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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 3 | Petrogenesis of keratophyes in the Pingshui Group,Zhejiang:Constraints from zircon U-Pb ages and Hf isotopes显示文摘Zircon LA-ICP-MS U-Pb ages and Hf isotopic as well as whole-rock geochemical data are reported for keratophyes in the Pingshui Group, Zhejiang. The results are used to discuss their petrogenesis and geological significance. The keratophyes were dated at 904±8 to 906±10 Ma. These intermediate-felsic rocks are characterized by high LREE contents and depletion of HREE and HFSE (e.g., Nb, Ta, Ti, P), resembling arc-derived rocks. The keratophyes exhibit positive εHf(t) values of 8.6 to 15.4, consistent with their εNd(t) values of 6.4 to 7.9 but far away from those of crust-derived rocks. Such features indi-cate that they were likely originated from prompt reworking of juvenile crust by arc-continent collision during the early-Neoproterozoic assembly between the Cathaysia and Yangtze Blocks. Combining with their Hf model ages, we suggest that there may exist not only remarkable growth of juvenile crust at ca.1.3―1.1 Ga but also production of juvenile arc-derived crust along the southeastern margin of the Yangtze Block (e.g., the Pingshui area) at ca.1.0―0.9 Ga. | CHEN ZhiHong XING GuangFu GUO KunYi DONG YongGuan CHEN Rong ZENG Yong LI LongMing HE ZhengYu ZHAO Ling | 2009 | Chinese Science Bulletin2009，54，9： | 9 |
| 4 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 5 | Model evidence for climatic impact of thermohaline circulation on China at the century scale显示文摘Based on transient simulation of the last deglaciation(significant global warming period)using a fully coupled model and sensitivity experiment,we show explicitly how the thermohaline circulation(THC)affects the climate of China,especially during periods of abrupt climate change.The simulated evolution of the Chinese climate was consistent with the paleoclimate record during the last deglaciation.For example,the whole Chinese region warmed significantly during the BФlling-AllerФd warming event(BA).When the magnitude of the THC was reduced in the sensitivity experiment during BA,warming of the Chinese region was greatly affected.Our work shows that in addition to orbital forcing and greenhouse gases,the THC is an important factor influencing climate change in China at the century scale. | CHENG Jun LIU ZhengYu HE Feng GUO PinWen CHEN ZhongXiao OTTO-BLIESNER Bette | 2010 | Chinese Science Bulletin2010，55，27： | 6 |
| 6 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 7 | 温盐环流在百年尺度上影响中国气候的一个数值模拟证据显示文摘基于使用全耦合模式的末次冰消期(显著的全球增暖阶段)瞬变模拟结果,通过敏感性试验明确指出温盐环流(Thermohaline Circulation,THC)在百年尺度上大幅度影响中国气候,特别是在气候突变阶段.结果表明,该瞬变模拟中中国地区的气候演变符合古气候资料的纪录,如Bφlling-Allerφd(BA)增暖事件期间中国地区的年平均气温大幅度升高;在敏感性试验中,当人为限制THC在BA事件期间的变化幅度时,中国地区的升温幅度明显减小.结果同时表明,除温室气体、太阳辐射强度因素外,THC是另外一个在百年尺度上影响中国气候的重要因素. | 程军 LIU ZhengYu HE Feng 郭品文 陈中笑 OTTO-BLIESNER Bette | 2010 | 科学通报2010，55，24： | 4 |
| 8 | Assessment of Changes in the Cesarean Scar and Uterus Between One and Two Years after Cesarean Section Using 3D T2w SPACE MRI显示文摘Objective Io evaluate changes in morphology of the cesarean scar and uterus between one and two years after cesarean section using high-resolution,three dimensional T2-weighted sampling perfection with application optimized contrast using diflerent flip angle evolutions Magnetic Resonance Imaging(3DT2w SPACE MRI).Methods This prospective study was performed to investigate morphological changes in the cesarean scars and uterus from one to two years after cesarean section using high-resolution,3D T2w SPACE MRI.The healthy volunteers having no childbearing history were recruited as the controls.All data were measured by two experienced radiologists.All data with normal distribution between the one-year and two-year groups were compared using a paired-sample t test or independent t test.Results Finally,46 women took a pelvic MR examination one year after cesarean section,and a subset of 15 completed the same examination again after two years of cesarean section.Both the uterine length and the anterior wall thickness after two years of cesarean section(5.75±0.46 and 1.45±0.35 cm)were significantly greater than those measured at one year(5.33±0.59 and 1.25±0.27 cm)(t=-2.363 and-2.175,P=0.033 and 0.048).No significant difference was shown in myometrial thickness two years after cesarean section(1.45±0.35 cm)with respect to the control group(1.58±0.21 cm,P=0.170).Nine women who underwent MRI twice were considered to have scar diverticula one year after cesarean section,and still had diverticula two years after cesarean section.The thickness,height,and width of the uterine scar showed no significant change from one to two years(all P>0.05).Conclusions 3D T2w SPACE MRI provides overall morphologic details and shows dynamic changes in the scar and the uterus between one and two years after cesarean section.Scar morphology after cesarean section reached relatively stable one year after cesarean section,and uterine morphology was closer to normal two years after cesarean section. | Yafei Qi Yonglan He Ning Ding Liangkun Ma Tianyi Qian Yuan Li Huadan Xue Zhengyu Jin | 2022 | Chinese Medical Sciences Journal2022，37，2： | 3 |
