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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack: A Prespecified Secondary Analysis of a Randomized, Placebo-Controlled Trial and Meta-Analysis显示文摘 | Graeme J. Hankey Andrew H. Ford Qilong Yi John W. Eikelboom Kennedy R. Lees Christopher Chen Denis Xavier Jose C. Navarro Udaya K. Ranawaka Wasim Uddin Stefano Ricci John Gommans Reinhold Schmidt Osvaldo P. Almeida Frank M. van Bockxmeer | 2013 | Stroke2013，，8： | 2 |
| 3 | Diversity and seasonal fluctua- tions of the dominant members of the bacterial soil community in a wheat field as determined by cultivation and molecular methods 显示文摘 | Smit E Leeflang P Gommans S | 2001 | Applied and Environmental Microbiology2001，67，： | 1 |
| 4 | Seamless live migra- tion of virtual machines over the MAN/WAN 显示文摘 | TRAVOSTINO F DASPIT P GOMMANS L | 2006 | Elsevier Future Generation Computer Systems2006，22，8： | 1 |
| 5 | Diversity and seasonal fluctuations of the dominant members of the bacterial soil community in a wheat field as determined by cultivation and molecular methods 显示文摘 | Smit E Leeflang P Gommans S | 2001 | Applied and Environmental Microbiology2001，67，5： | 1 |
| 6 | 查看详情显示文摘 | Haggenmueller R Gommans H H Rinzler A G Fischer J E Winey K | | 0，，： | 1 |
| 7 | Seamless live migration of virtual machines over the MAN/WAN 显示文摘 | Travostino F Daspit P Gommans L | 2006 | Elsevier Future Generation Computer Systems2006，22，8： | 1 |
| 8 | Aligned single-wall carbon nanotubes in composites by melt processing methods显示文摘 | Haggenmueller R Gommans HH Rinzler AG Fischer JE Winey KI | 2000 | Chem Phys Lett2000，330，34： | 1 |
| 9 | Diversity and seasonal fluctuations of the dominant members of the bacterial soil community in a wheat field as determined by cultivation and molecular methods 显示文摘 | Smit E Leeflang P Gommans S | 2001 | Appl Environ Microbiol2001，67，5： | 1 |
| 10 | Diversity and seasonal fluctuations of the dominant members of the bacterial soil community in a wheat field as determined by cultivation and molecular methods显示文摘 | Smit E Leeflang P Gommans S | 2001 | Applied Environmental Microbiology2001，67，5： | 1 |
| 11 | A locus on chromosome 15q for a dominantly inherited nemaline myopathy with core-like lesions显示文摘 | Gommans IM Davis M Saar K | 2003 | Brain2003，26，： | 1 |
| 12 | Influence of creep deformation on the corrosion behavior of a CeO2 surface-modified alloy 800H in a sulphidising-oxidising-carburising environment显示文摘 | STROOSNIJDE M F GUTTMANN V GOMMANS R J N de WIT J H W | 1989 | Mater Sci Eng1989，121，： | 1 |
| 13 | Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment 显示文摘 | Gommans WM McLaughlin PM | 2007 | Mol Carcinog2007，46，5： | 1 |
| 14 | A locus on chromosome 15q for a dominantly inherited nemaline myopathy with core-like lesions显示文摘 | Gommans IM Davis M Saar K | 2003 | Brain2003，26，7： | 1 |
| 15 | et al From Brand Loyalty to E - Loyalty : A Conceptual Framework 显示文摘 | Gommans Marcel | 2001 | Journal of E- conomic & Social Research2001，3，1： | 1 |
| 16 | Exciton diffusion length and lifetime in subphthalocyanine films显示文摘 | Gommans H Schols S>Kadashchuk A | 2009 | J PhysChem C2009，113，7： | 1 |
| 17 | Seamless live mi- gration of virtual machines over the MAN/WAN 显示文摘 | TRAVOSTINO F DASPIT P GOMMANS L | 2006 | Elsevier Future Generation Computer Systems2006，22，8： | 1 |
| 18 | 查看详情显示文摘 | Haggenmueller R Gommans H H Rinzler A G Fischer J E Winey K I | | 0，，： | 1 |
| 19 | Seamless live migration of virtual machines over the MAN/WAN显示文摘 | Travostino F Daspit P Gommans L | 2006 | Future Generation Computer System2006，22，8： | 1 |
| 20 | Typical failures in pyrolysis coils for ethylene cracking 显示文摘 | Jakobi D Gommans R | 2003 | Materials and Corrosion2003，54，11： | 1 |
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