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| 1 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 2 | Interactions between aboveground and belowground biodi- versity in terrestrial ecosystems: patterns, mechanisms, and feed backs显示文摘 | HOOPER D U BIGNELL D E BROWN V K | 2000 | BioScience2000，50，： | 1 |
| 3 | NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus 显示文摘 | Truong Boldue Q C Strahilevitz J Hooper D C | 2006 | Antimierob Agents Chemother2006，50，： | 1 |
| 4 | Insitu expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis显示文摘 | Zagazag D Hooper A Friedlander DR | 1999 | Clin Cancer Res1999，5，9： | 1 |
| 5 | Mechanisms of action and resistance of older and newer fluoroquinolones 显示文摘 | HOOPER D C | 2000 | Clin Infect Dis2000，31，2： | 1 |
| 6 | In situ expression of angiopoietins in astrocytomas identifies anagiopoietin-2 as an early marker of tumour angiogenesis显示文摘 | ZAGZAG D HOOPER A FRIEDLANDER D R | 1999 | Exp Neurol1999，159，： | 1 |
| 7 | Low glycaemic index diets and blood lipids:a systematic review and meta analysis of randomised controlled trials显示文摘 | Goff L M Cowland D E Hooper L | 2013 | Nutr Metab Cardiovasc Dis2013，23，1： | 1 |
| 8 | Uric acid,a peroxynitrite scavenger,inhibits CNS inflammation,blood-CNS barrier permeability changes,and tissue damage in a mouse model of multiple sclerosis显示文摘 | Hooper D Scott G Zborek A | 2000 | The FASEB Journal2000，14，5： | 1 |
| 9 | The role of complementary and competetion in ecosystem responses variation in plant diversity显示文摘 | HOOPER D U | 1998 | Ecology1998，79，： | 1 |
| 10 | The pVHL-associated SCF ubiquitin ligase complex:molecular genetic analysis of elongin B and C, Rbxl and HIF-1 alpha in renal cell carcinoma显示文摘 | Clifford SC Astuti D Hooper L | 2001 | Oncogene2001，20，36： | 1 |
| 11 | Nitrogen limitation in dryland ecosystems: responses to geographical and temporal variation in precipitation 显示文摘 | Hooper D U Johnson L | 1999 | Biogeochemistry1999，46，： | 1 |
| 12 | The effects of plant composition and diversity on ecosystem processes 显示文摘 | Hooper D U Vitousek P M | 1997 | Science1997，277，5330： | 1 |
| 13 | Lesions of experimental equine morbillivirus pneumonia in horses显示文摘 | Hooper P T Ketterer P J Hyatt A D | 1997 | Vet Pathol1997，34，： | 1 |
| 14 | Hospital-acquired infections due to gram- negative bacteria 显示文摘 | Peleg A Y Hooper D C | 2010 | N Engl J Med2010，362，19： | 1 |
| 15 | qnr gene nomenclature 显示文摘 | Jaeoby G Cattoir V Hooper D | 2008 | Antimicrob Agents Chemother2008，52，7： | 1 |
| 16 | Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes显示文摘 | Raghu Kadaba Hanna Birke Jun Wang Steven Hooper Claudia D Andl Francesco Di Maggio Erdinc Soylu Mohammed Ghallab Daniel Bor Fieke EM Froeling Satyajit Bhattacharya Anil K Rustgi Erik Sahai Claude Chelala Peter Sasieni Hemant M Kocher | 2013 | J. Pathol2013，，1： | 1 |
| 17 | CO1 phylogenies in diploblasts and the 'Bareoding of Life' - are we sequencing a suboptimal partiton? 显示文摘 | ERPENBECK D HOOPER J N A WORHEIDE G | 2005 | Molecular Ecology Notes2005，1，： | 1 |
| 18 | Management of Submacular Hemorrhage with Intravitreal Injection of Tissue Plasminogen Activator and expansile GAS显示文摘 | CHEN CY HOOPER C CHIU D | 2007 | Retina2007，27，3： | 1 |
| 19 | The effect of precipitation on wind-profiler clear air returns 显示文摘 | McDonald A J Carey-Smith T K Hooper D A | 2004 | Ann Geophys2004，22，： | 1 |
| 20 | Hormonal responses of elite swimmers to overtraining显示文摘 | Hooper S L MacKinnon L T Gordon R D | 1993 | Med Sci Sports Exerc1993，25，6： | 1 |
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