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158篇 您的检索式:作者名="Libo Liu"
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1Solar activity effects of the ionosphere: A brief review显示文摘Solar radiation, which varies over multiple temporal scales, modulates remarkably the evolution of the ionosphere. The solar activity dependence of the ionosphere is a key and fundamental issue in ionospheric physics, providing information essential to understanding the variations in the ionosphere and its processes. Selected recent studies on solar activity effects of the ionosphere are briefly reviewed in this report. This report focuses on (1) observations of solar irradiance at X-ray and extreme ultraviolet wavelengths and the outstanding problems of solar proxies, in the view of ionospheric studies, (2) new findings and improved representations of the features of the solar activity dependence of ionospheric key parameters and the corresponding physical processes, (3) possible phenomena in the ionosphere under extremely high and low solar activity conditions that are unique, as indicated by historical solar datasets and the deep solar minimum of solar cycle 23/24, and (4) statistical studies and model simulations of the ionosphere response to solar flares. The above-mentioned studies provide new clues for comprehensively explaining basic processes in the ionosphere and improving the prediction capability of ionospheric models and related applications.LIU LiBo WAN WeiXing CHEN YiDing LE HuiJun 2011Chinese Science Bulletin2011,56,12:45
2Synthesis and properties of phosphorus-containing bio-based epoxy resin from itaconic acid显示文摘A phosphorus-containing bio-based epoxy resin(EADI)was synthesized from itaconic acid(IA)and 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide(DOPO).As a matrix,its cured epoxy network with methyl hexahydrophthalic anhydride(MHHPA)as the curing agent showed comparable glass-transition temperature and mechanical properties to diglycidyl ether in a bisphenol A(DGEBA)system as well as good flame retardancy with UL94 V-0 grade during a vertical burning test.As a reactive flame retardant,its flame-resistant effect on DGEBA/MHHPA system as well as its influence on the curing behavior and the thermal and mechanical properties of the modified epoxy resin were investigated.Results showed that after the introduction of EADI,not only were the flame retardancy determined by vertical burning test,LOI measurement,and thermogravimetric analysis significantly improved,but also the curing reactivity,glass transition temperature(T g),initial degradation temperature for 5%weight loss(T d(5%)),and flexural modulus of the cured system improved as well.EADI has great potential to be used as a green flame retardant in epoxy resin systems.MA SongQi LIU XiaoQing JIANG YanHua FAN LiBo FENG JianXiang ZHU Jin 2014Science China Chemistry2014,57,3:33
3NDRG2: a Myc-repressed gene involved in cancer and cell stress显示文摘作为为房间增长和区别的一个主人开关, Myc 主要通过它的目标基因的 transcrip-tional 规定施加它的生物功能,它涉及房间和他们的外部环境的相互作用和通讯。N-Myc 下游地调整的基因(NDRG ) 家庭由 NDRG1, NDRG2, NDRG3 和 NDRG4 组成,它在房间增长和区别是重要的。这评论在结构,组织分发和 NDRG2 的功能上总结最近的研究在学习癌症和它的治疗学的潜力显示出它的意义的那次尝试。Libo Yao Jian Zhang Xuewu Liu 2008Acta Biochimica et Biophysica Sinica2008,40,7:26
4Modeling the global ionospheric total electron content with empirical orthogonal function analysis显示文摘In the present work we model the global ionospheric total electron content (TEC) with the analysis of empirical orthogonal functions (EOF). The obtained statistical eigen modes, which makeup the modeled TEC, consist of two factors: the eigen vectors mapping TEC patterns at latitude and longitude (or local time LT), and the corresponding coefficients displaying the TEC variations in different time scales, i.e., the solar cycle, the yearly (annual and semiannual) and the diurnal universal time variations. It is found that the EOF analysis can separate the TEC variations into chief processes and the first two modes illustrate the most of the ionospheric climate properties. The first mode contains both the semiannual component which shows the semiannual ionospheric anomaly and the annual component which shows the annual or non-seasonal ionospheric anomaly. The second mode contains mainly the annual component and shows the normal seasonal ionospheric variation at most latitudes and local time sectors. The annual component in the second mode also manifests seasonal anomaly of the ionosphere at higher mid-latitudes around noontime. It is concluded that the EOF analysis, as a statistical eigen mode method, is resultful in analyzing the ionospheric climatology hence can be used to construct the empirical model for the ionospheric climatology.WAN WeiXing DING Feng REN ZhiPeng ZHANG ManLian LIU LiBo NING BaiQi 2012Science China(Technological Sciences)2012,55,5:15
