 1 |
| 4 | E-Nose and e-Tongue combination for improved recognition of fruit juice samples 显示文摘 | HADDI Z MABROUK S BOUGRINI M | 2014 | Food Chem2014，150，2： | 1 |
| 5 | Digitalislike circulating factor in hypertension: Potential messenger between salt balance and intracellular sodium显示文摘 | Francis J. Haddy MD PhD | 1990 | Cardiovascular Drugs and Therapy1990，，2： | 1 |
| 6 | Coupling of microanalytical techniques to study the relationship between chemical durability and irradiation resistance of alumino-borosilicate glasses 显示文摘 | Haddi A Trocellier P Djanarthany S | 2006 | Nucl Instr Meth Phys Res B2006，249，： | 1 |
| 7 | The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels:results from Apo Europe显示文摘 | Haddy N De Bacquer D Chemaly MM | 2002 | Eur J Hum Genet2002，10，12： | 1 |
| 8 | Role of dietary salt in hypertension 显示文摘 | Haddy FJ | 2006 | Life Sci2006，79，17： | 1 |
| 9 | Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioio- dine therapy 显示文摘 | Durante C Haddy N Baudin E | 2006 | J Clin Endocrinol Metab2006，91，8： | 1 |
| 10 | Drought and biodiversity in grasslands显示文摘 | Tilman D Haddi A E1 | | 0，，： | 1 |
| 11 | Long-term outcome of 444 patients with distant metastases fi'om papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy 显示文摘 | Durante C Haddy N Baudin E | 2006 | ] Clin Endocrinol Metab2006，9，8： | 1 |
| 12 | Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy 显示文摘 | Durante C Haddy N Baudin E | 2006 | J Clin Endocfinol Metab2006，91，8： | 1 |
| 13 | Stress-induced changes in concentrations of plasma sex steroids in black bream 显示文摘 | Haddy J A | 1999 | Fish Biology1999，55，6： | 1 |
| 14 | IL-6, TNF-α and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort显示文摘 | Nadia Haddy Catherine Sass Suzanne Droesch Mohamed Zaiou Gérard Siest Anne Ponthieux Daniel Lambert Sophie Visvikis | 2003 | Atherosclerosis2003，，2： | 1 |
| 15 | Anesthesia for robotic heart surgery显示文摘 | Haddy S Cunningham M | | 0，，： | 1 |
| 16 | CLostridial bacteremia In the community hospital显示文摘 | Haddy RI NadKarmi DD Mann BL | 2000 | Scand J Infect Dis2000，32，8： | 1 |
| 17 | E-Nose and e-Tongue combination for improved recognition of fruit juice samples 显示文摘 | Haddi Z Mabrouk S Bougrini M | 2014 | Food Chem2014，150，1： | 1 |
| 18 | Protective effects of dietary potassium chloride on hemodynamics of Dahl salt-sensitive rats in response to chronic administration of sodium chloride显示文摘 | William M Manger Shlomoh Simchon Charles T Stier Joseph Loscalzo Kung-Ming Jan Rex Jan Francis Haddy | 2003 | Journal of Hypertension2003，，12： | 1 |
| 19 | Hyperinflation resulting in hemodynamic collapse following living donor lobar transplantation显示文摘 | Haddy SM Bremner RM Moore-Jefferies EW | 2002 | Anesthesiology2002，97，5： | 1 |
| 20 | Community-acquired pneumonia in infants and children 显示文摘 | Ostapchuk M Roberts DM Haddy R | 2004 | Am Fam Physician2004，70，5： | 1 |
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