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| 1 | B vitamins for stroke prevention显示文摘Supplementation with B vitamins(vitamin B9(folic acid),vitamin B_(12) and vitamin B_(6))lowers blood total homocysteine(tHcy)concentrations by about 25%and reduces the relative risk of stroke overall by about 10%(risk ratio(RR)0.90,95%CI 0.82 to 0.99)compared with placebo.Homocysteine-lowering interventions have no significant effect on myocardial infarction,death from any cause or adverse outcomes.Factors that appear to modify the effect of B vitamins on stroke risk include low folic acid status,high tHcy,high cyanocobalamin dose in patients with impaired renal function and concurrent antiplatelet therapy.In regions with increasing levels or established policies of population folate supplementation,evidence from observational genetic epidemiological studies and randomised controlled clinical trials is concordant in suggesting an absence of benefit from lowering of homocysteine with folic acid for prevention of stroke.Clinical trials indicate that in countries which mandate folic acid fortification of food,folic acid supplementation has no significant effect on reducing stroke risk(RR 1.05,95%CI 0.90 to 1.23).However,in countries without mandatory folic acid food fortification,folic acid supplementation reduces the risk of stroke by about 15%(RR 0.85,95%CI 0.77 to 0.94).Folic acid alone or in combination with minimal cyanocobalamin(≤0.05 mg/day)is associated with an even greater reduction in risk of future stroke by 25%(RR 0.75,95%CI 0.66 to 0.86),whereas the combination of folic acid and a higher dose of cyanocobalamin(≥0.4 mg/day)is not associated with a reduced risk of future stroke(RR 0.95,95%CI 0.86 to 1.05).The lack of benefit of folic acid plus higher doses of cyanocobalamin(≥0.4 mg/day)was observed in trials which all included participants with chronic kidney disease.Because metabolic B_(12)deficiency is very common and usually not diagnosed,future randomised trials of homocysteine-lowering interventions for stroke prevention should probably test a combination of folic acid and methylcobalamin or hydroxocobalamin instead of cyanocobalamin,and perhaps vitamin B_(6). | Graeme J Hankey | 2018 | Stroke & Vascular Neurology2018，3，2： | 7 |
| 2 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 国际脑血管病杂志2007，15，3： | 5 |
| 3 | Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack: A Prespecified Secondary Analysis of a Randomized, Placebo-Controlled Trial and Meta-Analysis显示文摘 | Graeme J. Hankey Andrew H. Ford Qilong Yi John W. Eikelboom Kennedy R. Lees Christopher Chen Denis Xavier Jose C. Navarro Udaya K. Ranawaka Wasim Uddin Stefano Ricci John Gommans Reinhold Schmidt Osvaldo P. Almeida Frank M. van Bockxmeer | 2013 | Stroke2013，，8： | 2 |
| 4 | Antiplatelet Therapy in the Secondary Prevention of Stroke显示文摘 | Graeme J. Hankey | 2004 | 中国循证医学杂志2004，4，3： | 2 |
| 5 | Association between high homocysteine and ischemic stroke due to large-and small-artery disease but not other etiolical subtype of ischemic stroke显示文摘 | Eikelboom JW Hankey GJ Anard SS | 2000 | Stroke2000，31，： | 2 |
| 6 | Mechanical thrombectomy with the S olitaire AB device in large intracerebral artery occlusions显示文摘 | John J McCabe Timothy J Phillips Con Phatouros Tejinder Singh David Blacker Graeme J Hankey William McAuliffe | 2012 | Journal of Medical Imaging and Radiation Oncology2012，，2： | 2 |
| 7 | Association Between High Homocyst(e)ine and Ischemic Stroke due to Large- and Small-Artery Disease but Not Other Etiologic Subtypes of Ischemic Stroke显示文摘 | John W. Eikelboom Graeme J. Hankey Sonia S. Anand Elizabeth Lofthouse Nicole Staples Ross I. Baker | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 2 |
| 8 | 年龄≥65岁男性收缩压与血管疾病的相关性显示文摘老年人血压与血管疾病的关系尚不确定。1996-1999年,在澳大利亚西部帕斯普通人群中建立65~94岁男性7564人的前瞻性队列,评估收缩压与主要血管事件的相关性。测定基线和2001-2004年再调查时的收缩压。记录受试者的致命性及非致命性血管事件。 | Lacey B Golledge J Yeap BB Lewington S McCaul KA Norman PE Flicker L Almeida OP Hankey GJ 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 9 | Alternative polyadenylation of mRNA and its role in cancer显示文摘Alternative polyadenylation(APA)is a molecular process that generates diversity at the 3′end of RNA polymeraseⅡtranscripts from over 60%of human genes.APA is derived from the existence of multiple polyadenylation signals(PAS)within the same transcript,and results in the differential inclusion of sequence information at the 3′end.While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene,most APA occurs within the untranslated region(3′UTR)and changes the length and content of these non-coding sequences.APA within the 3′UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms,and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development.Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression.Here,we review the current knowledge of APA and its impacts on mRNA stability,translation,localization and protein localization.We also discuss the implications of APA dysregulation in cancer research and therapy. | Fuwen Yuan William Hankey Eric J.Wagner Wei Li Qianben Wang | 2021 | Genes & Diseases2021，8，1： | 2 |
| 10 | Aspirin resistance显示文摘 | Hankey GJ Eikelboom JW | 2004 | BMJ2004，328，7438： | 1 |
| 11 | Secondary Prevention of Recurrent Stroke 显示文摘 | Graeme J Hankey | 2005 | Stroke2005，36，： | 1 |
| 12 | Aspirin resistance显示文摘 | TRAN H A ANAND S S HANKEY G J | 2007 | Thromb Res2007，120，3： | 1 |
| 13 | B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial:a randomised,double-blind,parallel,placebo-controlled trial显示文摘 | Hankey GJ Eikelboom JW Baker RI | | 0，，09： | 1 |
| 14 | Annual report to the nation on the status of cancer, 1975 - 2000, featuring the uses of surveillance da- ta for cancer prevention and control 显示文摘 | Weir HK Thun M J Hankey BF | 2003 | Natl Cancer lnst2003，95，17： | 1 |
| 15 | Homocy steine and vascular disease 显示文摘 | Hankey GJ Eikelboom JW | 1999 | Lancet1999，54，9176： | 1 |
| 16 | Premorbid personality traits are associated with post-stroke behavioral and psychological symptoms: a three-month follow-up study in Perth, Western Australia显示文摘 | Greenop KR Almeida OP Hankey GJ | 2009 | Int Psychogeriatr2009，9，： | 1 |
| 17 | Aspirin resistance 显示文摘 | Eikelboom JW | 2004 | BMJ2004，328，7438： | 1 |
| 18 | Folic acid-based multivitamin therapy to prevent stroke:the jury is still out显示文摘 | HANKEY G J EIKELBOOM J W | 2004 | Stroke2004，35，5： | 1 |
| 19 | MIC expression in renal and pancreatic allografts 显示文摘 | Hankey KG Drachenberg CB Papadimitriou JC | 2002 | Transplantation2002，73，2： | 1 |
| 20 | Homocysteine levels in patients with stroke: clinical relevance and therapeutic implications显示文摘 | Hankey GJ Eikelboom JW | 2001 | CNS Drugs2001，15，6： | 1 |
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