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| 1 | Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice显示文摘Introduction:We previously demonstrated that magnesium ions(Mg^(2+))was a novel therapeutic alternative for osteoarthritis(OA)through promoting the hypoxia inducible factor-1α(HIF-1α)-mediated cartilage matrix synthesis.However,oxidative stress can inhibit the expression of HIF-1α,amplify the inflammation that potentially impairs the therapeutic efficacy of Mg^(2+) in OA.Vitamin(VC),a potent antioxidant,may enhance the efficacy of Mg^(2+) in OA treatment.This study aims to investigate the efficacy of combination of Mg^(2+)and VC on alleviating joint destruction and pain in OA.Material and methods:Anterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular injection of either saline,MgCl2(0.5 mol/L),VC(3 mg/ml)or MgCl2(0.5 mol/L)plus VC(3 mg/ml)at week 2 post-operation,twice weekly,for 2 weeks.Joint pain and pathological changes were assessed by gait analysis,histology,western blotting and micro-CT.Results:Mg^(2+) and VC showed additive effects to significantly alleviate the joint destruction and pain.The efficacy of this combined therapy could sustain for 3 months after the last injection.We demonstrated that VC enhanced the promotive effect of Mg^(2+) on HIF-1αexpression in cartilage.Additionally,combination of Mg^(2+) and VC markedly promoted the M2 polarization of macrophages in synovium.Furthermore,combination of Mg^(2+) and VC inhibited osteophyte formation and expressions of pain-related neuropeptides.Conclusions:Intra-articular administration of Mg^(2+)and VC additively alleviates joint destruction and pain in OA.Our current formulation may be a cost-effective alternative treatment for OA. | Hao Yao Jiankun Xu Jiali Wang Yifeng Zhang Nianye Zheng Jiang Yue Jie Mi Lizhen Zheng Bingyang Dai Wenhan Huang Shuhang Yung Peijie Hu Yechun Ruan Qingyun Xue Kiwai Ho Ling Qin | 2021 | Bioactive Materials2021，6，5： | 1 |
| 2 | 镁元素及镁材料在关节软骨损伤修复中的作用及机制研究进展显示文摘软骨损伤是由炎症、创伤、肿瘤等造成的,由于关节软骨自身解剖因素,使其损伤后的愈合能力较差,制备组织工程材料促进软骨损伤修复备受研究者关注。镁元素及镁材料因其良好的生物安全性、生物相容性、可降解性及可获得性受到广泛关注,其在骨关节炎等软骨损伤修复中起到重要作用,笔者就镁元素及镁材料在关节软骨损伤修复中的作用及机制作一综述。 | 褚云峰 于红燕 杨琪 彭艳斌 陈仲 刘明 于斐 | 2022 | 中国骨质疏松杂志2022，28，7： | 0 |
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