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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | The development of the DIGE system: 2D fluorescence difference gel analysis technology显示文摘 | Marouga R David S Hawkins E | 2005 | Anal Bioanal Chem2005，382，3： | 1 |
| 4 | Rickettsia and mollicute infections in hapatopancreatic cells of cultured Pacific white shrimp (Penaeus vannamei)显示文摘 | Krol R M Hawkins W E Overstreet R M | 1991 | J Invertebr Pathol1991，59，： | 1 |
| 5 | Matrix metalloproteinase inhibitors显示文摘 | Wojtowicz-Praga S Dickson R B Hawkins M J | 1997 | Invest New Drugs1997，15，1： | 1 |
| 6 | New biomarkers of acute kidney injury and the cardio-renal syndrome显示文摘 | HAWKINS R | 2011 | Korean J Lab Med2011，31，2： | 1 |
| 7 | Impact of a pa- tient - centered, computer - based health information/sup- port system显示文摘 | Gustafson DH Hawkins R Boberg E | 1999 | Am J Prey Med1999，16，1： | 1 |
| 8 | A review of analytical methods for assessing the public health risk from microcystin in the aquatic environment 显示文摘 | Hawkins P R Novic S Cox P | 2005 | J Water Supply Res T2005，54，8： | 1 |
| 9 | Human interleukin-I0 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages显示文摘 | Hawkins D L Mackay R J Mackay S L | 1998 | Veterinary Immunology & Immunopathology1998，66，1： | 1 |
| 10 | Explaining full and partial success in the acqui- sition of second language grammatical properties显示文摘 | Hawkins R | 2005 | Second Lan- guage2005，，4： | 1 |
| 11 | Effect of Computer Support on Younger Women with Breast Cancer显示文摘 | Gustafson DH Hawkins R Pingrec S | 2001 | J Gen Intern Med2001，16，7： | 1 |
| 12 | Constructing a validity argument for the mini-Clinical Evaluation Exercise: a review of the research显示文摘 | Hawkins R E Margolis M J Durning S J | 2010 | Academic Medicine2010，85，9： | 1 |
| 13 | Effect of com- puter support on younger women with breast cancer 显示文摘 | Gustafson DH Hawkins R Pingree S | 2001 | J Gen Intern Med2001，16，7： | 1 |
| 14 | Load Transfer Mechanisms in Pile and Pile Groups 显示文摘 | O' NELL M W HAWKINS R S MAHAR L J | 1982 | Geotechnical Engineering ASCE1982，108，12： | 1 |
| 15 | Phylogenetic determination of the pace of transposable element proliferation in plants: copia and LINE-like elements in Gossypium显示文摘 | Hawkins J S Hu G Rapp R A | 2007 | Genome2007，51，1： | 1 |
| 16 | Runoff curve number:has it reached maturity显示文摘 | PONCE V M HAWKINS R H | 1996 | Hydrologic Engineering1996，1，1： | 1 |
| 17 | Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE):an update显示文摘 | Wells G A H Hawkins S A C Green R B | 1998 | 142:103-1061998，142，： | 1 |
| 18 | Internet - based interactive support for cancer patients:are integrated systems better显示文摘 | Gustafson DH Hawkins R McTavish F | 2008 | J Commun2008，58，2： | 1 |
| 19 | Fluid-attenuated Inversiou recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors显示文摘 | Parmar HA Hawkins C Ozelame R | 2007 | J Comput Assist Tomogr2007，31，3： | 1 |
| 20 | Agonist-stimulated synthesis of phosphatidylinositol (3,4,5)-triphosphate:a new intracellular signaling system?显示文摘 | JACKSON T R HAWKINS P T | 1993 | Biochim Biophys Acta1993，1179，1： | 1 |
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