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| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | Preferential induction of apoptosis for primary human leukemic stem cells显示文摘 | GUZMAN M L SWIDERSKI C F HOWARD D S | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 4 | Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease显示文摘 | Howard L M Miller S D | 2004 | Autoimmunity2004，37，5： | 1 |
| 5 | Total knee arthroplasty after high tibial osteotomy:no differences between medial and lateral osteotomy approaches显示文摘 | Preston S Howard J Naudie D | 2014 | Clin Orthop Relat Res2014，472，1： | 1 |
| 6 | Research strategies for safety evaluation of nanomaterials, Part IV : Risk assessment of nanopartlcles显示文摘 | TSUJI J S MAYNARD A D HOWARD C P | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 7 | Chirp sensing codes: deterministic compressed sensing measurements for fast recovery 显示文摘 | APPLEBAUM L HOWARD S D SEARLE S | 2009 | Applied and Com- putational Harmonic Analysis2009，26，2： | 1 |
| 8 | Ego Involvement and Leisure Be- havior: A Conceptual Specification显示文摘 | Selin S W Howard D R | 1988 | Journal of Leisure Research1988，20，3： | 1 |
| 9 | A simple signal processing architecture for instantaneous radar polarimetry 显示文摘 | Howard S D Calderbank A R Moran W | 2007 | IEEE Transactions on Information Theory2007，53，4： | 1 |
| 10 | Double-blind,randomized,controlled trial of atosiban and rito drine in the treatment of pretterm labor: a multicenter effectiveness and safety study显示文摘 | Moutquin J M herman D S Howard C | | Am J Obstet Gynecol0，182，5： | 1 |
| 11 | Developing a Tourism Impact Attitude Scale显示文摘 | Lankford S V Howard D R | 1994 | Annals of Tourism Research1994，21，01： | 1 |
| 12 | Dynamic response and wave propagation in plane masses and frames显示文摘 | PAO Y H KEH D C HOWARD S M | 1999 | AIAA J1999，37，： | 1 |
| 13 | M3+-modified LiM n2O4 spinel intercalation cathodes 显示文摘 | LU S H HOWARD W F | 1997 | J Electrochem Soc1997，144，： | 1 |
| 14 | Developing a Tourism Impact Attitude Scale显示文摘 | Lankford S V D Howard | 1994 | Annals of Tourism Research1994，21，1： | 1 |
| 15 | Developing a tourism impact attitude scale 显示文摘 | Lank Howard D R | 1994 | Annals of Tourism Research1994，21，1： | 1 |
| 16 | Marrow-isolated AdultMultilineage Inducible (M IAMI) Cells, a Unique Population ofPostnatal Young and Old Human Cells With Extensive Expansionand Differentiation Potential 显示文摘 | D 'Ippolito G Diabira S Howard G A | 2004 | J Cell Sci2004，117，： | 1 |
| 17 | Why Is a Verb Like an Inanimate Object? Grammatical Category and Semantic Category Deficits显示文摘 | Bird H Howard D Franklin S | | 0，，： | 1 |
| 18 | Relationshipbetween blood pressure and stroke risk in patients with symp-tomatic carotid occlusive disease显示文摘 | Rothwell P M Howard S C Spence J D | 2003 | Stroke2003，34，11： | 1 |
| 19 | Developing a Tourism Impact Attitude Scale显示文摘 | Lankford S V Howard D R | 1994 | Annals of Tourism Research1994，21，1： | 1 |
| 20 | Developing a tourism impact attitude scale显示文摘 | Lankford S L Howard D R | 1994 | Annals of Tourism Research1994，21，1： | 1 |
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