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| 1 | Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation显示文摘Treatment of physeal fractures(15%–30%of all paediatric fractures)remains a challenge as in approximately 10%of the cases,significant growth disturbance may occur.Bioresorbable Magnesium-based implants represent a strategy to minimize damage(i.e.,load support until bone healing without second surgery).Nevertheless,the absence of harmful effects of magnesium-implants and their degradation products on the growth plate should be confirmed.Here,the proteome of human mesenchymal stem cells undergoing chondrogenesis was evaluated when exposed to the products of various Magnesium-based materials degradation.The results of this study indicate that the materials induced regulation of proteins associated with cell chondrogenesis and cartilage formation,which should be beneficial for cartilage regeneration. | Adela Helvia Martínez Sánchez Maryam Omidi Marcus Wurlitzer Marceline Manka Fuh Frank Feyerabend Hartmut Schlüter Regine Willumeit-Römer Bérengère J.C.Luthringer | 2019 | Bioactive Materials2019，4，1： | 2 |
| 2 | Laparoscopic partial adrenalectomy for bilateral pheochromocytomas in a boy with von Hippel-Lindau disease显示文摘 | Chriatian R Hartmut N Georg B | | 0，，03： | 2 |
| 3 | Ertapenem:the new carbapenem 5 years after first FDA licensing for clinical practice显示文摘 | Olaf B Hartmut D Tobias W | | 0，，02： | 1 |
| 4 | Postoperative analgesia after knee surgery:a comparison of three different concentrations of ropivacaine for continuous femoral nerve blockade显示文摘 | Gerhard B Hartmut B Hugo VA | 2007 | Anesth Analg2007，105，1： | 1 |
| 5 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 6 | Mid-term course after pediatric right ventricular outflow tract reconstruction:a comparison of homografts,porcine xenografts and contegras显示文摘 | Dietmar B Wolf-Rudiger T Hartmut H | 2005 | European Cardiothorac Surg2005，27，1： | 1 |
| 7 | Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects 显示文摘 | Johann B Hartmut B | 2006 | Cardiovascular Res2006，72，： | 1 |
| 8 | Finite element analysis of the membrane used in a novel bioMEMS显示文摘 | SANG S B HARTMUT W | 2009 | J Biomimetics Biomater Tissue Eng2009，3，： | 1 |
| 9 | Detection of photosyntheticactivity and water stress by imaging the red chlorophyllfluorescence显示文摘 | Hartmut K Lichtenthaler Fatbardha B | 2000 | Plant Physiol Bio-chem2000，38，： | 1 |
| 10 | An inverted triplesalen ligand by a convergent synthesis and its influence on trinuclear Fe_3~Ⅲ complexes显示文摘The inverted triplesalen ligand H 6 feld Me has been synthesized from 2,4,6-triformyl-phloroglucinol and a ketimine salen half-unit in a convergent synthesis. NMR, IR, and UV-vis spectroscopy reveal that this ligand is not in the O-protonated tautomer but in the N-protonated tautomer with substantial heteroradialene contribution. This ligand and the conventional triplesalen ligand H 6 talen t-Bu 2 have been used to synthesize the trinuclear Fe III complexes [(feld Me )(FeCl) 3 ] and [(talen t-Bu 2 )(FeCl) 3 ], respectively. The molecular structures of these complexes were obtained by single-crystal X-ray diffraction. Two trinuclear Fe III complexes of [(feld Me )(FeCl) 3 ] dimerize via two Fe-phenolate bonds, whereas due to steric hindrance no dimerization is observed for [(talen t-Bu 2 )(FeCl) 3 ]. The structural data also reveal some heteroradialene contribution in the trinuclear complexes. Whereas UV-vis and M bauer spectroscopy are not suitable to distinguish between the two complexes, FT-IR spectra show characteristic features due to the different substitution patterns of the conventional and the inverted triplesalen ligands. Another handle is provided by electrochemistry. Whereas both complexes exhibit an irreversible oxidation wave (0.94 V vs. Fc + /Fc for [(feld Me )(FeCl) 3 ] and 0.84 V vs. Fc + /Fc for [(talen t-Bu 2 )(FeCl) 3 ]), which is assigned to the oxidation of the central backbone, higher potential oxidations are reversible for [(talen t-Bu 2 )(FeCl) 3 ]) but irreversible for [(feld Me )(FeCl) 3 ]. This is attributed to the reversible oxidation of the terminal phenolates in the di-tert-butyl substituted [(talen t-Bu 2 )(FeCl) 3 ] in contrast to the mono-methyl-substituted phenolates in [(feld Me )(FeCl) 3 ]. The magnetic properties of [(talen t-Bu 2 )(FeCl) 3 ] reveal a very small ferromagnetic coupling with significant zero-field splitting of the FeⅢ S = 5/2 ions. In contrast, the dimerization of two trinuclear complexes in [(feld Me )(FeCl) 3 ] results in antiferromagnetic interactions between the two phenolate-bridged Fe III ions, which mask the intra-trinuclear interactions transmitted by the central phloroglucinol backbone. | FELDSCHER Bastian KRICKEMEYER Erich MOSELAGE Marc THEIL Hubert HOEKE Veronika KAISER Yvonne STAMMLER Anja BGGE Hartmut GLASER Thorsten | 2012 | Science China Chemistry2012，55，6： | 1 |
