|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances and challenges in the treatment of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common cancers with high morbidity and mortality rates.EC includes two histological subtypes,namely esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC).ESCC primarily occurs in East Asia,whereas EAC occurs in Western countries.The currently available treatment strategies for EC include surgery,chemotherapy,radiation therapy,molecular targeted therapy,and combinations thereof.However,the prognosis remains poor,and the overall five-year survival rate is very low.Therefore,achieving the goal of effective treatment remains challenging.In this review,we discuss the latest developments in chemotherapy and molecular targeted therapy for EC,and comprehensively analyze the application prospects and existing problems of immunotherapy.Collectively,this review aims to provide a better understanding of the currently available drugs through in-depth analysis,promote the development of new therapeutic agents,and eventually improve the treatment outcomes of patients with EC. | Shiming He Jian Xu Xiujun Liu Yongsu Zhen | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 26 |
| 2 | DETECTION OF LONGITUDINAL DEFECT IN PIPES USING TORSIONAL MODES显示文摘多模式并且在管子中驱散扭力的模式的特征 reinvestigated 理论上并且试验性地。根本频率,最低扭力的模式的阶段速度和组速度(0,1 ) 7 不变、相等砍波浪速度。7 (0,1 ) 模式根本频率是最快的扭力的模式。在实验, 7 (0,1 ) 模式在用 9 厚度的管子中激动、收到砍颤动模式压电的陶器的元素。而且, 4 m 的一个人工的纵的缺点长管子用 7 被检测(0,1 ) 模式 at50 kHz。它为纵的缺点察觉在是可行的试验性的结果表演用 7 尖叫(0,1 ) 超声的指导波浪的模式。 | LIU Zenghua WU Bin HE Cunfu YANG Shiming WANG Xiuyan | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 7 |
| 3 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 4 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 5 | Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion显示文摘Glioblastoma (GBM ) 是在成年人的最流行的恶意的主要大脑肿瘤并且展出异常地好攻击的显型的一个系列。肿瘤房间增长和侵略被 chemokines 和他们的受体极其调整。最近的研究证明了 chemokine CCL5 和它的受体 CCR5 在肿瘤侵略和转移起重要作用。尽管如此,在 GBM 的 CCR5 的角色仍然保持不清楚。现在的学习提供 chemokine 受体 CCR5 高度被表示并且在人的 GBM 把预后与穷人联系了的证据。机械学地, CCL5CCR5 调停 Akt 的激活,并且随后在 U87 和 U251 房间导致增长和侵略回答。而且, CCR5 的下面规定显著地在 U87 肿瘤禁止了 glioma 的生长异种皮移植老鼠模型。最后,在 GBM 的高 CCR5 表示在耐心的样品与增加的 p-Akt 表示被相关。一起,这些调查结果建议 CCR5 是与 gliomagenesis 联系的一个批评分子的事件。 | Lanfu Zhao Yuan Wang Yafei Xue Wenhai Lv Yufu Zhang Shiming He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 6 | Progress and perspective of the cathode/electrolyte interface construction in all-solid-state lithium batteries显示文摘Security risks of flammability and explosion represent major problems with the use of conventional lithium rechargeable batteries using a liquid electrolyte.The application of solid-state electrolytes could effectively help to avoid these safety concerns.However,integrating the solid-state electrolytes into the all-solid-state lithium batteries is still a huge challenge mainly due to the high interfacial resistance present in the entire battery,especially at the interface between the cathode and the solid-state electrolyte pellet and the interfaces inside the cathode.Herein,recent progress made from investigations of cathode/solid-state electrolyte interfacial behaviors including the contact problem,the interlayer diffusion issue,the space-charge layer effect,and electrochemical compatibility is presented according to the classification of oxide-,sulfide-,and polymer-based solid-state electrolytes.We also propose strategies for the construction of ideal next-generation cathode/solid-state electrolyte interfaces with high room-temperature ionic conductivity,stable interfacial contact during long cycling,free formation of the space-charge region,and good compatibility with high-voltage cathodes. | Shiming Su Jiabin Ma Liang Zhao Kui Lin Qidong Li Shasha Lv Feiyu Kang Yan-Bing He | 2021 | Carbon Energy2021，3，6： | 3 |
| 7 | Identification of QTL for kernel number-related traits in a rice chromosome segment substitution line and fine mapping of qSP1显示文摘A chromosome segment substitution line (CSSL) is a powerful tool for combining quantitative trait locus (QTL) mapping with the pyramiding of desirable alleles. The rice CSSL Z1364 with increased kernel number was identified in a BC3F8 population derived from a cross of Nipponbare as the recipient with Xihui 18 as the donor parent. Z1364 carried three substitution segments distributed on chromosomes 1, 6, and 8. The mean substitution length was 1.19 Mb. Of 17 QTL identified on the substitution segments, qSP1 for spikelets per panicle, qSSD1 for seed-set density, and qNSB1 for number of secondary branches explained respectively 57.34%, 87.7%, and 49.44% of the corresponding phenotypic variance and were all linked to RM6777. Chi-square analysis showed that the