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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Independent component analysis applied to self-paced functional MR imaging paradigms显示文摘 | MORITZ C H CA_NEW J D MCMILLAN A B | 2005 | Neurolmage2005，，： | 1 |
| 3 | Serotonin promotes tumor growth in human hepatocellular cancer显示文摘 | SOLL C JANG J H RIENER M O MORITZ W WILD P J GRAF R | 2010 | Hepatology2010，51，： | 1 |
| 4 | A strategy for modeling dynam-ic responses in metabolic samples characterized by GC/MS 显示文摘 | Jonsson P Stenlund H Moritz T | 2006 | Metabolomics2006，2，3： | 1 |
| 5 | Competitive anxiety and cortisol awakening response in the week leading up to a competition显示文摘 | Katharina S Felix E Moritz H | 2010 | Psychology of Sport and Exercise2010，11，2： | 1 |
| 6 | Analysis of Rasinduced oncogenic transformation of NIH3T3 cells using differentialdisplay 2DE proteomics显示文摘 | Ji H Moritz R L Kim Y S | 2007 | Electrophoresis2007，28，12： | 1 |
| 7 | GeodeticReferenceSystem1980显示文摘 | MORITZ H | 1980 | BulletinGeodesique1980，54，3： | 1 |
| 8 | Increase in viscosity and its influence on polymerization processes 显示文摘 | MORITZ H U | 1989 | Chemical Engineering & Technology1989，12，1： | 1 |
| 9 | Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors显示文摘 | Dong Wook Han Natalia Tapia Andreas Hermann Kathrin Hemmer Susanne H?ing Marcos J. Araúzo-Bravo Holm Zaehres Guangming Wu Stefan Frank S?ren Moritz Boris Greber Ji Hun Yang Hoon Taek Lee Jens C. Schwamborn Alexander Storch Hans R. Sch?ler | 2012 | Cell Stem Cell2012，，4： | 1 |
| 10 | A proteome strategy for fractionating proteins and peptides using continuous free-flow electrophoresis coupled off-line to reversed-phase high-performance liquid chromatography显示文摘 | Moritz RL Ji H Schütz F | 2004 | Anal Chem2004，76，16： | 1 |
| 11 | Compliance and formation of distal anastomotic intimal hyperplasia in Dacron mesh tube constricted veins used as arterial bypass grafts 显示文摘 | Trubel W Moritz A Schima H | 1994 | Asaio J1994，40，3： | 1 |
| 12 | Laser induced interstitial thermotherapy 显示文摘 | EYRICH G SAILER H MORITZ M N | 1999 | International Journal of Oral and Maxillofacial Surgery1999，28，1： | 1 |
| 13 | Statistical foundations of collocation显示文摘 | Moritz H | 1980 | Bollettino Di geodesia e scienze affini1980，2，： | 1 |
| 14 | Immunosuppression in pregnancy:choices for infant and maternal health显示文摘 | Armenti V T Moritz M J Cardonick E H | 2002 | Drugs2002，62，16： | 1 |
| 15 | Subclavian steal syndrome : a review显示文摘 | Pollard H Rigby S Moritz G | 1998 | Australas Chimpr Osteopathy1998，7，1： | 1 |
| 16 | Geodetic Reference System 1980显示文摘 | MORITZ H | 2000 | Journal of Geodesy2000，74，1： | 1 |
| 17 | History improves predic- tion of biodiversity in rainforest fauna 显示文摘 | Graham C H Moritz C Williams S E | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，3： | 1 |
| 18 | Fetal hyperglycemia alters lung structural development in neonatal rat显示文摘 | Koskinen A Lukkarinen H Moritz N | 2012 | Pediatr Pulmonol2012，47，3： | 1 |
| 19 | Least squares collocation 显示文摘 | H Moritz | 1978 | Reviews of Geophysics and Space Physics1978，16，： | 1 |
| 20 | Geodetic Reference System 1980显示文摘 | MORITZ H | 2000 | Journal of Geodesy2000，74，1： | 1 |
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