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| 1 | PhaseⅠ/Ⅱtrial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma显示文摘Background: After deinitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma(NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present signiicant challenges for locally recurrent NPC. Surgery, stereotactic ablative body radiotherapy, and brachytherapy have been used to treat locally recurrent NPC. However, only patients with small-volume tumors can beneit from these treatments. Re-irradiation with X-ray—based intensity-modulated radiotherapy(IMXT) has been more widely used for salvage treatment of locally recurrent NPC with a large tumor burden, but over-irradiation to the surrounding normal tissues has been shown to cause frequent and severe toxicities. Furthermore, locally recurrent NPC represents a clinical entity that is more radioresistant than its primary counterpart. Due to the inherent physical advantages of heavy-particle therapy, precise dose delivery to the target volume(s), without exposing the surrounding organs at risk to extra doses, is highly feasible with carbon-ion radiotherapy(CIRT). In addition, CIRT is a high linear energy transfer(LET) radiation and provides an increased relative biological efectiveness compared with photon and proton radiotherapy. Our prior work showed that CIRT alone to 57.5 Gy E(gray equivalent), at 2.5 Gy E per daily fraction, was well tolerated in patients who were previously treated for NPC with a deinitive dose of IMXT. The short-term response rates at 3–6 months were also acceptable. However, no patients were treated with concurrent chemotherapy. Whether the addition of concurrent chemotherapy to CIRT can beneit locally recurrent NPC patients over CIRT alone has never been addressed. It is possible that the beneits of high-LET CIRT may make radiosensitizing chemotherapy unnecessary. We therefore implemented a phase I/II clinical trial to address these questions and present our methodology and results.Methods and design: The maximal tolerated dose(MTD) of re-treatment using raster-scanning CIRT plus concurrent cisplatin will be determined in the phase I, dose-escalating stage of this study. CIRT dose escalation from 52.5 to 65 Gy E(2.5 Gy E × 21–26 fractions) will be delivered, with the primary endpoints being acute and subacute toxicities. Eicacy in terms of overall survival(OS) and local progression-free survival of patients after concurrent chemotherapy plus CIRT at the determined MTD will then be studied in the phase II stage of the trial. We hypothesize that CIRT plus chemotherapy can improve the 2-year OS rate from the historical 50% to at least 70%.Conclusions: Re-treatment of locally recurrent NPC using photon radiation techniques, including IMXT, provides moderate eicacy but causes potentially severe toxicities. Improved outcomes in terms of eicacy and toxicity proile are expected with CIRT plus chemotherapy. However, the MTD of CIRT used concurrently with cisplatin-based chemotherapy for locally recurrent NPC remains to be determined. In addition, whether the addition of chemotherapy to CIRT is needed remains unknown. These questions will be evaluated in the dose-escalating phase I and randomized phase II trials. | Lin Kong Jing Gao Jiyi Hu Weixu Hu Xiyin Guan Rong Lu Jiade J.Lu | 2016 | Chinese Journal of Cancer2016，35，12： | 8 |
| 2 | Low-Temperature Nitriding by Means of SMAT显示文摘The microstructure in the surface layer of iron and steel samples can be refined at the nanometer scale by means of a surface mechanical attrition treatment (SMAT) that generates repetitive severe plastic deformation to the surface layer. The subsequent nitriding kinetics of the as-treated samples with the nanostructured surface layer is greatly enhanced so that the nitriding temperatures can be reduce to 300 - 400 °C regions. This enhanced processing method demonstrates both the technological significance of nanomaterials in advancing the traditional processing techniques, and provides a new approach for selective surface reactions in solids. This article reviews the present state of the art in this field. The microstructure and properties of SMAT samples nitrided will be summarized. Further considerations of the development and applications of this new technique will also be presented. | W.P.Tong H.W.Zhang N.R.Tao Z.B.Wang J.Lu K.Lu | 2004 | 材料热处理学报2004，25，5： | 3 |