increased kernel number in Z1364 was inherited recessively by a single gene. By fine mapping, qSP1 was delimited to a 50-kb region on the short arm of chromosome 1. Based on DNA sequence, a previously uncharacterized rice homolog of Arabidopsis thaliana AT4G32551 was identified as a candidate gene for qSP1 in which mutation increases the number of spikelets and kernels in Z1364. qSP1 was expressed in all tissues, but particularly in 1-cm panicles. The expression levels of OsMADS22, GN1A, and DST were upregulated and those of LAX2, GNP1, and GHD7 were downregulated in Nipponbare. These results provide a foundation for functional research on qSP1. | Fuying Ma Xiaoyan Zhu Hui Wang Shiming Wang Guoqing Cui Ting Zhang Zhenglin Yang Guanghua He Yinghua Ling Nan Wang Fangming Zhao | 2019 | The Crop Journal2019，7，4： | 3 |
| 8 | Olfactory and gustatory dysfunctions of COVID-19 patients in China:A multicenter study显示文摘Introduction:With the spread of the epidemic worldwide,an increasing number of doctors abroad have observed the following atypical symptoms of coronavirus disease 2019(COVID-19):olfactory or taste disorders.Therefore,clarifying the incidence and clinical characteristics of olfactory and taste disorders in Chinese COVID-19 patients is of great significance and urgency.Materials and Methods:A retrospective study was conducted,which included 229 severe acute respiratory syndrome coronavirus 2 confirmed patients,through face-to-face interviews and telephone follow-up.Following the completion of questionnaires,the patients participating in the study,were categorized according to the degree of olfactory and taste disorders experienced,and the proportion of each clinical type of patient with olfactory and taste disorders and the time when symptoms appeared were recorded.Results:Among the 229 patients,31(13.54%)had olfactory dysfunction,and 44(19.21%)had gustatory dysfunction.For the patients with olfactory dysfunction,6(19.35%)developed severe disease and became critically ill.Olfactory dysfunction appeared before the other symptoms in 21.43%of cases.The proportion of females with olfactory and gustatory dysfunction was higher than that of males(P<0.001).Conclusions:The incidence of olfactory and gustatory dysfunction was much lower than that reported abroad;the prognosis of patients with olfactory dysfunction is relatively favorable;olfactory and gustatory dysfunction can be used as a sign for early screening;females are more prone to olfactory and gustatory dysfunction. | Jianhui Li Yi Sun Enqiang Qin Hu Yuan Mingbo Liu Wenqi Yi Zhu Chen Chengcheng Huang Fengjie Zhou Ruiyao Chen Leibo Zhang Ning Yu Qiong Liu Xuejun Zhou Jingjing He Boyu Li Fusheng Wang Changliang Yang Shiming Yang | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 2 |
| 9 | Distributed Low-Complexity Channel Assignment for Opportunistic Routing显示文摘Opportunistic Routing (OR) involves multiple forwarding candidates to relay packets by taking advantage of the broadcast nature and multi-user diversity of a wireless medium. Compared with Traditional Routing (TR), OR is more suitable in the case of an unreliable wireless link and can evidently improve the end-to-end throughput of Wireless Mesh Networks (WMNs). In this paper, we focus on OR in Multi-Radio Multi-Channel WMNs (MRMC-WMNs). This problem has not been well examined and is considerably more challenging than the OR in single-radio wireless networks considered in the existing literature. First, we validate the advantage of OR in MRMC-WMNs. Second, we propose Low-complexity Channel Assignment for Opportunistic Routing (LcCAOR), which assigns channels to flows according to the interference state of every node. Third, we implement the LcCOAR in a fully distributed manner. The simulation result shows that compared with OR in Single-Radio Single-Channel WMNs (SRSC-WMNs), the proposed OR can significantly enhance the throughput to 87.11% and 100.3% in grid and tree WMNs, respectively. | He Shiming Zhang Dafang Xie Kun Qiao Hong Zhang Ji | 2012 | China Communications2012，9，11： | 2 |
| 10 | Factors influencing wellbore stability during underbalanced drilling of horizontal wells- When fluid seepage is considered显示文摘 | He Shiming Wang Wei Shen Hua | 2015 | Journal of Natural Gas Science and Engineering2015，23，： | 1 |
| 11 | Effects of fluid se- epage on wellbore stability of horizontal wells drilled underbalanced 显示文摘 | HE Shiming WANG Wei TANG Ming | 2014 | Journal of Natural Gas Science and Engineering2014，21，： | 1 |
