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| 1 | Dynamic mechanism and present situation of rural settlement evolution in China显示文摘这篇论文提供影响农村解决的进化的因素的详细分析,包括自然环境限制,基础结构,地区性的文化继承和集成,都市化和农村工业转变,陆地使用改革和革新,农村家庭行为变换,宏控制政策因素等等。在农村解决进化上基于效果的方法和度之间的差别,这些因素被分类进基本因素,新型的因素和变化因素。基本因素的开车主要集中于农村解决的传统的继承,新型的因素主要影响因素可以引起的农村解决转变,和变化突然的变化。所有这些因素为农村解决的进化组成三车轮的开车机制,并且塑造三条典型司机路径:慢在变化因素下面在基本因素,到在新型的因素下面的快速的开发的新路径,和突然的变化路径下面弄平路径。纸也在解决系统的方面调查农村解决进化的全面状况,解决规模,解决形态学,解决功能,解决文化,解决环境,等等。农村解决进化的一般过程被划分成四个阶段:起始、过渡、发展、成熟的阶段。 | ZHOU Guohua HE Yanhua TANG Chengli YU Tao XIAO Guozhen ZHONG Ting | 2013 | Journal of Geographical Sciences2013，23，3： | 65 |
| 2 | Spatio-temporal variation of photosynthetically active radiation in China in recent 50 years显示文摘在中国上基于 weather/ecological 车站的长期的测量数据,计算并且生产每年平均、平均 seasonally 的光合地活跃的放射(同等) 的这份报纸从 1961 ~ 2007 的空间数据,用 climatological 计算和 spatialization 技术。在中国在上的每年平均、平均 seasonally 的同等空间数据的时间空间的变化特征最近 50 年与 Mann-Kendall 趋势分析方法和 GIS 被分析空间分析技术。结果显示出那:(1 ) 总体上,同等的空间分发越过中国复杂、不同类,与在中国的东方、南部的部分的更低的同等和在西方的部分的更高的同等。在中国上的吝啬的年度同等从 17.7 摩尔 m ? 2 d ? 1 ~ 39.5 摩尔 m ? 2 d ? 1。(2 ) 在中国上的每个象素的每年平均、平均 seasonally 的同等总体上被平均,平均数与变动进程显然珍视衰落,并且每年平均的同等的变化的率是 ? 0.138 摩尔 m ? 2 d ? 1/10a。在四个季节之中的变化振幅是不同的,与在里面的最大的落下夏天,和同等的下降速度在 1990 年代,速度在以后慢下来前是更快的。(3 ) 由每个象素的分析证明那同等显著地衰退(=0.05 ) 在中国的大多数部分。夏天和冬季在同等的 interannual 可变性起更重要的作用。诺思中国总是是在四个季节的一个减少的地区,当 Qinghai 西藏高原的西北转弯是在四个季节的一个增加的地区时。(4 ) 同等的 interannual 可变性的空间分布在不同时期之中变化。在某个区域的同等的 interannual 可变性不仅在四个季节之中,而且在不同时期之中是不同的。 | ZHU Xudong HE Honglin LIU Min YU Guirui SUN Xiaomin GAO Yanhua | 2010 | Journal of Geographical Sciences2010，20，6： | 12 |
| 3 | The influencing factors of urban land expansion in Changsha显示文摘这研究系统地在时间的不同时期分析长沙城市的陆地使用地图。空间形式;结构的进化被学习象城市陆地使用结构比例那样的索引分析,扩大紧张,经济灵活性,人口灵活性,变化紧密索引;那么上。城市的陆地扩大的动态机制被集成地区性的社会经济发展状况讨论了;许多方面象地文学的包围那样,人口;经济开发,交通基础结构,计划;地区性的发展策略;系统革新。研究显示城市的陆地扩大加速;紧张稳定地从 1949 ~ 2004 在长沙增加了。扩大形式从单个外部扩大到一种联合形式外部;内部扩大,从一个通报或线性连续形式到一短而粗或凝块形状。总的来说,长沙城市的城市的陆地扩大是一局面,多样化;复杂过程。并且不管阶段是什么,包含多重速度是一个器官的系统的,模式;塑造,它被多重动力驾驶。因为平衡,在不同阶段的主导的特征被加亮;在不同力量之间的变化,;存在城市的陆地边阶;形状源于这些局面的力量的联合努力。 | ZHOU Guohua HE Yanhua | 2007 | Journal of Geographical Sciences2007，17，4： | 9 |
| 4 | The origin of Wx^(la) provides new insights into the improvement of grain quality in rice显示文摘Appearance and taste are important factors in rice(Oryza sativa) grain quality. Here, we investigated the taste scores and related eating-quality traits of533 diverse cultivars to assess the relationships between—and genetic basis of—rice taste and eating-quality. A genome-wide association study highlighted the Wx gene as the major factor underlying variation in taste and eating quality. Notably, a novel waxy(Wx) allele, Wx^(la), which combined two mutations from Wx^(b) and Wx^(in), exhibited a unique phenotype. Reduced GBSSI activity conferred Wx^(la) rice with both a transparent appearance and good eating quality. Haplotype analysis revealed that Wx^(la) was derived from intragenic recombination. In fact,the recombination rate at the Wx locus was estimated to be 3.34 kb/c M, which was about 75-fold higher than the genome-wide mean, indicating that intragenic recombination is a major force driving diversity at the Wx locus. Based on our results, we propose a new network for Wx evolution, noting that new Wx alleles could easily be generated by crossing genotypes with different Wx alleles. This study thus provides insights into the evolution of the Wx locus and facilitates molecular breeding for quality in rice. | Hao Zhou Duo Xia Da Zhao Yanhua Li Pingbo Li Bian Wu Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Journal of Integrative Plant Biology2021，63，5： | 8 |
