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| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | Randomized controlled trial of bipolar diathermy vs ultrasonic scalpel for closed hemorrhoidectomy显示文摘AIM:To compare hemorrhoidectomy with a bipolar electrothermal device or hemorrhoidectomy using an ultrasonically activated scalpel.METHODS:Sixty patients with grade Ⅲ or Ⅳ hemorrhoids were prospectively randomized to undergo closed hemorrhoidectomy assisted by bipolar diathermy(group 1) or hemorrhoidectomy with the ultrasonic scalpel(group 2).Operative data were recorded,and patients were followed at 1,3,and 6 wk to evaluate complications.Independent assessors were assigned to obtain postoperative pain scores,oral analgesic requirement and satisfaction scores.RESULTS:Reduced intraoperative blood loss median 0.9 mL(95% CI:0.8-3.7) vs 4.6 mL(95% CI:3.8-7.0),P = 0.001 and a short operating time median 16(95% CI:14.6-18.2) min vs 31(95% CI:28.1-35.3) min,P < 0.0001 was observed in group 1 compared with group 2.There was a trend towards lower postoperative pain scores on day 1 group 1 median 2(95% CI:1.8-3.5) vs group 2 median 3(95% CI:2.6-4.2),P = 0.135.Reduced oral analgesic requirement during postoperative 24 h after operation median 1(95% CI:0.4-0.9) tablet vs 1(95% CI:0.9-1.3) tablet,P = 0.006 was observed in group 1 compared with group 2.There was no difference between the two groups in the degree of patient satisfaction or number of postoperative complications.CONCLUSION:Bipolar diathermy hemorrhoidectomy is quick and bloodless and,although as painful as closed hemorrhoidectomy with the ultrasonic scalpel,is associated with a reduced analgesic requirement immediately after operation. | Akira Tsunoda Haruki Sada Takuya Sugimoto Nobuyasu Kano Mariko Kawana Tadanori Sasaki Hideki Hashimoto | 2011 | World Journal of Gastrointestinal Surgery2011，3，10： | 6 |
| 3 | B?cell translocation gene 1 serves as a novel prognostic indicator ofhepatocellular carcinoma显示文摘 | Mitsuro Kanda Hiroyuki Sugimoto Shuji Nomoto Hisaharu Oya Soki Hibino Dai Shimizu Hideki Takami Ryoji Hashimoto Yukiyasu Okamura Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | International Journal of Oncology2015，，2： | 3 |
| 4 | Effect of integrated rice-duck farming on rice yield,farm productivity,and rice-provisioning ability of farmers显示文摘 | SHAIKH TANVEER HOSSAIN HIDEKI SUGIMOTO GAZI JASHIM UDDIN AHMED | 2005 | Asian Journal of Agriculture and Development2005，2，1： | 1 |
| 5 | Function and diagnostic value of Anosmin‐1 in gastric cancer progression显示文摘 | Mitsuro Kanda Dai Shimizu Tsutomu Fujii Satoshi Sueoka Yuri Tanaka Kazuhiro Ezaka Hideki Takami Haruyoshi Tanaka Ryoji Hashimoto Naoki Iwata Daisuke Kobayashi Chie Tanaka Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasu | 2016 | Int. J. Cancer2016，，3： | 1 |
| 6 | Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells显示文摘 | Hideki Kimura Daisuke Mikami Kazuko Kamiyama Hidehiro Sugimoto Kenji Kasuno Naoki Takahashi Haruyoshi Yoshida Masayuki Iwano | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 7 | Translational implication of Kallmann syndrome-1 gene expression inhepatocellular carcinoma显示文摘 | Yuri Tanaka Mitsuro Kanda Hiroyuki Sugimoto Dai Shimizu Satoshi Sueoka Hideki Takami Kazuhiro Ezaka Ryoji Hashimoto Yukiyasu Okamura Naoki Iwata Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro | 2015 | International Journal of Oncology2015，，6： | 1 |
