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| 1 | Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocompetent rats显示文摘AIM: To characterize the host response to hepatitis B virus (HBV) infection in human hepatocytes transplanted into immunocompetent rodent rats tolerized by, and transplanted with primary human hepatocytes.METHODS: One week after the transplantation, rats were inoculated with HBV, and viral gene expression, replication,and host response was monitored.RESULTS: HBV DNA was detectable in serum for at least 60 days. HBsAg levels rose steadily for 3 weeks postinoculation and then plateaued at a level of about 0.6 pg/mi. HBV RNA was also found in liver at levels that remained constant through the time course. Immunofluorescence revealed clusters of hepatocytes that stained positive for HBcAg. The presence of HBV covalently closed circular DNA (cccDNA) in liver was demonstrated using nuclease digestion of single-stranded DNA followed by PCR. Serum ALT levels rose and reached a peak level of 180 IU/L on day 18, but remained elevated for 60 days. Histology revealed a progressive predominantly mononuclear lobular hepatitis.CONCLUSION: These data indicate that human hepatocytestransplanted into rats rendered tolerant to these cells, when infected by HBV, results in biochemical as well as histological evidence of hepatitis that accompanies viral gene expression,and DNA replication. | Catherine H.Wu Edwin C.Ouyang Cherie Walton Kittichai Promrat Faripour Forouhar George Y. Wu | 2003 | World Journal of Gastroenterology2003，9，5： | 19 |
| 2 | Stability analyses of the mass abrasive projectile high-speed penetrating into a concrete target Part III: Terminal ballistic trajectory analyses显示文摘During the high-speed penetration of projectiles into concrete targets(the impact velocity ranges from 1.0 to1.5 km/s), important factors such as the incident oblique and attacking angles, as well as the asymmetric abrasions of the projectile nose induced by the target-projectile interactions,may lead to obvious deviation of the terminal ballistic trajectory and reduction of the penetration efficien y. Based on the engineering model for the mass loss and nose-blunting of ogive-nosed projectiles established, by using the Differential Area Force Law(DAFL) method and semi-empirical resistance function, a finit differential approach was programmed(PENTRA2D) for predicting the terminal ballistic trajectoryofmassabrasivehigh-speedprojectilespenetrating into concrete targets. It accounts for the free-surface effects on the drag force acting on the projectile, which are attributed to the oblique and attacking angles, as well as the asymmetric noseabrasionoftheprojectile.Itsvalidationontheprediction of curvilinear trajectories of non-normal high-speed penetrators into concrete targets is verifie by comparison with available test data. Relevant parametric influentia analyses show that the most influentia factor for the stability of terminal ballistic trajectories is the attacking angle, followed by the oblique angle, the discrepancy of asymmetric nose abrasion, and the location of mass center of projectile. The terminal ballistic trajectory deviations are aggravated as the above four parameters increase. | H.Wu X.W.Chen Q.Fang X.Z.Kong L.L.He | 2015 | Acta Mechanica Sinica2015，31，4： | 4 |
| 3 | 丙型肝炎病毒NS_5B在Hub-7细胞中的转染与表达显示文摘目的建立丙型肝炎病毒(HCV)NS5B表达的人肝细胞系。方法以脂质体共转染NS5SB基因人Hub-7细胞,以PCR和Southern blot在DNA水平检测转染的结果,以western blot证实了Hub-7细胞中有NSuB的蛋白表达。结累在转染过NSSB质粒的细胞系中有NSSB基因的存在和HCV-RNA多聚酶的表达。结论我们在Hub-7细胞中建立了HCV-RNA多聚酶表达系统,它有助于研究HCV复制机制和为基因治疗丙型肝炎打下基础。 | 房静远 Edwin Ouyang Catheine H.Wu George Y.Wu 邱德凯 曾民德 萧树东 | 2000 | 中华肝脏病杂志2000，8，1： | 3 |
| 4 | Modified spherical cavity-expansion model for projectile penetration into concrete targets显示文摘A modified spherical cavity-expansion model is developed in this paper.(1) We introduce a piecewise hyperbolic yield criterion suitable for pressure less than fc/3 to describe the mechanical behavior in the elastic region for the elastic-plastic response and modify the crack occurrence condition for the elastic-cracked-plastic response.(2) The hyperbolic yield criterion and a piecewise equation of state (EOS) are adopted for a better description of the plastic behavior of concrete material. Then, the modified model is validated by several projectile penetration tests in both the normal strength concrete (NSC) and ultra-high performance cement-based composite (UHPCC) targets. Finally, the hydrostatic pressure of the targets under rigid ogive-nosed projectile penetrations is found to be nearly within (0, 1.6 GPa), which usually exceeds the range that the shear strength-pressure test data covered. The influence of yield criterion on depth of penetration is discussed and it is recommended that the pressure should arrive at least 400 MPa in the related triaxial compression tests. | Y.Peng H.Wu Q.Fang X.Z.Kong | 2019 | Acta Mechanica Sinica2019，35，3： | 3 |