5The first time observations of low-latitude ionospheric irregularities by VHF radar in Hainan显示文摘Sanya VHF radar (18.4°N, 109.6°E, dip latitude 12.8°N) at Hainan Island is the first coherent backscatter radar for sounding low-latitude ionospheric irregularities in the mainland of China. In this paper, we present the first results of low-latitude ionospheric E and F region irregularities using the radar data during the period from February 2009 to March 2010. The Doppler velocity of radar echoes from E region field aligned irregularities (FAIs) was about several tens of meters per second, while the Doppler spectral width was appreciably larger than the velocity, and could reach one hundred meters per second, indicating that the observed E region FAIs belonged to type 2 irregularities. The observations of range time intensity (RTI) maps of FAIs showed that E region irregularities most often occurred at night within the altitude range 85-115 km, and were rarely observed at afternoon hours. The percentage occurrence of E region FAIs maximized during spring months (Feb.-May) with a peak value over 80%. The heights at which the strongest echo related FAIs occurred were mainly around 100 km, lower than h'Es and the difference is mostly 10-20 km. December solstice seemed to be the minimum period of occurrence when the FAI echoes were commonly detected at a narrow altitude range 90-100 km. Moreover, simultaneous radar and GPS observations during spread F events in the pre-midnight hours of solar minimum revealed that significant GPS L band scintillations coincided with the appearance of F region plasma plume structures, which extended up to 450 km in altitude.NING BaiQi HU LianHuan LI GuoZhu LIU LiBo WAN WeiXing 2012Science China(Technological Sciences)2012,55,5:15
6Static aeroelastic analysis of very flexible wings based on non-planar vortex lattice method显示文摘A rapid and efficient method for static aeroelastic analysis of a flexible slender wing when considering the structural geometric nonlinearity has been developed in this paper. A non-planar vortex lattice method herein is used to compute the non-planar aerodynamics of flexible wings with large deformation. The finite element method is introduced for structural nonlinear statics analysis. The surface spline method is used for structure/aerodynamics coupling. The static aeroelastic characteristics of the wind tunnel model of a flexible wing are studied by the nonlinear method presented, and the nonlinear method is also evaluated by comparing the results with those obtained from two other methods and the wind tunnel test. The results indicate that the traditional linear method of static aeroelastic analysis is not applicable for cases with large deformation because it produces results that are not realistic. However, the nonlinear methodology, which involves combining the structure finite element method with the non-planar vortex lattice method, could be used to solve the aeroelastic deformation with considerable accuracy, which is in fair agreement with the test results. Moreover, the nonlinear finite element method could consider complex structures. The non-planar vortex lattice method has advantages in both the computational accuracy and efficiency. Consequently, the nonlinear method presented is suitable for the rapid and efficient analysis requirements of engineering practice. It could be used in the preliminary stage and also in the detailed stage of aircraft design.Xie Changchuan Wang Libo Yang Chao Liu Yi 2013Chinese Journal of Aeronautics2013,26,3:13
7Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou 2016Cell Research2016,26,1:12