| 9 | 基于数值仿真的全箭动特性获取技术显示文摘and then in the absence of test data to establish the dynamic model.The issue was,how to accurately obtain the mode data of LM-8 with numerical simulations which directly affects the control reliability of flight.In this paper,various approaches to obtain the dynamic characteristics of LM-8 are described from the perspective of refined dynamic modeling and simulating,mode slope prediction,vertical modal test,etc.The numerical simulations were found to be in good agreement with the experimental data,and satisfied the requirements for the engineering application,which effectively supported the successful maiden flight mission of LM-8. | YANG Shutao YUAN He XU Shanshu WU Yitian SONG Zhengyu | 2021 | Aerospace China2021，22，2： | 2 |
| 10 | Autonomous mission reconstruction during the ascending flight of launch vehicles under typical propulsion system failures显示文摘In recent years, Chinese Long March(LM) launchers have experienced several launch failures, most of which occurred in their propulsion systems, and this paper studies Autonomous Mission Reconstruction(AMRC) technology to alleviate losses due to these failures. The status of the techniques related to AMRC, including trajectory and mission planning, guidance methods,and fault tolerant technologies, are reviewed, and their features are compared, which reflect the challenges faced by AMRC technology. After a brief introduction about the failure modes of engines that can occur during flight, and the fundamentals of trajectory planning and joint optimization of the target orbit and flight path, an AMRC algorithm is proposed for geostationary transfer orbit launch missions. The algorithm evaluates the residual performance onboard, and plans new objectives and corresponding flight path by iterative guidance mode or segmented state triggered optimization methods in real-time. Three failure scenarios that have occurred during previous LM missions are simulated to check the robustness of the algorithm: imminent explosion risk of the boosters’ engines, thrust drop during the first stage of flight, and being unable to start the engine during the second stage. The payloads would fall from space according to the current design under these conditions, but they were saved with the AMRC algorithm in the simulations, which allowed the rocket to get into the target orbit as intended or the payloads were deployed in other orbits without crashing. Although spaceflight can be very unforgiving, the AMRC algorithm has the potential to avoid the total loss of a launch mission when faced with these kinds of typical failures. | Zhengyu SONG Yin LIU Yong HE Cong WANG | 2022 | Chinese Journal of Aeronautics2022，35，6： | 2 |
| 11 | Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth显示文摘 | Yi Li Huan Zhao Xiuzhen Huang Juan Tang Shaohua Zhang Yan Li Xiuxiu Liu Lingjuan He Zhengyu Ju Kathy O. Lui Bin-Zhou | 2018 | Cell Research2018，28，7： | 2 |
| 12 | A new feature fusion method for gesture reeognition based on 3d accelerometer 显示文摘 | HE Zhengyu | 2010 | Applied Mechanics and Materials2010，，： | 1 |
| 13 | Model–proxy comparison for overshoot phenomenon of Atlantic thermohaline circulation at Bφlling–Allerφd显示文摘The overshoot phenomenon of the Atlantic thermohaline circulation(THC) is a transient climate response to meltwater forcing and could induce intense climate change by increasing the magnitudes of Atlantic THC changes at the end of meltwater discharges. This phenomenon was formally presented with the successfully simulated Bφlling–Allerφd(BA) event in the first transient simulation of the last deglaciation with fully coupled model NCAR-CCSM3(TraCE-21K). Currently, not all proxy records of Atlantic THC support the occurrence of the THC overshoot at BA. Commonly used THC proxy from Bermuda Rise(GGC5) does not exhibit THC overshoot at BA but other proxies such as TTR-451 at Eirik Drift do. How to interpret this regional discrepancy of proxy records is a key question for the validation of the Atlantic THC overshoot at BA. Here, we show that the vigor of deep circulation varies regionally during the Atlantic THC overshoot at BA in TraCE-21 K simulation, and this regional discrepancy in the simulation is consistent with that in the marine sediment records in North Atlantic. The consistent model–proxy evidence supports the occurrence of Atlantic THC overshoot at BA. | Jun Cheng Zhengyu Liu Feng He Bette Otto-Bliesner Esther Brady Jean Lynch-Stieglitz | 2014 | Chinese Science Bulletin2014，59，33： | 1 |
| 14 | 新一代低温液体中型运载火箭显示文摘The maiden flight of LM-8 performed perfectly on December 22,2020.The design concept of modularization,seriation and combination has been perfectly exhibited in LM-8.The four main technical innovations,including rapid integrated design based on modularization,engine thrust regulation,modal parameters acquisition technology based on numerical simulation,and flight load control,were verified during the maiden flight.LM-8 is now positioned to be the main force in China’s medium launch vehicles for commercial launch.In the future,the mission adaptability of LM-8 will be improved to provide efficient and low-cost launch services.In addition,new technologies to allow repeated use and autonomous flight will be validated. | CHEN Xiaofei YU Long YUAN He ZHAO Yongzhi SONG Zhengyu ZHANG Tao | 2021 | Aerospace China2021，22，2： | 1 |