| 5 | Interface defeat studies of long-rod projectile impacting on ceramic targets显示文摘The interface defeat phenomenon always occurs when a long-rod projectile impacting on the ceramic target with certain velocity,i.e.,the projectile is forced to flow radially on the surface of ceramic plates for a period of time without significant penetration.Interface defeat has a direct effect upon the ballistic performance of the armor piercing projectile,which is studied numerically and theoretically at present.Firstly,by modeling the projectiles and ceramic targets with the SPH(Smoothed Particle Hydrodynamics)particles and Lagrange finite elements,the systematic numerical simulations on interface defeat are performed with the commercial finite element program AUTODYN.Three different responses,i.e.,complete interface defeat,dwell and direct penetration,are reproduced in different types of ceramic targets(bare,buffered,radially confined and oblique).Furthermore,by adopting the validated numerical algorithms,constitutive models and the corresponding material parameters,the influences of projectile(material,diameter,nose shape),constitutive models of ceramic(JH-1 and JH-2 models),buffer and cover plate(thickness,constraints,material),as well as the prestress acted on the target(radial and hydrostatic) on the interface defeat(transition velocity and dwell time) are syste matically investigated.Finally,based on the energy conservation approach and taking the strain rate effect of ceramic material into account,a modified model for predicting the upper limit of transition velocity is proposed and validated.The present work and derived conclusions can provide helpful reference for the design and optimization of both the long-rod projectile and ceramic armor. | Y.X.Zhai H.Wu Q.Fang | 2020 | Defence Technology(防务技术)2020，16，1： | 3 |
| 6 | 数学教师的错误教育显示文摘如果我们想学校有好的法语教师,是应该要求他们在大学学习拉丁语而不是法语吗?毕竟,拉丁语是法国的母语,语言学方面比法语更复杂;教师通过掌握一门更复杂的语言能提高他们对学生时代已知的法语的理解.为了解他们的法语知识与学生成绩的关联度,我们可以看看他们拉丁语分数! | H.Wu 李晓莉(译) 谌稳固(校) | 2012 | 数学译林2012，31，2： | 3 |
| 7 | Meta‐analysis: the use of carbon dioxide insufflation vs. room air insufflation for gastrointestinal endoscopy显示文摘 | Z. H.Wu J. F.Wei D. K.Zhou H. Y.Xie | 2012 | Aliment Pharmacol Ther2012，，10： | 2 |
| 8 | Haemolytic disease of the newborn due to maternal irregular antibodies in the Chinese population in Taiwan显示文摘 | K. H.Wu S. L.Chu J. G.Chang M. C.Shih C. T.Peng | 2003 | Transfusion Medicine2003，，： | 1 |
| 9 | Effect of RBP4 gene variants on circulating RBP4 concentration and Type?2 diabetes in a Chinese population显示文摘 | C.Hu W.Jia R.Zhang C.Wang J.Lu H.Wu Q.Fang X.Ma K.Xiang | 2008 | Diabetic Medicine2008，，1： | 1 |
| 10 | Role of neurocrine somatostatin on sphincter of Oddi contractility and intestinal ischemia reperfusion‐induced acute pancreatitis in macaques显示文摘 | P.Chen B.Hu Q.Tan L.Liu D.Li C.Jiang H.Wu J.Li C.Tang | 2010 | Neurogastroenterology & Motility2010，，8： | 1 |
| 11 | Novel Solid Acid Catalysts: Sulfonic Acid Group‐Functionalized Mesostructured Polymers显示文摘 | R.Xing N.Liu Y.Liu H.Wu Y.Jiang L.Chen M.He P.Wu | 2007 | Adv Funct Mater2007，，14： | 1 |
| 12 | Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential显示文摘 | H.Wu A.Barusevicius J.Babb A.Klein‐Szanto A.Godwin R.Elenitsas J. M.Gelfand S.Lessin J. T.Seykora | 2004 | Journal of Cutaneous Pathology2004，，2： | 1 |
| 13 | Historical development of the Gauss-Bonnet theorem显示文摘A historical survey of the Gauss-Bonnet theorem from Gauss to Chern. | WU Hung-Hsi(H.Wu) | 2008 | Science China Mathematics2008，51，4： | 1 |
| 14 | Grey Relational Analysis of Correlation of Errors in Measurement显示文摘 | Wang Zhongyu Li Zhu John H.Wu | | 0，，01： | 1 |
| 15 | Generation of Uniformly Sized Alginate Microparticles for Cell Encapsulation by Using a Soft‐Lithography Approach显示文摘 | C.Qiu M.Chen H.Yan H.Wu | 2007 | Adv Mater2007，，12： | 1 |
| 16 | Meta‐analysis: the use of carbon dioxide insufflation vs. room air insufflation for gastrointestinal endoscopy显示文摘 | Z. H.Wu J. F.Wei D. K.Zhou H. Y.Xie | 2012 | Aliment Pharmacol Ther2012，，10： | 1 |
| 17 | Meta‐analysis: the use of carbon dioxide insufflation vs. room air insufflation for gastrointestinal endoscopy显示文摘 | Z. H.Wu J. F.Wei D. K.Zhou H. Y.Xie | 2012 | Aliment Pharmacol Ther2012，，10： | 1 |
| 18 | 查看详情显示文摘 | Y.Zhu D.Michalovich H.Wu | | 0，，： | 1 |
| 19 | Household Income Determination and Regional Income Differential in Rural China显示文摘 | X.Meng H.Wu | | 0，，01： | 1 |
| 20 | Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments显示文摘 | J. R.Sheu W. C.Hung C. H.Wu Y. M.Lee M. H.Yen | 2001 | British Journal of Haematology2001，，1： | 1 |
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