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| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | Characteristics,sources and health risks assessment of VOCs in Zhengzhou,China during haze pollution season显示文摘Zhengzhou is one of the most haze-polluted cities in Central China with high organic carbon emission,which accounts for 15%-20%of particulate matter(PM_(2.5))in winter and causes significantly adverse health effects.Volatile organic compounds(VOCs)are the precursors of secondary PM_(2.5)and O_(3)formation.An investigation of characteristics,sources and health risks assessment of VOCs was carried out at the urban area of Zhengzhou from 1^(st) to 31^(st) December,2019.The mean concentrations of total detected VOCs were 48.8±23.0 ppbv.Alkanes(22.0±10.4 ppbv),halocarbons(8.1±3.9 ppbv)and aromatics(6.5±3.9 ppbv)were the predominant VOC species,followed by alkenes(5.1±3.3 ppbv),oxygenated VOCs(3.6±1.8 ppbv),alkyne(3.5±1.9,ppbv)and sulfide(0.5±0.9 ppbv).The Positive Matrix Factorization model was used to identify and apportion VOCs sources.Five major sources of VOCs were identified as vehicular exhaust,industrial processes,combustion,fuel evaporation,and solvent use.The carcinogenic and non-carcinogenic risk values of species were calculated.The carcinogenic and non-carcinogenic risks of almost all air toxics increased during haze days.The total non-carcinogenic risks exceeded the acceptable ranges.Most VOC species posed no non-carcinogenic risk during three haze events.The carcinogenic risks of chloroform,1,2-dichloroethane,1,2-dibromoethane,benzyl chloride,hexachloro-1,3-butadiene,benzene and naphthalene were above the acceptable level(1.0×10^(-6))but below the tolerable risk level(1.0×10^(-4)).Industrial emission was the major contributor to non-carcinogenic,and solvent use was the major contributor to carcinogenic risks. | Dong Zhang Bing He Minghao Yuan Shijie Yu Shasha Yin Ruiqin Zhang | 2021 | Journal of Environmental Sciences2021，33，10： | 10 |
| 3 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 4 | Topographical relief characteristics and its impact on population and economy:A case study of the mountainous area in western Henan,China显示文摘Topographical relief is a key factor that limits population distribution and economic development in mountainous areas.The limitation is especially apparent in the mountain?plain t「ansition zone.Taking the transition zone between the Qinling Mountains and the North China Plain(i.e.the mountainous area in western Henan Province)as an example and based on the 200-m resolution DEM data,we used the mean change-point analysis to determine the optimal statistical unit for topographical relief,and thereafter extracted the relief degree.Taking the 1:100,000 land use data,township population and county-level industrial data,population and economic spatial models were constructed,and 200?m resolution grid population and economic density maps were gen erated.Afterwards,statistical analysis was carried out to quantitatively reveal the impact of topographical relief on population and economy.In addition,the impacts of other topographical factors were discussed.The results showed the following.(1)The relief degree in western Henan is generally low,where 58.6%of the regional topography does not exceed half the height of a reference mountain(relative elevation W250 m).Spatially,the relief degree is high in the west while low in the east,and high in the middle while low in the north and south.There is a positive correlation between relief degree and elevation,and a much stronger correlation between relief degree and slope.(2)The linear fitting degree between the population and economic validation data and the corresponding simulation data are 0.943 and 0.909,respectively,indicating that the spatialized results can reflect the actual population and economic distribution.(3)The impact of topographical relief on population and economy was stronger than that of other topographical factors.The relief degree showed a good logarithmic fit relati on ship with population density(0.911)and economic density(0.874).Specifically,88.65%of the population lives in areas where the topographical relief is W0.5 and 88.03%of the gross regional product was from areas where the relief is W0.3.Compared with the population distribution,the economic development showed an obvious agglomeration trend towards low relief areas. | ZHANG Jingjing ZHU Wenbo ZHU Lianqi CUI Yaoping HE Shasha REN Han | 2019 | Journal of Geographical Sciences2019，29，4： | 8 |
