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| 1 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | 高速机车现代化转向架设计的发展显示文摘铁路网多曲线的国家对转向架的设计提出了专门的要求,为满足有最好的高速性能和最优的曲线通过性能,必须采用新的解决方法。 SGP交通技术公司在广泛的理论研究(走行技术计算)的基础上为奥地利联邦铁路1014型和1012型电力机车开发了新型转向架,它们有别于其他转向架,轮对用柔性导向和通过机车车体来控制以及有递减特性的轮对横向弹性装置。牵引电动机弹性地横向固定在转向架构架中。有有源横向弹性的新型二系支承具有很好的垂向、横向和抗侧滚性能。 | H.Hdei A.Haigermoser 王渤洪 | 1995 | 大功率变流技术1995，0，Z1： | 7 |
| 3 | 间接竞争酶联免疫吸附法测定黄原胶显示文摘目的建立间接竞争酶联免疫吸附法测定食品中的黄原胶。方法应用黄原胶抗原免疫的绵羊多克隆抗体,采用间接竞争酶联免疫吸附方法,对黄原胶进行检测分析。结果黄原胶的检测限为0.1ng/ml,有效检测区间为0.1~1×103ng/ml。组间及组内差异均小于10%。烧烤酱和凯撒沙拉酱中的黄原胶检测限为50ng/ml,有效检测区间为50~5×103ng/ml。烧烤酱和凯撒沙拉酱中黄原胶回收率分别为72.0%~89.8%和102.6%~119.0%。结论本方法简单、快速、成本低,重现性好,适合检测食品中的黄原胶。 | 秦红梅 黄飚 郑剑玲 JOHN H.H WILLIAMS | 2008 | 中国食品卫生杂志2008，20，3： | 4 |
| 4 | Neoadjuvant treatment for advanced esophageal cancer: response assessment before surgery and how to predict response to chemoradiation before starting treatment显示文摘Patients with advanced esophageal cancer(T3-4, N) have a poor prognosis. Chemoradiation or chemotherapy before esophagectomy with adequate lymphadenectomy is the standard treatment for patients with resectable advanced esophageal carcinoma. However, only patients with major histopathologic response(regression to less than 10% of the primary tumor) after preoperative treatment will have a prognostic benefit of preoperative chemoradiation. Using current therapy regimens about 40% to 50% of the patients show major histopathological response. The remaining cohort does not benefit from this neoadjuvant approach but might benefit from earlier surgical resection. Therefore, it is an aim to develop tools for response prediction before starting the treatment and for early response assessment identifying responders. The current review discusses the different imaging techniques and the most recent studies about molecular markers for early response prediction. The results show that [18F]-fluorodeoxyglucose-positron emission tomography(FDGPET) has a good sensitivity but the specificity is not robust enough for routine clinical use. Newer positron emission tomography detector technology, the combination of FDG-PET with computed tomography, additional evaluation criteria and standardization of evaluation may improve the predictive value. There exist a great number of retrospective studies using molecular markers for prediction of response. Until now the clinical use is missing. But the results of first prospective studies are promising. A future perspective may be the combination of imaging technics and special molecular markers for individualized therapy. Another aspect is the response assessment after finishing neoadjuvant treatment protocol. The different clinical methods are discussed. The results show that until now no non-invasive method is valid enough to assess complete histopathological response. | Elfriede Bollschweiler Arnulf H.Hlscher Matthias Schmidt Ute Warnecke-Eberz | 2015 | Chinese Journal of Cancer Research2015，27，3： | 3 |
