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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 3 | Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration显示文摘In this review,we summarise the evidence for a role of the ribonuclease angiogenin in the pathophysiology of neurodegenerative disorders,with a specific focus on Parkinson’s disease(PD).Angiogenin is a stress-induced,secreted ribonuclease with both nuclear and cytosolic activities.Loss-of-function mutations in the angiogenin gene(ANG)have been initially discovered in familial cases of amyotrophic lateral sclerosis(ALS),however,variants in ANG have subsequently been identified in PD and Alzheimer’s disease.Delivery of angiogenin protein reduces neurodegeneration and delays disease progression in in vitro and in vivo models of ALS and in vitro models of PD.In the nucleus,angiogenin promotes ribosomal RNA transcription.Under stress conditions,angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments,in particular transfer RNAs(tRNAs).Stress-induced tRNA fragments have been proposed to have multiple cellular functions,including inhibition of ribosome biogenesis,inhibition of protein translation and inhibition of apoptosis.We will discuss recent evidence of tRNA fragment accumulation in PD,as well as their potential neuroprotective activities. | Jochen H M Prehn Elisabeth Jirstrom | 2020 | Acta Pharmacologica Sinica2020，41，4： | 2 |
| 4 | Getting acquaintedthrough scial network sites testing a model of online uncertainty re-duction and social attraction显示文摘 | ANTHEUNIS M L PATTI M V JOCHEN P | 2009 | Computer in human behavior2009，，26： | 1 |
| 5 | Preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII显示文摘 | Sabine B. Zollner Elmar Raquet Jochen Müller-Cohrs Hubert J. Metzner Thomas Weimer Ingo Pragst Gerhard Dickneite Stefan Schulte | 2013 | Thrombosis Research2013，，： | 1 |
| 6 | 显示文摘 | Oskarsdottir Gudbjorg Lauterbach Jochen | 2001 | Catalysis Today2001，67，： | 1 |
| 7 | Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model显示文摘Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).Methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about 5months.Whole brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort level.Results were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal loss.Results:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal tract.Neuronal loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to wt.Conclusion:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas M1/M2.WBSS and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker. | Hans-Peter Müller David Brenner Francesco Roselli Diana Wiesner Alireza Abaei Martin Gorges Karin M.Danzer Albert C.Ludolph William Tsao Philip C.Wong Volker Rasche Jochen H.Weishaupt Jan Kassubek | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 8 | Peripheral and intestinal regulatory CD4+ CD25 high T cells in inflammatory Bowel disease显示文摘 | Jochen M Christoph L Pamela M | 2005 | Gastroenterology2005，128，： | 1 |
| 9 | Protein engineering of α/β-hydrolase fold enzymes显示文摘 | Jochens H Hesseler M Stiba K | 2011 | Chembiochem2011，12，10： | 1 |
| 10 | Interactions between APP secretases and inflammatory mediators 显示文摘 | MAGDALENA SASTRE JOCHEN WALTER STEVE M GENTLEMAN | 2008 | Neuroinflammation2008，5，： | 1 |
| 11 | Comparison of CT angiography with MR angiography in the preoperative assessment of living kidney donors显示文摘 | Thomas M Michael M Jochen S | 2008 | Transplantation2008，86，9： | 1 |
| 12 | A Massively Parallel Road Follower显示文摘 | Jochen T M Baluja S | 1993 | Computer Architecture for Machine Perception1993，，11： | 1 |
| 13 | Rational assignment of key motifs for function guides in silico enzyme identification显示文摘 | Hohne M Schatzle S Jochens H | 2010 | Nat Chem Biol2010，6，11： | 1 |
| 14 | Somatostatin receptors subtypes in human pheochromocytoma: subcellular expressing pattern and functional relevance for octreotide scintigraphy显示文摘 | Jochen M Nicole U Stefan S | 2003 | J Clin Endocrinol Metab2003，88，11： | 1 |
| 15 | Safety culture by crm training experiences from 2 trainings and German hospital simulation in healthcare显示文摘 | Wolfgang H Stefan M Jochen V | | 0，，03： | 1 |
| 16 | Analysis of toxic alkaloids in body samples 显示文摘 | JOCHEN B OLAF H D HANS H M | 2009 | Forensic Science International2009，185，： | 1 |
| 17 | Values, beliefs,attitudes : An empirical studyon the structure of environmental concern and recycling participation显示文摘 | HENNING B JOCHEN M | 2013 | Social Science2013，3，94： | 1 |
| 18 | Effects of a single inhalative exposure to formaldehyde on the open field behavior of mice显示文摘 | Fathi A. Malek Klaus-Uwe M?ritz Jochen Fangh?nel | 2004 | International Journal of Hygiene and Environmental Health2004，，2： | 1 |
| 19 | Bending and Torsional Stiffness in Cadaver Humeri Fixed With a Self-Locking Expandable or Interlocking Nail System: A Mechanical Study显示文摘 | Jochen Blum G?ksen Karagül Werner Sternstein Pol M Rommens | 2005 | Journal of Orthopaedic Trauma2005，，8： | 1 |
| 20 | Hindsight Bias: On Being Wise After the Event显示文摘 | Hartmut B Jochen M Rudiger F P | 2007 | Social Cognition2007，，1： | 1 |
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