|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | 肩关节注射治疗冻结肩的研究进展显示文摘冻结肩是导致肩关节疼痛及活动受限的常见疾病,肩关节注射是治疗冻结肩的最常用方法,包括糖皮质激素注射、液体扩张疗法、玻璃酸钠注射等。近年来肩关节注射治疗的研究较多,且有较多高质量随机对照研究,该文就糖皮质激素注射与其它治疗手段之间以及注射治疗的不同方式之间在疼痛缓解、活动度及功能改善等方面的疗效及安全性比较作一综述。 | 刘全辉 Sah Murli Manohar 戴祝 | 2019 | 中南医学科学杂志2019，47，6： | 8 |
| 3 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 4 | Integrated environmental assessment: an urban perspective显示文摘A broadening of the strategic approach to environmental issues coupled with changes in the mechanisms of environmental governance and management has generated demands for new kinds of environmental knowledge and for new ways of using it. In particular there is now a strong demand for information about the environment to be linked to information about the impacts of human activities so that the unsustainable aspects of economic development can be anticipated and controlled. The scope of environmental assessment has enlarged to provide information that will help a wide range of stakeholders, including business and publics to make decisions, choosing between alternatives on the basis of sound environmental information set in a social and economic context. This paper provides a discussion of these developments and illustrates how integrated environmental assessment of a specific urban environmental problem, the reduction of health impacts of air borne particles, can deliver broad strategic information for participants in the solution. | John Murlis Jackson Environment Institute, University College London, London WC1E 6HA, UK | 1999 | Journal of Environmental Sciences1999，11，3： | 2 |
| 5 | Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs显示文摘 | Geou-Yarh Liou Heike D?ppler Brian Necela Murli Krishna Howard C. Crawford Massimo Raimondo Peter Storz | 2013 | The Journal of Cell Biology2013，，3： | 2 |
| 6 | Diagnostic Accuracy of Probe-based Confocal Laser Endomicroscopy and Narrow Band Imaging in Detection of Dysplasia in Duodenal Polyps显示文摘 | Muhammad W. Shahid Anna Buchner Victoria Gomez Murli Krishna Timothy A. Woodward Massimo Raimondo Michael B. Wallace | 2012 | Journal of Clinical Gastroenterology2012，，5： | 2 |
| 7 | Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation 显示文摘 | Wagner SJ Cifone MA Murli H | 1995 | Transfusion1995，35，4： | 1 |
| 8 | Structure of turbulent boundary layers at low Reynolds numbers显示文摘 | Murlis J Tsai H M Bradshaw P | 1998 | Fluid Mech1998，72，9： | 1 |
| 9 | The structure of turbulent boundary layers at low Reynolds number显示文摘 | MURLIS J TSAI H M and BRADSHAW P | 1982 | Journal of Fluid Mechanics1982，122，： | 1 |
| 10 | Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides显示文摘 | SCHIRMER A KENNEDY J MURLI S | 2006 | PNAS2006，103，11： | 1 |
| 11 | Odor plumes and how insects use them显示文摘 | Murlis J | 1992 | Ann Rev Entomol1992，37，： | 1 |
| 12 | Filament-based atmospheric dispersion model to achieve short time-scale structure of odor plumes显示文摘 | Farrell J A Murlis J Long X | 2002 | Environmental Fluid Mechanics2002，2，： | 1 |
| 13 | Chemical and biological studies of a new cigarette that primarily heats tobacco, part 2: In vitro toxicology of mainstream smoke condensate 显示文摘 | Bombick B R Murli H Avalos J T | 1998 | Food Chem Toxicol1998，36，： | 1 |
| 14 | Pressure Induced Phase Transformation in UzO(PO4)2显示文摘 | Mishra A K Murli C Singhal A | 2008 | Journal of Solid State Chemistry2008，181，5： | 1 |
| 15 | Absence of mutagenic effects of sodium dichloroactate显示文摘 | Fox AW Yang XQ Murli H | | 0，，： | 1 |
| 16 | Filament-based atmo- spheric dispersion model to achieve short time-scale structure of odor plumes显示文摘 | Farrell J A Murlis J Long X Z | 2002 | Environmental Fluid Mechanics2002，2，12： | 1 |
| 17 | The Wiener filter and regularization methods for image restoration problems 显示文摘 | Murli A D'Amore L De Simone V | 1999 | Image Analysis and Processing1999，11，2： | 1 |
| 18 | Heart disease in dibetes mellitus显示文摘 | Richard WN Murli Raman | 1996 | Endocrinal Metab Clin North Am1996，2，6： | 1 |
| 19 | Prospective, Controlled Tandem Endoscopy Study of Narrow Band Imaging for Dysplasia Detection in Barrett’s Esophagus显示文摘 | Herbert C. Wolfsen Julia E. Crook Murli Krishna Sami R. Achem Kenneth R. Devault Ernest P. Bouras David S. Loeb Mark E. Stark Timothy A. Woodward Lois L. Hemminger Frances K. Cayer Michael B. Wallace | 2008 | Gastroenterology2008，，： | 1 |
| 20 | Prospective, Controlled Tandem Endoscopy Study of Narrow Band Imaging for Dysplasia Detection in Barrett’s Esophagus显示文摘 | Herbert C. Wolfsen Julia E. Crook Murli Krishna Sami R. Achem Kenneth R. Devault Ernest P. Bouras David S. Loeb Mark E. Stark Timothy A. Woodward Lois L. Hemminger Frances K. Cayer Michael B. Wallace | 2008 | Gastroenterology2008，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员