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| 1 | Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease显示文摘原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习,在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择,磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间,身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程,更最近,这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论,特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要,磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记,以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。 | I Jane Cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，30： | 10 |
| 2 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 3 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 4 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 5 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 6 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet . 2005 (9493)2005，，： | 3 |
| 7 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 8 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 9 | Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs显示文摘 | Geou-Yarh Liou Heike D?ppler Brian Necela Murli Krishna Howard C. Crawford Massimo Raimondo Peter Storz | 2013 | The Journal of Cell Biology2013，，3： | 2 |
| 10 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet2005，，9493： | 2 |
| 11 | Optimum imaging for sinonasal malignancy 显示文摘 | Lloyd G Lund VJ Howard D | 2000 | J Laryngol Otol2000，114，7： | 1 |
| 12 | phenomena of scintillation noise in radar-tracking system显示文摘 | Dunn J H Howard D D king A M | 1959 | Proceedings of IRE1959，47，5： | 1 |
| 13 | The apparent, of polyphenol oxidase and phloridzin in the production of apple rooting cofactors显示文摘 | Bassuk N L Hunter L D Howard B H | 1981 | J Hort Sci1981，56，4： | 1 |
| 14 | The functional anatomy of the female pelvic floor and stress continence control system 显示文摘 | Ashton - Miller Howard D DaLancey OL | 2001 | Scand J Urol Nephrol2001，207，： | 1 |
| 15 | Preferential induction of apoptosis for primary human leukemic stem cells显示文摘 | GUZMAN M L SWIDERSKI C F HOWARD D S | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 16 | Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 17 | Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease显示文摘 | Howard L M Miller S D | 2004 | Autoimmunity2004，37，5： | 1 |
| 18 | Chronic subclinical inflammation as part of the insulin-resistance syndrome: the insulin resistance atherosclerosis study (IRAS)显示文摘 | Festa A D Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 19 | Chronic sub-clinical inflammation as part of the insulin resistance syn-drome:the insulin restance atherosclerosis study(IRSA)显示文摘 | Festa A D Agostion R J R Howard G | 2000 | Circulation2000，102，： | 1 |
| 20 | Chronic sub clinical inflammation as part of the insulin resistance syn drome: the insulin resistance atherosclerosis study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
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