8Aeroelastic trim and flight loads analysis of flexible aircraft with large deformations显示文摘A method for static aeroelastic trim analysis and flight loads computation of a flexible aircraft with large deformations has been presented in this paper,which considers the geometric nonlinearity of the structure and the nonplanar effects of aerodynamics.A nonplanar vortex lattice method is used to compute the nonplanar aerodynamics.The nonlinear finite element method is introduced to consider the structural geometric nonlinearity.Moreover,the surface spline method is used for structure/aerodynamics coupling.Finally,by combining the equilibrium equations of rigid motions of the deformed aircraft,the nonlinear trim problem of the flexible aircraft is solved by iterative method.For instance,the longitudinal trim analysis of a flexible aircraft with large-aspect-ratio wings is carried out by both the nonlinear method presented and the linear method of MSC Flightloads.Results obtained by these two methods are compared,and it is indicated that the results agree with each other when the deformation is small.However,because the linear method of static aeroelastic analysis does not consider the nonplanar aerodynamic effects or structural geometric nonlinearity,it is not applicable as the deformations increase.Whereas the nonlinear method presented could solve the trim problem accurately,even the deformations are large,which makes the nonlinear method suitable for rapid and efficient analysis in engineering practice.It could be used not only in the preliminary stage but also in the detail stage of aircraft design.YANG Chao WANG LiBo XIE ChangChuan LIU Yi 2012Science China(Technological Sciences)2012,55,10:10
9Efficient Synthesis of Graphene Nanoribbons Sonochemically Cut from Graphene Sheets显示文摘We report a facile approach to synthesize narrow and long graphene nanoribbons (GNRs) by sonochemically cutting chemically derived graphene sheets (GSs). The yield of GNRs can reach ~5 wt% of the starting GSs. The resulting GNRs are several micrometers in length, with ~75% being single-layer, and ~40% being narrower than 20 nm in width. A chemical tailoring mechanism involving oxygen-unzipping of GSs under sonochemical conditions is proposed on the basis of experimental observations and previously reported theoretical calculations;it is suggested that the formation and distribution of line faults on graphite oxide and GSs play crucial roles in the formation of GNRs. These results open up the possibilities of the large-scale synthesis and various technological applications of GNRs.Zhong-Shuai Wu Wencai Ren Libo Gao Bilu Liu Jinping Zhao Hui-Ming Cheng 2010Nano Research2010,3,1:10
10Carbon dioxide adsorption of two-dimensional carbide MXenes显示文摘Two-dimensional carbide MXenes(Ti_3C_2T_x and V_2CT_x)were prepared by exfoliating MAX phases(Ti_3AlC_2 and V_2AlC)powders in the solution of sodium fluoride(NaF)and hydrochloric acid(HCl).The specific surface area(SSA)of as-prepared Ti_3C_2T_x was 21 m^2/g,and that of V_2CT_x was 9 m^2/g.After intercalation with dimethylsulfoxide,the SSA of Ti_3C_2T_x was increased to 66 m^2/g;that of V_2CT_x was increased to 19 m^2/g.Their adsorption properties on carbon dioxide(CO_2)were investigated under 0–4 MPa at room temperature(298 K).Intercalated Ti_3C_2T_x had the adsorption capacity of 5.79 mmol/g,which is close to the capacity of many common sorbents.The theoretical capacity of Ti_3C_2T_x with the SSA of 496 m^2/g was up to 44.2 mmol/g.Additionally,due to high pack density,MXenes had very high volume-uptake capacity.The capacity of intercalated Ti_3C_2T_(x )measured in this paper was 502 V·v^(–1).This value is already higher than volume capacity of most known sorbents.These results suggest that MXenes have some advantage features to be researched as novel CO_2 capture materials.Bingxin WANG Aiguo ZHOU Fanfan LIU Jianliang CAO Libo WANG Qianku HU 2018Journal of Advanced Ceramics2018,7,3:9
11Meteor radar observation of circulation near mesopause over Wuhan显示文摘The Wuhan meteor radar is the first all-sky meteor radar in China. The circulation near the mesopause from February to September 2002 is studied based on the data obtained by the Wuhan meteor radar. The zonal wind is usually eastward in winter from 80 to 100 km. The mean zonal wind become westward from March to early of May, when the winter circulation reverses to the summer circulation. But at the meteor heights, the zonal circulation usually becomes eastward after the middle of May. The meridional circulation is always equatorward. The peaks of the meridional wind move downward with the height, and the peak value reaches its maximum of 21 ms-1 in July. Having made a comparison between monthly mean wind and HWM93 model wind, the value of southward wind, the maximal value of eastward wind as well as the reversal height of zonal wind are found to be quite different from each other.XIONG Jiangang, WAN Weixin, NING Baiqi & LIU Libo Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China Correspondence should be addressed to Xiong Jiangang (e-mail: xjg@wipm.ac.cn) 2003Chinese Science Bulletin2003,48,15:8