| 5 | Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea显示文摘在内耳的感觉毛细胞为健全识别负责。因为这些房间不能再生,在成年哺乳动物的毛细胞的损坏引起永久听觉缺陷。由对比,因为各种各样的发信号的小径的活跃参予,新生的哺乳动物拥有有限再生能力,包括 Wnt 并且槽口发信号。Wnt 和槽口小径高度复杂、保存表明控制为感觉毛细胞的形成必要的多重细胞的事件的小径。两个都发信号的小径允许支持房间在新生的蜗改革毛细胞的居民。在这方面, Wnt 并且槽口发信号在毛细胞新生获得了增加的研究注意。这评论在内耳的听觉的部分介绍 Wnt 和槽口发信号小径的当前的理解并且讨论与毛细胞命运限定词 Atoh1 控制这些小径在哺乳动物的蜗调整毛细胞新生的可能性。 | Muhammad Waqas Shasha Zhang Zuhong He Mingliang Tang Renjie Chai | 2016 | Frontiers of Medicine2016，10，3： | 7 |
| 6 | Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages显示文摘Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic signaling motifs,are highly expressed by myeloid cells.Due to the potential redundancy,whether these two receptors regulate macrophage function remains largely unknown.Here,we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation.To overcome the redundancy,we generated mice that simultaneously lacked SLAMF8 and SLAMF9 using CRISPR-Cas9 technology.Although macrophage differentiation was not altered by the combined deficiency of SLAMF8 and SLAMF9,the loss of these two receptors significantly protected against lipopolysaccharide(LPS)-induced liver injury.SLAMF8 and SLAMF9 double-deficient mice had a prolonged survival rate and less infiltration of inflammatory cells.The depletion of macrophages using clodronate liposomes abolished the effects of SLAMF8 and SLAMF9 deficiencies on LPS-induced liver injury,which demonstrates that these receptors are required for macrophage activation following LPS challenge.Moreover,the deficiency of SLAMF8 and SLAMF9 suppressed the secretion of inflammatory cytokines by downregulating the expression of Toll-like receptor-4(TLR4),a receptor that specifically binds LPS,which led to decreased mitogen-activated protein kinases(MAPK)signaling activation.Notably,combined injections of truncated extracellular SLAMF8 and SLAMF9 proteins significantly alleviated LPS-induced liver injury.Thus,our findings provide insights into the role of SLAMF8 and SLAMF9 in endotoxin-induced liver injury and suggest that SLAMF8 and SLAMF9 are potential therapeutic targets for acute hepatic injury. | Xiaokang Zeng Guangao Liu Wanwen Peng Junming He Chenxu Cai Wei Xiong Shasha Chen Meixiang Yang Zhongjun Dong | 2020 | Cellular & Molecular Immunology2020，17，2： | 5 |
| 7 | Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance显示文摘The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau(TP)are very useful in neotectonic and paleoclimatic studies.Firstly,the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon,and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon.Secondly,the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.The formation ages of | QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu PENG Shasha GE Junyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 5 |
| 8 | Developmental Gerontology and Active Population Aging in China显示文摘Population aging is an irreversible process in the development of modern society,which brings challenges to comprehensive modernized social governance.Population aging is a“dualistic”development issue that not only leads to aging of the labor force structure but also creates new demographic dividends.This study describes the core thoughts of developmental gerontology(DG),which provides new insight into the relationship between active aging and comprehensive governance for modernized society.The development of DG will provide a feasible and sustainable path to integrate and coordinate the relationship between population aging,society,and economy. | Xiaoying Zheng Yanan Luo Binbin Su Ping He Chao Guo Yaohua Tian Shasha Han Chen Chen Yiran Wang Jufen Liu Jun Li | 2023 | China CDC weekly2023，5，8： | 4 |