| 5 | Mechanism of acupuncture regulating visceral sensation and mobility显示文摘Chinese ancient medical scientists have long focused on the internal and external contacts between acupoints on the surface of the body and the viscera.The Miraculous Pivot(it is one of the earliest medical classics in China)stated,“Twelve regular channels belong to the zang-fu organs internally,and connect to the extremities and joints externally.”Traditional Chinese medicine considers acupoints as defined areas where the Qi of viscera and meridians are transfused.These include the reaction points of visceral diseases on the body surface as well as the acupuncture trigger points that promote the flow of Qi and blood,and regulate visceral function.Chinese ancient medical scientists classified the specificity of the main acupoints in the body based on the meridian doctrine,which has been instructing clinical application for about 2000 years.Laws on the domino effect of acupoints have mainly focused on conclusions to clinical experiences.Indications of some acupoints exceed the practical paradigm since the excessive extension occurred during theory derivation.The current research direction on acupuncture focuses on three aspects:the effectiveness of acupuncture and moxibustion;the relevances and associations between meridians and viscera;and the physical and chemical properties and relevant physical basis of acupoints.The relevance between meridians and viscera is the central theory in the meridian doctrine,and acupoints are regarded as an important link in the relationship between meridians and viscera.Specific relationships between acupoints and target organs exist.Stimulating different acupoints on the body surface can help deal with different diseases,especially visceral diseases.In addition,acupoints have a dual function of reflecting and treating visceral diseases.There is no systemic research available on acupoint specificity,despite current knowledge and clinical experiences,which results in a weak foundation for acupuncture theory.This study focuses on the relevance and associations between meridians and viscera.A summary of the mechanisms of acupuncture regulating visceral sensation and mobility and the specific relationships between acupoints and their target organs are presented in this review. | Peijing Rong Bing Zhu Yuqing Li Xinyan Gao Hui Ben Yanhua Li Liang Li Wei He Rupeng Liu Lingling Yu | 2011 | Frontiers of Medicine2011，5，2： | 8 |
| 6 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 7 | Spatial pattern and drivers of urbanization in China's mid-level developing urban agglomeration:A case study of Chang-Zhu-Tan显示文摘Urban agglomeration has become the main form of regional spatial organization in China.While most of the existing studies of urban agglomeration in China have focused on the eastern coastal areas,urban agglomeration with mid-level development in the rest of the country has been overlooke1.To better understand the urbanization process of the mid-level developing urban agglomeration,this study investigated the clustering pattern and the drivers of both urban population and firm dynamics during 2005-2015 in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan)urban agglomeration of China using the methods ofkernel density estimation and geographic detection.Our results show that centralization was obvious,although decentralization also occurred in Chang-Zhu-Tan,and that the spatial agglomeration was promoted by several factors,such as administrative resources,location advantage,labor cost,and consumption capacity.Some problems hindering the development of this region were also discovered:administrative resources played a critical role in urbanization because small towns and villages did not receive enough attention,and the effect of local policy was not as beneficial as expected.These findings partly explain the relatively slow development of mid-level developing urban agglomerations and have important implications for promoting healthier urbanization. | Yanhua He Yi Lin Guohua Zhou Yixuan Zhu Kai Tang | 2021 | Regional Sustainability2021，2，1： | 6 |