| 15 | Evaluation of pharmaceutical activities of G-protein coupled receptor targeted pharmaceuticals in Chinese wastewater effluent显示文摘The occurre nce of biologically active pharmaceuticals in aquatic enviro nments raised the potential risks to aquatic species.Among these marketed biological active pharmaceuticals,it has been estimated that40%of them target G-protein-coupled receptors(GPCRs).We have illustrated pharmaceutical activities of GPCR targeted pharmaceuticals in English and Japanese wastewater by the in vitro transforming growth factor-α(TGFα)shedding assay.However,as the most important producer and consumer of pharmaceuticals,the occurrence of GPCR targeted pharmaceuticals in China had remained unclear.In this study,we investigated the pharmaceutical activities of GPCR targeted pharmaceuticals in secondary effluents of Chinese wastewater treatment plants.We discovered antagonistic activities against angiotensin(AT1)receptor at up to 7.2×102 ng-valsartan-equivalent quantity/L in Chinese wastewater for the first time as well as agonistic activities against dopamine(D2)receptor.Furthermore,in parallel with the assay,we determined concentrations of GPCR targeted pharmaceuticals in target wastewater by liquid chromatography coupled with tandem mass spectrometry(LC-MS/MS).Through the comparison of predicted antagonistic activities calculated by concentrations and potency values from the assay,we found that the measured antagonistic activities against AT1 receptor from the assay were higher than the predicted AT1 activities from valsartan,irbesartan,and losartan,indicating the potential existence of other unknown AT1 antagonists in wastewater. | Han Zhang Yingchao Lin Zhengyu Men Masaru Ihara Weizun Li Kai He | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 16 | A Compact Triple-band Fork-shaped Antenna for WLAN/WiMAX Applications显示文摘 | Xu Liang Xin Zhengyu He Jun | 2013 | Progress in Electromagnetics Research Letters2013，40，： | 1 |
| 17 | Complete genome sequence of a novel porcine circovirus-like agent显示文摘 | LIBIN WEN KONGWANG HE ZHENGYU YU | 2012 | J Virol2012，86，： | 1 |
| 18 | In-situ growth of CoNi bimetal anchored on carbon nanoparticle/nanotube hybrid for boosting rechargeable Zn-air battery显示文摘Exploring highly efficient non-precious metal based catalysts for bifunctional oxygen electrode is crucial for rechargeable metal-air batteries.In this study,with MOFs as precursors,a facile coprecipitation method is designed to realize in-situ growth of the CoNi anchored carbon nanoparticle/nanotube(CoNi/N-CNN)hybrid,which can achieve the simultaneous maximum exposure of both oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)active centers.Benefiting from the unique structure,the CoNi/N-CNN catalyst exhibits excellent electrocatalytic performance for ORR(E_(onset)=1.183 V,E_(1/2)=0.819 V)and a low operating voltage of 1.718 V at 10 mA cm^(−2)(Ej=10)for OER.Delightfully,the home-made rechargeable Zn-air battery with CoNi/N-CNN delivers a high discharge power density up to 209 mW cm^(−2),and an outstanding charge–discharge cycling stability.The boosted bifunctional electrocatalytic activity can be ascribed to the strong coupling effect between Co/Ni center sites and defect-rich N-anchored carbon featured with porous and nanotube structure,which can introduce uniformly dispersed active sites,tailored electronic configuration,superb conductivity and convenient charge transfer process.The hybrid non-precious bimetal based electrocatalyst provides the possibility to develop the low-cost and high-efficient ORR/OER bifunctional electrocatalysts in rechargeable metal-air battery. | Jun Li Yongxia Wang Zhengyu Yin Rui He Yihao Wang Jinli Qiao | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 19 | Lipopolysaccharide induces lung fibroblast proliferation through Toll-like receptor 4signaling and the phosphoinositide3-kinase-Akt pathway显示文摘 | ZHENGYU HE YUAN GAO YUXIAO DENG | 2012 | Plos one2012，7，35： | 1 |
| 20 | Genetic Diversity of Intragenomic Rearrangement of Porcine Circovirus Type 2 in vitro and in vivo显示文摘We characterized the genome sequences of defective-interfering(DI) particle DNA of porcine circovirus type 2(PCV2) by sequencing and bioinformatics analyses. DI particles were both generated by serial passage of PCV2 in PK15 cells and obtained from sera of pigs with postweaning multisystemic wasting syndrome(PMWS). These subviral isolates ranged from 358 nt to 1 125 nt genomes. Investigating the complexity and diversity of PCV2 DI in vivo and in vitro can help elucidating the evolutionary history of PCV2. | Libin WEN Fengzhi WANG Bin LI Yang YU Zhengyu YU Aihua MAO Jianping XIE Kong-wang HE | 2013 | Agricultural Science & Technology2013，14，12： | 1 |
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