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| 1 | Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective显示文摘Non-small cell lung cancer is a prevalent and rapidly-expanding challenge to modern medicine. While generalized medicine with traditional chemotherapy yielded comparatively poor response rates and treatment results, the cornerstone of personalized medicine using genetic profiling to direct treatment has exalted the successes seen in the field and raised the standard for patient treatment in lung and other cancers. Here, we discuss the current state and advances in the field of personalized medicine for lung cancer, reviewing several of the mutation-targeting strategies that are approved for clinical use and how they are guided by patient genetic information. These classes include inhibitors of tyrosine kinase(TKI), anaplastic lymphoma kinase(ALK), and monoclonal antibodies. Selecting from these treatment plans and determining the optimal dosage requires in-depth genetic guidance with consideration towards not only the underlying target genes but also other factors such as individual metabolic capability and presence of resistance-conferring mutations both directly on the target gene and along its cascade(s).Finally, we provide our viewpoints on the future of personalized medicine in lung cancer, including target-based drug combination, mutation-guided drug design and the necessity for data of population genetics, to provide rough guidance on treating patients who are unable to get genetic testing. | Wenxiao Jiang Guiqing Cai Peter C.Hu Yue Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 10 |
| 2 | Effect of RBP4 gene variants on circulating RBP4 concentration and Type?2 diabetes in a Chinese population显示文摘 | C.Hu W.Jia R.Zhang C.Wang J.Lu H.Wu Q.Fang X.Ma K.Xiang | 2008 | Diabetic Medicine2008，，1： | 1 |
| 3 | Three‐day lansoprazole quadruple therapy for Helicobacter pylori‐positive duodenal ulcers: a randomized controlled study显示文摘 | B. C. Y.Wong W. H.Wang W. M.Wong G. K. K.Lau F. M. Y.Fung N. N. S.Kung K. M.Chu K. C.Lai W. H. C.Hu F. L.Hu X. G.Liu C. K.Chan M. F.Yuen W. M.Hui S. K.Lam | 2002 | Alimentary Pharmacology & Therapeutics2002，，： | 1 |
| 4 | 查看详情显示文摘 | C.Hu Y.Jin | | 0，，： | 1 |
| 5 | A validated symptoms questionnaire (Chinese GERDQ) for the diagnosis of gastro‐oesophageal reflux disease in the Chinese population显示文摘 | W. M.Wong K. F.Lam K. C.Lai W. M.Hui W. H. C.Hu C. L. K.Lam N. Y. H.Wong H. H. X.Xia J. Q.Huang A. O. O.Chan S. K.Lam B. C. Y.Wong | 2003 | Alimentary Pharmacology & Therapeutics2003，，： | 1 |
| 6 | Inkjet printing of nanoporous gold electrode arrays on cellulose membranes for high-sensitive paper-like electrochemical oxygen sensors using ionic liquid electrolytes显示文摘 | C.Hu X.Bai Y.Wang W.Jin X.Zhang S.Hu | | 0，，08： | 1 |
| 7 | Effect of RBP4 gene variants on circulating RBP4 concentration and Type?2 diabetes in a Chinese population显示文摘 | C.Hu W.Jia R.Zhang C.Wang J.Lu H.Wu Q.Fang X.Ma K.Xiang | 2008 | Diabetic Medicine2008，，： | 1 |
| 8 | Improvement of A21978C production in Streptomyces roseosporus by reporter‐guided rpsL mutation selection显示文摘 | L.Wang Y.Zhao Q.Liu Y.Huang C.Hu G.Liao | 2012 | Journal of Applied Microbiology2012，，6： | 1 |
| 9 | 科学家们为何造假?显示文摘对于干细胞研究不端行为的最新调查以悲剧告终。 近期最大的科学丑闻之一发生在日本最负盛名的一家研究机构——位于神户的理化学研究所发育生物学中心。过去几个月来,针对两篇有关制造干细胞的简便新方法的论文展开了一项对不端行为的调查。这两篇论文描述了这一被称为“刺激触发获得多能性”的方法,今年1月发表在著名的《自然》杂志上,引发了不小的轰动。 | Jane C.Hu 卢荻 | 2014 | 英语文摘2014，，10： | 0 |
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