| 8 | Genetic architecture and key genes controlling the diversity of oil composition in rice grains显示文摘Rice grain oil is a valuable nutrient source.However,the genetic basis of oil biosynthesis in rice grains remains unclear.In this study,we performed a genome-wide association study on oil composition and oil concentration in a diverse panel of 533 cultivated rice accessions.High variation for 11 oil-related traits was observed,and the oil composition of rice grains showed differentiation among the subpopulations.We identified 46 loci that are significantly associated with grain oil concentration or composition,16 of which were detected in three recombinant inbred line populations.Twenty-six candidate genes encoding enzymes involved in oil metabolism were identified from these 46 loci,four of which(PAL6,LIN6,MYR2,and ARA6)were found to contribute to natural variation in oil composition and to show differentiation among the subpopulations.Interestingly,population genetic analyses revealed that specific haplotypes of PAL6 and LIN6 have been selected in japonica rice.Based on these results,we propose a possible oil biosynthetic pathway in rice grains.Collectively,our results provide new insights into the genetic basis of oil biosynthesis in rice grains and can facilitate marker-based breeding of rice varieties with enhanced oil and grain quality. | Hao Zhou Duo Xia Pingbo Li Yiting Ao Xiaodong Xu Shanshan Wan Yanhua Li Bian Wu Huan Shi Kaiyue Wang Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Molecular Plant2021，14，3： | 4 |
| 9 | Drift potential of UAV with adjuvants in aerial applications显示文摘The reduction of pesticide aerial spraying drift is still one of the major challenges in modern agriculture.The aim of this study was to evaluate the drift potential of different types of unmanned aerial vehicle(UAV)and adjuvant products for reducing spray drift in aerial applications.Three types of UAV(3WQF120-12 and 3CD-15 fuel oil powered single-rotor UAV and HY-B-15L battery powered single-rotor UAV)were selected in this study with regular application parameters to compare each spray drift,and 3WQF120-12 fuel oil powered UAV was selected to quantify spray drift of 6 adjuvants dissolved in water under field conditions.Solutions were marked with brillant sulfoflavin dye(BSF)at 0.1%.Petri dishes and rotary impactors were used to collect airborne and sediment drift,respectively.Drift deposits were evaluated by spectrophotometry in order to quantify deposits.The results showed that when the flight height was 1.5-2.0 m above the crop at the flight speed of 4-5 m/s and the average wind speed of 1.63-1.73 m/s,3WQF120-12 fuel oil powered UAV had lower drift potential than the other two types;DV0.5 and percentage of droplets with diameter≤75μm had very significant effects on spray drift percentage(p=0.01);the risk of drift in agricultural spraying could be significantly decreased not only by reducing the percentage of fine droplets but also by changing droplet spectra.Compared to water,Silwet DRS-60,ASFA+B,T1602,Break-thru Vibrant,QF-LY and Tmax could reduce by 65%,62%,59%,46%,42%,and 19%spray drift,respectively.when water without adjuvants were sprayed,90%of drift droplets were located within a range of 10.1 m of the target area while with 0.8%Silwet DRS-60 adjuvant in water,the distance was shortened to 6.4 m. | Xiaonan Wang Xiongkui He Jianli Song Zhichong Wang Changling Wang Shilin Wang Ruochen Wu Yanhua Meng | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 3 |
