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| 1 | Morphological and biochemical responses of Oryza sativa L.(cultivar MR219) to ion beam irradiation显示文摘Objective: Heavy ion beam, which has emerged as a new mutagen in the mutation breeding of crops and ornamental plants, is expected to result in the induction of novel mutations. This study investigates the morphological and biochemical responses of Oryza sativa toward different doses of carbon ion beam irradiation. Methods: In this study, the dry seeds of O. sativa were irradiated at 0, 20, 40, 60, 80, 100, and 120 Gy, followed by in-vitro germination under controlled conditions. Morphological and biochemical studies were conducted to investigate the morphological and physiological responses of O. sativa towards ion beam irradiation. Results: The study demonstrated that low doses(10 Gy) of ion beam have a stimulating effect on the height, root length, and fresh weight of the plantlets but not on the number of leaves. Meanwhile, doses higher than 10 Gy caused reductions in all the morphological parameters studied as compared to the control samples. The highest total soluble protein content [(2.11±0.47) mg/g FW] was observed in plantlets irradiated at 20 Gy. All irradiated plantlets were found to have 0.85% to 58.32% higher specific activity of peroxidase as compared to the control samples. The present study also revealed that low doses of ion beam(10 and 20 Gy) had negligible effect on the total chlorophyll content of O. sativa plantlets while 40 Gy had a stimulating effect on the chlorophyll content. Plantlets irradiated between 40 to 120 Gy were shown to be 0.38% to 9.98% higher in total soluble nitrogen content which, however, was not significantly different from the control samples. Conclusions: Carbon ion beam irradiation administered at low to moderate doses of 10 to 40 Gy may induce O. sativa mutants with superior characteristics. | Anna Pick Kiong LING Ying Chian UNG Sobri HUSSEIN Abdul Rahim HARUN Atsushi TANAKA Hase YOSHIHIRO | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，12： | 5 |
| 2 | HIV/AIDS in Asia:The Shape of Epidemics and Their Molecular Epidemiology显示文摘The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS annually in Asia,becoming the second largest epicenter of global AIDS epidemic. Molecular epidemiology has been useful tool to track a course of HIV spread. In-depth knowledge from the studies on molecular epidemiology elucidates the dynamics of HIV spread and the interrelationship of epidemics in the different regions in Asia. | Rie Uenishi Saiki Hase Tee Kok Keng Shigeru Kusagawa Yutaka Takebe | 2007 | Virologica Sinica2007，22，6： | 4 |
| 3 | Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy显示文摘Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, rather than its specific receptors. | Keitaro Hase Atsuhiro Kanda Kousuke Noda Susumu Ishida | 2019 | International Journal of Ophthalmology(English edition)2019，12，4： | 3 |
| 4 | 玻璃体腔组织纤溶酶原激活剂治疗玻璃体黄斑粘连(英文)显示文摘目的:评估仅玻璃体腔注射组织纤溶酶原激活剂(TPA)对玻璃体黄斑牵引以及玻璃体腔注射TPA和贝伐单抗对视网膜血管疾病的改善作用。方法:前瞻性研究。对24例24眼患者进行干预性系统研究。其中5眼玻璃体黄斑牵引综合征(VMT),19眼视网膜血管疾病包括:糖尿病黄斑水肿(DME)眼,糖尿病性玻璃体出血(VH)眼,视网膜中央静脉阻塞(CRVO)和新生血管年龄相关性黄斑变性眼(AMD)。在注射前及注射1mo后分别进行视力,B超和OCT检查。3眼VMT接受玻璃体腔单次注射TPA50μg,2眼接受100μg注射。19例视网膜血管疾病患者接受玻璃体腔组织纤溶酶原激活剂(50μg)和贝伐单抗(1.25 mg)联合治疗。结果:纳入病例中男性10眼视网膜血管疾病和VMT患者平均年龄分别为56.8y和60.4y。纳入病例中男性10眼(41.7%),女性14眼(58.3%)。22眼(91.7%)晶状体眼,2眼(8.3%)人工晶状体眼。VMT和视网膜血管疾病的玻璃体后部脱离(PVD)分别为0(0/5)和57.8%(11/19)(P=0.04)。在改善最佳矫正视力(BCVA)和降低黄斑中心凹厚度(CMT)方面,与无PVD眼相比,有PVD眼改善更多。结论:在VMT患者中,单独玻璃体腔内注射TPA不能成功诱导玻璃体后部完全脱离。玻璃体腔联合注射TPA和贝伐单抗可引起视网膜血管疾病患者玻璃体后部脱离,提高最佳矫正视力以及降低黄斑中心凹厚度。 | Saeed Karimi Masoud Soheilian Homayoun Nikkhah Azadeh Haseli Mofrad | 2018 | 国际眼科杂志2018，18，2： | 3 |
