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| 1 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 2 | 利用太阳能灌溉——滴灌系统与光电水泵系统的联合运行显示文摘经过十多年对太阳能利用的大力研究,大大提高了光电系统的效率与使用寿命,因此在灌溉中的应用日益增多,已有收益。本文论述的是需水量的计算以及水泵的最优化选择问题,以便将光电系统应用于滴灌设备的运行中。 | Edzard Hafner Gunter Marotz 杨应玖 许崇武 | 1992 | 灌溉排水1992，11，1： | 5 |
| 3 | 大功率CO_2压缩机运行效率的实验研究显示文摘本文在不同压力和转速工况下,对一台由挪威科技大学与Sintef联合研发的100 k W大功率单级活塞式CO_2制冷压缩机进行了实验测试,得出压缩机效率、容积效率以及油循环率随压缩比和转速的变化曲线,以及效率最优时各参数的范围。结果表明:当压缩比为2.1、转速为2 500 r/min时,油循环率达到最大值2.84%;当压缩比为1.88,转速为1 000 r/min时,容积效率达到最大值85.8%;当压缩比为1.5~2.5,转速约为1 500 r/min时,压缩机效率最优;当转速为1 500 r/min,压缩比为2.0时,可达到最大值79.1%。针对压缩机效率的实验数据进行了数学拟合,并与两台同类压缩机的产品效率作对比分析,结果表明:大功率压缩机当压缩比为1.5~3.2时的效率比同类压缩机约高11.5%。 | 韩毅 吴静怡 Hafner Armin | 2017 | 制冷学报2017，38，3： | 5 |
| 4 | Indian Ocean Capacitor Effect on Indo-Western Pacific Climate during the Summer following El Ni?o显示文摘 | Xie Shang-Ping Hu Kaiming Hafner Jan Tokinaga Hiroki Du Yan Huang Gang Sampe Takeaki | 2009 | Journal of Climate2009，，3： | 4 |
| 5 | 两级R744超市中央制冷系统节能特性显示文摘比较了以二氧化碳(R744)为工质的超市中央制冷系统制冷技术方案,包括普通两级制冷(CB)、旁通压缩两级制冷(PC)和多引射器-旁通压缩耦合两级制冷(EJ),讨论了配置空调系统(AC)之后的功耗变化。根据计算得到,在环境温度20℃以上,相较于CB系统,PC系统的功耗减少了6.8%~12.3%;EJ系统功耗降低了6.3%~17.5%。在耦合了AC系统之后,相较于PC-AC系统,EJ-AC系统的功耗降低了4.9%~6.5%。与R404a系统相比,超市两级R744系统都有明显的节能效果。 | 林励冠 代彦军 Hafner Armin | 2018 | 化工学报2018，69，A02： | 3 |
| 6 | Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging显示文摘BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited. | Georg Wimmer Michael Gadermayr Gernot Wolkersdorfer Roland Kwitt Toru Tamaki Jens Tischendorf Michael Hafner Shigeto Yoshida Shinji Tanaka Dorit Merhof Andreas Uhl | 2019 | World Journal of Gastroenterology2019，25，10： | 2 |
| 7 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease显示文摘 | Christoph Bickel Hans J Rupprecht Stefan Blankenberg Gerd Rippin Gerd Hafner Alexander Daunhauer Klaus-Peter Hofmann Jürgen Meyer | 2002 | The American Journal of Cardiology2002，，1： | 2 |
| 8 | 全球开始关注卫生体系加强显示文摘在过去很长一段时间内,某一具体疾病是主要研究对象,但近几十年特别是2005年以来,许多组织开始参与全球卫生研究并关注卫生体系加强。本文对这一关注产生的原因及方式展开研究。研究采用了过程追踪的定性方法,并对政治层面引发和限制其关注的因素进行分析。研究发现加强卫生体系之所以得到广泛关注,主要是因为:全球卫生的参与者担心卫生体系方面的问题会影响千年发展目标的实现,并担心全球卫生行动可能会给国家卫生体系带来负面影响。此外,许多全球卫生组织已经意识到,薄弱的卫生体系会成为实现组织既定目标的瓶颈。尽管目前有众多的参与者支持加强卫生体系,但这些行动者还未形成有凝聚力的政策联盟。此外,加强卫生体系的概念不清晰,而且加强卫生体系的证据很薄弱。由于全球金融危机、全球卫生政策的不确定性以及一些行动者暂时性地支持等,对加强卫生体系的关注是否具有可持续性,目前尚未有定论。 | Tamara Hafner Jeremy Shiffman | 2013 | 中国卫生政策研究2013，6，8： | 2 |
| 9 | Interleukin-6 and oncostatin M are elevated in liver disease inconjunction with candidate hepatocellular carcinoma biomarker GP73显示文摘 | Hongyan Liang Timothy M. Block Mengjun Wang Bradley Nefsky Ronald Long Julie Hafner Anand S. Mehta Jorge Marrero Robert Gish Pamela A. Norton | 2012 | Cancer Biomarkers2012，，4： | 2 |
| 10 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 11 | NANOTUBES AS NANOPROBES IN SCANNING PROBE MICROSCOPY显示文摘 | Dai H Hafner J H Rinzler A G Colbert D T Smalley R E | | 0，，： | 2 |
| 12 | Open Reduction and Internal Fixation of Proximal Humerus Fractures Using a Proximal Humeral Locked Plate: A Prospective Multicenter Analysis显示文摘 | Felix Brunner Christoph Sommer Christian Bahrs Rainer Heuwinkel Christian Hafner Paavo Rillmann Georges Kohut Anders Ekelund Mathias Muller Laurent Audigé Reto Babst | 2009 | Journal of Orthopaedic Trauma2009，，3： | 2 |
| 13 | A shunt active power filter applied to high voltage distribution lines显示文摘 | HAFNER J AREDS M HEUMANN K | 1997 | IEEE Trans on Power Delivery1997，12，1： | 1 |
| 14 | Unraveling nanotubes:Field emission from an atomic wire显示文摘 | Hafner J H Nikolaev P | 1995 | Science1995，269，： | 1 |
| 15 | Role of hysteroscopy in detection and extraction of endometrial polyps:results of a prospective study显示文摘 | Gebauer G Hafner A Siebzehnrü bl E | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
| 16 | Brain-stem trigeminal and auditory evoked potentials in multiple sclerosis:phsiological insights显示文摘 | SOUSTIEL J F HAFNER H CHISTYAKOV A V | 1996 | Electroencephalogr Clin Neurophysiol1996，100，： | 1 |
| 17 | Structural(n,m)determination of isolated single-walled carbonnanotubes by resonant Raman scattering显示文摘 | Jorio A Saito R Hafner J H | 2001 | Phys Rve Lett2001，86，6： | 1 |
| 18 | Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein显示文摘 | Hafner A Brandenburg B Hildt E | 2003 | EMBO reports2003，4，8： | 1 |
| 19 | Clonellty of muhifoeal urothelial carcinomas: 10 years of molecular genetic studies显示文摘 | Hafner C Knuechel R Stoehr R | 2002 | Int J Cancer2002，101，1： | 1 |
| 20 | Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract显示文摘 | Hafner C Knuechel R Zanardo L | 2001 | Oncogene2001，20，35： | 1 |
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