12Actively priming autophagic cell death with novel transferrin receptor-targeted nanomedicine for synergistic chemotherapy against breast cancer显示文摘Recently, considerable attention in the field of cancer therapy has been focused on the mammalian rapamycin target(m TOR), inhibition of which could result in autophagic cell death(ACD). Though novel combination chemotherapy of autophagy inducers with chemotherapeutic agents is extensively investigated, nanomedicine-based combination therapy for ACD remains in infancy. In attempt to actively trigger ACD for synergistic chemotherapy, here we incorporated autophagy inducer rapamycin(RAP) into 7 pep-modified PEG-DSPE polymer micelles(7 pep-M-RAP) to specifically target and efficiently priming ACD of MCF-7 human breast cancer cells with high expression of transferrin receptor(Tf R). Cytotoxic paclitaxel(PTX)-loaded micelle(7 pep-M-PTX) was regarded as chemotherapeutic drug model. We discovered that with superior intracellular uptake in vitro and more tumor accumulation of micelles in vivo, 7 pep-M-RAP exhibited excellent autophagy induction and synergistic antitumor efficacy with 7 pep-M-PTX. Mechanism study further revealed that 7 pep-M-RAP and 7 pep-MPTX used in combination provided enhanced efficacy through induction of both apoptosis-and mitochondria-associated autophagic cell death. Together, our findings suggested that the targeted excess autophagy may provide a rational strategy to improve therapeutic outcome of breast cancer, and simultaneous induction of ACD and apoptosis may be a promising anticancer modality.Dong Mei Binlong Chen Bing He Haibin Liu Zhiqiang Lin Jialiang Lin Xiaoyan Zhang Ning Sun Libo Zhao Xiaoling Wang Qiang Zhang 2019Acta Pharmaceutica Sinica B2019,9,5:8
13Angiosperm phylogeny inferred from sequences of four mitochondrial genes显示文摘An angiosperm phylogeny was reconstructed in a maximum likelihood analysis of sequences of four mitochondrial genes,atp1,matR,nad5,and rps3,from 380 species that represent 376 genera and 296 families of seed plants.It is largely congruent with the phylogeny of angiosperms reconstructed from chloroplast genes atpB,matK,and rbcL,and nuclear 18S rDNA.The basalmost lineage consists of Amborella and Nymphaeales(including Hydatellaceae).Austrobaileyales follow this clade and are sister to the mesangiosperms,which include Chloranthaceae,Ceratophyllum,magnoliids,monocots,and eudicots.With the exception of Chloranthaceae being sister to Ceratophyllum,relationships among these five lineages are not well supported.In eudicots,Ranunculales,Sabiales,Proteales,Trochodendrales,Buxales,Gunnerales,Saxifragales,Vitales,Berberidopsidales,and Dilleniales form a basal grade of lines that diverged before the diversification of rosids and asterids.Within rosids,the COM(Celastrales-Oxalidales-Malpighiales) clade is sister to malvids(or rosid II),instead of to the nitrogen-fixing clade as found in all previous large-scale molecular analyses of angiosperms.Santalales and Caryophyllales are members of an expanded asterid clade.This study shows that the mitochondrial genes are informative markers for resolving relationships among genera,families,or higher rank taxa across angiosperms.The low substitution rates and low homoplasy levels of the mitochondrial genes relative to the chloroplast genes,as found in this study,make them particularly useful for reconstructing ancient phylogenetic relationships.A mitochondrial gene-based angiosperm phylogeny provides an independent and essential reference for comparison with hypotheses of angiosperm phylogeny based on chloroplast genes,nuclear genes,and non-molecular data to reconstruct the underlying organismal phylogeny.Yin-Long QIU Libo LI Bin WANG Jia-Yu XUE Tory A. HENDRY Rui-Qi LI Joseph W. BROWN Yang LIU Geordan T. HUDSON Zhi-Duan CHEN 2010Journal of Systematics and Evolution2010,48,6:8
14A theoretical model for mid-and low-latitude ionospheric electric fields in realistic geomagnetic fields显示文摘The geomagnetic fields,which play important roles in the ionospheric dynamo,can greatly affect the global distribution of ionospheric electric fields,currents and other ionospheric electrodynamics phenomena.In the study of ionospheric electrodynamics phenomena,such as the longitudinal variations of ionospheric electric fields,the non-dipolar component of the geomagnetic fields must be taken into account.In this paper,we deduce a theoretical electric field model for ionospheric dynamo at mid-and low-latitude which adopt a modified magnetic apex coordinates system.In the new electric field model,the geomagnetic fields can be calculated from either the IGRF model or the dipole field model,and the neutral winds and conductivities are calculated based on empirical models.Then the dynamo equation for the electric potential is finally solved in terms of the line-by-line iteration method,and the ionospheric electric fields and currents are derived from the calculated potential.Our model can reproduce the main features of the ionospheric electrodynamics processes,so it will be a useful tool for the investigation of the upper atmosphere and ionosphere.REN ZhiPeng WAN WeiXing WEI Yong LIU LiBo YU Tao 2008Chinese Science Bulletin2008,53,24:7