| 5 | Train-induced wave propagation in layered soils using finite/infinite element simulation显示文摘 | Y.B Yang H.H Hung D.W Chang | 2003 | Soil Dynamics and Earthquake Engineering2003，，4： | 3 |
| 6 | 瑞士采用欧洲列车控制系统(ETCS)显示文摘瑞士今后以160km/h以上速度运行的新铁路线需采用新的信号和列车安全防护系统,对此选择了欧洲列车控制系统(ETCS)。该系统不但能满足所提出的要求,而且是一种长期经济的和欧洲铁路互用的最佳方法。瑞士整个准轨铁路不久将都要采用ETCS系统。文章扼要介绍瑞士铁路现有的列车安全防护系统SIGNUM和ZUB121的情况,按运营和经济观点介绍由现有系统变更的第2级ETCS,目的是在过渡时期内尽快地取消多重车载装置。 | H.Hanni 王渤洪 | 2004 | 变流技术与电力牵引2004，，3： | 2 |
| 7 | Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomised FAMTX trial 1显示文摘 | H.H Hartgrink C.J.H van de Velde H Putter I Songun M.E.T Tesselaar E.Klein Kranenbarg J.E de Vries J.A Wils J van der Bijl J.H.J.M van Krieken | 2004 | European Journal of Surgical Oncology2004，，6： | 2 |
| 8 | Origin of Polycyclic Aromatic Hydrocarbons (PAHs) in Coastal Marine Sediments: Case Studies in Cotonou (Benin) and Aquitaine (France) Areas显示文摘 | H.H Soclo Ph Garrigues M Ewald | 2000 | Marine Pollution Bulletin2000，，5： | 2 |
| 9 | A modified Al2O3 coating process to enhance the electrochemical performance of Li(Ni1/3Co1/3Mn1/3)O2 and its comparison with traditional Al2O3 coating process显示文摘 | Huang Y.Y Chen J.T Cheng F.Q Wan W Liu W Zhou H.H and Zhang X.X | | 0，，24： | 1 |
| 10 | A summary of European experience with shore nourishment显示文摘 | L Hamm M Capobianco H.H Dette A Lechuga R Spanhoff M.J.F Stive | 2002 | Coastal Engineering2002，，2： | 1 |
| 11 | Pitting formation under rolling contact显示文摘 | C.H Chue H.H Chung | 2000 | Theoretical and Applied Fracture Mechanics2000，，1： | 1 |
| 12 | Model Uncertainty,Limited Market Participation and Asset Prices显示文摘 | Cao H Wang T Zhang H.H | | 0，，18： | 1 |
| 13 | The fracture of particulate-filled epoxide resins显示文摘 | MOLONEY A.C KAUSCH H.H STIEGER H.R | | 0，，04： | 1 |
| 14 | Employee participation in decision making,psychological ownership and knowledge sharing:Mediating role of organizational commitment in Taiwanesc high-tech organizations显示文摘 | Han T.S Chiang H.H Chang A | | 0，，12： | 1 |
| 15 | Adoption of the mobile internet:an empirical study of multime-dia message service(MMS)显示文摘 | Hsu C.L Lu H.P Hsu H.H | | 0，，06： | 1 |
| 16 | A modified ZrO2-coating process to improve electrochemical performace of Li(Ni1/3Co1/3Mn1/3)O2显示文摘 | Huang Y.Y Chen J.T Ni J.F Zhou H.H and Zhang X.X | | 0，，02： | 1 |
| 17 | Surface Lidar Remote Sensing of Basal Area and Biomass in Deciduous Forests of Eastern Maryland, USA显示文摘 | Michael A Lefsky D Harding W.B Cohen G Parker H.H Shugart | 1998 | Remote Sensing of Environment1998，，1： | 1 |
| 18 | Appreciation of metaphoric alternative word meanings by left and right brain damaged patients显示文摘 | Brownell H.H Simpson T.L Bihrle A.M | | 0，，28： | 1 |
| 19 | Predicting intention to adopt interorganizational linkages:an institutional perspective显示文摘 | Teo H.H Wei K.K Benbasat I | | 0，，01： | 1 |
| 20 | Stylish spinsters:Spark,Pyr and the post-war comedy of the object显示文摘 | Hodgkins H.H | | 0，，03： | 1 |
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