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6篇 您的检索式：作者名="N.Liu"

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		题名	作者	年代	出处	被引量
	1	An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP^(+)mononuclear cells and PDGF-BB secretion显示文摘Osteoporosis(OP)is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures.Pharmaceutical therapies that promote anabolic bone formation in OP patients and OP-induced fracture are needed.We investigated whether a neutralizing antibody against Siglec-15 can simultaneously inhibit bone resorption and stimulate bone formation.We found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody treatment.The secretion of platelet-derived growth factor-BB(PDGF-BB),the number of tartrate-resistant acid phosphatase-positive(TRAP+)mononuclear cells,and bone formation were significantly increased in the SIGLEC-15 conditional knockout mice and antibody-treated mice.The anabolic effect of the Siglec-15 neutralizing antibody on bone formation was blunted in mice with Pdgfb deleted in TRAP-1'cells.These findings showed that the anabolic effect of the Siglec-15 neutralizing antibody was mediated by elevating PDGF-BB production of TRAP4 mononuclear cells.To test the therapeutic potential of the Siglec-15 neutralizing antibody,we injected the antibody in an ovariectomy-induced osteoporotic mouse model,which mimics postmenopausal osteoporosis in women,and in two fracture healing models because fracture is the most serious health consequence of osteoporosis.The Siglec-15 neutralizing antibody effectively reduced bone resorption and stimulated bone formation in estrogen deficiency-induced osteoporosis.Of note,the Siglec-15 neutralizing antibody promoted intramembranous and endochondral ossification at the damaged area of cortical bone in fracture healing mouse models.Thus,the Siglec-15 neutralizing antibody shows significant translational potential as a novel therapy for OP and bone fracture.	Gehua Zhen Yang Dan Ruomei Wang Ce Dou Qiaoyue Guo Melissa Zarr Linda N.Liu Lieping Chen Ruoxian Deng Yusheng Li Zengwu Shao Xu Cao	2021	Bone Research2021，9，4：	6
	2	Detection and widespread distribution of sodium channel alleles characteristic of insecticide resistance in Culex pipiens complex mosquitoes in China显示文摘	Z.‐M.WANG C.‐X.LI D.XING Y.‐H.YU N.LIU R.‐D.XUE Y.‐D.DONG T.‐Y.ZHAO	2012	Medical and Veterinary Entomology2012，，2：	2
	3	Forming mechanism of metastable 'dendrite core' in undercooled Fe-Ni alloy显示文摘	Y.Z.Chen G.C.Yang F.Liu N.Liu H.Xie D.Chen C.L.Yang Y.P.Su Y.H.Zhou		0，，：	1
	4	Novel Solid Acid Catalysts: Sulfonic Acid Group‐Functionalized Mesostructured Polymers显示文摘	R.Xing N.Liu Y.Liu H.Wu Y.Jiang L.Chen M.He P.Wu	2007	Adv Funct Mater2007，，14：	1
	5	Origin of solid electrolyte interphase on nanosized LiCoO2显示文摘	N.Liu H.Li Z.X.Wang X.J.Huang L.Q.Chen		0，，：	1
	6	Novel Solid Acid Catalysts: Sulfonic Acid Group‐Functionalized Mesostructured Polymers显示文摘	R.Xing N.Liu Y.Liu H.Wu Y.Jiang L.Chen M.He P.Wu	2007	Adv Funct Mater2007，，14：	1

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