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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | New England Journal of Medicine0，，： | 3 |
| 3 | Evolution of animal mitochondrial:relevance for population biology and systematics 显示文摘 | MORITZ C DOWLING T E BROWN W M | 1987 | Annu Rev Ecol Syst1987，187，： | 2 |
| 4 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | 0，，： | 1 |
| 5 | Human hopping on damped surfaces:Strategies for adjusting leg mechanics显示文摘 | Moritz C Farley C | 2003 | Proceedings of the Royal Society B:Biological Sciences2003，270，1525： | 1 |
| 6 | Independent component analysis applied to self-paced functional MR imaging paradigms显示文摘 | MORITZ C H CA_NEW J D MCMILLAN A B | 2005 | Neurolmage2005，，： | 1 |
| 7 | Imagery use in sport:A literature review and applied model 显示文摘 | Martin K A Moritz S E Hall C R | 1999 | The Sport Psychologist1999，13，24： | 1 |
| 8 | Serotonin promotes tumor growth in human hepatocellular cancer显示文摘 | SOLL C JANG J H RIENER M O MORITZ W WILD P J GRAF R | 2010 | Hepatology2010，51，： | 1 |
| 9 | DNA barcoding will often fail to discover new animal species over broad parameter space显示文摘 | Hickerson MJ Meyer CP Moritz C | 2006 | Syst Biol2006，55，5： | 1 |
| 10 | Nucleotide polymorphisms and an improved PCR-based mtDNA diagnostic for parthenogenetic root-knot nematodes(Meloidogyne spp)显示文摘 | STANTON J HUGALL A MORITZ C | 1997 | Fundamental and Applied Nematology1997，20，30： | 1 |
| 11 | Cytokinin metabolites and gradients in wild type and transgenic tobacco with moderate cytokinin over-production显示文摘 | EKL(O)F S (A)STOT C MORITZ T | 1996 | Physiol Plantarum1996，98，： | 1 |
| 12 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 13 | Phylogenetic analysis and structural predictions ofhumanadenovirus penton proteins asa basis for tissuespecific adenovirus vector design显示文摘 | Madisch I Hofmayer S Moritz C | 2007 | J Virol2007，81，： | 1 |
| 14 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | 0，，02： | 1 |
| 15 | CD8+ T cells reactive to Survivin antigen in patients with multiple myeloma显示文摘 | Grube M Moritz S Obermann E C | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 16 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | 0，，02： | 1 |
| 17 | DNA barcoding: promise and pitfalls 显示文摘 | Moritz C Cicero C | 2004 | PLoS Biol2004，2，10： | 1 |
| 18 | Functional and nutritional characteristics of proteins and lipids recovered by isoelectric processing of fish by- products and low- value fish : a review显示文摘 | Gehring C K Gigliotti J C Moritz J S | 2011 | Food chemistry2011，124，2： | 1 |
| 19 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 20 | Evolution of animal mitochondrial DNA:Relevance for population biology and systematics显示文摘 | MORITZ C DOWLING T E BRORN W M | | Annu Rev Ecol Syst0，18，： | 1 |
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