| 8 | Preparation of ruthenic acid nanosheets and utilization of its interlayer surface for electrochemical energy storage 显示文摘 | Sugimoto Wataru Iwata Hideki Yasunaga Yutaka | 2003 | Angewandte Chemic International Edition2003，42，34： | 1 |
| 9 | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer显示文摘 | Mitsuro Kanda Dai Shimizu Shuji Nomoto Soki Hibino Hisaharu Oya Hideki Takami Daisuke Kobayashi Suguru Yamada Yoshikuni Inokawa Chie Tanaka Tsutomu Fujii Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 10 | Prepartion and properties of poly (methylmelhactylate) silica hybrid materiuls incorporating reactive silica nanoparticles显示文摘 | HIDEKI SUGIMOTO KAZUKI DAIMATSU EIJI NAKANISHI | 2006 | Polymer2006，，47： | 1 |
| 11 | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer显示文摘 | Mitsuro Kanda Dai Shimizu Shuji Nomoto Soki Hibino Hisaharu Oya Hideki Takami Daisuke Kobayashi Suguru Yamada Yoshikuni Inokawa Chie Tanaka Tsutomu Fujii Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2014 | Oncol2014，，2： | 1 |
| 12 | Cardiac tamponade originating from primary gastric signet ring cell carcinoma显示文摘 | Yoshio Sakai Keiji Minouchi Hideki Ohta Yusei Annen Tatsuho Sugimoto | 1999 | Journal of Gastroenterology1999，，2： | 1 |
| 13 | Rendezvous gastrotomy technique using direct percutaneous endoscopic gastrostomy for transgastric cholecystectomy in hybrid natural orifice translumenal endoscopic surgery显示文摘 | Maki Sugimoto Hideki Yasuda Keiji Koda Masato Suzuki Masato Yamazaki Tohru Tezuka Chihiro Kosugi Ryota Higuchi Yoshihisa Watayo Yohsuke Yagawa Shuichiro Uemura Hironori Tsuchiya Atsushi Hirano Ro Shoki | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 1 |
| 14 | Evaluation of MAGE‐D4 expression in hepatocellular carcinoma in Japanese patients显示文摘 | Hideki Takami Mitsuro Kanda Hisaharu Oya Soki Hibino Hiroyuki Sugimoto Masaya Suenaga Suguru Yamada Yoko Nishikawa Mikako Asai Tsutomu Fujii Shuji Nomoto Yasuhiro Kodera | 2013 | J Surg Oncol2013，，8： | 1 |
| 15 | Does 'clonal progression' relate to the development of intraductal papillary mucinous tumors of the pancreas?显示文摘 | Keita Wada M.D. Tadahiro Takada M.D. Hideki Yasuda M.D. Hodaka Amano M.D. Masahiro Yoshida M.D. Maki Sugimoto M.D. Hiroshi Irie M.D | 2004 | Journal of Gastrointestinal Surgery2004，，3： | 1 |
| 16 | Preparation and properties of poly ( methylmethacrylate ) - silica hy- brid materials incorporating reactive silica nanoparticles 显示文摘 | HIDEKI SUGIMOTO KAZUKI DAIMATSU EIJI NAKANISHI | 2006 | Polymer2006，，47： | 1 |
| 17 | Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter, randomized controlled trial in Japan (EARTH Study)显示文摘迟了发作的性腺机能减退(LOH ) 上的雄激素代替治疗(艺术) 功效广泛地在西方的国家被调查了;然而,艺术是否能改进健康并且延长活跃生活方式,仍然保持争论。我们有希望地在在日本与 LOH 使人变老的物理、心理的地位上估计了长期的艺术效果。主要端点是问询表估计的生活的健康相关的质量。第二等的端点包括了 glycemic 控制,类脂化合物参数,血压,腰圆周,身体作文,肌肉发达的力量,国际前列腺症状分数(IPSS ) ,可勃起的 Function-5 (IIEF-5 ) 分数的国际索引,和前列腺特定的抗原铺平的浆液。1637 个合格志愿者, 334 个病人 > 有 LOH 的 40 年随机被分到 ART 也(n = 169 ) 或控制组(n = 165 ) 。在起始的治疗以后的 52 个星期,艺术显著地影响了角色短 form-36 健康调查(SF-36 ) 的物理子域规模(P = 0.0318 ) 。艺术也在腰情形与重要减少被联系( P = 0.002 )并且浆液 triglyceride ( TG )( P = 0.013 )并且随的重要增加整个身体并且腿肌肉团体积( P = 0.071 和 0.0108 ,分别地),浆液血红素( P < 0.001 ), IPSS voiding subscore ( P = 0.0418 ),并且 IIEF-5 上的第二个问题( P = 0.0049 )。以严重不利事件这些组之间没有重要差别。在结论,在有 LOH 的病人,长期的艺术在 SF-36 规模,浆液 TG,腰情形,肌肉团体积, IPSS 的 voiding subscore,和 IIEF-5 的第二个问题的角色物理子域上施加了有益的效果。我们希望我们的学习将贡献这个区域的未来发展。 | Hiroyuki Konaka Kazuhiro Sugimoto Hideki Orikasa Teruaki Iwamoto Toshinari Takamura Yoshiyu Takeda Kazuyoshi Shigehara Masashi Iijima Eitetsu Koh Mikio Namiki | 2016 | Asian Journal of Andrology2016，18，1： | 1 |