| 10 | Operation of the CSNS Penning surface H^- ion source显示文摘The accelerator complex of the China Spallation Neutron Source (CSNS) consists of a H- linear accelerator (linac) and a rapid cycling synchrotron (RCS). The linac contains a Penning surface H- ion source. The designed energy and the beam current of the source are 50 keV and 20 mA respectively, with a normalized root mean square (norm. rms.) emittance of 0.2π mm mrad. The manufactures and tests of the discharge chamber are in great progress. The construction of H- ion source test stand has been completed, and the operation of the source is also in progress. Stable H- ion beams with energy of 50 keV and current up to 50 mA are attained. Emittance measurement for the H- beam is being prepared. | WU XiaoBing OUYANG HuaFu CHI YunLong HE Wei HUANG Tao LI Gang LIU YingMan LU YanHua XU TaoGuang ZHANG JunSong ZHANG HuaShun ZHAO FuXiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 2 |
| 11 | Adversarial Training for Supervised Relation Extraction显示文摘Most supervised methods for relation extraction(RE) involve time-consuming human annotation. Distant supervision for RE is an efficient method to obtain large corpora that contains thousands of instances and various relations. However, the existing approaches rely heavily on knowledge bases(e.g., Freebase), thereby introducing data noise. Various relations and noisy labeling instances make the issue difficult to solve. In this study, we propose a model based on a piecewise convolution neural network with adversarial training. Inspired by generative adversarial networks, we adopt a heuristic algorithm to identify noisy datasets and apply adversarial training to RE. Experiments on the extended dataset of SemEval-2010 Task 8 show that our model can obtain more accurate training data for RE and significantly outperforms several competitive baseline models. Our model has an F1 score of 89.61%. | Yanhua Yu Kanghao He Jie Li | 2022 | Tsinghua Science and Technology2022，27，3： | 2 |
| 12 | Development of Bi/Er co-doped optical fibers for ultra-broadband photonic applications显示文摘 | Yanhua LUO Binbin YAN Jianzhong ZHANG Jianxiang WEN Jun HE Gang-Ding PENG | 2018 | Frontiers of Optoelectronics2018，11，1： | 2 |
| 13 | CAPE promotes the expansion of human umbilical cord blood-derived hematopoietic stem and progenitor cells in vitro显示文摘Due to the low number of collectable stem cells from single umbilical cord blood(UCB)unit,their initial uses were limited to pediatric therapies.Clinical applications of UCB hematopoietic stem and progenitor cells(HSPCs)would become feasible if there were a culture method that can effectively expand HSPCs while maintaining their self-renewal capacity.In recent years,numerous attempts have been made to expand human UCB HSPCs in vitro.In this study,we report that caffeic acid phenethyl ester(CAPE),a small molecule from honeybee extract,can promote in vitro expansion of HSPCs.Treatment with CAPE increased the percentage of HSPCs in cultured mononuclear cells.Importantly,culture of CD34+HSPCs with CAPE resulted in a significant increase in total colony-forming units and high proliferative potential colony-forming units.Burst-forming unit-erythroid was the mostly affected colony type,which increased more than 3.7-fold in 1μg mL 1CAPE treatment group when compared to the controls.CAPE appears to induce HSPC expansion by upregulating the expression of SCF and HIF1-α.Our data suggest that CAPE may become a potent medium supplement for in vitro HSPC expansion. | LIU YiMing ZHANG BoWen ZHANG Jing WANG SiHan YAO HaiLei HE LiJuan CHEN Lin YUE Wen LI YanHua PEI XueTao | 2014 | Science China(Life Sciences)2014，57，2： | 2 |
| 14 | Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain: Down-regulated TRAF6 and up-regulated p-ERK1/2 expression, ameliorated brain infaction and edema显示文摘 | Zongjie Liu Dan He Xiangjian Zhang Yanhua Li Chunhua Zhu Lipeng Dong Xiaolin Zhang Yinxue Xing Chaohui Wang Huimin Qiao Linyu Chen | 2012 | Brain Research Bulletin2012，，4： | 2 |