| 3 | Carbon ion radiotherapy boost in the treatment of glioblastoma:a randomized phase Ⅰ/Ⅲ clinical trial显示文摘Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. The particle therapy represents a new promising therapeutic approach to circumvent these prohibitive conditions with improved treatment efficacy. Methods and design: Patients with newly diagnosed malignant gliomas will have their tumor tissue samples submitted for the analysis of the status of O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. In Phase I, the patients will undergo an induction carbon ion radiotherapy (CIRT) boost followed by 60 GyE of proton irradiation with concurrent temozolomide (TMZ) at 75 mg/m2. To determine the maximal dose of safe induction boost, the tolerance, and acute toxicity rates in a dose-escalation manner from 9 to 18 GyE in three fractions will be used. In Phase III, GBM-only patients will be randomized to receive either 60 GyE (2 GyE per fraction) of proton irradia-tion with concurrent TMZ (control arm) or a CIRT boost (dose determined in Phase I of this trial) followed by 60 GyE of proton irradiation with concurrent TMZ. The primary endpoints are overall survival (OS) and toxicity rates (acute and long-term). Secondary endpoints are progression-free survival (PFS), and tumor response (based upon assess-ment with C-methionine/fluoro-ethyl-tyrosine positron emission tomography [MET/FET PET] or magnetic resonance imaging [MRI] and detection of serologic immune markers). We hypothesize that the induction CIRT boost will result in a greater initial tumor-killing ability and prime the tumor microenvironment for enhanced immunologic tumor clearance, resulting in an expected 33% improvement in OS rates. Discussion: The prognosis of GBM remains grim. The mechanism underpinning the poor prognosis of this malig-nancy is its chronic state of tumor hypoxia, which promotes both immunosuppression/immunologic evasion and radio-resistance. The unique physical and biological properties of CIRT are expected to overcome these microenviron-mental limitations to confer an improved tumor-killing ability and anti-tumor immune response, which could result in an improvement in OS with minimal toxicity. Trial registration number This trial has been registered with the China Clinical Trials Registry, and was allocated the number ChiCTR-OID-17013702. | Lin Kong Jing Gao Jiyi Hu Rong Lu Jing Yang Xianxin Qiu Weixu Hu Jiade J.Lu | 2019 | Cancer Communications2019，39，1： | 3 |
| 4 | The combined effects of grain and sample sizes on the mechanical properties and fracture modes of gold microwires显示文摘Hall-Petch relation was widely applied to evaluate the grain size effect on mechanical properties of metallic material. However, the sample size effect on the Hall-Petch relation was always ignored. In the present study, the mechanical test and microstructure observation were performed to investigate the combined effects of grain and sample sizes on the deformation behaviors of gold microwires. The polycrystalline gold microwires with diameter of 16 ?m were annealed at temperatures from 100°C to 600°C, leading to different ratios(t/d) of wire diameter(t) to grain size(d) from 0.9 to 16.7. When the t/d was lower than 10, the yield stress dropped fast and deviated from the Hall-Petch relation. The free-surface grains played key role in the yield stress softening, and the volume fraction of free-surface grains increased with the t/d decreasing. Furthermore, the effects of t/d on work-hardening behaviors and fracture modes were also studied. With t/d value decreasing from 17 to 3.4, the samples exhibited necking fracture and the dislocation pile-ups induced work-hardening stage was gradually activated.With the t/d value further decreasing(t/d < 3.4), the fracture mode turned into shear failure, and the work-hardening capability lost. As the gold microwire for wire bonding is commonly applied in the packaging of integrated circuit chips, and the fabrication of microwire suffers multi-pass cold-drawing and annealing treatments to control the grain size. The present study could provide instructive suggestion for gold microwire fabrication and bonding processes. | H.K.Yang K.Cao Y.Han M.Wen J.M.Guo Z.L.Tan J.Lu Y.Lu | 2019 | Journal of Materials Science & Technology2019，35，1： | 2 |
| 5 | Property rights protection and access to bank loans显示文摘 | Bai C.E J.Lu Z.Tao | | 0，，04： | 1 |
| 6 | Effect of RBP4 gene variants on circulating RBP4 concentration and Type?2 diabetes in a Chinese population显示文摘 | C.Hu W.Jia R.Zhang C.Wang J.Lu H.Wu Q.Fang X.Ma K.Xiang | 2008 | Diabetic Medicine2008，，1： | 1 |
| 7 | Nuclear factor‐κB/p65 responds to changes in the Notch signaling pathway in murine BV‐2 cells and in amoeboid microglia in postnatal rats treated with the γ‐secretase complex blocker DAPT显示文摘 | Q.Cao P.Li J.Lu S.T.Dheen C.Kaur E.‐A.Ling | 2010 | J Neurosci Res2010，，12： | 1 |
| 8 | Theory and application of distribution electronic power transformer显示文摘 | D.Wang C.Mao J.Lu S.Fan F.Z.Peng | | 0，，： | 1 |
| 9 | Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta‐analysis显示文摘 | W.Wu O.Shen Y.Qin J.Lu X.Niu Z.Zhou C.Lu Y.Xia S.Wang X.Wang | 2012 | International Journal of Andrology2012，，1： | 1 |
| 10 | Adaptive feedback synchronizatio:of a unified chaotic system显示文摘 | J.Lu X.Wu X.Han J.Lü | | 0，，329： | 1 |
| 11 | Upper and lower solution method for fourth-order four-point boundary value problems显示文摘 | Q.Zhang S.Chen J.Lu(') | | 0，，： | 1 |