| 9 | Progress and perspective of the cathode/electrolyte interface construction in all-solid-state lithium batteries显示文摘Security risks of flammability and explosion represent major problems with the use of conventional lithium rechargeable batteries using a liquid electrolyte.The application of solid-state electrolytes could effectively help to avoid these safety concerns.However,integrating the solid-state electrolytes into the all-solid-state lithium batteries is still a huge challenge mainly due to the high interfacial resistance present in the entire battery,especially at the interface between the cathode and the solid-state electrolyte pellet and the interfaces inside the cathode.Herein,recent progress made from investigations of cathode/solid-state electrolyte interfacial behaviors including the contact problem,the interlayer diffusion issue,the space-charge layer effect,and electrochemical compatibility is presented according to the classification of oxide-,sulfide-,and polymer-based solid-state electrolytes.We also propose strategies for the construction of ideal next-generation cathode/solid-state electrolyte interfaces with high room-temperature ionic conductivity,stable interfacial contact during long cycling,free formation of the space-charge region,and good compatibility with high-voltage cathodes. | Shiming Su Jiabin Ma Liang Zhao Kui Lin Qidong Li Shasha Lv Feiyu Kang Yan-Bing He | 2021 | Carbon Energy2021，3，6： | 3 |
| 10 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 11 | Intensification of the East Asian Monsoon in Southern China at about300-400 kaBP Inferred from Eolian Deposits in the Middle-lower Reaches of the Yangtze River显示文摘In the East Asian monsoon region,eolian deposits widely distributed in the middle-lower reaches of the Yantgze River are among the best materials available for studies on Quaternary climate change in the subtropical zone of Southern China.Typical eolian deposits in this region include upper Xiashu Loess(XL) and underlying Vermiculated Red Soil(VRS) layers.In this paper,chronological and paleoclimatic studies are conducted on an eolian deposit sequence near Jiujiang(JJ) city in northern Jiangxi province.A magnetostratigraphic study,combined with optically stimulated luminescence(OSL) dating,is conducted on the JJ section and provides further evidence that eolian deposits in the middle-lower reaches of the Yangtze River have been formed since the late Early Pleistocene,and that the boundary age between the XL and VRS layers is about 300-400 kaBP.In grain-size records of the JJ section,the median grain-size and content of the >30 μm size fraction increase sharply after 300-400 kaBP,representing an East Asian winter monsoon intensification event.Further pollen analysis reveals differing pollen assemblages before and after 300-400 kaBP:there is an evident increase in plants adapted to grow in a warm humid environment after 300-400 kaBP,implying an increase in precipitation caused by intensification of the East Asian summer monsoon.Global ice volume and uplift of the Tibet Plateau(TP) are regarded as crucial factors influencing variations of the East Asian monsoon on a long-term scale.The deep-sea δ^(18)O record,which reflects variations in global ice volume,shows no obvious change after 300-400 kaBP.Moreover,the influence of global ice volume changes on the East Asian summer and winter monsoons is inverse;the global ice volume increase(decrease) implies a strengthened(weakened) winter monsoon and weakened(strengthened) summer monsoon.We therefore interpret the coupled intensifications of the East Asian summer and winter monsoons at about 300-400 kaBP to the uplift of the TP in the Middle Pleistocene.This climate event is also documented in eolian deposits from the southern margin of the Chinese Loess Plateau(CLP) and from the desert-loess transitional belt.However,it is not recorded in the loess-paleosol sequences from the central part of the CLP,thereby indicating differing climate responses to TP uplift in different regions,which requires further study. | QI Lin QIAO Yansong LI Yuehui WANG Yan PENG Shasha HE Zexin YANG Shuaibin HAN Chao ZHANG Xujiao | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 3 |
| 12 | Habitat restoration is the greatest challenge for population recovery of Hainan gibbons(Nomascus hainanus)显示文摘Hainan gibbons are among the world’s most critically endangered primates,with a remaining population of only 35 individuals distributed across 5 social groups in the Bawangling Branch of the Hainan Tropical Rainforest National Park,China.Habitat conversion and forest fragmentation over the past 40 years have reduced their geographical distribution by 95%.In the absence of a quantitative assessment of the availability of remaining suitable habitat,it is unclear whether this species can survive to the end of this century.We used behavioral observations,ArcGIS,remote sensing,stereo optical imagery,and MaxEnt modeling to identify patterns of Hainan gibbon range use and compare changes in the distribution of suitable forest types and areas