| 12 | All-optical two-channel polarization-multiplexing format conversion from QPSK to BPSK signals in a silicon waveguide显示文摘All-optical two-channel format conversion is proposed and experimentally demonstrated from a 40 Gbit/s polarization multiplexing(Pol-MUX) non-return-to-zero quadrature phase-shift keying(QPSK) signal to Pol-MUX binary phase-shift keying(BPSK) signals by using phase-doubled four-wave mixing effects with two polarization-angled pumps in a silicon waveguide. The eye diagrams and constellation diagrams of the original QPSK sequences and the converted BPSK sequences of each channel are clearly observed on the two polarization states. Moreover,the bit error rates(BERs) of the two converted idlers are measured. The power penalties of all these converted BPSK sequences on both X and Y polarization states are less than 3.4 dB at a BER of 3.8 × 10^(-3). | Xianglian Feng Zhihang Wu Xiaoyan Wang Sailing He Shiming Gao | 2016 | Photonics Research2016，4，6： | 1 |
| 13 | Hydrogen-rich gas from catalytic steam gasification of municipal solid waste (MSW): influence of catalyst and temperature on yield and product composition 显示文摘 | He Maoyun Hu Zhiquan Xiao Bo Li Jianfen Guo Xianjun Luo Siyi Yang Fan Feng Yu Yang Guangjun Liu Shiming | 2009 | International Journal of Hydrogen Energy2009，34，1： | 1 |
| 14 | Experimental study on combustion of biomass micron fuel (BMF) in cyclone furnace显示文摘 | Siyi Luo Bo Xiao Zhiquan Hu Shiming Liu Maoyun He | 2010 | Energy Conversion and Management2010，，11： | 1 |
| 15 | Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients显示文摘 | Yanyang Tu Shiming He Jianfang Fu Gang Li Ruxiang Xu Hongliu Lu Jianping Deng | 2012 | Clinical and Translational Oncology2012，，3： | 1 |
| 16 | Parameters Compressing in Deep Learning显示文摘With the popularity of deep learning tools in image decomposition and natural language processing,how to support and store a large number of parameters required by deep learning algorithms has become an urgent problem to be solved.These parameters are huge and can be as many as millions.At present,a feasible direction is to use the sparse representation technique to compress the parameter matrix to achieve the purpose of reducing parameters and reducing the storage pressure.These methods include matrix decomposition and tensor decomposition.To let vector take advance of the compressing performance of matrix decomposition and tensor decomposition,we use reshaping and unfolding to let vector be the input and output of Tensor-Factorized Neural Networks.We analyze how reshaping can get the best compress ratio.According to the relationship between the shape of tensor and the number of parameters,we get a lower bound of the number of parameters.We take some data sets to verify the lower bound. | Shiming He Zhuozhou Li Yangning Tang Zhuofan Liao Feng Li Se-Jung Lim | 2020 | Computers, Materials & Continua2020，，1： | 1 |
| 17 | Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery 显示文摘 | Guodong Gao Xuelian Wang Shiming He | 2003 | Sterotact Funct Neurosurg2003，81，： | 1 |
| 18 | LogUAD: Log Unsupervised Anomaly Detection Based on Word2Vec显示文摘System logs record detailed information about system operation and areimportant for analyzing the system's operational status and performance. Rapidand accurate detection of system anomalies is of great significance to ensure system stability. However, large-scale distributed systems are becoming more andmore complex, and the number of system logs gradually increases, which bringschallenges to analyze system logs. Some recent studies show that logs can beunstable due to the evolution of log statements and noise introduced by log collection and parsing. Moreover, deep learning-based detection methods take a longtime to train models. Therefore, to reduce the computational cost and avoid loginstability we propose a new Word2Vec-based log unsupervised anomaly detection method (LogUAD). LogUAD does not require a log parsing step and takesoriginal log messages as input to avoid the noise. LogUAD uses Word2Vec togenerate word vectors and generates weighted log sequence feature vectors withTF-IDF to handle the evolution of log statements. At last, a computationally effi-cient unsupervised clustering is exploited to detect the anomaly. We conductedextensive experiments on the public dataset from Blue Gene/L (BGL). Experimental results show that the F1-score of LogUAD can be improved by 67.25%compared to LogCluster. | Jin Wang Changqing Zhao Shiming He Yu Gu Osama Alfarraj Ahed Abugabah | 2022 | Computer Systems Science & Engineering2022，41，6： | 1 |
| 19 | Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery 显示文摘 | Guodond Gao Xuelian Wang Shiming He | 2003 | Stereotactic and func Neurosurg2003，81，： | 1 |
| 20 | Self-Formed Adaptor PCR: A Simple and Efficient Method for Chromosome Walking 显示文摘 | Shiming Wang Jian He | 2007 | Appl Environ Microbiol2007，73，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员