| 18 | A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia显示文摘 | Hideki Nonaka Tetsuhiro Niidome Yoriko Shinozuka Akinori Akaike Takeshi Kihara Hachiro Sugimoto | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 19 | Preparation and Physical Properties of Flame Retardant Acrylic Resin Containing Nano-sized Aluminum Hydroxide显示文摘 | Daimatsu Kazuki Sugimoto Hideki Kato Yasunori | 2007 | Polymer Degradation and Stability2007，92，8： | 1 |
| 20 | Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy显示文摘AIM:To identify sensitive predictors of clinically relevant postoperative pancreatic fistula(POPF)at the acute phase after pancreatectomy.METHODS:This study included 153 patients diagnosed as having POPFs at postoperative day(POD)3after either open pancreatoduodenectomy or distal pancreatectomy between January 2008 and March 2013.The POPFs were categorized into three grades based on the International Study Group on Pancreatic Fistula Definition,and POPFs of grades B or C were considered to be clinically relevant.The predictive performance for the clinically relevant POPF formation of values at PODs 1,3 and 5 as well as time-dependent changes in levels of inflammatory markers,including white blood cell count,neutrophil count,total lymphocyte count,C-reactive protein(CRP),procalcitonin level,plateletto-lymphocyte ratio and neutrophil-to-lymphocyte ratio,and amylase content in the drain fluid were compared using the receiver operating characteristic(ROC)curve and multivariable analyses.A scoring system for the prediction of clinically relevant POPFs was created using five risk factors identified in this study,and its diagnostic performance was also evaluated.RESULTS:Over time,77(50%)of 153 enrolled patients followed a protracted course and were categorized as having clinically relevant POPFs.ROC curve analyses revealed that changes in CRP levels from POD1 to POD 3 had the greatest area under the curve value(0.767)and that an elevated CRP level of 28.4 mg/L yielded the most optimal predictive value for clinically relevant POPFs.Multivariable analyses for the risk factors of clinically relevant POPFs identified invasive carcinomas of the pancreas and elevation of the CRP level(≥28.4 mg/L,from POD 1 to POD 3)as independent diagnostic factors for clinically relevant POPFs(OR 2.94,95%CI:1.08-8.55,P=0.035 and OR 4.82,95%CI:1.25-20.2,P=0.022,respectively).A gradual increase in the prevalence of clinically relevant POPFs in proportion to the risk classification score was confirmed.A highly elevated CRP level and a risk score≥8 were significantly associated with a prolonged duration of drain placement and postoperative hospitalization.CONCLUSION:A steep rise in the serum CRP level from POD 1 to POD 3 was a highly predictive factor for subsequent clinically relevant POPFs. | Mitsuro Ka Tsutomu Fujii Hideki Takami Masaya Suenaga Yoshikuni Inokawa Suguru Yamada Daisuke Kobayashi Chie Tanaka Hiroyuki Sugimoto Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro Kodera | 2014 | World Journal of Gastroenterology2014，20，26： | 1 |
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