of forest fragmentation over the past 20 years(2000–2020).The results indicate that the combined range of the 5 extant Hainan gibbon groups totaled 14.89 km2.The home range of the smallest group(Group E,3 individuals)was 1.51 km2,which likely represents the minimum home range size for this species.The remaining area of highly suitable and moderately suitable habitat totals 26.9 km2.However,habitat connectivity across the gibbon range is very low(less than 0.5),limiting the ability of Hainan gibbons to move between forest patches.The results of this study indicate that the availability of suitable habitat in Bawangling is insufficient to allow for future Hainan gibbon population growth.Therefore,immediate action must be taken to restore,reforest,and establish ecological corridors to reconnect areas of suitable habitat for these critically endangered gibbons. | Qingqing HE Shasha YAN Paul A.GARBER Baoping REN Xvming QI Jiang ZHOU | 2023 | Integrative Zoology2023，18，4： | 2 |
| 13 | The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy显示文摘Chemotherapeutic and radiation therapy have emerged as two most important treatment strategies to treat cancer in clinical practice;however,to improve anticancer efficacy,combination chemotherapy still remains challenge.Dichloroacetate(DCA)could produce significant cytotoxic effects in certain tumor cells through its distinct mechanism.Radiation therapy with fast neutrons(FNT)has high relative biolgical effectiveness compared to other radiotherapeutics.Herein,we reported the combination chemotherapy with FNT for effective tumor growth inhibition with the assistance of a multilayered nanofiber loading DCA and DCA derivatives.We first synthesized a biodegradable polylysine to condense DCA with negative charge,or to conjugate DCA by condensing synthesis,to obtain Ion-DCA and Co-DCA,respectively.DCA,Ion-DCA or Co-DCA was then loaded into fibers to form multilayer drug-loaded mats.Upon adhesion on the surface of subcutaneous and orthotopic liver tumors,the multilayer drug-loaded mats realized a controllable release of DCA,which reversed the Warburg effect and inhibited cancer cell proliferation.Meantime,irradiation of fast neutrons could seriously damage DNA structure.Combination of the controllable release of DCA and FNT resulted in synergistic cell apoptosis in vitro,and the tumor inhibition in vivo.This study thus provides a new approach to integrate chemotherapy and FNT with the assistance of biocompatible nanofiber for synergistic tumor therapy. | Yanxin Qi Shiwei Jing Shasha He Hejian Xiong Guohua Yang Yubin Huang Ningyi Jin | 2021 | Nano Research2021，14，3： | 2 |
| 14 | Comparison of the differentiation of dental pulp stem cells and periodontal ligament stem cells into neuron-like cells and their effects on focal cerebral ischemia显示文摘Recent studies have reported an in creasing in cidence of ischemic stroke,particularly in younger age groups.Dental pulp stem cells(DPSCs)and periodontal ligament stem cells(PDLSCs)are the most comm on stem cells acquired from the teeth of adults,even elderly people.However,there are no detailed reports on whether DPSCs or PDLSCs are suitable for the treatment of ischemic stroke.In this study,the in vitro differentiation of DPSCs and PDLSCs into neuron-like cells was evaluated.Then,we established a rat model of cerebral ischemia.DPSCs or PDLSCs were administered to animals,and the therapeutic effects of these two types of cells were investigated.The results showed that PDLSCs had a higher differentiation rate than DPSCs.Immunofluorescence studies showed that the expression of the neuronal differentiation markerThy-1 was higher in PDLSCs than in DPSCs,and other gene markers of neuronal differentiation showed corresponding trends,which were confirmed by western blot analysis.In this process,the Notch and Wnt signaling pathways were inhibited and activated,respectively.Fin ally,rats with transient occlusion of the right middle cerebral artery were used as a model to assess the therapeutic effect of PDLSCs and DPSCs on ischemia.The results showed that rats in the PDLSC-treated group emitted significantly greater red fluorescence signal than the DPSC-treated group.PDLSC transplantation promoted the recovery of neurological function more effectively than DPSC transplantation.Hence,PDLSCs represent an autogenous source of adult mesenchymal stem cells with desirable biological properties and may be an ideal candidate for clinical applications. | Tingting Wu Wanting Xu Hanlin Chen Shasha Li Rengang Dou Hongtao Shen Xue Liu Xiaoyu Liu Yongfeng Hong Jiacai He | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 2 |