| 12 | Adaptive synchronization of an uncertain complex dynamical network显示文摘 | J.Zhou J.Lu J.Lü | | 0，，61： | 1 |
| 13 | Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs显示文摘 | J.Lu M.Liong J.I.Zink F.Tamanoi | | 0，，： | 1 |
| 14 | A new low temperature one-step route to metal chalcogenide semiconductors: PbE, Bi2E3 (E = S, Se, Te)显示文摘 | S.H.Yu J.Yang Y.S.Wu Z.H.Han J.Lu Y.Xie and Y.T.Qian | | 0，，9： | 1 |
| 15 | 查看详情显示文摘 | J.Lu P.S.Yeo C.K.Gan P.Wu and K.P.Loh | | 0，，04： | 1 |
| 16 | Effect of RBP4 gene variants on circulating RBP4 concentration and Type?2 diabetes in a Chinese population显示文摘 | C.Hu W.Jia R.Zhang C.Wang J.Lu H.Wu Q.Fang X.Ma K.Xiang | 2008 | Diabetic Medicine2008，，： | 1 |
| 17 | Theory and application of distribution electronic power transformer显示文摘 | D.Wang C.Mao J.Lu S.Fan F.Z.Peng | | 0，，： | 1 |
| 18 | Universality of quenching-partitioning-tempering local equilibrium model显示文摘1.Introduction As typical 3rd generation advanced high strength steels(AHSSs),quenching and partitioning(Q&P)steel has attracted lots of attention for excellent performance in strength-ductility[1–5].With absorbing carbon partitioning as the core idea of Q&P process,quenching-partitioning-tempering(Q-P-T)process was proposed with emphasis on precipitation strengthening for better combination of strength and ductility[6–10]. | J.Z.Zhang L.Y.Zeng X.W.Zuo J.F.Wan Y.H.Rong N.Min J.Lu N.L.Chen | 2022 | Journal of Materials Science & Technology2022，，29： | 0 |
| 19 | Grating‐like anechoic layer for broadband underwater sound absorption显示文摘To address the challenging task of effective sound absorption in the low and broad frequency band for underwater structures,we propose a novel grating‐like anechoic layer by filling rubber blocks and an air backing layer into metallic grating.The metallic gratings are incorporated into the anechoic layer as a skeleton for enhanced viscoelastic dissipation by promoting shear deformation between rubber and metal plates.The introduction of an air backing layer releases the bottom constraint of the rubber,thus intensifying its deformation under acoustic excitation.Based on the homogenization method and the transfer matrix method,a theoretical model is developed to evaluate the sound absorption performance of the proposed anechoic layer,which is validated against finite element simulation results.It is demonstrated that a sound absorption coefficient of the grating‐like anechoic layer of 0.8 can be achieved in the frequency range of 1294-10000 Hz.Given the importance of sound absorption at varying frequencies,the weighted average method is subsequently used to comprehensively evaluate the performance of the anechoic layer.Then,with structural density taken into consideration,an integrated index is proposed to further evaluate the acoustic properties of the proposed anechoic layer.Finally,the backing conditions and the boundary conditions of finite‐size structures are discussed.The results provide helpful theoretical guidance for designing novel acoustic metamaterials with broadband low‐frequency underwater sound absorption. | Chenlei Yu Mingyu Duan Wei He Xin Chen Fengxian Xin Tian J.Lu | 2022 | International Journal of Mechanical System Dynamics2022，2，3： | 0 |
| 20 | Hardness-thermal stability synergy in nanograined Ni and Ni alloys:Superposition of nanotwin and low-energy columnar boundary显示文摘Refining grains into nanoscale can significantly strengthen and harden metallic materials;however,nanograined metals generally exhibit low thermal stability,hindering their practical applications.In this work,we exploit the superposition of the contribution of nanotwins,low-angle grain boundaries,and microalloying to tailor superior combinations of high hardness and good thermal stability in Ni and Ni alloys.For the nanotwinned Ni having a twin thickness of∼2.9 nm and grain size of 28 nm,it exhibits a hardness over 8.0 GPa and an onset coarsening temperature of 623 K,both of which are well above those of nanograined Ni.Re/Mo microalloying can further improve the onset coarsening temperature to 773 K without comprising hardness.Our analyses reveal that high hardness is achieved via strengthen-ing offered by extremely fine nanotwins.Meanwhile,the superior thermal stability is mainly ascribed to the low driving force for grain growth induced by the low-angle columnar boundary architecture and to the additional pinning effect on the migration of twin/columnar boundaries provided by minor Re/Mo solutes.The present work not only reveals a family of nanotwinned metals possessing the combination of ultra-high hardness and high thermal stability but also provides a strategy for tailoring properties of metallic materials by pairing low-angle grain boundaries and twin boundaries. | F.H.Duan Y.Lin Q.Li J.H.Luan J.Lu J.Pan Y.Li | 2023 | Journal of Materials Science & Technology2023，，6： | 0 |
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