| 15 | Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children显示文摘A total of 24 children with cerebral palsy were enrolled in this study and underwent ultrasound guided transplantation of neural stem cells through the lateral ventricle. Neural stem cells (3.8 × 106-7.3 × 107) were injected into the lateral ventricles. Mild injury of lateral ventricular blood vessels occurred in only two cases (8.3%). Seven cases (29.2%) experienced a fever. Clinical manifestations were improved to varying degrees in eight cases (28.0%) within 3 months after transplantation. Patient condition did not worsen, and no patient experienced severe adverse reactions. | Sheng He Zuo Luan Suqing Qu Xuan Qiu Daqing Xin Wenkai Jia Yanhua Shen Zehui Yu Tao Xu | 2012 | Neural Regeneration Research2012，7，32： | 2 |
| 16 | Bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression显示文摘Type 2 diabetes(T2D)is highly associated with obesity.However,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune disorder.Mucosal-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during obesity.By studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese people.We further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell abnormalities.Specifically,accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese individuals.Overall,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate T2D.Importantly,CD27−MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional strategies.Our findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms. | Yue Li Yi Yang Jin Wang Peihong Cai Mei Li Xixiang Tang Ying Tan Yuchan Wang Fan Zhang Xiaofeng Wen Qiaoxing Liang Yuanpeng Nie Tufeng Chen Xiang Peng Xuemin He Yanhua Zhu Guojun Shi Wai WCheung Lai Wei Yanming Chen Yan Lu | 2022 | Cellular & Molecular Immunology2022，19，7： | 2 |
| 17 | ADAM10 overexpression in human non-small cell lung cancer correlateswith cell migration and invasion through the activation of the Notch1 signalingpathway显示文摘 | Jianli Guo Lei He Ping Yuan Peng Wang Yanjun Lu Fangli Tong Yu Wang Yanhua Yin Jun Tian Jun Sun | 2012 | Oncology Reports2012，，： | 1 |
| 18 | Naringenin nanocrystals for improving antirheumatoid arthritis activity显示文摘Naringenin(NAR)is recognized for its anti-inflammatory activity.However,the clinical application of NAR is limited by low bioavailability,which is attributed to its poor aqueous solubility.In this study,we aimed to improve the therapeutic efficacy of NAR by formulating it into nanocrystals(NCs)via wet milling.The obtained NARNCs exhibited superior dissolution behaviors,increased cellular uptake,and enhanced transcellular diffusion relative to those of bulk NAR.Oral administration of NARNCs also significantly improved bioavailability in rats.In addition,the NARNCs effectively improved rheumatoid arthritis treatment in collagen-induced arthritic rats by reducing inflammatory cell infiltration and synovial damage.These results indicate that NARNCs provides a promising strategy for rheumatoid arthritis treatment. | Guangshuai Zhang Guangyuan Sun Haishan Guan Mo Li Yanhua Liu Baocheng Tian Zhonggui He Qiang Fu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 19 | Study on semi-transverse smoke exhaust in extra long road tunnel 显示文摘 | ZHANG Yuchun HE Chuan ZENG Yanhua | 2009 | Highway Tunnel2009，，1： | 1 |
| 20 | Topographic heterogeneity and temperature amplitude explain species richness patterns of birds in the Qinghai-Tibetan Plateau显示文摘 | Chunlan ZHANG Qing QUAN Yongjie Wu Youhua CHEN Peng HE Yanhua Qu Fumin LEI | 2017 | Current Zoology2017，63，2： | 1 |
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