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| 1 | 局部无缝垂直参考基准面的建立方法研究显示文摘为在局域建立一个无缝垂直参考基准面,提出了两步转换的思想和方法,即从大地高到正高然后到海图高。利用该方法,构造了Saint John河高程转换模型,并在该河段建立了无缝垂直参考基准面,且得到了实际验证。 | 赵建虎 张红梅 John E Hughes Clarke | 2006 | 武汉大学学报(信息科学版)2006，31，5： | 12 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States.The majority of patients are candidates only for palliative chemotherapy,which has proven largely ineffective in halting tumor progression.One proposed mechanism of chemoresistance involves signaling via the mesenchymalepithelial transition factor protein(MET),a previously established pathway critical to cell proliferation and migration.Here,we review the literature to characterize the role of MET in the development of tumorigenesis,metastasis and chemoresistance,highlighting the potential of MET as a therapeutic target in pancreatic cancer.In this review,we characterize the role of c-Met in the development of tumorigenesis,metastasis and chemoresistance,highlighting the potential of c-Met as a therapeutic target in pancreatic cancer. | Daniel Delitto Eva Vertes-George Steven J Hughes Kevin E Behrns Jose G Trevino | 2014 | World Journal of Gastroenterology2014，20，26： | 6 |
| 4 | Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associteed with reduced B ceils and serum cytotoxicity on mouse cell line expressing AehR显示文摘 | Poussin M A Goluszko E Hughes T K | 2000 | J Neuroimmunol2000，111，： | 2 |
| 5 | Management of infected pancreatic necrosis in the setting of concomitant rectal cancer:A case report and review of literature显示文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant treatment and resection for his concomitant colorectal cancer. | Kihoon Choi David E Flynn Anitha Karunairajah Andrew Hughes Ambika Bhasin Benedict Devereaux Manju D Chandrasegaram | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 2 |
| 6 | Long-Term Outcomes for Patients with Post–Liver Transplant Anastomotic Biliary Strictures Treated by Endoscopic Stent Placement显示文摘 | Joseph Morelli Hugh E Mulcahy Ira R Willner John T Cunningham Peter Draganov | 2003 | Gastrointestinal Endoscopy2003，，3： | 2 |
| 7 | 多波束测量中换能器瞬时精密高程的确定显示文摘分析了GPS高程信号和Heave信号的频段特征,利用数字信号处理技术,提取了GPS高程和Heave中的有效频段信号,合成了一个全新的信号。该合成信号能够全面反映多波束换能器的实际垂直运动,并能够克服传统多波束测量和数据处理方法的缺陷,大大提高了多波束在垂直方向的成果精度。实验证明了该方法的正确性和可行性。 | 赵建虎 张红梅 John E Hughes Clarke 王胜平 | 2006 | 武汉大学学报(信息科学版)2006，31，11： | 2 |
| 8 | Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues显示文摘AIM:To investigate the expression of chondroitin sulphate proteoglycans(CSPGs)in rat liver tissues of hepatocellular carcinoma(HCC).METHODS:Thirty male Sprague Dawley rats were randomly divided into two groups:control group(n=10) and HCC model group(n=20).Rats in the HCC model groups were intragastrically administrated with 0.2%(w/v)N-diethylnitrosamine(DEN)every 5 d for 16 wk,whereas 0.9%(w/v)normal saline was administered to rats in the control group.After 16 wk from the initiation of experiment,all rats were killed and livers were collected and fixed in 4%(w/v)paraformaldehyde.All tissues were embedded in paraffin and sectioned.Histological staining(hematoxylin and eosin and Toluidine blue)was performed to demonstrate the onset of HCC and the content of sulphated glycosaminoglycan(sGAG).Immunohistochemical staining was performed to investigate the expression of chondroitin sulphate(CS)/dermatan sulphate(DS)-GAG,heparan sulphate(HS)-GAG,keratan sulphate(KS)-GAG in liver tissues.Furthermore,expression and distribution of CSPG family members,including aggrecan,versican,biglycan and decorin in liver tissues,were also immunohistochemically determined.RESULTS:After 16 wk administration of DEN,malignant nodules were observed on the surface of livers from the HCC model group,and their hepatic lobule structures appeared largely disrupted under microscope.Toluidine blue staining demonstrated that there was an significant increase in sGAG content in HCC tissues when compared with that in the normal liver tissues from the control group[0.37±0.05 