| 5 | BALLOON-BORNE MEASUREMENTS OF AEROSOL VERTICAL DISTRIBUTIONS OVER BEIJING DURING THE SUMMER AND AUTUMN OF 1993显示文摘The results of two balloon soundings during the summer and autumn of 1993 from the Xianghe Observation Stationare being utilized in a study of the temporal and spatial distribution of the atmospheric aerosols.The balloon,gondola,instrumentation and atmospheric conditions during the observation period are described.The temporal and spatialcharacteristics of aerosol concentration,size ratio,mixing ratio,and size distribution for both troposphere and strato-sphere are presented and analyzed. | 周军 谭锟 邵石生 龚知本 石广玉 郭建东 王标 张豹武 孙宝来 Yasunobu Iwasaka Masahiko Hayashi Masahiro Hase | 1994 | Acta meteorologica Sinica1994，8，4： | 3 |
| 6 | Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis显示文摘 | Hirotoshi Kobayashi Kenjiro Kotake Kimihiko Funahashi Kazuo Hase Koichi Hirata Tsuneo Iiai Shingo Kameoka Yukihide Kanemitsu Koutarou Maeda Akihiko Murata Masayuki Ohue Kazuo Shirouzu Keiichi Takahashi Toshiaki Watanabe Hideaki Yano Toshimasa Yatsuoka Yoj | 2014 | Journal of Gastroenterology2014，，4： | 2 |
| 7 | Strawberry sweetness and consumer preference are enhanced by specific volatile compounds显示文摘Breeding crops for improved flavor is challenging due to the high cost of sensory evaluation and the difficulty of connecting sensory experience to chemical composition.The main goal of this study was to identify the chemical drivers of sweetness and consumer liking for fresh strawberries(Fragaria×ananassa).Fruit of 148 strawberry samples from cultivars and breeding selections were grown and harvested over seven years and were subjected to both sensory and chemical analyses.Each panel consisted of at least 100 consumers,resulting in more than 15,000 sensory data points per descriptor.Three sugars,two acids and 113 volatile compounds were quantified.Consumer liking was highly associated with sweetness intensity,texture liking,and flavor intensity,but not sourness intensity.Partial least square analyses revealed 20 volatile compounds that increased sweetness perception independently of sugars;18 volatiles that increased liking independently of sugars;and 15 volatile compounds that had positive effects on both.Machine learning-based predictive models including sugars,acids,and volatiles explained at least 25%more variation in sweetness and liking than models accounting for sugars and acids only.Volatile compounds such asγ-dodecalactone;5-hepten-2-one,6-methyl;and multiple medium-chain fatty acid esters may serve as targets for breeding or quality control attributes for strawberry products.A genetic association study identified two loci controlling ester production,both on linkage group 6 A.Co-segregating makers in these regions can be used for increasing multiple esters simultaneously.This study demonstrates a paradigm for improvement of fruit sweetness and flavor in which consumers drive the identification of the most important chemical targets,which in turn drives the discovery of genetic targets for marker-assisted breeding. | Zhen Fan Tomas Hasing Timothy S.Johnson Drake M.Garner Michael L.Schwieterman Christopher R.Barbey Thomas A.Colquhoun Charles A.Sims Marcio F.R.Resende Vance M.Whitaker | 2021 | Horticulture Research2021，8，1： | 2 |
| 8 | Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation显示文摘 | Hironori Tsujimoto Takashi Ichikura Shigeaki Nagao Tomoki Sato Satoshi Ono Satoshi Aiko Shuichi Hiraki Yoshihisa Yaguchi Naoko Sakamoto Takemaru Tanimizu Junji Yamamoto Kazuo Hase | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 9 | Numerical Simulation for Fan Broadband Noise Prediction显示文摘In order to elucidate the broadband noise of fan,the numerical simulation of fan operating at two different rotational speeds is carried out using the three-dimensional unsteady Reynolds-averaged Navier-Stokes (URANS) equations.The computed results are compared to experiment to estimate its accuracy and are found to show good agreement with experiment.A method is proposed to evaluate the turbulent kinetic energy in the framework of the Spalart-Allmaras one equation turbulence model.From the calculation results,the turbulent kinetic energy is visualized as the turbulence of the flow which leads to generate the broadband noise,and its noise sources are identified. | Takaaki Hase Nobuhiko Yamasaki Tsutomu Ooishi | 2011 | Journal of Thermal Science2011，20，1： | 2 |
