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| 1 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 2 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 3 | VIP immunoreactive nerves and somatostatin and serotonin containing cellsin Crohn′s disease显示文摘 | Lu SJ Liu YQ Lin JS Wu HJ Sun YH Tan YB | 1999 | World Journal of Gastroenterology1999，5，6： | 4 |
| 4 | A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine显示文摘AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal injection.Theexpression and distribution of the plasmid wereobserved at different time periods by in situhybridization and immunohistochemistry.RESULTS The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and intraperitonealroutes.One week later the expression began todecrease,and could still be observed three weekslater.Although both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the latter.CONCLUSION Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route. | Yang CQ Wang JY Fang GT Liu JJ Guo JS | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 5 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 6 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 7 | Evaluation of various solutions for small bowel graft preservation显示文摘EvaluationofvarioussolutionsforsmalbowelgraftpreservationLIYouSheng1,LIJieShou1,LINing1,JIANGZhiWei1,ZHAOYunZhao1,LINan?.. | Li YS Li JS Li N Jiang ZW Zhao YZ Li NY Liu FN | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 8 | Molecular diversity of microbial community in acid mine drainages of Yunfu sulfide mine显示文摘 | He ZG Xiao SM Xie XH Zhong H Hu YH Li QH Gao FL Li GY Liu JS Qiu GZ | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 9 | dl-3 n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP 显示文摘 | Liu CL Liao S J Zeng JS | 2007 | J Neurol Sei2007，260，12： | 1 |
| 10 | Visfatin stimulates production of monocyte chemotactic protein-1 and interleukin-6 in human vein umbilical endothelial cells显示文摘 | Liu SW Qiao SB Yuan JS | 2009 | Horm Metab Res2009，41，4： | 1 |
| 11 | Polyethylene glycol-grafted poly-Llysine as polymeric gene carrier 显示文摘 | Choi YH Liu F Kim JS | 1998 | J Control Release1998，54，1： | 1 |
| 12 | An interleukin-21 -interleukin-10-STAT3 pathway is critical for functional maturation of memoryCD8+ T ceUs显示文摘 | Cui W Liu Y Weinstein JS | 2011 | Immunity2011，35，5： | 1 |
| 13 | Epidemiology,diagnosis and management ofintracranial atherosclerotic disease显示文摘 | Jeng JS Tang SC Liu H M | 2010 | Expert Rev Cardiovasc Ther2010，8，10： | 1 |
| 14 | The use of posterior vertebral column resection in the management of severe posttuberculous kyphosis:a retrospective study and literature review显示文摘 | Zhang HQ Li JS Liu SH | 2013 | Arch Orthop Trauma Surg2013，133，9： | 1 |
| 15 | Role of microglia in inflammation-mediated neurodegenerative diseases:mechanisms and strategies for therapeutic intervention显示文摘 | Liu B Hong JS | 2003 | J Pharmacol Exp Ther2003，304，： | 1 |
| 16 | Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions 显示文摘 | Liu JS Zhao ML Brosnan CF | 2001 | Am J Pathol2001，158，： | 1 |
| 17 | Body mass index and risk, age of onset, and survival in patients with pancreatic cancer显示文摘 | Li D Morris JS Liu J | 2009 | JAMA2009，301，24： | 1 |
| 18 | Epidemiology,diagnosis and management ofintracranial atherosclerotic disease显示文摘 | Jeng JS Tang SC Liu H M | 2010 | Expert Rev Cardiovasc Ther2010，8，10： | 1 |
| 19 | Association of plasma homocysteine concentration with cerebral white hyperintensity on magneticresonance image in stroke patients显示文摘 | Tseng YL Chang YY Liu JS | 2009 | J Neurol Sci2009，284，12： | 1 |
| 20 | Klotho attenuates high glucose- induced fibronectin and cell hypertrophy via the ERKll2-p38 kinase signaling pathway in renal interstitial fibroblasts 显示文摘 | Huang JS Chuang CT Liu MH | 2014 | Mol Cell Endocrinol2014，390，12： | 1 |
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