integrated optical density per stained area(IOD/area)and 0.21± 0.01 IOD/area,P<0.05].Immunohistochemical studies demonstrated that this increased sGAG in HCC tissues was induced by an elevated expression of CS/DS(0.28±0.02 IOD/area and 0.18±0.02 IOD/area,P< 0.05)and HS(0.30±0.03 IOD/area and 0.17±0.02 IOD/area,P<0.01)but not KS GAGs in HCC tissues.Further studies thereby were performed to investigate the expression and distribution of several CSPG components in HCC tissues,including aggrecan,versican,biglycan and decorin.Interestingly,there was a distinct distribution pattern for these CSPG components between HCC tissues and the normal tissues.Positive staining of aggrecan,biglycan and decorin was localized in hepatic membrane and/or pericellular matrix in normal liver tissues;however,their expression was mainly observed in the cytoplasm,cell membranes in hepatoma cells and/or pericellular matrix within HCC tissues.Semi-quantitative analysis indicated that there was a higher level of expression of aggrecan(0.43± 0.01 and 0.35±0.03,P<0.05),biglycan(0.32±0.01 and 0.25±0.01,P<0.001)and decorin(0.29±0.01 and 0.26±0.01,P<0.05)in HCC tissues compared with that in the normal liver tissues.Very weak versican positive staining was observed in hepatocytes near central vein in normal liver tissues;however there was an intensive versican distribution in fibrosis septa between the hepatoma nodules.Semi-quantitative analysis indicated that the positive rate of versican in hepatoma tissues from the HCC model group was much higher than that in the control group(33.61%and 21.28%,P <0.05).There was no positive staining in lumican and keratocan,two major KSPGs,in either normal or HCC liver tissues.CONCLUSION:CSPGs play important roles in the onset and progression of HCC,and may provide potential therapeutic targets and clinical biomarkers for this prevalent tumor in humans. | Xiao-Li Jia Si-Yuan Li Shuang-Suo Dang Yan-An Cheng Xin Zhang Wen-Jun Wang Clare E Hughes Bruce Caterson | 2012 | World Journal of Gastroenterology2012，18，30： | 2 |
| 9 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 10 | The relations among environmental disclosure, environmental performance, and economic performance: a simultaneous equations approach显示文摘 | Sulaiman A Al-Tuwaijri Theodore E Christensen K.E Hughes | 2003 | Accounting, Organizations and Society2003，，5： | 2 |
| 11 | Biomass cofiring: economics, policy and opportunities显示文摘 | Hughes E | 2000 | Biomass and Bioenergy2000，15，： | 1 |
| 12 | C/EBPα and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells显示文摘 | HUGHES D E RAUSA F M | 2006 | Hepatology2006，43，2： | 1 |
| 13 | Video OCR: Indexing digital news libraries by recognition of superimposed caption 显示文摘 | T Sato T Kanade E K Hughes | 1999 | ACM Multimedia Systems1999，7，5： | 1 |
| 14 | Global-Scale temperature patterns and climate forcing over the past six Centuries显示文摘 | Mann M E Bradley R S Hughes M K | 1998 | Nature1998，392，： | 1 |
| 15 | Formation and use of coal combustion residues from three types power plants burning Illinois coals 显示文摘 | DEMIR I HUGHES R E DEMARIES P J | 2001 | Fuel2001，，80： | 1 |
| 16 | Role of tubule epithelial cells in pathogene- sis of tubulointerstitial fibrosis induced by glomerular disease 显示文摘 | Healy E Hugh RB | 1998 | Curt Opin Nephrol Hypertens1998，7，5： | 1 |
| 17 | Practical Free- Space Quantum Key Distribution over 10kin in Daylight and at Night显示文摘 | Richard J Hughes Jane E Nordholt | 2002 | New Journal of Physics2002，，4： | 1 |
| 18 | Modulation of theglycogen synthase kinase-3 family by tyrosine phosphorylation显示文摘 | Hughes K Nikolakaki E Plyte S E ei al | 1993 | EMBO J1993，12，2： | 1 |
| 19 | Supportive care for patients with Guillain-Barr syndrome显示文摘 | Hughes RA Wijdicks EF Benson E et al | 2005 | Arch Neurol2005，62，8： | 1 |
| 20 | Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies显示文摘 | Dalmau J Gleichman A J Hughes E G | 2008 | Lancet Neuro12008，7，12： | 1 |
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