| 15 | Isolation an identification of an angiotensin I-converting enzyme inhibitory peptide from yeast(Saccharomyces cerevisiae)显示文摘 | Ni He Li Lin Guo Shasha | 2012 | Current Analytical Chemistry2012，8，1： | 1 |
| 16 | Surface resonant-states-enhanced acoustic wave tunneling in two- dimensional phononic crystals显示文摘 | Ke Manzhu He Zhaojian Peng Shasha | 2007 | Physical Review Let- ters2007，99，04： | 1 |
| 17 | Sesamin induces melanogenesis by microphthalmia-associated transcription factor and tyrosinase up-regulation via cAMP signaling pathway显示文摘在这研究,我们证实了那芝麻明,从芝麻种子和油孤立的活跃 lignan,是新奇晒黑皮的混合物。黑素内容和 tyrosinase 活动被芝麻明在 B16 黑瘤房间以一种剂量依赖者方式增加。tyrosinase 的 mRNA 和蛋白质层次也与芝麻明在处理以后被提高。西方的污点分析揭示了导致并且支撑联系 microphthalmia 的抄写因素(MITF ) 的起来规定的那芝麻明。芝麻明能激活营地反应元素(CRE ) 有约束力的蛋白质(CREB ) ,但是它没在 p38 的 phosphorylation 上有效果激活 mitogen 的蛋白质 kinase (MAPK ) 或 Akt。而且,芝麻明经由一条营地依赖者小径激活蛋白质 kinase A (PKA ) 。与这些结果一致,黑素合成的调停芝麻明的增加被 H-89 显著地减少,一个 PKA 禁止者,然而并非由 SB203580,一个 p38 MAPK 禁止者或由 LY294002,一个 phosphatidylinositol-3-kinase (PI3K ) 禁止者。CREB 的调停芝麻明的 phosphorylation 和 MITF 和 tyrosinase 表示的正式就职被 H-89 也禁止。这些调查结果显示那芝麻明能经由 MITF 和 tyrosinase 的起来规定在 B16 房间刺激 melanogenesis,接着,它由于营地发信号的激活。 | Zequn Jiang Shasha Li Yunyi Liu Pengyi Deng Jianguo Huang Guangyuan He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 1 |
| 18 | Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy显示文摘CRISPR/Cas9 system has become a promising gene editing tool for cancer treatment.However,development of a simple and effective nanocarrier to incorporate CRISPR/Cas9 system and chemotherapeutic drugs to concurrently tackle the biological safety and packaging capacity of viral vectors and combine gene editing-chemo for cancer therapy still remains challenges.Herein,a chain-shattering Pt(IV)-backboned polymeric nanoplatform is developed for the delivery of EZH2-targeted CRISPR/Cas9 system(NPCSPt/pEZH2)and synergistic treatment of prostate cancer.The pEZH2/Pt(II)could be effectively triggered to unpack/release from NPCSPt/pEZH2 in a chain-shattering manner in cancer cells.The EZH2 gene disruption efficiency could be achieved up to 32.2%of PC-3 cells in vitro and 21.3%of tumor tissues in vivo,leading to effective suppression of EZH2 protein expression.Moreover,significant H3K27me3 downregulation could occur after EZH2 suppression,resulting in a more permissive chromatin structure that increases the accessibility of released Pt(II)to nuclear DNA for enhanced apoptosis.Taken together,substantial proliferation inhibition of prostate cancer cells and further 85.4%growth repression against subcutaneous xenograft tumor could be achieved.This chain-shattering Pt(IV)-backboned polymeric nanoplatform system not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery,but also broadens the potential of combining gene editing-chemo synergistic cancer therapy. | Qingfei Zhang Gaizhen Kuang Shasha He Sha Liu Hongtong Lu Xiaoyuan Li Dongfang Zhou Yubin Huang | 2021 | Nano Research2021，14，3： | 1 |
| 19 | Trends, temporaland spatial characteristics, and uncertainties in biomass burn-ing emissions in the Pearl River Delta?China显示文摘 | HE Min ZHENG Junyu YIN Shasha | 2011 | AtmosphericEnvironment2011，45，24： | 1 |
| 20 | Changes in plasma calcitonin gene-related peptide and serum neuron specific enolase in rats with acute cerebral ischemia after low-frequency electrical stimulation with different waveforms and intensities显示文摘Following acute cerebral ischemia in rats,plasma calcitonin gene-related peptide decreased and the level of serum neuron specific enolase and the volume of the infarction increased.Square-wave and triangular-wave electrical stimulation with low or high intensities could increase the plasma calcitonin gene-related peptide,decrease the serum neuron specific enolase and reduce the infarction volume in the brain in rats with cerebral ischemia.There was no significant difference between different wave forms and intensities.The experimental findings indicate that low-frequency electrical stimulation with varying waveforms and intensities can treat acute cerebral ischemia in rats. | Qiang Gao Yonghong Yang Shasha Li Jing He Chengqi He | 2011 | Neural Regeneration Research2011，6，28： | 1 |
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