| 11 | Hindsight Bias: On Being Wise After the Event显示文摘 | Hartmut B Jochen M Rudiger F P | 2007 | Social Cognition2007，，1： | 1 |
| 12 | 显示文摘 | Anindita G Susanta B Hartmut K | 2010 | Macromolecules2010，43，： | 1 |
| 13 | Mid-term course after pediatric right ventricular outflow tract reconstruction: a comparison of homografts, porcine xenografts and contegras 显示文摘 | Dietmar B Wolf-Rudiger T Hartmut H | 2005 | European Cardiothorac Surg2005，27，1： | 1 |
| 14 | Postoperative analgesia af- ter knee surgery: a comparison of three different concentra- tions of ropivacaine for continuous femoral nerve blockade 显示文摘 | Gerhard B Hartmut B Hugo VA | 2007 | Anesth Analg2007，105，： | 1 |
| 15 | A derived grid-based model for simulation of pedestrian flow显示文摘We present a derived grid-based model for the simulation of pedestrian flow. Interactions among pedestrians are considered as the result of forces within a certain neighbourhood. Unlike the social force model,the forces here,as in Newtonian physics,are proportional to the inverse of the square of the distance. Despite the notion of neighbourhood and the underlying grid,this model differs from the existing cellular automaton(CA) models in that the pedestrians are treated as individuals. Bresenham's algorithm for line rastering is applied in the step calculation. | Günter BRWOLFF Hartmut SCHWANDT | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，2： | 1 |
| 16 | Tyrosinase involved in betalain biosynthesis of higher plants显示文摘 | Ulrike S Willibald S Hartmut B H | 1999 | Planta1999，208，： | 1 |
| 17 | NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different?显示文摘AIM: To analyse the impact of NOD2/CARD15 mutations on the clinical course of Crohn's disease patients from an eastern European country (Hungary).METHODS: We investigated the prevalence of the three common NOD2/CARD15 mutations (Arg702Trp, Gly908Arg,1007finsC) in 148 patients with Crohn's disease, 128patients with ulcerative colitis and 208 controls recruited from the University of Szeged, Hungary. In patients with Crohn's disease, the prevalence of NOD2/CARD15 mutations was correlated to the demographical and clinical parameters.RESULTS: In total, 32.4% of Crohn's disease patients carried at least one mutant allele within NOD2/CARD15compared to 13.2% of patients with ulcerative colitis (P = 0.0002) and to 11.5% of controls (P<0.0001). In Crohn's disease patients, the allele frequencies for Arg702Trp,Gly908Arg and 1007finsC were 7.1%, 3.0% and 10.8%respectively. Interestingly, only the 1007finsC mutation was associated with a distinct clinical phenotype. The patients positive for the 1007finsC mutation suffered more frequently from stenotic disease behaviour (P = 0.008). Furthermore,51.9% of patients positive for the 1007finsC mutation underwent a surgical resection within the ileum compared to only 17.4% of patients without the 1007finsC mutation (P = 0.001). With respect to the other two mutations (Arg702Trp and Gly908Arg), no associations were found with all investigated clinical parameters.CONCLUSION: NOD2/CARD15 mutations are frequently found in Crohn's disease patients from Hungary. The 1007finsC mutation is associated with stenotic disease behaviour and frequent ileal resections. | Carsten Büning Tomas Molnar Ferenc Nagy Janos Lonovics Renita Weltrich Bettina Bochow Janine Genschel Hartmut Schmidt Herbert Lochs | 2005 | World Journal of Gastroenterology2005，11，3： | 1 |
| 18 | Design rules for MR fluid actuators in different working modes 显示文摘 | Rail B Hartmut J | 1998 | SPIE1998，3045，： | 1 |
| 19 | Oxygen limitation is a pitfall during screening for industrial strains显示文摘 | Hartmut F. Zimmermann Tibor Anderlei Jochen Büchs Michael Binder | 2006 | Applied Microbiology and Biotechnology2006，，6： | 1 |
| 20 | Mid - termcourse after pediatric right ventricul ar outflow tract reconstruction : a comparison of homografts, porcine xenografts and contegras 显示文摘 | Dietmar B Wolf - Rudiger T Hartmut H el al | 2005 | European Cardiothorac Surg2005，27，1： | 1 |
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