15Characterization and Apparent Kinetics of Polymerization of 1-Decene Catalyzed by Boron Trifluoride/Alcohol System显示文摘Poly-α-olefin(PAO) synthetic oil is the base oil of high-quality lubricants, and has a huge market potential.We illustrate PAO synthesis by catalytic polymerization of 1-decene with a boron trifluoride(BF_3)/alcohol system. Gas chromatography–mass spectrometry, proton nuclear magnetic resonance and ^(13) C nuclear magnetic resonance analysis confirmed dimer, trimer and tetramer structures of PAO. Each component contained branched chains with a 1,2 insertion of a head-to-tail link; a 2,1 insertion of a tail-to-tail link and a methyl-containing linked structure. At a low conversion rate, the reaction rate was related directly with the reaction temperature and the catalyst/1-decene concentration. An apparent kinetic equation for PAO formation was determined during 1-decene polymerization.Wang Sihan Wang Libo Liu Tong Ma Lili Huo Hongliang Wang Jian 2017China Petroleum Processing & Petrochemical Technology2017,19,3:7
16Development of a middle and low latitude theoretical ionospheric model and an observation system data assimilation experiment显示文摘On the basis of previous work, we develop a middle and low latitude theoretical ionospheric model in this paper, named Theoretical Ionospheric Model of the Earth in the Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME-IGGCAS). TIME-IGGCAS solves the equations of mass continuity, motion and energy of electron and ions self-consistently and uses an eccentric dipole field approxima-tion to the Earth’s magnetic field. We combine the Eulerian and Lagrangian approaches in the model and take account of the plasma E×B drift velocity. Calculation results reveal that the model is steady and credible and can reproduce most large-scale features of ionosphere. By using TIME-IGGCAS, we carried out an observation system data assimilation experiment. Assimilation results show that the E×B drift velocity can be accurately estimated by ingesting the observed foF2 and hmF2 into the model ap-plying nonlinear least-square fit method. We suggest that this work is of great significance in the de-velopment of ionospheric data assimilation model to give better nowcast and forecast of ionosphere.YUE XinAn WAN WeiXing LIU LiBo LE HuiJun CHEN YiDing YU Tao 2008Chinese Science Bulletin2008,53,1:7
17First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2].ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma 2020Science China(Physics,Mechanics & Astronomy)2020,63,10:6
18Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC.YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang 2019Signal Transduction and Targeted Therapy2019,4,1:6
19Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou 2017Cell Research2017,27,9:6
20Measurements and thermodynamic modeling of liquid–liquid equilibria in ternary system 2-methoxy-2-methylpropane+p-cresol+water显示文摘Liquid–liquid equilibrium(LLE)data for the ternary system 2-methoxy-2-methylpropane(methyl tert-butyl ether)+ p-cresol + water was measured at atmospheric pressure and temperatures of 298.15 K and 313.15 K.From the distribution coefficients and selectivity,it was found that 2-methoxy-2-methylpropane is an efficient solvent to extract p-cresol from wastewater.The consistency of the experimental tie-line data was verified with the Hand and Bachman equations.These data were also correlated with the non-random two liquid(NRTL)and universal quasi-chemical correlation activity coefficient(UNIQUAC)models to yield binary interaction parameters for p-cresol extraction process evaluation.Both models agreed with experiments very well,yet the NRTL model showed even smaller average deviation than the UNIQUAC model.Liejin Luo Dong Liu Libo Li Yun Chen 2016Chinese Journal of Chemical Engineering2016,24,3:5
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