| 10 | Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathologicalsignificance显示文摘 | Yojiro Hashiguchi Naohiro Nishida Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Hidetaka Mochizuki Kazuo Hase Yuichiro Doki Masaki Mori | 2012 | International Journal of Oncology2012，，5： | 2 |
| 11 | Pneumatosis intestinalis with obstructing intussusception:A case report and literature review显示文摘Pneumatosis intestinalis(PI) often represents a benign condition that should not be considered as an argument for surgery. We report a patient with PI and obstructing intussusception who underwent urgent colectomy and review the literatures regarding PI with intussusception. A 20-year-old man presented at our hospital with a 3-d intermittent lower abdominal pain history. He underwent steroid therapy for membranoproliferative glomerulonephritis for 4 years. Computed tomography revealed ascending colon intussusception with air within the wall. Intraoperative colonoscopy revealed numerous soft polypoid masses with normal overlying mucosa and right hemicolectomy was performed. Histological examination of colonic wall sections revealed large cysts in the submucosal layer. The pathological diagnosis was PI. Nine cases of intussusception associated with primary PI have been reported. Although primary PI often represents a benign condition that should not be considered as an argument for surgery,if the case involves intussusception and obstruction,emergent laparotomy should be considered. | Yujiro Itazaki Hironori Tsujimoto Nozomi Ito Hiroyuki Horiguchi Shinsuke Nomura Kyohei Kanematsu Shuichi Hiraki Suefumi Aosasa Junji Yamamoto Kazuo Hase | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 2 |
| 12 | Cyto-chrome P450 2B6 and 2C9 do not metabolize midazolam:kinetic analysis and inhibition study with monoclonal antibodies显示文摘 | HAMAOKA N ODA Y HASE I | 2001 | Br J Anaesth2001，86，1： | 1 |
| 13 | Spinal cord repair in neonatal rats:a correlation between axonal regeneration and functional recovery显示文摘 | Hase T Kawaguchi S Hayashi H | 2002 | Eur J Neurosci2002，15，6： | 1 |
| 14 | Accelerated reaction by loop-mediated isothermal amplication using loop primers显示文摘 | Hase T Notomi T | 2002 | Molecular and Cellular Probes2002，16，： | 1 |
| 15 | Is posterior spinal cord shifting by extensive posterior decompression clinically significant for multiseg- mental cervical spondylotic myelopathy 显示文摘 | Hatta Y Shiraishi T Hase H | 2005 | Spine2005，30，： | 1 |
| 16 | The influence of thedecompressive operation on the intracranial pressure andthe pressure-volume relation in patients with severe headinjuries显示文摘 | Hase U Reulen HJ Meinig G | 1978 | Acta Neurochir (Wien)1978，45，： | 1 |
| 17 | Ligans and flavonoids inhibit aromatase enzyme in human preadipocytes 显示文摘 | Wang C F Makela T Hase T | 1994 | J Steriod Biochem Mol Biol1994，50，： | 1 |
| 18 | CeU differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium显示文摘 | Hase K Eckmann L Leopard J D | 2002 | Infect Immun2002，70，： | 1 |
| 19 | Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome 显示文摘 | Nakata T Hashimoto A Hase M | 2003 | Cardiology2003，99，2： | 1 |
| 20 | Bell pepper fruit fatty acid hydroperoxide lyase is a cytochrome P450(CYP74B)显示文摘 | Matsui K Shibutani M Hase T | 1996 | FEBS Letters1996，394，： | 1 |
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