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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Cloning and identification of an angiostatic molecule IP-10/crg-2显示文摘AIM To obtain human and murine cDNAsencoding IFN--y inducible protein 10 (lP--10) andcytokine responsive gene--2 (Crg-2).METHODS The encoding genes of lP-10 and Crg2 were amplified by RT--PCR from Cultured humanfibroblast cells and Balb/ c mouse liver treatedby IFN-y and TNF-a, respectively, and clonedinto plasmids of PUC19 and PGEM3Zf(+ ).RESULTS The nucleotide sequences ot theamplified DNA were confirmed by endonucleasesdigestion and sequencing.CONCLUSION Recombinant lP-10/ crg--2 geneclones with 306 hp and 314 hp inserts wereestablished for further research on biologicalactivities and ligands of hiP-10/mCrg--2. | Liu ZG Yang JH An HZ Wang HY He FT Han ZY Han Y Wu HP Xiao B Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 3 | Molecular diversity of microbial community in acid mine drainages of Yunfu sulfide mine显示文摘 | He ZG Xiao SM Xie XH Zhong H Hu YH Li QH Gao FL Li GY Liu JS Qiu GZ | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 4 | Preparation and pharmacokinetic characterization of sustained release melatonin tablet显示文摘 | HE ZG ZHANG TH TANG X | 2003 | J Chin Pharm Sci2003，12，2： | 1 |
| 5 | AT1R A1166C polymorphism and risk of pregnancy-induced hypertension:a meta-analysis of case control studies显示文摘 | Wang HY He XQ Wang ZG | 2015 | Clin Exp Obstet Gynecol2015，42，5： | 1 |
| 6 | Optimization of the configuration of 290 × 140 × 90 hollow clay bricks with 3 - D numerical simulation by finite volume method 显示文摘 | Li LP Wu ZG He YL | 2008 | Energy and Buildings2008，40，10： | 1 |
| 7 | Multidrug resistance p-glycoprotein: crucial significance in drug disposition and interaction 显示文摘 | Sun J He ZG Cheng G | 2004 | Med Sci Monit2004，10，1： | 1 |
| 8 | RSD:A metric for achieving range-free lo- calization beyond connectivity显示文摘 | Zhong ZG He T | 2011 | IEEE Transactions on Par- allel and Distributed Systern2011，22，10： | 1 |
| 9 | Glial inhibition of CNS axon regeneration显示文摘 | He ZG | 2006 | Nat Rev Neurosci2006，，7： | 1 |
| 10 | AT1R A1166C polymorphism and risk of pregnancy-induced hypertension:a meta-analysis of case control studies显示文摘 | Wang HY He XQ Wang ZG | 2015 | Clin Exp Obstet Gynecol2015，42，5： | 1 |
| 11 | Muhidrug resistance P - glycoprotein : crucial significance in drug disposition and interaction 显示文摘 | Sun J He ZG Cheng G | 2004 | Med Sci Monit2004，10，： | 1 |
| 12 | Downregulation of CDH13 expression promotes invasiveness of bladder transitional cell carcinoma显示文摘 | Lin YL He ZK Li ZG | 2013 | Urol Int2013，90，2： | 1 |
| 13 | Fractalgeneration of char pores through random walk显示文摘 | LIANG ZG HE R CHEN Q | 2007 | Combustion Science and Technology2007，179，3： | 1 |
| 14 | Effects of Multi-glycosides of Tripterygium wilfordiion in the Treatment of Sjgren's Syndrome in the Non-obese Diabetic Mouse Model显示文摘 | Li CL He J Li ZG | 2015 | Chin J Dent Res2015，18，2： | 1 |
| 15 | New records of submarine hydrothermal activity in middle part of the Okinawa Trough显示文摘THE hydrothermal activity area investigated is located at the middle of the trough (126°50′—127°30′E; 27°20′—27°50′N). Some surface sediment samples and core samples were collected, with other samples from non-hydrothermal activity area (128°20′—129°10′E; 30°30′—31°40′N) in the north of the trough for comparison. Analyses for elements and | Zhao, YY Zhai, SK Li, RZ Li, FY Gao, AG He, LJ Wang, ZG Zhu, XQ | 1997 | Chinese Science Bulletin1997，42，7： | 1 |
| 16 | Protective immunity induced by Toxoplasma gondii rhoptry protein 16 against toxoplasmosis in mice显示文摘 | Yuan ZG Zhang XX He XH | 2011 | Clin Vaccine Immunol2011，18，1： | 1 |
| 17 | Protective immunity induced by Toxoplasma gondii rhoptry protein 16 against toxoplasmosis in mice显示文摘 | Yuan ZG Zhang XX He XH | 2011 | Clin Vaccine Immunol2011，18，1： | 1 |
| 18 | Protective immunity induced by Toxoplasma gondii rhoptry protein 16 against toxoplasmosis in mice显示文摘 | Yuan ZG Zhang XX He XH | 2011 | Clin Vaccine Immunol2011，18，1： | 1 |
| 19 | Differential expression of microRNAs in GH-secreting pituitary adenomas显示文摘 | Mao ZG He DS Zhou J et 81 | 2010 | Diagn Pathol2010，5，： | 1 |
| 20 | Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis显示文摘 | Cui T Zhang L Wang X He ZG | 2009 | BMC Genomics2009，10，： | 1 |
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